BR112021016046A2 - Células assassinas naturais modificadas (nk) para imunoterapia - Google Patents

Células assassinas naturais modificadas (nk) para imunoterapia

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Publication number
BR112021016046A2
BR112021016046A2 BR112021016046A BR112021016046A BR112021016046A2 BR 112021016046 A2 BR112021016046 A2 BR 112021016046A2 BR 112021016046 A BR112021016046 A BR 112021016046A BR 112021016046 A BR112021016046 A BR 112021016046A BR 112021016046 A2 BR112021016046 A2 BR 112021016046A2
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Brazil
Prior art keywords
cells
immunotherapy
natural killer
engineered natural
engineered
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BR112021016046A
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English (en)
Inventor
Christopher Borges
Grant Welstead Gordon
Ka Wai Wong Karrie
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Editas Medicine Inc
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Application filed by Editas Medicine Inc filed Critical Editas Medicine Inc
Publication of BR112021016046A2 publication Critical patent/BR112021016046A2/pt

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4613—Natural-killer cells [NK or NK-T]
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/463—Cellular immunotherapy characterised by recombinant expression
    • A61K39/4631—Chimeric Antigen Receptors [CAR]
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    • A61K39/46—Cellular immunotherapy
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    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
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    • A61K39/464403—Receptors for growth factors
    • A61K39/464404—Epidermal growth factor receptors [EGFR]
    • A—HUMAN NECESSITIES
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464402—Receptors, cell surface antigens or cell surface determinants
    • A61K39/464403—Receptors for growth factors
    • A61K39/464406—Her-2/neu/ErbB2, Her-3/ErbB3 or Her 4/ ErbB4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464466—Adhesion molecules, e.g. NRCAM, EpCAM or cadherins
    • A61K39/464468—Mesothelin [MSLN]
    • A—HUMAN NECESSITIES
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2315—Interleukin-15 (IL-15)
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
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    • C12N2510/00—Genetically modified cells

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Abstract

células assassinas naturais modificadas (nk) para imunoterapia. a presente divulgação é direcionada à geração de células nk (ou outros linfócitos) a partir de células pluripotentes induzidas que foram derivadas a partir de células, por exemplo, células t maduras em desenvolvimento e seus usos para imunoterapia.
BR112021016046A 2019-02-15 2020-02-14 Células assassinas naturais modificadas (nk) para imunoterapia BR112021016046A2 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962806457P 2019-02-15 2019-02-15
US201962841066P 2019-04-30 2019-04-30
US201962841684P 2019-05-01 2019-05-01
US201962943649P 2019-12-04 2019-12-04
PCT/US2020/018443 WO2020168300A1 (en) 2019-02-15 2020-02-14 Modified natural killer (nk) cells for immunotherapy

Publications (1)

Publication Number Publication Date
BR112021016046A2 true BR112021016046A2 (pt) 2021-11-09

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ID=70009368

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Application Number Title Priority Date Filing Date
BR112021016046A BR112021016046A2 (pt) 2019-02-15 2020-02-14 Células assassinas naturais modificadas (nk) para imunoterapia

Country Status (14)

Country Link
US (1) US20220143084A1 (pt)
EP (1) EP3924467A1 (pt)
JP (1) JP2022520402A (pt)
KR (1) KR20210129105A (pt)
CN (1) CN113518821A (pt)
AU (1) AU2020221409A1 (pt)
BR (1) BR112021016046A2 (pt)
CA (1) CA3128888A1 (pt)
CL (1) CL2021002147A1 (pt)
IL (1) IL285543A (pt)
MX (1) MX2021009742A (pt)
PE (1) PE20211959A1 (pt)
SG (1) SG11202108644UA (pt)
WO (1) WO2020168300A1 (pt)

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EP3746554A1 (en) 2018-01-30 2020-12-09 Editas Medicine, Inc. Systems and methods for modulating chromosomal rearrangements
CN112040960B (zh) * 2018-05-11 2024-02-13 加利福尼亚大学董事会 修饰免疫细胞以增加活性

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CN113518821A (zh) 2021-10-19
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KR20210129105A (ko) 2021-10-27
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