CN113924309A - 寡核苷酸合成中使用的多氟嵌段聚体以及使用其的寡核苷酸合成方法 - Google Patents

寡核苷酸合成中使用的多氟嵌段聚体以及使用其的寡核苷酸合成方法 Download PDF

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Publication number
CN113924309A
CN113924309A CN202080037793.8A CN202080037793A CN113924309A CN 113924309 A CN113924309 A CN 113924309A CN 202080037793 A CN202080037793 A CN 202080037793A CN 113924309 A CN113924309 A CN 113924309A
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alkyl
formula
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Chinese (zh)
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片冈正典
兵藤守
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Nathias Co ltd
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Nathias Co ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
CN202080037793.8A 2019-05-21 2020-05-21 寡核苷酸合成中使用的多氟嵌段聚体以及使用其的寡核苷酸合成方法 Pending CN113924309A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2019095591 2019-05-21
JP2019-095591 2019-05-21
PCT/JP2020/020203 WO2020235658A1 (ja) 2019-05-21 2020-05-21 オリゴヌクレオチド合成に用いるマルチフルオラスブロックマーおよびこれを用いたオリゴヌクレオチド合成方法

Publications (1)

Publication Number Publication Date
CN113924309A true CN113924309A (zh) 2022-01-11

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CN202080037793.8A Pending CN113924309A (zh) 2019-05-21 2020-05-21 寡核苷酸合成中使用的多氟嵌段聚体以及使用其的寡核苷酸合成方法

Country Status (6)

Country Link
US (1) US12559516B2 (https=)
EP (1) EP3960749B1 (https=)
JP (1) JP7393807B2 (https=)
KR (1) KR102692448B1 (https=)
CN (1) CN113924309A (https=)
WO (1) WO2020235658A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112424213A (zh) 2018-05-02 2021-02-26 株式会社纳蒂亚斯 寡核苷酸合成用片段及其制造方法、以及使用其的寡核苷酸的合成方法
CN114269764A (zh) * 2018-05-02 2022-04-01 株式会社纳蒂亚斯 立体控制寡核苷酸合成用光学活性片段及其制造方法、以及使用其的立体控制寡核苷酸的合成方法
EP4293035A4 (en) 2021-02-12 2025-03-05 Ajinomoto Co., Inc. METHOD FOR THE PRODUCTION OF OLIGONUCLEOTIDES
JPWO2024228396A1 (https=) 2023-05-01 2024-11-07

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006040558A1 (en) * 2004-10-15 2006-04-20 Astrazeneca Ab Substituted adenines and the use thereof
CN101479289A (zh) * 2006-06-27 2009-07-08 比奥维特罗姆上市公司 治疗化合物
WO2018212236A1 (ja) * 2017-05-16 2018-11-22 日産化学株式会社 オリゴヌクレオチドの製造方法
WO2019042888A1 (de) * 2017-08-27 2019-03-07 Caperis Gmbh Perfluorierte nukleinsäuren als tenside mit spezifischen eigenschaften

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4945129B2 (ja) 2004-01-27 2012-06-06 株式会社キラルジェン フルオラス担体およびそれを用いたオリゴヌクレオチド誘導体の製造方法
US20060178507A1 (en) 2004-12-30 2006-08-10 Berry & Associates, Inc. Fluorous oligonucleotide reagents and affinity purification of oligonucleotides
US20140065223A1 (en) * 2011-03-31 2014-03-06 Jeanette Libera-Koerner Perfluorinated compounds for the non-viral transfer of nucleic acids
CN108350018A (zh) 2015-11-17 2018-07-31 日产化学工业株式会社 寡核苷酸的制造方法
JP7431723B2 (ja) 2017-08-18 2024-02-15 アジレント・テクノロジーズ・インク オリゴヌクレオチドのアフィニティー精製のためのオルトエステル組成物

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006040558A1 (en) * 2004-10-15 2006-04-20 Astrazeneca Ab Substituted adenines and the use thereof
CN101479289A (zh) * 2006-06-27 2009-07-08 比奥维特罗姆上市公司 治疗化合物
WO2018212236A1 (ja) * 2017-05-16 2018-11-22 日産化学株式会社 オリゴヌクレオチドの製造方法
WO2019042888A1 (de) * 2017-08-27 2019-03-07 Caperis Gmbh Perfluorierte nukleinsäuren als tenside mit spezifischen eigenschaften

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Publication number Publication date
US20220235089A1 (en) 2022-07-28
EP3960749A1 (en) 2022-03-02
WO2020235658A1 (ja) 2020-11-26
JP7393807B2 (ja) 2023-12-07
US12559516B2 (en) 2026-02-24
EP3960749A4 (en) 2023-02-22
KR20220002469A (ko) 2022-01-06
EP3960749B1 (en) 2025-08-13
KR102692448B1 (ko) 2024-08-05
JPWO2020235658A1 (https=) 2020-11-26

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