KR102692448B1 - 올리고뉴클레오티드 합성에 사용하는 멀티플루오로스블록머 및 이를 사용한 올리고뉴클레오티드 합성방법 - Google Patents

올리고뉴클레오티드 합성에 사용하는 멀티플루오로스블록머 및 이를 사용한 올리고뉴클레오티드 합성방법 Download PDF

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KR102692448B1
KR102692448B1 KR1020217038369A KR20217038369A KR102692448B1 KR 102692448 B1 KR102692448 B1 KR 102692448B1 KR 1020217038369 A KR1020217038369 A KR 1020217038369A KR 20217038369 A KR20217038369 A KR 20217038369A KR 102692448 B1 KR102692448 B1 KR 102692448B1
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nucleoside
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KR20220002469A (ko
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마사노리 카타오카
마모루 효도
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나티아스 인크.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
KR1020217038369A 2019-05-21 2020-05-21 올리고뉴클레오티드 합성에 사용하는 멀티플루오로스블록머 및 이를 사용한 올리고뉴클레오티드 합성방법 Active KR102692448B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JPJP-P-2019-095591 2019-05-21
JP2019095591 2019-05-21
PCT/JP2020/020203 WO2020235658A1 (ja) 2019-05-21 2020-05-21 オリゴヌクレオチド合成に用いるマルチフルオラスブロックマーおよびこれを用いたオリゴヌクレオチド合成方法

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KR20220002469A KR20220002469A (ko) 2022-01-06
KR102692448B1 true KR102692448B1 (ko) 2024-08-05

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Country Link
US (1) US12559516B2 (https=)
EP (1) EP3960749B1 (https=)
JP (1) JP7393807B2 (https=)
KR (1) KR102692448B1 (https=)
CN (1) CN113924309A (https=)
WO (1) WO2020235658A1 (https=)

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Publication number Priority date Publication date Assignee Title
CN112424213A (zh) 2018-05-02 2021-02-26 株式会社纳蒂亚斯 寡核苷酸合成用片段及其制造方法、以及使用其的寡核苷酸的合成方法
CN114269764A (zh) * 2018-05-02 2022-04-01 株式会社纳蒂亚斯 立体控制寡核苷酸合成用光学活性片段及其制造方法、以及使用其的立体控制寡核苷酸的合成方法
EP4293035A4 (en) 2021-02-12 2025-03-05 Ajinomoto Co., Inc. METHOD FOR THE PRODUCTION OF OLIGONUCLEOTIDES
JPWO2024228396A1 (https=) 2023-05-01 2024-11-07

Citations (1)

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Publication number Priority date Publication date Assignee Title
WO2019042888A1 (de) 2017-08-27 2019-03-07 Caperis Gmbh Perfluorierte nukleinsäuren als tenside mit spezifischen eigenschaften

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JP4945129B2 (ja) 2004-01-27 2012-06-06 株式会社キラルジェン フルオラス担体およびそれを用いたオリゴヌクレオチド誘導体の製造方法
WO2006040558A1 (en) * 2004-10-15 2006-04-20 Astrazeneca Ab Substituted adenines and the use thereof
US20060178507A1 (en) 2004-12-30 2006-08-10 Berry & Associates, Inc. Fluorous oligonucleotide reagents and affinity purification of oligonucleotides
AU2007263728A1 (en) * 2006-06-27 2008-01-03 Biovitrum Ab (Publ) Adenosine derivatives for the treatment of pain
US20140065223A1 (en) * 2011-03-31 2014-03-06 Jeanette Libera-Koerner Perfluorinated compounds for the non-viral transfer of nucleic acids
CN108350018A (zh) 2015-11-17 2018-07-31 日产化学工业株式会社 寡核苷酸的制造方法
WO2018212236A1 (ja) * 2017-05-16 2018-11-22 日産化学株式会社 オリゴヌクレオチドの製造方法
JP7431723B2 (ja) 2017-08-18 2024-02-15 アジレント・テクノロジーズ・インク オリゴヌクレオチドのアフィニティー精製のためのオルトエステル組成物

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019042888A1 (de) 2017-08-27 2019-03-07 Caperis Gmbh Perfluorierte nukleinsäuren als tenside mit spezifischen eigenschaften

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US20220235089A1 (en) 2022-07-28
EP3960749A1 (en) 2022-03-02
WO2020235658A1 (ja) 2020-11-26
JP7393807B2 (ja) 2023-12-07
US12559516B2 (en) 2026-02-24
EP3960749A4 (en) 2023-02-22
CN113924309A (zh) 2022-01-11
KR20220002469A (ko) 2022-01-06
EP3960749B1 (en) 2025-08-13
JPWO2020235658A1 (https=) 2020-11-26

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