WO2020222300A1 - Hybrid optical system - Google Patents

Hybrid optical system Download PDF

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Publication number
WO2020222300A1
WO2020222300A1 PCT/JP2020/017447 JP2020017447W WO2020222300A1 WO 2020222300 A1 WO2020222300 A1 WO 2020222300A1 JP 2020017447 W JP2020017447 W JP 2020017447W WO 2020222300 A1 WO2020222300 A1 WO 2020222300A1
Authority
WO
WIPO (PCT)
Prior art keywords
light
range
wavelengths
cars
target
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2020/017447
Other languages
English (en)
French (fr)
Inventor
Lukas BRUECKNER
David Anderson
Prakash Sreedhar Murthy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Atonarp Inc
Original Assignee
Atonarp Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Atonarp Inc filed Critical Atonarp Inc
Priority to KR1020217033027A priority Critical patent/KR102952398B1/ko
Priority to US17/420,152 priority patent/US11944407B2/en
Priority to JP2020563803A priority patent/JP6887708B1/ja
Priority to CN202080022563.4A priority patent/CN113631897B/zh
Publication of WO2020222300A1 publication Critical patent/WO2020222300A1/en
Anticipated expiration legal-status Critical
Priority to US18/588,108 priority patent/US12343113B2/en
Ceased legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/0205—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0062—Arrangements for scanning
    • A61B5/0066—Optical coherence imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0073—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by tomography, i.e. reconstruction of 3D images from 2D projections
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B9/00—Measuring instruments characterised by the use of optical techniques
    • G01B9/02—Interferometers
    • G01B9/0209—Low-coherence interferometers
    • G01B9/02091—Tomographic interferometers, e.g. based on optical coherence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/10—Arrangements of light sources specially adapted for spectrometry or colorimetry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/4795—Scattering, i.e. diffuse reflection spatially resolved investigating of object in scattering medium
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/06—Means for illuminating specimens
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/16—Microscopes adapted for ultraviolet illumination ; Fluorescence microscopes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N2021/653—Coherent methods [CARS]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/061—Sources
    • G01N2201/06113—Coherent sources; lasers

Definitions

  • the hybrid optical system (optical system) 10 includes a laser source 30 for generating a first laser 30a with a first wave length 1040 nm for a Stokes light (Stokes beam, Stokes pulse, a first light) 11 and a pump light (pump beam, pump pulse, second light) 12, a second laser 30b with a second wavelength 780 nm, an OCT light 13, and a probe light (probe beam, fourth light) 14.
  • One of preferable laser source 30 is a fiber laser.
  • the first laser 30a may include one to several hundred fS (femtosecond)-order pulses with tens to hundreds of mW.
  • the optical system 10 includes a pump light path (second optical path, pump unit) 22 that is configured to supply the pump light (second light) 12 with a second range R2 of wavelengths 1070 nm that is shorter than the first wavelength range (first range) R1 from the first laser 30a which is common to the Stokes light 11.
  • the optical system 10 includes a common optical path 28a that supplies the Stokes light 11 provided by the path 21 and the pump light 12 provided by path 22 to the optical I/O unit 25.
  • the optical path 21, 22, and 28a include necessary optical elements 32 such as filters, fibers, dichroic mirrors and prisms to configure each optical path. The same applies to the optical paths described below.
  • the probe light path 24 includes a time delay unit 24a that is configured to control a time difference between emission of the probe light (fourth light) 14 and emission of the pump light (second light) 12.
  • the time delay unit may have collimators and a motorized delay stage that can control the distance between the collimators. Time delay may be controlled by the laser control unit 58 in the controller 55.
  • the probe light path 24 can supply the probe light 14 with a time difference from the emitting of the pump light 12 for emitting to the target 5 via the optical I/O unit 25.
  • FIG. 14 depicts another embodiment of the probe light 14.
  • the probe pulse 14 may be generated and emitted prior to or at the same time of that of the Stokes light 11 and pump light 12 till the duration of vibration response.
  • a system 1 for using the CARS light and the OCT light comprises: (a) a first unit 21 that is configured to emit a first light 11 with a first range of wavelengths; (b) a second unit 22 that is configured to emit a second light 12 with a second range of wavelengths shorter than the first range; (c) a third unit 23 that is configured to emit a third light 13 with a third range of wavelengths shorter than the second range; (d) an optical unit 25 that is configured to coaxially output the first light 11, the second light 12, and the third light 13 to a target (sample) 5 and acquire a light from the target 5; (e) a reference unit 34 that is configured to split off a reference light 13r from the third light 13; (f) a selecting unit 28b that is configured to select a reflected light 15 of the third light and a CARS light 17 with a range of wavelengths at least partially overlapping the third range from the acquired light and the CARS light is generated by the first light and the second light at the target;

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  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Pathology (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Surgery (AREA)
  • Optics & Photonics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Emergency Medicine (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
PCT/JP2020/017447 2019-04-29 2020-04-23 Hybrid optical system Ceased WO2020222300A1 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
KR1020217033027A KR102952398B1 (ko) 2019-04-29 2020-04-23 하이브리드 광학 시스템
US17/420,152 US11944407B2 (en) 2019-04-29 2020-04-23 Hybrid optical system
JP2020563803A JP6887708B1 (ja) 2019-04-29 2020-04-23 ハイブリッド光学システム
CN202080022563.4A CN113631897B (zh) 2019-04-29 2020-04-23 混合光学系统
US18/588,108 US12343113B2 (en) 2019-04-29 2024-02-27 Hybrid optical system

