KR102952398B1 - 하이브리드 광학 시스템 - Google Patents

하이브리드 광학 시스템

Info

Publication number
KR102952398B1
KR102952398B1 KR1020217033027A KR20217033027A KR102952398B1 KR 102952398 B1 KR102952398 B1 KR 102952398B1 KR 1020217033027 A KR1020217033027 A KR 1020217033027A KR 20217033027 A KR20217033027 A KR 20217033027A KR 102952398 B1 KR102952398 B1 KR 102952398B1
Authority
KR
South Korea
Prior art keywords
light
wavelength range
cars
target
optical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
KR1020217033027A
Other languages
English (en)
Korean (ko)
Other versions
KR20220005449A (ko
Inventor
루카스 브루크너
데이비드 앤더슨
프라카시 스리달 무르티
Original Assignee
아토나프 가부시키가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 아토나프 가부시키가이샤 filed Critical 아토나프 가부시키가이샤
Publication of KR20220005449A publication Critical patent/KR20220005449A/ko
Application granted granted Critical
Publication of KR102952398B1 publication Critical patent/KR102952398B1/ko
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/0205—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0062—Arrangements for scanning
    • A61B5/0066—Optical coherence imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0073—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by tomography, i.e. reconstruction of 3D images from 2D projections
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B9/00—Measuring instruments characterised by the use of optical techniques
    • G01B9/02—Interferometers
    • G01B9/0209—Low-coherence interferometers
    • G01B9/02091—Tomographic interferometers, e.g. based on optical coherence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/10—Arrangements of light sources specially adapted for spectrometry or colorimetry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/4795—Scattering, i.e. diffuse reflection spatially resolved investigating of object in scattering medium
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/06—Means for illuminating specimens
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/16—Microscopes adapted for ultraviolet illumination ; Fluorescence microscopes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N2021/653—Coherent methods [CARS]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/061—Sources
    • G01N2201/06113—Coherent sources; lasers

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Pathology (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Surgery (AREA)
  • Optics & Photonics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Emergency Medicine (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
KR1020217033027A 2019-04-29 2020-04-23 하이브리드 광학 시스템 Active KR102952398B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962840001P 2019-04-29 2019-04-29
US62/840,001 2019-04-29
PCT/JP2020/017447 WO2020222300A1 (en) 2019-04-29 2020-04-23 Hybrid optical system

Publications (2)

Publication Number Publication Date
KR20220005449A KR20220005449A (ko) 2022-01-13
KR102952398B1 true KR102952398B1 (ko) 2026-04-13

Family

ID=73028975

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020217033027A Active KR102952398B1 (ko) 2019-04-29 2020-04-23 하이브리드 광학 시스템

Country Status (6)

Country Link
US (2) US11944407B2 (https=)
JP (3) JP6887708B1 (https=)
KR (1) KR102952398B1 (https=)
CN (1) CN113631897B (https=)
TW (1) TW202107067A (https=)
WO (1) WO2020222300A1 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113631897B (zh) * 2019-04-29 2024-07-16 Atonarp株式会社 混合光学系统
JP7565554B2 (ja) * 2020-05-22 2024-10-11 国立大学法人山梨大学 分光計、分析システム及び分析方法
JP7477933B2 (ja) * 2021-04-22 2024-05-02 アトナープ株式会社 Ｃａｒｓスペクトルの取得方法およびシステム
AU2022272873A1 (en) * 2021-05-12 2023-11-30 Illumisonics Inc. Photoabsorption remote sensing (pars) imaging methods
JP7577388B2 (ja) * 2021-08-20 2024-11-05 アトナープ株式会社 Ｃａｒｓスペクトルを取得するための方法およびシステム
JP7694673B2 (ja) * 2021-08-31 2025-06-18 株式会社島津製作所 ラマン分光装置
EP4413355A1 (en) * 2021-10-06 2024-08-14 Atonarp Inc. Method and system for acquiring cars spectrum
US12535422B2 (en) 2021-10-14 2026-01-27 Atonarp Inc. System including a laser module
CN113812929B (zh) * 2021-11-22 2022-05-13 北京航空航天大学 一种多模态成像装置
KR102753085B1 (ko) * 2021-12-27 2025-01-10 고려대학교 산학협력단 광대역 비표지 분자 이미징 시스템
KR20240169663A (ko) * 2022-03-31 2024-12-03 온투 이노베이션 아이엔씨. 다중 파장 레이저 음향을 사용하여 샘플의 특성화를 수행하기 위한 시스템 및 방법
GB202212043D0 (en) * 2022-08-18 2022-10-05 Univ Of Lancaster Glucose concentration measuring device

