ECSP045121A - Agonistas del receptor activado por proliferador de peroxisoma - Google Patents

Agonistas del receptor activado por proliferador de peroxisoma

Info

Publication number
ECSP045121A
ECSP045121A EC2004005121A ECSP045121A ECSP045121A EC SP045121 A ECSP045121 A EC SP045121A EC 2004005121 A EC2004005121 A EC 2004005121A EC SP045121 A ECSP045121 A EC SP045121A EC SP045121 A ECSP045121 A EC SP045121A
Authority
EC
Ecuador
Prior art keywords
alkyl
group
substituted
optionally
heteroaryl
Prior art date
Application number
EC2004005121A
Other languages
English (en)
Inventor
Tracey Ann Gibson
Richard Duane Johnston
Nathan Bryan Mantlo
Richard Craig Thompson
Leonard Larry Winneroski
Yanping Xu
Xiaodong Wang
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of ECSP045121A publication Critical patent/ECSP045121A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F210/00—Copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond
    • C08F210/16—Copolymers of ethene with alpha-alkenes, e.g. EP rubbers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F4/00—Polymerisation catalysts
    • C08F4/42—Metals; Metal hydrides; Metallo-organic compounds; Use thereof as catalyst precursors
    • C08F4/44—Metals; Metal hydrides; Metallo-organic compounds; Use thereof as catalyst precursors selected from light metals, zinc, cadmium, mercury, copper, silver, gold, boron, gallium, indium, thallium, rare earths or actinides
    • C08F4/60—Metals; Metal hydrides; Metallo-organic compounds; Use thereof as catalyst precursors selected from light metals, zinc, cadmium, mercury, copper, silver, gold, boron, gallium, indium, thallium, rare earths or actinides together with refractory metals, iron group metals, platinum group metals, manganese, rhenium technetium or compounds thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J37/00—Processes, in general, for preparing catalysts; Processes, in general, for activation of catalysts
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F10/00—Homopolymers and copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F10/00—Homopolymers and copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond
    • C08F10/02—Ethene
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F4/00—Polymerisation catalysts
    • C08F4/02—Carriers therefor
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F4/00—Polymerisation catalysts
    • C08F4/42—Metals; Metal hydrides; Metallo-organic compounds; Use thereof as catalyst precursors
    • C08F4/44—Metals; Metal hydrides; Metallo-organic compounds; Use thereof as catalyst precursors selected from light metals, zinc, cadmium, mercury, copper, silver, gold, boron, gallium, indium, thallium, rare earths or actinides
    • C08F4/60—Metals; Metal hydrides; Metallo-organic compounds; Use thereof as catalyst precursors selected from light metals, zinc, cadmium, mercury, copper, silver, gold, boron, gallium, indium, thallium, rare earths or actinides together with refractory metals, iron group metals, platinum group metals, manganese, rhenium technetium or compounds thereof
    • C08F4/62—Refractory metals or compounds thereof
    • C08F4/64—Titanium, zirconium, hafnium or compounds thereof
    • C08F4/659—Component covered by group C08F4/64 containing a transition metal-carbon bond
    • C08F4/65912—Component covered by group C08F4/64 containing a transition metal-carbon bond in combination with an organoaluminium compound
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F4/00—Polymerisation catalysts
    • C08F4/42—Metals; Metal hydrides; Metallo-organic compounds; Use thereof as catalyst precursors
    • C08F4/44—Metals; Metal hydrides; Metallo-organic compounds; Use thereof as catalyst precursors selected from light metals, zinc, cadmium, mercury, copper, silver, gold, boron, gallium, indium, thallium, rare earths or actinides
    • C08F4/60—Metals; Metal hydrides; Metallo-organic compounds; Use thereof as catalyst precursors selected from light metals, zinc, cadmium, mercury, copper, silver, gold, boron, gallium, indium, thallium, rare earths or actinides together with refractory metals, iron group metals, platinum group metals, manganese, rhenium technetium or compounds thereof
    • C08F4/62—Refractory metals or compounds thereof
    • C08F4/64—Titanium, zirconium, hafnium or compounds thereof
    • C08F4/659—Component covered by group C08F4/64 containing a transition metal-carbon bond
    • C08F4/65916—Component covered by group C08F4/64 containing a transition metal-carbon bond supported on a carrier, e.g. silica, MgCl2, polymer
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F4/00—Polymerisation catalysts
    • C08F4/42—Metals; Metal hydrides; Metallo-organic compounds; Use thereof as catalyst precursors
    • C08F4/44—Metals; Metal hydrides; Metallo-organic compounds; Use thereof as catalyst precursors selected from light metals, zinc, cadmium, mercury, copper, silver, gold, boron, gallium, indium, thallium, rare earths or actinides
    • C08F4/60—Metals; Metal hydrides; Metallo-organic compounds; Use thereof as catalyst precursors selected from light metals, zinc, cadmium, mercury, copper, silver, gold, boron, gallium, indium, thallium, rare earths or actinides together with refractory metals, iron group metals, platinum group metals, manganese, rhenium technetium or compounds thereof
    • C08F4/62—Refractory metals or compounds thereof
    • C08F4/64—Titanium, zirconium, hafnium or compounds thereof
    • C08F4/659—Component covered by group C08F4/64 containing a transition metal-carbon bond
    • C08F4/6592—Component covered by group C08F4/64 containing a transition metal-carbon bond containing at least one cyclopentadienyl ring, condensed or not, e.g. an indenyl or a fluorenyl ring
    • C08F4/65922—Component covered by group C08F4/64 containing a transition metal-carbon bond containing at least one cyclopentadienyl ring, condensed or not, e.g. an indenyl or a fluorenyl ring containing at least two cyclopentadienyl rings, fused or not
    • C08F4/65925—Component covered by group C08F4/64 containing a transition metal-carbon bond containing at least one cyclopentadienyl ring, condensed or not, e.g. an indenyl or a fluorenyl ring containing at least two cyclopentadienyl rings, fused or not two cyclopentadienyl rings being mutually non-bridged

