KR20000005178A - 엔도텔린 길항제로 심부전증을 치료하는 방법 - Google Patents

엔도텔린 길항제로 심부전증을 치료하는 방법 Download PDF

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Publication number
KR20000005178A
KR20000005178A KR1019980707850A KR19980707850A KR20000005178A KR 20000005178 A KR20000005178 A KR 20000005178A KR 1019980707850 A KR1019980707850 A KR 1019980707850A KR 19980707850 A KR19980707850 A KR 19980707850A KR 20000005178 A KR20000005178 A KR 20000005178A
Authority
KR
South Korea
Prior art keywords
pyridine
carboxy
methoxyphenyl
cyclopenteno
methylenedioxyphenyl
Prior art date
Application number
KR1019980707850A
Other languages
English (en)
Korean (ko)
Inventor
조셉 제이. 쥬니어 린치
유-탕 셴
Original Assignee
나가사까 겐지로
반유 세이야꾸 가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 나가사까 겐지로, 반유 세이야꾸 가부시끼가이샤 filed Critical 나가사까 겐지로
Publication of KR20000005178A publication Critical patent/KR20000005178A/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Materials For Photolithography (AREA)
  • Photosensitive Polymer And Photoresist Processing (AREA)
KR1019980707850A 1996-04-04 1997-03-19 엔도텔린 길항제로 심부전증을 치료하는 방법 KR20000005178A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1488296P 1996-04-04 1996-04-04
US60/014,882 1996-04-04

Publications (1)

Publication Number Publication Date
KR20000005178A true KR20000005178A (ko) 2000-01-25

Family

ID=21768326

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019980707850A KR20000005178A (ko) 1996-04-04 1997-03-19 엔도텔린 길항제로 심부전증을 치료하는 방법

Country Status (25)

Country Link
US (3) US5834483A (ja)
EP (1) EP0906108B1 (ja)
JP (2) JP3345891B2 (ja)
KR (1) KR20000005178A (ja)
CN (1) CN1215335A (ja)
AT (1) ATE297739T1 (ja)
AU (1) AU723351B2 (ja)
BG (1) BG102716A (ja)
BR (1) BR9708525A (ja)
CA (1) CA2249330C (ja)
CZ (1) CZ296098A3 (ja)
DE (1) DE69733557T2 (ja)
EA (1) EA003587B1 (ja)
EE (1) EE9800315A (ja)
ES (1) ES2241047T3 (ja)
HU (1) HUP9903893A3 (ja)
IL (1) IL126175A (ja)
IS (1) IS4847A (ja)
NO (1) NO984564L (ja)
NZ (1) NZ331789A (ja)
PL (1) PL329077A1 (ja)
SK (1) SK130098A3 (ja)
TR (1) TR199801988T2 (ja)
UA (1) UA50761C2 (ja)
WO (1) WO1997037665A1 (ja)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3345891B2 (ja) * 1996-04-04 2002-11-18 萬有製薬株式会社 エンドセリン拮抗薬を含有することを特徴とする心不全治療剤
CA2262676A1 (en) * 1996-08-09 1998-02-19 Merck & Co., Inc. Stereoselective deoxygenation reaction
AU742423B2 (en) 1998-01-21 2002-01-03 Msd K.K. Substituted 5-(2,2-difluoro-1,3-benzodioxol-5-yl) cyclopentenopyridine derivative
US8168616B1 (en) 2000-11-17 2012-05-01 Novartis Ag Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension
WO2004060885A1 (ja) * 2002-12-27 2004-07-22 Kaneka Corporation 光学活性２−チオメチル−３−フェニルプロピオン酸誘導体およびその合成中間体の製造法
KR20150028829A (ko) 2003-11-17 2015-03-16 노파르티스 아게 디펩티딜 펩티다제 ⅳ 억제제의 용도
GB0327839D0 (en) 2003-12-01 2003-12-31 Novartis Ag Organic compounds
EP1729749A2 (en) 2004-03-17 2006-12-13 Novartis AG Use of renin inhibitors in therapy
EP1894582A1 (en) 2005-06-24 2008-03-05 Tokyo Medical and Dental University Method for control of drug elution rate and composition for coating of drug-eluting stent
WO2011116115A1 (en) 2010-03-16 2011-09-22 Novartis Ag Aliskiren composition comprising a medium chain fatty acid, their process of manufacturing

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4971959A (en) * 1987-04-14 1990-11-20 Warner-Lambert Company Trisubstituted phenyl analogs having activity for congestive heart failure
GB9007762D0 (en) * 1990-04-05 1990-06-06 Beecham Group Plc Novel compounds
US5565485A (en) * 1993-03-19 1996-10-15 Merck & Co., Inc. Biphenyl compounds useful or endothelin antagonists
US5571813A (en) * 1993-06-10 1996-11-05 Beiersdorf-Lilly Gmbh Fused pyrimidine compounds and their use as pharmaceuticals
CN1049219C (zh) * 1993-08-18 2000-02-09 万有制药株式会社 具有内皮素拮抗活性的芳香杂环并环戊烯衍生物
US5389620A (en) * 1993-08-18 1995-02-14 Banyu Pharmaceutical Co., Ltd. Endothelin antagonistic heteroaromatic ring-fused cyclopentene derivatives
US5658943A (en) * 1995-01-05 1997-08-19 Warner-Lambert Company Phenylalanine derivatives as endothelin antagonists
JP3345891B2 (ja) * 1996-04-04 2002-11-18 萬有製薬株式会社 エンドセリン拮抗薬を含有することを特徴とする心不全治療剤

Also Published As

Publication number Publication date
JP2000510824A (ja) 2000-08-22
IL126175A0 (en) 1999-05-09
AU723351B2 (en) 2000-08-24
EA199800889A1 (ru) 1999-04-29
EP0906108A4 (en) 2000-12-06
BG102716A (en) 1999-09-30
JP2002220337A (ja) 2002-08-09
EP0906108A1 (en) 1999-04-07
TR199801988T2 (xx) 2000-08-21
IS4847A (is) 1998-09-15
NO984564L (no) 1998-12-04
UA50761C2 (uk) 2002-11-15
NZ331789A (en) 2000-05-26
AU2202597A (en) 1997-10-29
ES2241047T3 (es) 2005-10-16
IL126175A (en) 2003-05-29
ATE297739T1 (de) 2005-07-15
HUP9903893A2 (hu) 2001-04-28
EA003587B1 (ru) 2003-06-26
EE9800315A (et) 1999-06-15
JP3345891B2 (ja) 2002-11-18
CZ296098A3 (cs) 1999-06-16
CA2249330C (en) 2005-08-09
DE69733557T2 (de) 2005-11-03
HUP9903893A3 (en) 2001-05-28
WO1997037665A1 (en) 1997-10-16
DE69733557D1 (de) 2005-07-21
CA2249330A1 (en) 1997-10-16
US6087360A (en) 2000-07-11
EP0906108B1 (en) 2005-06-15
NO984564D0 (no) 1998-09-30
SK130098A3 (en) 1999-05-07
US6380195B1 (en) 2002-04-30
CN1215335A (zh) 1999-04-28
PL329077A1 (en) 1999-03-15
US5834483A (en) 1998-11-10
BR9708525A (pt) 1999-08-03

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