DE60123643D1 - Benzimidazolonderivate mit affinität zu serotonin- und dopaminrezeptoren - Google Patents
Benzimidazolonderivate mit affinität zu serotonin- und dopaminrezeptorenInfo
- Publication number
- DE60123643D1 DE60123643D1 DE60123643T DE60123643T DE60123643D1 DE 60123643 D1 DE60123643 D1 DE 60123643D1 DE 60123643 T DE60123643 T DE 60123643T DE 60123643 T DE60123643 T DE 60123643T DE 60123643 D1 DE60123643 D1 DE 60123643D1
- Authority
- DE
- Germany
- Prior art keywords
- derivatives
- benzimidazolon
- serotonin
- affinity
- dopamine receptors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00830625 | 2000-09-19 | ||
EP00830625 | 2000-09-19 | ||
PCT/EP2001/010465 WO2002024662A1 (en) | 2000-09-19 | 2001-09-11 | New benzimidazolone derivatives displaying affinity at the serotonin and dopamine receptors |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60123643D1 true DE60123643D1 (de) | 2006-11-16 |
DE60123643T2 DE60123643T2 (de) | 2007-08-16 |
Family
ID=8175484
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60123643T Expired - Lifetime DE60123643T2 (de) | 2000-09-19 | 2001-09-11 | Benzimidazolonderivate mit affinität zu serotonin- und dopaminrezeptoren |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP1322621B1 (de) |
JP (1) | JP5062939B2 (de) |
AT (1) | ATE341538T1 (de) |
AU (1) | AU2001293804A1 (de) |
CA (1) | CA2417082C (de) |
DE (1) | DE60123643T2 (de) |
ES (1) | ES2273891T3 (de) |
MX (1) | MXPA03002329A (de) |
WO (1) | WO2002024662A1 (de) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7183410B2 (en) | 2001-08-02 | 2007-02-27 | Bidachem S.P.A. | Stable polymorph of flibanserin |
US6951849B2 (en) | 2001-10-02 | 2005-10-04 | Acadia Pharmaceuticals Inc. | Benzimidazolidinone derivatives as muscarinic agents |
RU2288919C2 (ru) | 2001-10-02 | 2006-12-10 | Акадиа Фармасьютикалз, Инк. | Производные бензимидазолидинона в качестве агентов мускариновых рецепторов |
UA78974C2 (en) | 2001-10-20 | 2007-05-10 | Boehringer Ingelheim Pharma | Use of flibanserin for treating disorders of sexual desire |
US10675280B2 (en) | 2001-10-20 | 2020-06-09 | Sprout Pharmaceuticals, Inc. | Treating sexual desire disorders with flibanserin |
PL1912650T3 (pl) | 2005-08-03 | 2018-01-31 | Sprout Pharmaceuticals Inc | Zastosowanie flibanseryny w leczeniu otyłości |
CA2626134C (en) | 2005-10-29 | 2013-12-24 | Boehringer Ingelheim International Gmbh | Benzimidazolone derivatives for the treatment of premenstrual and other female sexual disorders |
EP2024364A1 (de) * | 2006-05-26 | 2009-02-18 | Neuromed Pharmaceuticals, Ltd. | Heterocyclische verbindungen als calciumkanalblocker |
JP2009541443A (ja) | 2006-06-30 | 2009-11-26 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 尿失禁及び関連疾患の治療のためのフリバンセリン |
JP5793828B2 (ja) | 2006-08-14 | 2015-10-14 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | フリバンセリンの製剤及びその製造方法 |
EP2056797A2 (de) | 2006-08-25 | 2009-05-13 | Boehringer Ingelheim International GmbH | System mit kontrollierter freisetzung und verfahren zu seiner herstellung |
JP5514716B2 (ja) | 2007-05-11 | 2014-06-04 | コリア・リサーチ・インスティテュート・オブ・ケミカル・テクノロジー | アリールピペリジン置換基を有するイミダゾール誘導体、その製造方法及びこれを含む医薬組成物 |
KR100871077B1 (ko) | 2007-05-11 | 2008-11-28 | 한국화학연구원 | 아릴 피페리딘기-함유 이미다졸 유도체, 이의 제조방법 및이를 유효성분으로 포함하는 약학적 조성물 |
CL2008002693A1 (es) | 2007-09-12 | 2009-10-16 | Boehringer Ingelheim Int | Uso de flibanserina para el tratamiento de sintomas vasomotores seleccionados de sofocos, sudores nocturnos, cambios de estado de animo e irritabilidad |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2675800A1 (fr) * | 1991-04-26 | 1992-10-30 | Rhone Poulenc Rorer Sa | Derives heterocycliques antiserotonines leur preparation et les medicaments les contenant. |
