KR20010099700A - 무-간질 헤모글로빈의 제조 방법 - Google Patents

무-간질 헤모글로빈의 제조 방법 Download PDF

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Publication number
KR20010099700A
KR20010099700A KR1020017004781A KR20017004781A KR20010099700A KR 20010099700 A KR20010099700 A KR 20010099700A KR 1020017004781 A KR1020017004781 A KR 1020017004781A KR 20017004781 A KR20017004781 A KR 20017004781A KR 20010099700 A KR20010099700 A KR 20010099700A
Authority
KR
South Korea
Prior art keywords
solution
hemoglobin
blood
red blood
blood cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1020017004781A
Other languages
English (en)
Korean (ko)
Inventor
윈슬로로버트엠.
반데르리프킴디.
Original Assignee
추후제출
생가트, 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 추후제출, 생가트, 인코포레이티드 filed Critical 추후제출
Publication of KR20010099700A publication Critical patent/KR20010099700A/ko
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3692—Washing or rinsing blood or blood constituents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • A61M1/3696—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • A61M1/3698—Expressing processed fluid out from the turning rotor using another fluid compressing the treatment chamber; Variable volume rotors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0413—Blood
    • A61M2202/0429—Red blood cells; Erythrocytes
    • A61M2202/0433—Free haemoglobin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3306—Optical measuring means
    • A61M2205/331—Optical measuring means used as turbidity change detectors, e.g. for priming-blood or plasma-hemoglubine-interface detection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3317—Electromagnetic, inductive or dielectric measuring means

Landscapes

  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Anesthesiology (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • External Artificial Organs (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Centrifugal Separators (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
KR1020017004781A 1998-10-15 1999-10-15 무-간질 헤모글로빈의 제조 방법 Withdrawn KR20010099700A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US10431998P 1998-10-15 1998-10-15
US60/104,319 1998-10-15
US12218099P 1999-03-01 1999-03-01
US60/122,180 1999-03-01
PCT/US1999/024149 WO2000021591A1 (en) 1998-10-15 1999-10-15 Method for production of stroma-free hemoglobin

Publications (1)

Publication Number Publication Date
KR20010099700A true KR20010099700A (ko) 2001-11-09

Family

ID=26801402

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020017004781A Withdrawn KR20010099700A (ko) 1998-10-15 1999-10-15 무-간질 헤모글로빈의 제조 방법

Country Status (9)

Country Link
EP (1) EP1121165A1 (enExample)
JP (1) JP2002527149A (enExample)
KR (1) KR20010099700A (enExample)
CN (1) CN1332646A (enExample)
AU (1) AU771465B2 (enExample)
BR (1) BR9915734A (enExample)
CA (1) CA2346825C (enExample)
MX (1) MXPA01003836A (enExample)
WO (1) WO2000021591A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1740285A4 (en) * 2004-04-13 2007-07-04 Sangart Inc METHOD AND COMPOSITIONS FOR SIMULTANEOUS ISOLATION OF HEMOGLOBIN FROM RED BLOOD BODIES AND INACTIVATION OF VIRUSES
JP2006021121A (ja) * 2004-07-08 2006-01-26 Hitachi Koki Co Ltd 遠心分離機
ITLU20070013A1 (it) * 2007-06-22 2008-12-23 Kedrion Spa Processo per la purificazione di emoglobina umana apirogena e virus inattivata.
EP2433713B1 (en) * 2007-12-07 2017-07-26 Miltenyi Biotec GmbH Cell processing systems and methods
US9493616B2 (en) * 2010-02-25 2016-11-15 Sangart, Inc. Methods for preparing PEG-hemoglobin conjugates using reduced reactant ratios
JP2015536719A (ja) * 2012-11-05 2015-12-24 ヘモネティクス・コーポレーションＨａｅｍｏｎｅｔｉｃｓ Ｃｏｒｐｏｒａｔｉｏｎ 全血の連続分離のためのシステム及び方法
CN103091149B (zh) * 2013-01-10 2015-08-05 济南金域医学检验中心有限公司 血红蛋白电泳液的制备方法
EP2961760B1 (en) 2013-02-26 2021-03-24 EMD Millipore Corporation Selective removal of a protein from a mixture of proteins using activated carbon by adjusting solution conditions
WO2015158776A1 (en) * 2014-04-15 2015-10-22 Boehringer Ingelheim International Gmbh Methods, apparatuses, and systems for continuously inactivating a virus during manufacture of a biological product
US11666925B2 (en) * 2018-03-02 2023-06-06 Thermo Electron Led Gmbh Single-use centrifuge containers for separating biological suspensions and methods of use
CN109298171B (zh) * 2018-11-15 2022-06-28 武汉中生毓晋生物医药有限责任公司 醛化红细胞中内毒素的去除方法与应用
CO2023018740A1 (es) * 2023-12-29 2025-07-07 Lifefactors S A S Sistema de separación de componentes plasmáticos por descongelamiento controlado mediante unos mecanismos integrados de transferencia térmica controlada y sedimentación acelerada en unos medios continuos
CN119746044A (zh) * 2025-03-06 2025-04-04 润方（北京）生物医药研究院有限公司 血红蛋白氧载体在制备抗病毒药物中的应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4303193A (en) 1979-01-22 1981-12-01 Haemonetics Corporation Apparatus for separating blood into components thereof
US4401652A (en) * 1980-12-31 1983-08-30 Allied Corporation Process for the preparation of stroma-free hemoglobin solutions
US5464814A (en) * 1986-06-20 1995-11-07 Northfield Laboratories, Inc. Acellular red blood cell substitute
CA1312009C (en) 1986-11-10 1992-12-29 Carl W. Rausch Extra pure semi-synthetic blood substitute
JPH02121931A (ja) * 1988-10-29 1990-05-09 Res Inst For Prod Dev 濃縮ヘモグロビンの製造方法
US5646252A (en) * 1992-02-10 1997-07-08 Staat Der Nederlanden, De Minister Van Defensie, Voor Deze: Het Hoofd Van De Afdeling Militair Geneeskundig Beleid Hemoglobin composition and preparation thereof
US5676644A (en) 1995-06-07 1997-10-14 Cobe Laboratories, Inc. Extracorporeal blood processing methods and apparatus
US5814601A (en) 1997-02-28 1998-09-29 The Regents Of The University Of California Methods and compositions for optimization of oxygen transport by cell-free systems

Also Published As

Publication number Publication date
AU1117000A (en) 2000-05-01
AU771465B2 (en) 2004-03-25
BR9915734A (pt) 2001-10-02
MXPA01003836A (es) 2002-09-18
JP2002527149A (ja) 2002-08-27
CN1332646A (zh) 2002-01-23
CA2346825C (en) 2008-07-29
CA2346825A1 (en) 2000-04-20
WO2000021591A1 (en) 2000-04-20
EP1121165A1 (en) 2001-08-08

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Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20010416

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid