KR102830206B1 - (4s)-4-(4-시아노-2-메톡시페닐)-5-에톡시-2,8-디메틸-1,4-디히드로-1,6-나프티리딘-3-카르복스아미드의 제조 방법 및 활성 제약 성분으로서 사용하기 위한 그의 정제 - Google Patents

(4s)-4-(4-시아노-2-메톡시페닐)-5-에톡시-2,8-디메틸-1,4-디히드로-1,6-나프티리딘-3-카르복스아미드의 제조 방법 및 활성 제약 성분으로서 사용하기 위한 그의 정제 Download PDF

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KR102830206B1
KR102830206B1 KR1020237014295A KR20237014295A KR102830206B1 KR 102830206 B1 KR102830206 B1 KR 102830206B1 KR 1020237014295 A KR1020237014295 A KR 1020237014295A KR 20237014295 A KR20237014295 A KR 20237014295A KR 102830206 B1 KR102830206 B1 KR 102830206B1
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요아네스 플라트제크
군나르 가르케
알폰스 그루넨베르크
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바이엘 파마 악티엔게젤샤프트
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  • Hydrogenated Pyridines (AREA)
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KR1020237014295A 2014-08-01 2015-07-29 (4s)-4-(4-시아노-2-메톡시페닐)-5-에톡시-2,8-디메틸-1,4-디히드로-1,6-나프티리딘-3-카르복스아미드의 제조 방법 및 활성 제약 성분으로서 사용하기 위한 그의 정제 Active KR102830206B1 (ko)

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KR1020257022052A KR20250108757A (ko) 2014-08-01 2015-07-29 (4s)-4-(4-시아노-2-메톡시페닐)-5-에톡시-2,8-디메틸-1,4-디히드로-1,6-나프티리딘-3-카르복스아미드의제조 방법 및 활성 제약 성분으로서 사용하기 위한 그의 정제

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Application Number Priority Date Filing Date Title
EP14179544.3 2014-08-01
EP14179544 2014-08-01
KR1020177005278A KR102527893B1 (ko) 2014-08-01 2015-07-29 (4s)-4-(4-시아노-2-메톡시페닐)-5-에톡시-2,8-디메틸-1,4-디히드로-1,6-나프티리딘-3-카르복스아미드의 제조 방법 및 활성 제약 성분으로서 사용하기 위한 그의 정제
PCT/EP2015/067340 WO2016016287A1 (de) 2014-08-01 2015-07-29 Verfahren zur herstellung von (4s)- 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridin-3-carbox-amid und dessen aufreinigung für die verwendung als pharmazeutischer wirkstoff

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KR1020177005278A Division KR102527893B1 (ko) 2014-08-01 2015-07-29 (4s)-4-(4-시아노-2-메톡시페닐)-5-에톡시-2,8-디메틸-1,4-디히드로-1,6-나프티리딘-3-카르복스아미드의 제조 방법 및 활성 제약 성분으로서 사용하기 위한 그의 정제

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KR1020257022052A Division KR20250108757A (ko) 2014-08-01 2015-07-29 (4s)-4-(4-시아노-2-메톡시페닐)-5-에톡시-2,8-디메틸-1,4-디히드로-1,6-나프티리딘-3-카르복스아미드의제조 방법 및 활성 제약 성분으로서 사용하기 위한 그의 정제

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KR20230066477A KR20230066477A (ko) 2023-05-15
KR102830206B1 true KR102830206B1 (ko) 2025-07-07

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KR1020237014295A Active KR102830206B1 (ko) 2014-08-01 2015-07-29 (4s)-4-(4-시아노-2-메톡시페닐)-5-에톡시-2,8-디메틸-1,4-디히드로-1,6-나프티리딘-3-카르복스아미드의 제조 방법 및 활성 제약 성분으로서 사용하기 위한 그의 정제
KR1020257022052A Pending KR20250108757A (ko) 2014-08-01 2015-07-29 (4s)-4-(4-시아노-2-메톡시페닐)-5-에톡시-2,8-디메틸-1,4-디히드로-1,6-나프티리딘-3-카르복스아미드의제조 방법 및 활성 제약 성분으로서 사용하기 위한 그의 정제
KR1020177005278A Active KR102527893B1 (ko) 2014-08-01 2015-07-29 (4s)-4-(4-시아노-2-메톡시페닐)-5-에톡시-2,8-디메틸-1,4-디히드로-1,6-나프티리딘-3-카르복스아미드의 제조 방법 및 활성 제약 성분으로서 사용하기 위한 그의 정제