IT1251144B (it) * | 1991-07-30 | 1995-05-04 | Boehringer Ingelheim Italia | Derivati del benzimidazolone |
WO1995034555A1 (en) * | 1994-06-14 | 1995-12-21 | Pfizer Inc. | Benzimidazolone derivatives with central dopaminergic activity |
ATE247114T1 (de) * | 1994-09-12 | 2003-08-15 | Lilly Co Eli | Serotonergische modulatoren |
-
2001
- 2001-09-11 MX MXPA03002329A patent/MXPA03002329A/es active IP Right Grant
- 2001-09-11 CA CA002417082A patent/CA2417082C/en not_active Expired - Fee Related
- 2001-09-11 DE DE60123643T patent/DE60123643T2/de not_active Expired - Lifetime
- 2001-09-11 AU AU2001293804A patent/AU2001293804A1/en not_active Abandoned
- 2001-09-11 ES ES01974239T patent/ES2273891T3/es not_active Expired - Lifetime
- 2001-09-11 WO PCT/EP2001/010465 patent/WO2002024662A1/en active IP Right Grant
- 2001-09-11 AT AT01974239T patent/ATE341538T1/de active
- 2001-09-11 JP JP2002529073A patent/JP5062939B2/ja not_active Expired - Fee Related
- 2001-09-11 EP EP01974239A patent/EP1322621B1/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
AU2001293804A1 (en) | 2002-04-02 |
ATE341538T1 (de) | 2006-10-15 |
ES2273891T3 (es) | 2007-05-16 |
EP1322621A1 (de) | 2003-07-02 |
MXPA03002329A (es) | 2003-10-15 |
CA2417082C (en) | 2009-11-17 |
CA2417082A1 (en) | 2002-03-28 |
EP1322621B1 (de) | 2006-10-04 |
DE60123643T2 (de) | 2007-08-16 |
JP5062939B2 (ja) | 2012-10-31 |
JP2004509873A (ja) | 2004-04-02 |
WO2002024662A1 (en) | 2002-03-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE60123643D1 (de) | Benzimidazolonderivate mit affinität zu serotonin- und dopaminrezeptoren | |
AR004516A1 (es) | Derivados de pirimidina, su uso, procedimientos para prepararlos y medicamentos que los contienen | |
ATE245636T1 (de) | Benzofurylpiperazine: 5-ht2c serotoninrezeptor agonisten | |
CY1105688T1 (el) | Κυανοπυρρολες ως αγωνιστες υποδοχεων προγεστερονης | |
BR0115436A (pt) | Compostos de piperazinilpirazina atuando como antagonistas do receptor 5ht-2 de serotonina | |
TR200201004T2 (tr) | Monoamin reuptake önleyicileri olarak biaril eter türevleri | |
DE69105839T2 (de) | Neue Indolderivate. | |
NO20026253D0 (no) | Organiske forbindelser | |
TR200100659T2 (tr) | 5-HT2C agonistleri olarak piroloindoller, piridoindoller ve azepinoindoller. | |
ATE247639T1 (de) | Arylsubstituierte cyclische amine als selektive dopamin-d3-liganden | |
ATE175661T1 (de) | Benzamid-derivate als vasopressin-antagonisten | |
PE74899A1 (es) | Derivados de ergolina | |
DK1189900T3 (da) | Heterocykliske aminopyrrolidinderivater som melatonerge lægemidler | |
BR9908321A (pt) | Composto | |
DE60014339D1 (de) | Aryl- und heteroaryl-kondensierte aminoalkyl-imidazol-derivate: selektive modulatoren der gabaa-rezeptoren | |
IS6426A (is) | Píperasínómetýlbensamíð sem delta-ópíóíðviðtakagerandefni | |
ES2122253T3 (es) | Derivados (arilalcoxibencil)aminopropanamidicos sustituidos, su preparacion y su utilizacion como agentes antiepilepticos, neuroprotectores y antidepresivos. | |
FI842500A (fi) | Foerfarande foer framstaellning av -karbolinderivat. | |
DE69109132D1 (de) | Indanderivate. | |
HUP9904294A2 (hu) | Topiramát származékok alkalmazása neuropátiás fájdalom kezelésére alkalmas gyógyszer előállítására | |
FR2801585B1 (fr) | Nouveaux antagonistes des recepteurs de l'ii-8 | |
HUP0004565A2 (hu) | Szubsztituált krománszármazékok, intermedierjeik és azokat tartalmazó gyógyszerkészítmények | |
HUP0103358A2 (hu) | N-Szubsztituált aza-bicikloheptán-származékok, előállításuk és alkalmazásuk | |
HUP9800889A1 (hu) | Új naftil-piperazin-származékok | |
ES2162731B1 (es) | Nuevas arilpiperacilnilalquil-3(2h)-piridacinonas. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |