CN1332646A - 生产无基质血红蛋白的方法 - Google Patents

生产无基质血红蛋白的方法 Download PDF

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Publication number
CN1332646A
CN1332646A CN99813429A CN99813429A CN1332646A CN 1332646 A CN1332646 A CN 1332646A CN 99813429 A CN99813429 A CN 99813429A CN 99813429 A CN99813429 A CN 99813429A CN 1332646 A CN1332646 A CN 1332646A
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CN
China
Prior art keywords
solution
hemoglobin
blood
red blood
blood cells
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN99813429A
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English (en)
Chinese (zh)
Inventor
R·M·温斯洛
K·D·范德格里夫
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Sangart Inc
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Sangart Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Sangart Inc filed Critical Sangart Inc
Publication of CN1332646A publication Critical patent/CN1332646A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3692—Washing or rinsing blood or blood constituents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • A61M1/3696—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • A61M1/3698—Expressing processed fluid out from the turning rotor using another fluid compressing the treatment chamber; Variable volume rotors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0413—Blood
    • A61M2202/0429—Red blood cells; Erythrocytes
    • A61M2202/0433—Free haemoglobin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3306—Optical measuring means
    • A61M2205/331—Optical measuring means used as turbidity change detectors, e.g. for priming-blood or plasma-hemoglubine-interface detection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3317—Electromagnetic, inductive or dielectric measuring means

Landscapes

  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Anesthesiology (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • External Artificial Organs (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Centrifugal Separators (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
CN99813429A 1998-10-15 1999-10-15 生产无基质血红蛋白的方法 Pending CN1332646A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US10431998P 1998-10-15 1998-10-15
US60/104,319 1998-10-15
US12218099P 1999-03-01 1999-03-01
US60/122,180 1999-03-01

Publications (1)

Publication Number Publication Date
CN1332646A true CN1332646A (zh) 2002-01-23

Family

ID=26801402

Family Applications (1)

Application Number Title Priority Date Filing Date
CN99813429A Pending CN1332646A (zh) 1998-10-15 1999-10-15 生产无基质血红蛋白的方法

Country Status (9)

Country Link
EP (1) EP1121165A1 (enExample)
JP (1) JP2002527149A (enExample)
KR (1) KR20010099700A (enExample)
CN (1) CN1332646A (enExample)
AU (1) AU771465B2 (enExample)
BR (1) BR9915734A (enExample)
CA (1) CA2346825C (enExample)
MX (1) MXPA01003836A (enExample)
WO (1) WO2000021591A1 (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102859364A (zh) * 2010-02-25 2013-01-02 桑格特公司 通过减少反应物比例制备聚乙二醇-血红蛋白缀合物的方法
CN103091149A (zh) * 2013-01-10 2013-05-08 广州金域医学检验中心有限公司 血红蛋白电泳液的制备方法
CN111801412A (zh) * 2018-03-02 2020-10-20 赛默电子Led有限公司 用于分离生物悬浮液的一次性离心容器和使用方法
CN114225072A (zh) * 2014-04-15 2022-03-25 勃林格殷格翰国际公司 在制造生物制品期间连续灭活病毒的方法、装置和系统

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1740285A4 (en) * 2004-04-13 2007-07-04 Sangart Inc METHOD AND COMPOSITIONS FOR SIMULTANEOUS ISOLATION OF HEMOGLOBIN FROM RED BLOOD BODIES AND INACTIVATION OF VIRUSES
JP2006021121A (ja) * 2004-07-08 2006-01-26 Hitachi Koki Co Ltd 遠心分離機
ITLU20070013A1 (it) * 2007-06-22 2008-12-23 Kedrion Spa Processo per la purificazione di emoglobina umana apirogena e virus inattivata.
EP2433713B1 (en) * 2007-12-07 2017-07-26 Miltenyi Biotec GmbH Cell processing systems and methods
JP2015536719A (ja) * 2012-11-05 2015-12-24 ヘモネティクス・コーポレーションＨａｅｍｏｎｅｔｉｃｓ Ｃｏｒｐｏｒａｔｉｏｎ 全血の連続分離のためのシステム及び方法
EP2961760B1 (en) 2013-02-26 2021-03-24 EMD Millipore Corporation Selective removal of a protein from a mixture of proteins using activated carbon by adjusting solution conditions
CN109298171B (zh) * 2018-11-15 2022-06-28 武汉中生毓晋生物医药有限责任公司 醛化红细胞中内毒素的去除方法与应用
CO2023018740A1 (es) * 2023-12-29 2025-07-07 Lifefactors S A S Sistema de separación de componentes plasmáticos por descongelamiento controlado mediante unos mecanismos integrados de transferencia térmica controlada y sedimentación acelerada en unos medios continuos
CN119746044A (zh) * 2025-03-06 2025-04-04 润方（北京）生物医药研究院有限公司 血红蛋白氧载体在制备抗病毒药物中的应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4303193A (en) 1979-01-22 1981-12-01 Haemonetics Corporation Apparatus for separating blood into components thereof
US4401652A (en) * 1980-12-31 1983-08-30 Allied Corporation Process for the preparation of stroma-free hemoglobin solutions
US5464814A (en) * 1986-06-20 1995-11-07 Northfield Laboratories, Inc. Acellular red blood cell substitute
CA1312009C (en) 1986-11-10 1992-12-29 Carl W. Rausch Extra pure semi-synthetic blood substitute
JPH02121931A (ja) * 1988-10-29 1990-05-09 Res Inst For Prod Dev 濃縮ヘモグロビンの製造方法
US5646252A (en) * 1992-02-10 1997-07-08 Staat Der Nederlanden, De Minister Van Defensie, Voor Deze: Het Hoofd Van De Afdeling Militair Geneeskundig Beleid Hemoglobin composition and preparation thereof
US5676644A (en) 1995-06-07 1997-10-14 Cobe Laboratories, Inc. Extracorporeal blood processing methods and apparatus
US5814601A (en) 1997-02-28 1998-09-29 The Regents Of The University Of California Methods and compositions for optimization of oxygen transport by cell-free systems

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102859364A (zh) * 2010-02-25 2013-01-02 桑格特公司 通过减少反应物比例制备聚乙二醇-血红蛋白缀合物的方法
CN103091149A (zh) * 2013-01-10 2013-05-08 广州金域医学检验中心有限公司 血红蛋白电泳液的制备方法
CN114225072A (zh) * 2014-04-15 2022-03-25 勃林格殷格翰国际公司 在制造生物制品期间连续灭活病毒的方法、装置和系统
CN114225072B (zh) * 2014-04-15 2024-01-02 勃林格殷格翰国际公司 在制造生物制品期间连续灭活病毒的方法、装置和系统
CN111801412A (zh) * 2018-03-02 2020-10-20 赛默电子Led有限公司 用于分离生物悬浮液的一次性离心容器和使用方法

Also Published As

Publication number Publication date
AU1117000A (en) 2000-05-01
AU771465B2 (en) 2004-03-25
BR9915734A (pt) 2001-10-02
MXPA01003836A (es) 2002-09-18
JP2002527149A (ja) 2002-08-27
CA2346825C (en) 2008-07-29
KR20010099700A (ko) 2001-11-09
CA2346825A1 (en) 2000-04-20
WO2000021591A1 (en) 2000-04-20
EP1121165A1 (en) 2001-08-08

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C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication