CN113631897B - 混合光学系统 - Google Patents

混合光学系统 Download PDF

Info

Publication number
CN113631897B
CN113631897B CN202080022563.4A CN202080022563A CN113631897B CN 113631897 B CN113631897 B CN 113631897B CN 202080022563 A CN202080022563 A CN 202080022563A CN 113631897 B CN113631897 B CN 113631897B
Authority
CN
China
Prior art keywords
light
wavelength range
cars
optical
unit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN202080022563.4A
Other languages
English (en)
Chinese (zh)
Other versions
CN113631897A (zh
Inventor
L·布吕克纳
D·安德森
柏拉卡斯·斯里达尔·穆尔蒂
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Atonarp Corp
Original Assignee
Atonarp Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Atonarp Corp filed Critical Atonarp Corp
Publication of CN113631897A publication Critical patent/CN113631897A/zh
Application granted granted Critical
Publication of CN113631897B publication Critical patent/CN113631897B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/0205—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0062—Arrangements for scanning
    • A61B5/0066—Optical coherence imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0073—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by tomography, i.e. reconstruction of 3D images from 2D projections
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B9/00—Measuring instruments characterised by the use of optical techniques
    • G01B9/02—Interferometers
    • G01B9/0209—Low-coherence interferometers
    • G01B9/02091—Tomographic interferometers, e.g. based on optical coherence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/10—Arrangements of light sources specially adapted for spectrometry or colorimetry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/4795—Scattering, i.e. diffuse reflection spatially resolved investigating of object in scattering medium
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/06—Means for illuminating specimens
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/16—Microscopes adapted for ultraviolet illumination ; Fluorescence microscopes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N2021/653—Coherent methods [CARS]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/061—Sources
    • G01N2201/06113—Coherent sources; lasers

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Emergency Medicine (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
CN202080022563.4A 2019-04-29 2020-04-23 混合光学系统 Active CN113631897B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962840001P 2019-04-29 2019-04-29
US62/840,001 2019-04-29
PCT/JP2020/017447 WO2020222300A1 (en) 2019-04-29 2020-04-23 Hybrid optical system

Publications (2)

Publication Number Publication Date
CN113631897A CN113631897A (zh) 2021-11-09
CN113631897B true CN113631897B (zh) 2024-07-16

Family

ID=73028975

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080022563.4A Active CN113631897B (zh) 2019-04-29 2020-04-23 混合光学系统

Country Status (6)

Country Link
US (2) US11944407B2 (https=)
JP (3) JP6887708B1 (https=)
KR (1) KR102952398B1 (https=)
CN (1) CN113631897B (https=)
TW (1) TW202107067A (https=)
WO (1) WO2020222300A1 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113631897B (zh) * 2019-04-29 2024-07-16 Atonarp株式会社 混合光学系统
JP7565554B2 (ja) * 2020-05-22 2024-10-11 国立大学法人山梨大学 分光計、分析システム及び分析方法
JP7477933B2 (ja) * 2021-04-22 2024-05-02 アトナープ株式会社 Ｃａｒｓスペクトルの取得方法およびシステム
JP2024518972A (ja) * 2021-05-12 2024-05-08 イルミソニックス インコーポレイテッド 光吸収リモートセンシング（ｐａｒｓ）イメージング法
EP4388301A1 (en) * 2021-08-20 2024-06-26 Atonarp Inc. Method and system for acquiring cars spectrum
CN117881957A (zh) * 2021-08-31 2024-04-12 株式会社岛津制作所 拉曼分光装置
EP4413355A1 (en) * 2021-10-06 2024-08-14 Atonarp Inc. Method and system for acquiring cars spectrum
WO2023063415A1 (en) * 2021-10-14 2023-04-20 Atonarp Inc. System including a laser module
CN113812929B (zh) * 2021-11-22 2022-05-13 北京航空航天大学 一种多模态成像装置
KR102753085B1 (ko) * 2021-12-27 2025-01-10 고려대학교 산학협력단 광대역 비표지 분자 이미징 시스템
WO2023191801A1 (en) * 2022-03-31 2023-10-05 Onto Innovation Inc. System and method for performing characterization of a sample using multi-wavelength laser acoustics
GB202212043D0 (en) * 2022-08-18 2022-10-05 Univ Of Lancaster Glucose concentration measuring device

