JPH08507498A - 複素環式化合物、それらの使用および製法 - Google Patents
複素環式化合物、それらの使用および製法Info
- Publication number
- JPH08507498A JPH08507498A JP6519470A JP51947094A JPH08507498A JP H08507498 A JPH08507498 A JP H08507498A JP 6519470 A JP6519470 A JP 6519470A JP 51947094 A JP51947094 A JP 51947094A JP H08507498 A JPH08507498 A JP H08507498A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- methyl
- benzazepine
- tetrahydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/32—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems containing carbocyclic rings other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Rheumatology (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.次の一般式I: (式中、Aはα−およびβ−表示炭素原子と一緒になってシクロぺンテン、シク ロヘキセン、フラン、ジヒドロフラン、ピラン、ジヒドロピラン、チオフェン、 オキサゾール、ピロール、ピロリン、テトラヒドロピリジン又はジオキソール環 であり、 R1は水素、又はC1-6アルキルであり、R2およびR3は独立に水素、C1-6ア ルコキシ、ハロゲン、ニトロ、シアノ、又はヒドロキシであるか、又はR2とR3 は一緒になってフラン、ジヒドロフラン、シクロペンテン又はジオキソール環を 形成し、 R4は水素、C1-6アルコキシ、ニトロ、シアノ、ヒドロキシ、又はハロゲンで ある) で表わされる三環式2,3,4,5−テトラヒドロ−1H−3−ベンゾアゼピ ン又はその医薬として許容し得る塩。 2.R1がメチルである、請求の範囲第1項記載の化合物。 3.6−(ベンゾフラン−7−イル)−8−メチル−7,8,9,10−テトラ ヒドロ−6H−フロ〔2,3−g〕〔3〕ベンゾアゼピン、 6−(2,3−ジヒドロベンゾフラン−7−イル)−8−メチル− 2,3,7,8,9,10−ヘキサヒドロ−6H−フロ〔2,3−g〕〔3〕ベン ゾアゼピン、 5−(ベンゾフラン−7−イル)−3−メチル−1,2,3,4,5,8,9, 10−オクタヒドロインデノ〔4,5−d〕アゼピン、6−(ベンゾフラン−7− イル)−8−メチル−7,8,9,10−テトラヒドロ−6H−チエノ〔2,3− g〕〔3〕ベンゾアゼピン、 1−(2,3−ジヒドロベンゾフラン−7−イル)−6,7−メチレンジオキシ −3−メチル−2,3,4,5−テトラヒドロ−1H−3−ベンゾアゼピン、 3−メチル−5−フェニル−1,2,3,4,5,8,9,10,−オクタヒドロ インデノ〔4,5−d〕アゼピン、 3−メチル−5−フェニル−2,3,4,5,8,9,10,11−オクタヒドロ− 1H−ナフト〔1,2−d〕アゼピン、 8−メチル−6−フェニル−7,8,9,10−テトラヒドロ−6H−オキサゾロ 〔4,5−g〕〔3〕ベンゾアゼピン。 である、請求の範囲第1項記載の化合物。 4.請求の範囲第1〜3項のいずれか1項に記載の化合物又はその医薬として 許容し得る塩並びに医薬として許容し得る担体又は希釈剤を含んでなる医薬組成 物。 5.請求の範囲第1〜3項のいずれか1項に記載の化合物および医薬として許 容し得る担体又は希釈剤を含んでなる、中枢神経系疾患の治療において使用に適 する医薬組成物。 6. 0.1−100mgの活性化合物を含有する経口用量形態にある、請求の範囲第 4又は5項記載の医薬組成物。 7.中枢神経系疾患に関した症状の治療のための医薬組成物を製造するための 請求の範囲第1〜3項のいずれか1項に記載の化合物 の使用。 8.中枢神経系疾患の治療を必要とするヒトにおける中枢神経系疾患の治療方 法であって、該疾患の軽減に有効な量の請求の範囲第1〜3項のいずれか1項に 記載の化合物を該ヒトに投与する前記方法。 9.中枢神経系疾患の治療を必要とする被験者における中枢神経系疾患の治療 方法であって、請求の範囲第1〜3項のいずれか1項に記載の化合物の有効量を 該被験者に投与することを含んでなり、該化合物はその医薬組成物の形態でその ような疾患の軽減に有効であり、該化合物は医薬として許容し得る担体又は希釈 剤と共に存在する、前記方法。 10.請求の範囲第1項記載の化合物の製造方法であって a)次式IV: (式中、R1は水素又は低級アルキルでありそしてAは先に定義した意味である ) で表わされる2−アリールエチルアミンを、次式III: (式中、R2,R3およびR4は先に定義した意味である) で表わされるオキシランと反応させ次いで50℃〜110℃の温度で加熱し次式II : (式中、A,R1,R2,R3およびR4は先に定義した意味である) で表わされる化合物を形成し、次いで次式IIのアミノアルコールを酸性試剤又 は脱水剤と反応させることにより行なわれる分子内環化により、式IIの化合物を 式I: で表わされる化合物に変化させるか、又は b)次式V: (式中、R1は水素又は低級アルキルでありそしてR5およびR6は独立にヒドロ キシ、メルカプト、アミノ、カルボキシであるか、又はR5およびR6は独立に置 換基を表わし、この置換基は当業者に公知の標準的手段によりヒドロキシ、メル カプト、アミノ又はカルボキシ基に変換できる) で表わされる2−アリールエチルアミンを、次式III: (式中、R2,R3およびR4は先に定義した意味である) で表わされるオキシランと反応させ次いで50℃〜110℃の温度で加熱し、次式V I: (式中、R1,R2,R3,R4,R5およびR6は先に定義した意味である) で表わされる化合物を形成し次いで式VIのアミノアルコールを酸性試剤又は脱 水剤と反応させることによって行なわれる分子内環化によって式VIの化合物を次 式VII: で表わされるベンゾアゼピンに変化させ、次いでしかる後溶剤中ジハロメタンと 塩基との付加環化反応により式VIIのベンゾアゼピンを式Iの化合物に変化させ ることを含んでなる、前記方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK0267/93 | 1993-03-10 | ||
