KR102827558B1 - 암 면역요법을 위한 crispr-cas-관련 방법, 조성물 및 구성성분 - Google Patents
암 면역요법을 위한 crispr-cas-관련 방법, 조성물 및 구성성분 Download PDFInfo
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- KR102827558B1 KR102827558B1 KR1020237036403A KR20237036403A KR102827558B1 KR 102827558 B1 KR102827558 B1 KR 102827558B1 KR 1020237036403 A KR1020237036403 A KR 1020237036403A KR 20237036403 A KR20237036403 A KR 20237036403A KR 102827558 B1 KR102827558 B1 KR 102827558B1
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- A61K40/00—Cellular immunotherapy
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- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
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- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
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- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/55—Vector systems having a special element relevant for transcription from bacteria
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- Bioinformatics & Cheminformatics (AREA)
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- Animal Behavior & Ethology (AREA)
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- Pharmacology & Pharmacy (AREA)
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- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Hematology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020257021203A KR20250102123A (ko) | 2014-04-18 | 2015-04-17 | 암 면역요법을 위한 crispr-cas-관련 방법, 조성물 및 구성성분 |
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461981636P | 2014-04-18 | 2014-04-18 | |
| US61/981,636 | 2014-04-18 | ||
| US201562138246P | 2015-03-25 | 2015-03-25 | |
| US62/138,246 | 2015-03-25 | ||
| PCT/US2015/026504 WO2015161276A2 (en) | 2014-04-18 | 2015-04-17 | Crispr-cas-related methods, compositions and components for cancer immunotherapy |
| KR1020167032071A KR102595473B1 (ko) | 2014-04-18 | 2015-04-17 | 암 면역요법을 위한 crispr-cas-관련 방법, 조성물 및 구성성분 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020167032071A Division KR102595473B1 (ko) | 2014-04-18 | 2015-04-17 | 암 면역요법을 위한 crispr-cas-관련 방법, 조성물 및 구성성분 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020257021203A Division KR20250102123A (ko) | 2014-04-18 | 2015-04-17 | 암 면역요법을 위한 crispr-cas-관련 방법, 조성물 및 구성성분 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20230152175A KR20230152175A (ko) | 2023-11-02 |
| KR102827558B1 true KR102827558B1 (ko) | 2025-07-11 |
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ID=53059426
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020167032071A Active KR102595473B1 (ko) | 2014-04-18 | 2015-04-17 | 암 면역요법을 위한 crispr-cas-관련 방법, 조성물 및 구성성분 |
| KR1020237036403A Active KR102827558B1 (ko) | 2014-04-18 | 2015-04-17 | 암 면역요법을 위한 crispr-cas-관련 방법, 조성물 및 구성성분 |
| KR1020257021203A Pending KR20250102123A (ko) | 2014-04-18 | 2015-04-17 | 암 면역요법을 위한 crispr-cas-관련 방법, 조성물 및 구성성분 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020167032071A Active KR102595473B1 (ko) | 2014-04-18 | 2015-04-17 | 암 면역요법을 위한 crispr-cas-관련 방법, 조성물 및 구성성분 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020257021203A Pending KR20250102123A (ko) | 2014-04-18 | 2015-04-17 | 암 면역요법을 위한 crispr-cas-관련 방법, 조성물 및 구성성분 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20170175128A1 (enExample) |
| EP (2) | EP3132030B1 (enExample) |
| JP (5) | JP2017513485A (enExample) |
| KR (3) | KR102595473B1 (enExample) |
| CN (1) | CN108138183A (enExample) |
| AU (3) | AU2015247323B2 (enExample) |
| CA (1) | CA2945335A1 (enExample) |
| IL (4) | IL292512B2 (enExample) |
| SG (3) | SG10201809157VA (enExample) |
| WO (1) | WO2015161276A2 (enExample) |
Families Citing this family (240)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6261500B2 (ja) | 2011-07-22 | 2018-01-17 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ヌクレアーゼ切断特異性の評価および改善 |
| BR112014009346B1 (pt) | 2011-10-17 | 2020-09-15 | Massachusetts Institute Of Technology | Entrega intracelular |
| WO2013163628A2 (en) | 2012-04-27 | 2013-10-31 | Duke University | Genetic correction of mutated genes |
| US9828582B2 (en) | 2013-03-19 | 2017-11-28 | Duke University | Compositions and methods for the induction and tuning of gene expression |