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se refiere a compuestos representados por la siguiente fórmula estructural y sales, solvatos e hidratos farmacéuticamente aceptables de los mismos, en la que: (a) R1 se selecciona entre el grupo compuesto por hidrógeno, un grupo sustituido o no sustituido seleccionado entre alquilo C1-C8, aril-alquilo C0-4, heteroaril-alquilo C0-4, cicloalquilaril C3-C6-alquilo C0-2, y -CH2-C(O)-R17-R18, donde R17 es O, o NH y R18 es bencilo opcionalmente sustituido; (b) R2 es H o un grupo sustituido o no sustituido seleccionado entre el grupo compuesto por alquilo C1-C6, alquenilo C1-C6, aril-alquilo C0-4, heteroaril-alquilo C0-4, alquil C1-C4 sulfonamida, alquil C1-C4 amida, OR10 y cicloalquilo C3-C6; (c) W es O, o S; (d) X es un engarce alquileno C1-C5 opcionalmente sustituido donde un átomo de carbono del engarce se puede sustituir opcionalmente con O, NH, S y opcionalmente dos carbonos juntos pueden formar un doble enlace; (e) Y se selecciona entre el grupo compuesto por C, O, S, NH y un enlace simple; y (f) E se selecciona entre el grupo compuesto por C(R3)(R4)A, A y un grupo sustituido o no sustituido seleccionado entre el grupo compuesto por (CH2)nCOOR19.
EC2004005121A 2001-11-30 2004-05-26 Agonistas del receptor activado por proliferador de peroxisoma ECSP045121A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US33445601P 2001-11-30 2001-11-30

Publications (1)

Publication Number Publication Date
ECSP045121A true ECSP045121A (es) 2004-07-23

Family

ID=23307289

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2004005121A ECSP045121A (es) 2001-11-30 2004-05-26 Agonistas del receptor activado por proliferador de peroxisoma

Country Status (12)

Country Link
US (1) US20050003950A1 (es)
EP (1) EP1461151A4 (es)
JP (1) JP2005511802A (es)
KR (1) KR20050033542A (es)
CN (2) CN100584462C (es)
AR (1) AR036903A1 (es)
AU (1) AU2002365867A1 (es)
BR (1) BR0214554A (es)
CA (1) CA2465570A1 (es)
EC (1) ECSP045121A (es)
TW (1) TWI242568B (es)
WO (1) WO2003047752A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003233649B2 (en) * 2002-06-03 2006-04-13 Univation Technologies, Llc Solid, particulated, spray dried, heterogenous catalyst composition
CN1328310C (zh) * 2004-11-05 2007-07-25 中国科学院化学研究所 聚烯烃复合材料及其制备方法
KR101075404B1 (ko) 2004-12-17 2011-10-24 양지 페트로케미컬 컴퍼니 코., 리미티드. 지지된 비메탈로센 올레핀 중합 촉매, 제조 방법 및 그용도
US7323526B2 (en) * 2005-07-29 2008-01-29 Univation Technologies, Llc Supported metallocene-alkyl catalyst composition
JP5480148B2 (ja) 2007-10-16 2014-04-23 中国石化揚子石油化工有限公司 マグネシウム化合物担持非メタロセン触媒およびその製造
KR101207294B1 (ko) 2007-10-16 2012-12-03 시노펙 양지 페트로케미컬 컴퍼니 엘티디. 담지된 비-메탈로센 촉매 및 이의 제조방법
EP2196480A1 (en) 2008-12-15 2010-06-16 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Supported catalyst
CN104448066B (zh) 2014-12-16 2017-07-07 华东理工大学 一种负载型多金属烯烃聚合催化剂及其制备方法与应用
MX2017016934A (es) 2015-07-08 2018-04-10 Chevron Phillips Chemical Co Lp Sistemas de catalizadores duales de metaloceno y ziegler-natta con soportes activadores.
US9540457B1 (en) 2015-09-24 2017-01-10 Chevron Phillips Chemical Company Lp Ziegler-natta—metallocene dual catalyst systems with activator-supports
US11008412B2 (en) * 2016-09-29 2021-05-18 Dow Global Technologies Llc Method of polymerizing an olefin
EP3631440B1 (en) * 2017-06-02 2023-02-22 Univation Technologies, LLC Method of determining a relative decrease in catalytic efficacy of a catalyst in a catalyst solution
US11618791B2 (en) * 2019-11-26 2023-04-04 Exxonmobil Chemical Patents Inc. Systems and methods for producing a supported catalyst

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Also Published As

Publication number Publication date
WO2003047752A1 (en) 2003-06-12
CN1625440A (zh) 2005-06-08
KR20050033542A (ko) 2005-04-12
EP1461151A1 (en) 2004-09-29
BR0214554A (pt) 2004-11-09
JP2005511802A (ja) 2005-04-28
EP1461151A4 (en) 2010-03-24
CN101062959A (zh) 2007-10-31
US20050003950A1 (en) 2005-01-06
AU2002365867A1 (en) 2003-06-17
TWI242568B (en) 2005-11-01
AR036903A1 (es) 2004-10-13
CA2465570A1 (en) 2003-06-12
CN100584462C (zh) 2010-01-27

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