KR20010022405A - Ｖｌａ-4에 의해 매개된 백혈구 유착을 억제하는설포닐화된 디펩타이드 화합물 - Google Patents

Ｖｌａ-4에 의해 매개된 백혈구 유착을 억제하는설포닐화된 디펩타이드 화합물 Download PDF

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Publication number
KR20010022405A
KR20010022405A KR1020007000985A KR20007000985A KR20010022405A KR 20010022405 A KR20010022405 A KR 20010022405A KR 1020007000985 A KR1020007000985 A KR 1020007000985A KR 20007000985 A KR20007000985 A KR 20007000985A KR 20010022405 A KR20010022405 A KR 20010022405A
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KR
South Korea
Prior art keywords
substituted
alkyl
heterocyclic
heteroaryl
aryl
Prior art date
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KR1020007000985A
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English (en)
Korean (ko)
Inventor
토르셋유진디
셈코크리스토퍼엠
플레이스마이클에이
크레프트안토니
콘라디안드레이더블유
그랑프랑시에스
바우디라인하르트베른하르트
사란타키스디미트리오스
Original Assignee
진 엠. 듀발
엘란 파마슈티칼스, 인크.
이곤 이 버그
아메리칸 홈 푸로닥츠 코포레이션
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Application filed by 진 엠. 듀발, 엘란 파마슈티칼스, 인크., 이곤 이 버그, 아메리칸 홈 푸로닥츠 코포레이션 filed Critical 진 엠. 듀발
Publication of KR20010022405A publication Critical patent/KR20010022405A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020007000985A 1997-07-31 1998-07-31 Ｖｌａ-4에 의해 매개된 백혈구 유착을 억제하는설포닐화된 디펩타이드 화합물 KR20010022405A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US90442397A 1997-07-31 1997-07-31
US8/904,423 1997-07-31
PCT/US1998/016070 WO1999006437A1 (en) 1997-07-31 1998-07-31 Sulfonylated dipeptide compounds which inhibit leukocyte adhesion mediated by vla-4

Publications (1)

Publication Number Publication Date
KR20010022405A true KR20010022405A (ko) 2001-03-15

Family

ID=25419137

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020007000985A KR20010022405A (ko) 1997-07-31 1998-07-31 Ｖｌａ-4에 의해 매개된 백혈구 유착을 억제하는설포닐화된 디펩타이드 화합물

Country Status (12)

Country Link
EP (1) EP0994896A1 (ja)
JP (1) JP2001512139A (ja)
KR (1) KR20010022405A (ja)
CN (1) CN1265672A (ja)
AU (1) AU8823498A (ja)
BR (1) BR9811594A (ja)
CA (1) CA2290748A1 (ja)
HU (1) HUP0003921A3 (ja)
IL (1) IL133637A0 (ja)
NO (1) NO20000452L (ja)
PL (1) PL338457A1 (ja)
WO (1) WO1999006437A1 (ja)

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Also Published As

Publication number Publication date
CN1265672A (zh) 2000-09-06
PL338457A1 (en) 2000-11-06
WO1999006437A1 (en) 1999-02-11
EP0994896A1 (en) 2000-04-26
HUP0003921A3 (en) 2001-03-28
NO20000452L (no) 2000-03-27
IL133637A0 (en) 2001-04-30
CA2290748A1 (en) 1999-02-11
JP2001512139A (ja) 2001-08-21
BR9811594A (pt) 2000-09-05
HUP0003921A2 (hu) 2001-02-28
NO20000452D0 (no) 2000-01-28
AU8823498A (en) 1999-02-22

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