| US20150044192A1 (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease |
| KR102243597B1 (ko) | 2013-08-16 | 2021-04-26 | 메사추세츠 인스티튜트 오브 테크놀로지 | 세포로의 선택적 물질 전달 |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| US9737604B2 (en) | 2013-09-06 | 2017-08-22 | President And Fellows Of Harvard College | Use of cationic lipids to deliver CAS9 |
| PT3066201T (pt) | 2013-11-07 | 2018-06-04 | Massachusetts Inst Technology | Métodos e composições relacionadas com crispr com arng reguladores |
| US9068179B1 (en) | 2013-12-12 | 2015-06-30 | President And Fellows Of Harvard College | Methods for correcting presenilin point mutations |
| KR20170032406A (ko) | 2014-07-15 | 2017-03-22 | 주노 쎄러퓨티크스 인코퍼레이티드 | 입양 세포 치료를 위한 조작된 세포 |
| US10077453B2 (en) | 2014-07-30 | 2018-09-18 | President And Fellows Of Harvard College | CAS9 proteins including ligand-dependent inteins |
| KR20170075013A (ko) | 2014-10-31 | 2017-06-30 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | Cart 세포에서 유전자 발현의 변경 및 그의 용도 |
| CN107109362A (zh) | 2014-10-31 | 2017-08-29 | 麻省理工学院 | 递送生物分子至免疫细胞 |
| CN107002089B (zh) | 2014-11-14 | 2021-09-07 | 麻省理工学院 | 化合物和组合物向细胞中的破坏和场实现的递送 |
| CN107532162A (zh) | 2014-12-12 | 2018-01-02 | 托德·M·伍尔夫 | 用于利用寡核苷酸编辑细胞中核酸的组合物和方法 |
| WO2016094880A1 (en) | 2014-12-12 | 2016-06-16 | The Broad Institute Inc. | Delivery, use and therapeutic applications of crispr systems and compositions for genome editing as to hematopoietic stem cells (hscs) |
| WO2016094874A1 (en) | 2014-12-12 | 2016-06-16 | The Broad Institute Inc. | Escorted and functionalized guides for crispr-cas systems |
| WO2016094867A1 (en) | 2014-12-12 | 2016-06-16 | The Broad Institute Inc. | Protected guide rnas (pgrnas) |
| WO2016106244A1 (en) | 2014-12-24 | 2016-06-30 | The Broad Institute Inc. | Crispr having or associated with destabilization domains |
| WO2016115179A1 (en) | 2015-01-12 | 2016-07-21 | Massachusetts Institute Of Technology | Gene editing through microfluidic delivery |
| JP6929791B2 (ja) | 2015-02-09 | 2021-09-01 | デューク ユニバーシティ | エピゲノム編集のための組成物および方法 |
| US20180112213A1 (en) * | 2015-03-25 | 2018-04-26 | Editas Medicine, Inc. | Crispr/cas-related methods, compositions and components |
| BR112017020750A2 (pt) * | 2015-03-27 | 2018-06-26 | Harvard College | células t modificadas e métodos de produção e utilização das mesmas |
| JP2018515139A (ja) | 2015-05-08 | 2018-06-14 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 万能ドナー幹細胞および関連する方法 |
| EP3294888A1 (en) * | 2015-05-11 | 2018-03-21 | Editas Medicine, Inc. | Crispr/cas-related methods and compositions for treating hiv infection and aids |
| CA2986310A1 (en) * | 2015-05-11 | 2016-11-17 | Editas Medicine, Inc. | Optimized crispr/cas9 systems and methods for gene editing in stem cells |
| US20180161368A1 (en) | 2015-05-29 | 2018-06-14 | Juno Therapeutics, Inc. | Composition and methods for regulating inhibitory interactions in genetically engineered cells |
| EP3307887A1 (en) | 2015-06-09 | 2018-04-18 | Editas Medicine, Inc. | Crispr/cas-related methods and compositions for improving transplantation |
| AU2016279062A1 (en) | 2015-06-18 | 2019-03-28 | Omar O. Abudayyeh | Novel CRISPR enzymes and systems |
| WO2017008063A1 (en) | 2015-07-09 | 2017-01-12 | Massachusetts Institute Of Technology | Delivery of materials to anucleate cells |
| MA42895A (fr) | 2015-07-15 | 2018-05-23 | Juno Therapeutics Inc | Cellules modifiées pour thérapie cellulaire adoptive |
| ES2939084T3 (es) | 2015-07-29 | 2023-04-18 | Onk Therapeutics Ltd | Células asesinas naturales y líneas de células asesinas naturales modificadas que tienen citotoxicidad aumentada |
| US10906951B2 (en) | 2015-07-29 | 2021-02-02 | Onk Therapeutics Limited | Modified natural killer cells and natural killer cell lines having increased cytotoxicity |
| WO2017023803A1 (en) | 2015-07-31 | 2017-02-09 | Regents Of The University Of Minnesota | Modified cells and methods of therapy |
| US11613759B2 (en) | 2015-09-04 | 2023-03-28 | Sqz Biotechnologies Company | Intracellular delivery of biomolecules to cells comprising a cell wall |
| WO2017066497A2 (en) | 2015-10-13 | 2017-04-20 | Duke University | Genome engineering with type i crispr systems in eukaryotic cells |
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