CN1215335A - 用内皮素拮挤剂治疗心力衰竭的方法 - Google Patents

用内皮素拮挤剂治疗心力衰竭的方法 Download PDF

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Publication number
CN1215335A
CN1215335A CN97193645A CN97193645A CN1215335A CN 1215335 A CN1215335 A CN 1215335A CN 97193645 A CN97193645 A CN 97193645A CN 97193645 A CN97193645 A CN 97193645A CN 1215335 A CN1215335 A CN 1215335A
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CN
China
Prior art keywords
carboxyl
pyridine
cyclopenta
methoxyphenyl
methylenedioxyphenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN97193645A
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English (en)
Chinese (zh)
Inventor
小J·J·林奇
沈幼棠
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MSD KK
Original Assignee
Banyu Phamaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Banyu Phamaceutical Co Ltd filed Critical Banyu Phamaceutical Co Ltd
Publication of CN1215335A publication Critical patent/CN1215335A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Materials For Photolithography (AREA)
  • Photosensitive Polymer And Photoresist Processing (AREA)
CN97193645A 1996-04-04 1997-03-19 用内皮素拮挤剂治疗心力衰竭的方法 Pending CN1215335A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1488296P 1996-04-04 1996-04-04
US60/014,882 1996-04-04

Publications (1)

Publication Number Publication Date
CN1215335A true CN1215335A (zh) 1999-04-28

Family

ID=21768326

Family Applications (1)

Application Number Title Priority Date Filing Date
CN97193645A Pending CN1215335A (zh) 1996-04-04 1997-03-19 用内皮素拮挤剂治疗心力衰竭的方法

Country Status (25)

Country Link
US (3) US5834483A (ja)
EP (1) EP0906108B1 (ja)
JP (2) JP3345891B2 (ja)
KR (1) KR20000005178A (ja)
CN (1) CN1215335A (ja)
AT (1) ATE297739T1 (ja)
AU (1) AU723351B2 (ja)
BG (1) BG102716A (ja)
BR (1) BR9708525A (ja)
CA (1) CA2249330C (ja)
CZ (1) CZ296098A3 (ja)
DE (1) DE69733557T2 (ja)
EA (1) EA003587B1 (ja)
EE (1) EE9800315A (ja)
ES (1) ES2241047T3 (ja)
HU (1) HUP9903893A3 (ja)
IL (1) IL126175A (ja)
IS (1) IS4847A (ja)
NO (1) NO984564L (ja)
NZ (1) NZ331789A (ja)
PL (1) PL329077A1 (ja)
SK (1) SK130098A3 (ja)
TR (1) TR199801988T2 (ja)
UA (1) UA50761C2 (ja)
WO (1) WO1997037665A1 (ja)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69733557T2 (de) * 1996-04-04 2005-11-03 Banyu Pharmaceutical Co., Ltd. Endothelin-antagonisten zur behandlung von herzversagen
WO1998006700A1 (en) * 1996-08-09 1998-02-19 Merck & Co., Inc. Stereoselective deoxygenation reaction
EP1049691B1 (en) 1998-01-21 2004-02-18 Banyu Pharmaceutical Co., Ltd. Substituted 5-(2,2-difluoro-1,3-benzodioxol-5-yl) cyclopentenopyridine derivative
US8168616B1 (en) 2000-11-17 2012-05-01 Novartis Ag Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension
WO2004060885A1 (ja) * 2002-12-27 2004-07-22 Kaneka Corporation 光学活性２−チオメチル−３−フェニルプロピオン酸誘導体およびその合成中間体の製造法
KR20120008093A (ko) 2003-11-17 2012-01-25 노파르티스 아게 디펩티딜 펩티다제 ⅳ 억제제의 용도
GB0327839D0 (en) 2003-12-01 2003-12-31 Novartis Ag Organic compounds
CA2558020A1 (en) 2004-03-17 2005-09-29 Novartis Ag Use of renin inhibitors in therapy
WO2006137222A1 (ja) 2005-06-24 2006-12-28 Tokyo Medical And Dental University 薬剤溶出速度制御方法、及び薬剤溶出性ステント被膜用組成物
WO2011116115A1 (en) 2010-03-16 2011-09-22 Novartis Ag Aliskiren composition comprising a medium chain fatty acid, their process of manufacturing

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4971959A (en) * 1987-04-14 1990-11-20 Warner-Lambert Company Trisubstituted phenyl analogs having activity for congestive heart failure
GB9007762D0 (en) * 1990-04-05 1990-06-06 Beecham Group Plc Novel compounds
US5565485A (en) * 1993-03-19 1996-10-15 Merck & Co., Inc. Biphenyl compounds useful or endothelin antagonists
US5571813A (en) * 1993-06-10 1996-11-05 Beiersdorf-Lilly Gmbh Fused pyrimidine compounds and their use as pharmaceuticals
US5389620A (en) * 1993-08-18 1995-02-14 Banyu Pharmaceutical Co., Ltd. Endothelin antagonistic heteroaromatic ring-fused cyclopentene derivatives
CN1049219C (zh) * 1993-08-18 2000-02-09 万有制药株式会社 具有内皮素拮抗活性的芳香杂环并环戊烯衍生物
US5658943A (en) * 1995-01-05 1997-08-19 Warner-Lambert Company Phenylalanine derivatives as endothelin antagonists
DE69733557T2 (de) * 1996-04-04 2005-11-03 Banyu Pharmaceutical Co., Ltd. Endothelin-antagonisten zur behandlung von herzversagen

Also Published As

Publication number Publication date
PL329077A1 (en) 1999-03-15
BG102716A (en) 1999-09-30
US6380195B1 (en) 2002-04-30
EP0906108A1 (en) 1999-04-07
HUP9903893A3 (en) 2001-05-28
CA2249330C (en) 2005-08-09
US5834483A (en) 1998-11-10
IS4847A (is) 1998-09-15
NZ331789A (en) 2000-05-26
AU723351B2 (en) 2000-08-24
EP0906108A4 (en) 2000-12-06
JP3345891B2 (ja) 2002-11-18
KR20000005178A (ko) 2000-01-25
EA199800889A1 (ru) 1999-04-29
ES2241047T3 (es) 2005-10-16
DE69733557D1 (de) 2005-07-21
CZ296098A3 (cs) 1999-06-16
IL126175A0 (en) 1999-05-09
EE9800315A (et) 1999-06-15
NO984564L (no) 1998-12-04
NO984564D0 (no) 1998-09-30
BR9708525A (pt) 1999-08-03
US6087360A (en) 2000-07-11
TR199801988T2 (xx) 2000-08-21
AU2202597A (en) 1997-10-29
HUP9903893A2 (hu) 2001-04-28
SK130098A3 (en) 1999-05-07
JP2000510824A (ja) 2000-08-22
JP2002220337A (ja) 2002-08-09
DE69733557T2 (de) 2005-11-03
CA2249330A1 (en) 1997-10-16
WO1997037665A1 (en) 1997-10-16
EP0906108B1 (en) 2005-06-15
UA50761C2 (uk) 2002-11-15
IL126175A (en) 2003-05-29
EA003587B1 (ru) 2003-06-26
ATE297739T1 (de) 2005-07-15

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