DK0688320T3 - Heterocycliske forbindelser, anvendelse og fremstilling deraf - Google Patents

Heterocycliske forbindelser, anvendelse og fremstilling deraf

Info

Publication number
DK0688320T3
DK0688320T3 DK94908289T DK94908289T DK0688320T3 DK 0688320 T3 DK0688320 T3 DK 0688320T3 DK 94908289 T DK94908289 T DK 94908289T DK 94908289 T DK94908289 T DK 94908289T DK 0688320 T3 DK0688320 T3 DK 0688320T3
Authority
DK
Denmark
Prior art keywords
dihydrofuran
cyclopentene
furan
cyano
nitro
Prior art date
Application number
DK94908289T
Other languages
English (en)
Inventor
Rolf Hohlweg
Erik Bardrum Nielsen
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Application granted granted Critical
Publication of DK0688320T3 publication Critical patent/DK0688320T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, cocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D223/00Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D223/00Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/32Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems containing carbocyclic rings other than six-membered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK94908289T 1993-03-10 1994-02-18 Heterocycliske forbindelser, anvendelse og fremstilling deraf DK0688320T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK93267A DK26793D0 (da) 1993-03-10 1993-03-10 Benzofuranyl- eller dihydrobenzofuranyl-substituerede tricycliske benzazepiner, der anvendelse og fremstilling
PCT/DK1994/000069 WO1994020472A1 (en) 1993-03-10 1994-02-18 Heterocyclic compounds, their use and preparation

Publications (1)

Publication Number Publication Date
DK0688320T3 true DK0688320T3 (da) 1999-11-01

Family

ID=8091615

Family Applications (2)

Application Number Title Priority Date Filing Date
DK93267A DK26793D0 (da) 1993-03-10 1993-03-10 Benzofuranyl- eller dihydrobenzofuranyl-substituerede tricycliske benzazepiner, der anvendelse og fremstilling
DK94908289T DK0688320T3 (da) 1993-03-10 1994-02-18 Heterocycliske forbindelser, anvendelse og fremstilling deraf

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK93267A DK26793D0 (da) 1993-03-10 1993-03-10 Benzofuranyl- eller dihydrobenzofuranyl-substituerede tricycliske benzazepiner, der anvendelse og fremstilling

Country Status (19)

Country Link
US (1) US5512562A (da)
EP (1) EP0688320B1 (da)
JP (1) JP3779319B2 (da)
KR (1) KR960701022A (da)
CN (1) CN1045957C (da)
AT (1) ATE179700T1 (da)
AU (1) AU682494B2 (da)
CA (1) CA2157668C (da)
DE (1) DE69418321T2 (da)
DK (2) DK26793D0 (da)
ES (1) ES2133542T3 (da)
FI (1) FI111944B (da)
GR (1) GR3030864T3 (da)
IL (1) IL108730A (da)
NO (1) NO953543L (da)
NZ (1) NZ262098A (da)
TW (1) TW279861B (da)
WO (1) WO1994020472A1 (da)
ZA (1) ZA941377B (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0888324A1 (fr) * 1996-03-08 1999-01-07 Synthelabo Derives de 2-aminoethyl-benzofurane, leur preparation et leur application en therapeutique
FR2745815B1 (fr) * 1996-03-08 1998-06-26 Synthelabo Derives de benzofurane, leur preparations et compositions pharmaceutiques les comprenant
FR2752840A1 (fr) * 1996-08-29 1998-03-06 Synthelabo Derives de benzothiophene, leur preparation et leur application en therapeutique
AU742873B2 (en) * 1997-03-12 2002-01-17 Addex Pharma Sa Use of 2,3,4,5-tetrahydro-1h-3-benzazepines for the manufacture of a pharmaceutical composition for the treatment of sleep disorders
US6528529B1 (en) 1998-03-31 2003-03-04 Acadia Pharmaceuticals Inc. Compounds with activity on muscarinic receptors
CA2335310A1 (en) * 1998-06-30 2000-01-06 Kenneth Lee Hauser Azepine derivatives having effects on serotonin related systems
ATE307133T1 (de) 2001-07-13 2005-11-15 Pharmacia & Upjohn Co Llc Hexahydroazepino(4,5-g)indole und -indoline als 5-ht-rezeptor-liganden
GB0412314D0 (en) * 2004-06-02 2004-07-07 Glaxo Group Ltd Compounds
GB0414795D0 (en) * 2004-07-01 2004-08-04 Glaxo Group Ltd Compounds
PL2528922T3 (pl) * 2010-01-27 2018-01-31 Ab Pharma Ltd Związki poliheterocykliczne jako inhibitory hcv
MX2015008034A (es) * 2012-12-21 2016-03-07 Abt Holding Co Benzazepinas como ligandos de receptor de serotonina 5-ht2c y usos de las mismas.
CN105566262B (zh) * 2016-01-11 2017-10-27 华东理工大学 苯并呋喃‑7‑烷基胺类化合物及其用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4255445A (en) * 1980-03-07 1981-03-10 Smithkline Corporation 8-Hydroxy-6,7-(2-methyl-2,3-dihydrofuro)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
CA1234110A (en) * 1983-08-12 1988-03-15 Joel G. Berger Benzazepine derivatives, pharmaceutical compositions containing them and processes for the preparation of such compounds and compositions
DK157925C (da) * 1985-04-22 1990-08-27 Novo Industri As 2,3,4,5-tetrahydro-1h-3-benzazepinderivater og farmaceutiske praeparater indeholdende disse
DK180485D0 (da) * 1985-04-22 1985-04-23 Novo Industri As Nitrogenholdige forbindelser

Also Published As

Publication number Publication date
KR960701022A (ko) 1996-02-24
NZ262098A (en) 1996-11-26
JPH08507498A (ja) 1996-08-13
GR3030864T3 (en) 1999-11-30
ES2133542T3 (es) 1999-09-16
EP0688320A1 (en) 1995-12-27
NO953543D0 (no) 1995-09-08
ATE179700T1 (de) 1999-05-15
CN1121710A (zh) 1996-05-01
DK26793D0 (da) 1993-03-10
CA2157668C (en) 2006-05-30
CN1045957C (zh) 1999-10-27
ZA941377B (en) 1995-08-28
JP3779319B2 (ja) 2006-05-24
FI954229A0 (fi) 1995-09-08
IL108730A (en) 1999-08-17
FI954229A (fi) 1995-09-08
EP0688320B1 (en) 1999-05-06
CA2157668A1 (en) 1994-09-15
FI111944B (fi) 2003-10-15
US5512562A (en) 1996-04-30
WO1994020472A1 (en) 1994-09-15
TW279861B (da) 1996-07-01
DE69418321T2 (de) 1999-12-30
NO953543L (no) 1995-09-08
AU6138694A (en) 1994-09-26
IL108730A0 (en) 1994-05-30
DE69418321D1 (de) 1999-06-10
AU682494B2 (en) 1997-10-09

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