DK93267A DK26793D0 (da) | 1993-03-10 | 1993-03-10 | Benzofuranyl- eller dihydrobenzofuranyl-substituerede tricycliske benzazepiner, der anvendelse og fremstilling |
PCT/DK1994/000069 WO1994020472A1 (en) | 1993-03-10 | 1994-02-18 | Heterocyclic compounds, their use and preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH08507498A true JPH08507498A (ja) | 1996-08-13 |
JP3779319B2 JP3779319B2 (ja) | 2006-05-24 |
Family
ID=8091615
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP51947094A Expired - Fee Related JP3779319B2 (ja) | 1993-03-10 | 1994-02-18 | 複素環式化合物、それらの使用および製法 |
Country Status (19)
Country | Link |
---|---|
US (1) | US5512562A (ja) |
EP (1) | EP0688320B1 (ja) |
JP (1) | JP3779319B2 (ja) |
KR (1) | KR960701022A (ja) |
CN (1) | CN1045957C (ja) |
AT (1) | ATE179700T1 (ja) |
AU (1) | AU682494B2 (ja) |
CA (1) | CA2157668C (ja) |
DE (1) | DE69418321T2 (ja) |
DK (2) | DK26793D0 (ja) |
ES (1) | ES2133542T3 (ja) |
FI (1) | FI111944B (ja) |
GR (1) | GR3030864T3 (ja) |
IL (1) | IL108730A (ja) |
NO (1) | NO953543D0 (ja) |
NZ (1) | NZ262098A (ja) |
TW (1) | TW279861B (ja) |
WO (1) | WO1994020472A1 (ja) |
ZA (1) | ZA941377B (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2013518067A (ja) * | 2010-01-27 | 2013-05-20 | エービー・ファーマ・リミテッド | C型肝炎ウィルス阻害剤としてのポリ複素環式化合物 |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2000506157A (ja) * | 1996-03-08 | 2000-05-23 | サンテラボ | (2―アミノエチル)ベンゾフラン誘導体、その製造およびその治療的使用 |
FR2745815B1 (fr) * | 1996-03-08 | 1998-06-26 | Synthelabo | Derives de benzofurane, leur preparations et compositions pharmaceutiques les comprenant |
FR2752840A1 (fr) * | 1996-08-29 | 1998-03-06 | Synthelabo | Derives de benzothiophene, leur preparation et leur application en therapeutique |
US6211173B1 (en) * | 1997-03-12 | 2001-04-03 | Cenes Limited | Use of 2,3,4,5-tetrahydro-1H-3-benzazepines for the manufacture of a pharmaceutical composition for the treatment of sleep disorders |
US6528529B1 (en) * | 1998-03-31 | 2003-03-04 | Acadia Pharmaceuticals Inc. | Compounds with activity on muscarinic receptors |
EP1091741A4 (en) * | 1998-06-30 | 2002-12-18 | Lilly Co Eli | AZEPINE DERIVATIVES PLAYING A ROLE IN SEROTONIN ASSOCIATED SYSTEMS |
MXPA04000358A (es) | 2001-07-13 | 2004-05-04 | Pharmacia & Up John Company | Hexahidroazepino (4,5-g) indoles e indolinas como ligandos del receptor 5-ht. |
GB0412314D0 (en) * | 2004-06-02 | 2004-07-07 | Glaxo Group Ltd | Compounds |
GB0414795D0 (en) * | 2004-07-01 | 2004-08-04 | Glaxo Group Ltd | Compounds |
EP2938345B1 (en) | 2012-12-21 | 2018-08-22 | ABT Holding Company | Benzazepines as serotonin 5-ht2c receptor ligands and uses thereof |
CN105566262B (zh) * | 2016-01-11 | 2017-10-27 | 华东理工大学 | 苯并呋喃‑7‑烷基胺类化合物及其用途 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4255445A (en) * | 1980-03-07 | 1981-03-10 | Smithkline Corporation | 8-Hydroxy-6,7-(2-methyl-2,3-dihydrofuro)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines |
CA1234110A (en) * | 1983-08-12 | 1988-03-15 | Joel G. Berger | Benzazepine derivatives, pharmaceutical compositions containing them and processes for the preparation of such compounds and compositions |