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962840001P 2019-04-29 2019-04-29
US62/840,001 2019-04-29

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US17/420,152 A-371-Of-International US11944407B2 (en) 2019-04-29 2020-04-23 Hybrid optical system
US18/588,108 Continuation US12343113B2 (en) 2019-04-29 2024-02-27 Hybrid optical system

Publications (1)

Publication Number Publication Date
WO2020222300A1 true WO2020222300A1 (en) 2020-11-05

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2020/017447 Ceased WO2020222300A1 (en) 2019-04-29 2020-04-23 Hybrid optical system

Country Status (6)

Country Link
US (2) US11944407B2 (https=)
JP (3) JP6887708B1 (https=)
KR (1) KR102952398B1 (https=)
CN (1) CN113631897B (https=)
TW (1) TW202107067A (https=)
WO (1) WO2020222300A1 (https=)

Cited By (7)

* Cited by examiner, † Cited by third party
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JP2021183946A (ja) * 2020-05-22 2021-12-02 国立大学法人山梨大学 分光計、分析システム及び分析方法
WO2022224999A1 (en) * 2021-04-22 2022-10-27 Atonarp Inc. Method and system for acquiring cars spectrum
WO2023022037A1 (en) * 2021-08-20 2023-02-23 Atonarp Inc. Method and system for acquiring cars spectrum
WO2023058710A1 (en) * 2021-10-06 2023-04-13 Atonarp Inc. Method and system for acquiring cars spectrum
WO2023063415A1 (en) * 2021-10-14 2023-04-20 Atonarp Inc. System including a laser module
WO2024038268A1 (en) * 2022-08-18 2024-02-22 University Of Lancaster Glucose concentration measuring device
JP2024518972A (ja) * 2021-05-12 2024-05-08 イルミソニックス インコーポレイテッド 光吸収リモートセンシング（ｐａｒｓ）イメージング法

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CN113631897B (zh) * 2019-04-29 2024-07-16 Atonarp株式会社 混合光学系统
JP7694673B2 (ja) * 2021-08-31 2025-06-18 株式会社島津製作所 ラマン分光装置
CN113812929B (zh) * 2021-11-22 2022-05-13 北京航空航天大学 一种多模态成像装置
KR102753085B1 (ko) * 2021-12-27 2025-01-10 고려대학교 산학협력단 광대역 비표지 분자 이미징 시스템
KR20240169663A (ko) * 2022-03-31 2024-12-03 온투 이노베이션 아이엔씨. 다중 파장 레이저 음향을 사용하여 샘플의 특성화를 수행하기 위한 시스템 및 방법

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JP7565554B2 (ja) 2020-05-22 2024-10-11 国立大学法人山梨大学 分光計、分析システム及び分析方法
JP2021183946A (ja) * 2020-05-22 2021-12-02 国立大学法人山梨大学 分光計、分析システム及び分析方法
JP2024513386A (ja) * 2021-04-22 2024-03-25 アトナープ株式会社 Ｃａｒｓスペクトルの取得方法およびシステム
WO2022224999A1 (en) * 2021-04-22 2022-10-27 Atonarp Inc. Method and system for acquiring cars spectrum
JP7477933B2 (ja) 2021-04-22 2024-05-02 アトナープ株式会社 Ｃａｒｓスペクトルの取得方法およびシステム
JP2024518972A (ja) * 2021-05-12 2024-05-08 イルミソニックス インコーポレイテッド 光吸収リモートセンシング（ｐａｒｓ）イメージング法
JP2024529604A (ja) * 2021-08-20 2024-08-08 アトナープ株式会社 Ｃａｒｓスペクトルを取得するための方法およびシステム
JP7577388B2 (ja) 2021-08-20 2024-11-05 アトナープ株式会社 Ｃａｒｓスペクトルを取得するための方法およびシステム
WO2023022037A1 (en) * 2021-08-20 2023-02-23 Atonarp Inc. Method and system for acquiring cars spectrum
US12523611B2 (en) 2021-10-06 2026-01-13 Atonarp Inc. Method and system for acquiring cars spectrum
WO2023058710A1 (en) * 2021-10-06 2023-04-13 Atonarp Inc. Method and system for acquiring cars spectrum
JP2024535178A (ja) * 2021-10-06 2024-09-30 アトナープ株式会社 Ｃａｒｓスペクトルを取得するための方法およびシステム
JP7648264B2 (ja) 2021-10-06 2025-03-18 アトナープ株式会社 Ｃａｒｓスペクトルを取得するための方法およびシステム
WO2023063415A1 (en) * 2021-10-14 2023-04-20 Atonarp Inc. System including a laser module
JP2024539578A (ja) * 2021-10-14 2024-10-29 アトナープ株式会社 レーザーモジュールを含むシステム
JP7696187B2 (ja) 2021-10-14 2025-06-20 アトナープ株式会社 レーザーモジュールを含むシステム
US12535422B2 (en) 2021-10-14 2026-01-27 Atonarp Inc. System including a laser module
WO2024038268A1 (en) * 2022-08-18 2024-02-22 University Of Lancaster Glucose concentration measuring device

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US11944407B2 (en) 2024-04-02
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TW202107067A (zh) 2021-02-16
US20240197182A1 (en) 2024-06-20
US12343113B2 (en) 2025-07-01
JP2024079850A (ja) 2024-06-11
JP2021519437A (ja) 2021-08-10
KR102952398B1 (ko) 2026-04-13
JP7477882B2 (ja) 2024-05-02
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US20220087530A1 (en) 2022-03-24
CN113631897B (zh) 2024-07-16

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