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KR1020257022052A Pending KR20250108757A (ko) 2014-08-01 2015-07-29 (4s)-4-(4-시아노-2-메톡시페닐)-5-에톡시-2,8-디메틸-1,4-디히드로-1,6-나프티리딘-3-카르복스아미드의제조 방법 및 활성 제약 성분으로서 사용하기 위한 그의 정제
KR1020177005278A Active KR102527893B1 (ko) 2014-08-01 2015-07-29 (4s)-4-(4-시아노-2-메톡시페닐)-5-에톡시-2,8-디메틸-1,4-디히드로-1,6-나프티리딘-3-카르복스아미드의 제조 방법 및 활성 제약 성분으로서 사용하기 위한 그의 정제

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US (4) US10059707B2 (https=)
EP (2) EP3174875B1 (https=)
JP (1) JP6818674B2 (https=)
KR (3) KR102830206B1 (https=)
CN (4) CN116655629A (https=)
AR (1) AR101403A1 (https=)
AU (1) AU2015295376C1 (https=)
BR (1) BR112017001678B1 (https=)
CA (2) CA2956529A1 (https=)
CL (1) CL2017000263A1 (https=)
CO (1) CO2017000886A2 (https=)
DK (1) DK3174875T3 (https=)
ES (1) ES2828704T3 (https=)
HR (1) HRP20201800T1 (https=)
HU (1) HUE051350T2 (https=)
IL (1) IL250239B (https=)
JO (1) JO3648B1 (https=)
LT (1) LT3174875T (https=)
MX (1) MX369467B (https=)
MY (1) MY198066A (https=)
PE (1) PE20170141A1 (https=)
PL (1) PL3174875T3 (https=)
PT (1) PT3174875T (https=)
RS (1) RS60921B1 (https=)
RU (1) RU2729998C9 (https=)
SG (1) SG11201700785UA (https=)
SI (1) SI3174875T1 (https=)
TW (1) TWI684593B (https=)
UA (1) UA122773C2 (https=)
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WO (1) WO2016016287A1 (https=)

Families Citing this family (36)

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ES2828704T3 (es) * 2014-08-01 2021-05-27 Bayer Pharma AG Procedimiento para la preparación de (4S)-4-(4-ciano-2-metoxifenil)-5-etoxi-2,8-dimetil-1,4-dihidro-1,6-naftiridin-3-carboxamida y su purificación para su uso como principio activo farmacéutico
RS59055B1 (sr) * 2015-08-21 2019-08-30 Bayer Pharma AG Postupak za proizvodnju (4s)-4-(4-cijano-2-metoksifenil)-5-etoksi-2,8-dimetil-1,4-dihidro-1,6-naftiridin-3-karboksamida i njegovo prečišćavanje u svrhu upotrebe kao farmaceutski aktivne supstance
EP3560922A1 (de) 2018-04-24 2019-10-30 Bayer Aktiengesellschaft Verfahren zur herstellung von (4s)- 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridin-3-carbox-amid durch racemat-spaltung mittels diastereomerer weinsäureester
CN113474332B (zh) 2019-03-05 2025-03-04 拜耳公司 合成4-氨基-5-甲基-1h-吡啶-2-酮的方法
WO2020178177A1 (de) 2019-03-05 2020-09-10 Bayer Aktiengesellschaft Verfahren zur herstellung von 4-amino-5-methylpyridon
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EP4045499A1 (de) * 2019-10-17 2022-08-24 Bayer Aktiengesellschaft Verfahren zur herstellung von 2-cyanoethyl (4s)-4-(4-cyano-2-methoxy-phenyl)-5-hydroxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridin-3-carboxylat durch racemat-spaltung mittels diastereomerer weinsäureester
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