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140253919A1 (en) 2011-09-30 2014-09-11 Tokyo University Of Science Foundation Optical Interferometer, Data Acquisition Device, and Data Acquisition Method
US20150005641A1 (en) 2012-02-27 2015-01-01 Saitama Medical University Measurement device and measurement method
JP2015102505A (ja) 2013-11-27 2015-06-04 株式会社日立ハイテクノロジーズ 光計測装置及び光計測方法
US20160091429A1 (en) 2013-05-10 2016-03-31 Ludwig-Maximilians-Universität München System and Method for Stimulated Raman Spectroscopy

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1754033B1 (en) * 2004-05-27 2011-06-22 Yeda Research And Development Co., Ltd. Coherently controlled nonlinear raman spectroscopy
JP5100461B2 (ja) 2008-03-14 2012-12-19 英明 加納 非線形分光計測システム用の光源装置、非線形分光計測システム及び方法
JP2009258071A (ja) * 2008-03-28 2009-11-05 Fujifilm Corp 粒子分析装置および粒子分析方法
JP2010002256A (ja) * 2008-06-19 2010-01-07 Fujifilm Corp 非線形ラマン散乱光測定装置
US9285575B2 (en) * 2009-01-26 2016-03-15 President And Fellows Of Harvard College Systems and methods for selective detection and imaging in coherent Raman microscopy by spectral excitation shaping
GB0904739D0 (en) * 2009-03-19 2009-05-06 Univ Cardiff Coherent anti-stokes raman spectroscopy
JP5444457B2 (ja) * 2009-05-11 2014-03-19 コリア リサーチ インスティテュート オブ スタンダーズ アンド サイエンス 非線形光学顕微鏡を用いた血管内脂質の非破壊的病理的変化診断プログラム
US8553219B2 (en) * 2011-01-24 2013-10-08 Vanderbilt University Common detector for combined raman spectroscopy-optical coherence tomography
JP6003902B2 (ja) * 2011-12-05 2016-10-05 ソニー株式会社 測定装置及び測定方法
US9581497B2 (en) 2012-10-19 2017-02-28 Hitachi, Ltd. Cars microscope
EP2806263A1 (en) * 2013-05-24 2014-11-26 Nederlandse Organisatie voor toegepast -natuurwetenschappelijk onderzoek TNO Method and detector for detecting an analyte
WO2014205413A2 (en) * 2013-06-21 2014-12-24 Invenio Imaging Inc. Multi-photon systems and methods
US9869591B2 (en) * 2013-08-22 2018-01-16 Hitachi, Ltd. Cars microscope
US20160007840A1 (en) * 2014-07-10 2016-01-14 The Board Of Trustees Of The University Of Illinois Handheld Device for Identification of Microbiological Constituents in the Middle Ear
US20170023482A1 (en) * 2015-07-20 2017-01-26 United States Of America, As Represented By The Secretary Of Commerce Simultaneous plural color broadband coherent anti-stokes raman scattering microscope and imaging
WO2017217534A1 (ja) * 2016-06-17 2017-12-21 学校法人埼玉医科大学 被験対象可視化装置
JP6765648B2 (ja) * 2016-07-13 2020-10-07 国立大学法人東京農工大学 光検出装置、光検出方法および光検出プログラム
CN110178069B (zh) * 2016-11-12 2022-05-17 纽约市哥伦比亚大学理事会 显微镜设备、方法和系统
US10337995B2 (en) * 2017-06-12 2019-07-02 Boston Medical Center Corporation Systems and methods for oblique laser scanning
CN113631897B (zh) 2019-04-29 2024-07-16 Atonarp株式会社 混合光学系统

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140253919A1 (en) 2011-09-30 2014-09-11 Tokyo University Of Science Foundation Optical Interferometer, Data Acquisition Device, and Data Acquisition Method
US20150005641A1 (en) 2012-02-27 2015-01-01 Saitama Medical University Measurement device and measurement method
US20160091429A1 (en) 2013-05-10 2016-03-31 Ludwig-Maximilians-Universität München System and Method for Stimulated Raman Spectroscopy
JP2015102505A (ja) 2013-11-27 2015-06-04 株式会社日立ハイテクノロジーズ 光計測装置及び光計測方法

Also Published As

Publication number Publication date
JP6887708B1 (ja) 2021-06-16
JP2021113831A (ja) 2021-08-05
US11944407B2 (en) 2024-04-02
KR20220005449A (ko) 2022-01-13
TW202107067A (zh) 2021-02-16
US20240197182A1 (en) 2024-06-20
US12343113B2 (en) 2025-07-01
JP2024079850A (ja) 2024-06-11
WO2020222300A1 (en) 2020-11-05
JP2021519437A (ja) 2021-08-10
JP7477882B2 (ja) 2024-05-02
CN113631897A (zh) 2021-11-09
US20220087530A1 (en) 2022-03-24
CN113631897B (zh) 2024-07-16

Similar Documents

Publication Publication Date Title
KR102952398B1 (ko) 하이브리드 광학 시스템
JP5329449B2 (ja) 顕微鏡イメージングを実行する方法
CN1839307B (zh) 时间序列变换脉冲分光计测装置
JP2012237714A5 (https=)
KR20170057672A (ko) 라만 신호 측정 방법, 장치 및 라만 신호 측정 장치를 포함하는 생체 정보 분석 장치
CN115046987B (zh) 一种时间门控拉曼光谱系统及其时间同步补偿方法
EP4594736A1 (en) Autofluorescence enhanced photothermal infrared spectroscopy
US20070252978A1 (en) Method and Apparatus for Optical Spectroscopy
JP7648264B2 (ja) Ｃａｒｓスペクトルを取得するための方法およびシステム
EP3575778B1 (en) Multi-wavelength laser inspection
JP6453487B2 (ja) 光計測装置及び光計測方法
JP2007278768A (ja) 顕微鏡装置
JP7475707B2 (ja) Ｃａｒｓ光学系を含むシステム
JP7477933B2 (ja) Ｃａｒｓスペクトルの取得方法およびシステム
JP7590257B2 (ja) 試料観察装置及び試料観察方法
JP2010096667A (ja) レーザ顕微鏡装置
JP2017102265A (ja) 走査型顕微鏡
JPH05273129A (ja) 光エコー顕微鏡
KR102751037B1 (ko) 다중 신호 측정용 분광 장치
JP2005181581A (ja) レーザー走査型共焦点顕微鏡
JP6815846B2 (ja) 試料観察装置
JP3222270B2 (ja) 分光ファイバースコープ

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

A201 Request for examination
PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

P11 Amendment of application requested

Free format text: ST27 STATUS EVENT CODE: A-2-2-P10-P11-NAP-X000 (AS PROVIDED BY THE NATIONAL OFFICE)

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

D22 Grant of ip right intended

Free format text: ST27 STATUS EVENT CODE: A-1-2-D10-D22-EXM-PE0701 (AS PROVIDED BY THE NATIONAL OFFICE)

PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

F11 Ip right granted following substantive examination

Free format text: ST27 STATUS EVENT CODE: A-2-4-F10-F11-EXM-PR0701 (AS PROVIDED BY THE NATIONAL OFFICE)

PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

U12 Designation fee paid

Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U12-OTH-PR1002 (AS PROVIDED BY THE NATIONAL OFFICE)

Year of fee payment: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

Q13 Ip right document published

Free format text: ST27 STATUS EVENT CODE: A-4-4-Q10-Q13-NAP-PG1601 (AS PROVIDED BY THE NATIONAL OFFICE)