DK180485D0 (da) * | 1985-04-22 | 1985-04-23 | Novo Industri As | Nitrogenholdige forbindelser |
DK157925C (da) * | 1985-04-22 | 1990-08-27 | Novo Industri As | 2,3,4,5-tetrahydro-1h-3-benzazepinderivater og farmaceutiske praeparater indeholdende disse |
-
1993
- 1993-03-10 DK DK93267A patent/DK26793D0/da not_active Application Discontinuation
-
1994
- 1994-02-18 DK DK94908289T patent/DK0688320T3/da active
- 1994-02-18 EP EP94908289A patent/EP0688320B1/en not_active Expired - Lifetime
- 1994-02-18 WO PCT/DK1994/000069 patent/WO1994020472A1/en active IP Right Grant
- 1994-02-18 KR KR1019950703762A patent/KR960701022A/ko not_active Application Discontinuation
- 1994-02-18 DE DE69418321T patent/DE69418321T2/de not_active Expired - Lifetime
- 1994-02-18 NZ NZ262098A patent/NZ262098A/en not_active IP Right Cessation
- 1994-02-18 ES ES94908289T patent/ES2133542T3/es not_active Expired - Lifetime
- 1994-02-18 CA CA002157668A patent/CA2157668C/en not_active Expired - Fee Related
- 1994-02-18 CN CN94191882A patent/CN1045957C/zh not_active Expired - Fee Related
- 1994-02-18 JP JP51947094A patent/JP3779319B2/ja not_active Expired - Fee Related
- 1994-02-18 AU AU61386/94A patent/AU682494B2/en not_active Ceased
- 1994-02-18 AT AT94908289T patent/ATE179700T1/de not_active IP Right Cessation
- 1994-02-22 IL IL10873094A patent/IL108730A/en not_active IP Right Cessation
- 1994-02-22 TW TW083101509A patent/TW279861B/zh active
- 1994-02-24 US US08/202,401 patent/US5512562A/en not_active Expired - Lifetime
- 1994-02-28 ZA ZA941377A patent/ZA941377B/xx unknown
-
1995
- 1995-09-08 NO NO953543A patent/NO953543D0/no not_active Application Discontinuation
- 1995-09-08 FI FI954229A patent/FI111944B/fi not_active IP Right Cessation
-
1999
- 1999-07-27 GR GR990401950T patent/GR3030864T3/el unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2013518067A (ja) * | 2010-01-27 | 2013-05-20 | エービー・ファーマ・リミテッド | C型肝炎ウィルス阻害剤としてのポリ複素環式化合物 |
Also Published As
Publication number | Publication date |
---|---|
FI954229A (fi) | 1995-09-08 |
EP0688320A1 (en) | 1995-12-27 |
CN1121710A (zh) | 1996-05-01 |
ES2133542T3 (es) | 1999-09-16 |
DE69418321D1 (de) | 1999-06-10 |
JP3779319B2 (ja) | 2006-05-24 |
KR960701022A (ko) | 1996-02-24 |
ZA941377B (en) | 1995-08-28 |
NO953543L (no) | 1995-09-08 |
IL108730A0 (en) | 1994-05-30 |
AU682494B2 (en) | 1997-10-09 |
NZ262098A (en) | 1996-11-26 |
AU6138694A (en) | 1994-09-26 |
US5512562A (en) | 1996-04-30 |
TW279861B (ja) | 1996-07-01 |
ATE179700T1 (de) | 1999-05-15 |
CA2157668A1 (en) | 1994-09-15 |
EP0688320B1 (en) | 1999-05-06 |
DK0688320T3 (da) | 1999-11-01 |
FI954229A0 (fi) | 1995-09-08 |
DK26793D0 (da) | 1993-03-10 |
CN1045957C (zh) | 1999-10-27 |
DE69418321T2 (de) | 1999-12-30 |
WO1994020472A1 (en) | 1994-09-15 |
NO953543D0 (no) | 1995-09-08 |
GR3030864T3 (en) | 1999-11-30 |
IL108730A (en) | 1999-08-17 |
FI111944B (fi) | 2003-10-15 |
CA2157668C (en) | 2006-05-30 |
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