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE514060T1 (de) * 2004-05-27 2011-07-15 Yeda Res & Dev Kohärent gesteuerte nichtlineare raman- spektroskopie
JP5100461B2 (ja) * 2008-03-14 2012-12-19 英明 加納 非線形分光計測システム用の光源装置、非線形分光計測システム及び方法
JP2009258071A (ja) * 2008-03-28 2009-11-05 Fujifilm Corp 粒子分析装置および粒子分析方法
JP2010002256A (ja) * 2008-06-19 2010-01-07 Fujifilm Corp 非線形ラマン散乱光測定装置
US9285575B2 (en) 2009-01-26 2016-03-15 President And Fellows Of Harvard College Systems and methods for selective detection and imaging in coherent Raman microscopy by spectral excitation shaping
GB0904739D0 (en) * 2009-03-19 2009-05-06 Univ Cardiff Coherent anti-stokes raman spectroscopy
WO2010131785A1 (ko) * 2009-05-11 2010-11-18 한국표준과학연구원 비선형 광학현미경을 이용한 혈관 내 지질의 병리적 변화 진단시스템
US8553219B2 (en) * 2011-01-24 2013-10-08 Vanderbilt University Common detector for combined raman spectroscopy-optical coherence tomography
WO2013047698A1 (ja) * 2011-09-30 2013-04-04 学校法人東京理科大学 光干渉計、情報取得装置、及び情報取得方法
JP6003902B2 (ja) * 2011-12-05 2016-10-05 ソニー株式会社 測定装置及び測定方法
JP5901346B2 (ja) 2012-02-27 2016-04-06 学校法人 埼玉医科大学 計測装置及び計測方法
US9581497B2 (en) 2012-10-19 2017-02-28 Hitachi, Ltd. Cars microscope
US9638638B2 (en) 2013-05-10 2017-05-02 Ludwig-Maximilians-Universität München System and method for stimulated raman spectroscopy
EP2806263A1 (en) * 2013-05-24 2014-11-26 Nederlandse Organisatie voor toegepast -natuurwetenschappelijk onderzoek TNO Method and detector for detecting an analyte
US20160238532A1 (en) * 2013-06-21 2016-08-18 Invenio Imaging Inc. Multi-photon systems and methods
WO2015025389A1 (ja) * 2013-08-22 2015-02-26 株式会社日立製作所 Cars顕微鏡
JP6324709B2 (ja) 2013-11-27 2018-05-16 株式会社日立ハイテクノロジーズ 光計測装置及び光計測方法
US20160007840A1 (en) * 2014-07-10 2016-01-14 The Board Of Trustees Of The University Of Illinois Handheld Device for Identification of Microbiological Constituents in the Middle Ear
US20170023482A1 (en) * 2015-07-20 2017-01-26 United States Of America, As Represented By The Secretary Of Commerce Simultaneous plural color broadband coherent anti-stokes raman scattering microscope and imaging
JP6804773B2 (ja) * 2016-06-17 2020-12-23 学校法人 埼玉医科大学 被験対象可視化装置
JP6765648B2 (ja) * 2016-07-13 2020-10-07 国立大学法人東京農工大学 光検出装置、光検出方法および光検出プログラム
CN110178069B (zh) * 2016-11-12 2022-05-17 纽约市哥伦比亚大学理事会 显微镜设备、方法和系统
US10337995B2 (en) * 2017-06-12 2019-07-02 Boston Medical Center Corporation Systems and methods for oblique laser scanning
CN113631897B (zh) 2019-04-29 2024-07-16 Atonarp株式会社 混合光学系统

Also Published As

Publication number Publication date
JP2021113831A (ja) 2021-08-05
JP7477882B2 (ja) 2024-05-02
CN113631897A (zh) 2021-11-09
TW202107067A (zh) 2021-02-16
JP2024079850A (ja) 2024-06-11
KR20220005449A (ko) 2022-01-13
US20220087530A1 (en) 2022-03-24
US12343113B2 (en) 2025-07-01
KR102952398B1 (ko) 2026-04-13
JP6887708B1 (ja) 2021-06-16
JP2021519437A (ja) 2021-08-10
US11944407B2 (en) 2024-04-02
WO2020222300A1 (en) 2020-11-05
US20240197182A1 (en) 2024-06-20

Similar Documents

Publication Publication Date Title
CN113631897B (zh) 混合光学系统
JP5329449B2 (ja) 顕微鏡イメージングを実行する方法
US8294985B2 (en) Laser microscope apparatus
JP2012237714A5 (https=)
KR102444284B1 (ko) 라만 신호 측정 방법, 장치 및 라만 신호 측정 장치를 포함하는 생체 정보 분석 장치
JP6254096B2 (ja) 多光子イメージングシステム用多色励起モジュール並びにそれに関連する方法及びシステム
US9709382B2 (en) Light source apparatus and information acquisition apparatus including the same
US8868158B2 (en) Optical analyzer
JP2009047435A (ja) レーザ顕微鏡
US9097674B2 (en) Method for detecting a resonant nonlinear optical signal and device for implementing said method
JP2015197513A (ja) 光源装置およびそれを用いた情報取得装置
JP2007278768A (ja) 顕微鏡装置
JP7475707B2 (ja) Ｃａｒｓ光学系を含むシステム
WO2017217534A1 (ja) 被験対象可視化装置
JP7477933B2 (ja) Ｃａｒｓスペクトルの取得方法およびシステム
WO2017090075A1 (ja) 光計測装置及び光計測方法
CN117280264A (zh) 试样观察装置及试样观察方法
JP2010096667A (ja) レーザ顕微鏡装置
WO2023022037A1 (en) Method and system for acquiring cars spectrum
JP2009058578A (ja) 標本観察条件演算装置およびこれを備える顕微鏡システム
JP2014126491A (ja) 情報取得システム、情報取得装置、および情報取得方法

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant