KR102630013B1 - 항바이러스제로서 유용한 피롤로피리미딘 뉴클레오시드 및 그의 유사체 - Google Patents

항바이러스제로서 유용한 피롤로피리미딘 뉴클레오시드 및 그의 유사체 Download PDF

Info

Publication number
KR102630013B1
KR102630013B1 KR1020187006431A KR20187006431A KR102630013B1 KR 102630013 B1 KR102630013 B1 KR 102630013B1 KR 1020187006431 A KR1020187006431 A KR 1020187006431A KR 20187006431 A KR20187006431 A KR 20187006431A KR 102630013 B1 KR102630013 B1 KR 102630013B1
Authority
KR
South Korea
Prior art keywords
formula
compound
pharmaceutically acceptable
compound according
acceptable salt
Prior art date
Application number
KR1020187006431A
Other languages
English (en)
Korean (ko)
Other versions
KR20180039666A (ko
Inventor
르로이 타운센드
존 드라크
로이 더블유. 웨어
존 헨리 3세 보우거
라마머티 브이 에스 찬갈바라
아론 레이 다우니
어니스트 랜들 주니어 라니어
앤드루 루이스 맥아이버
브래들리 데이비드 로버트슨
딘 월리스 셀레세트
피로즈 베럼 세트나
Original Assignee
키메릭스 인크.
더 리젠츠 오브 더 유니버시티 오브 미시간
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 키메릭스 인크., 더 리젠츠 오브 더 유니버시티 오브 미시간 filed Critical 키메릭스 인크.
Publication of KR20180039666A publication Critical patent/KR20180039666A/ko
Application granted granted Critical
Publication of KR102630013B1 publication Critical patent/KR102630013B1/ko

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14—Pyrrolo-pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
KR1020187006431A 2015-08-06 2016-08-08 항바이러스제로서 유용한 피롤로피리미딘 뉴클레오시드 및 그의 유사체 KR102630013B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562202010P 2015-08-06 2015-08-06
US62/202,010 2015-08-06
GB201606645 2016-04-15
GB1606645.8 2016-04-15
PCT/US2016/046056 WO2017024310A1 (en) 2015-08-06 2016-08-08 Pyrrolopyrimidine nucleosides and analogs thereof useful as antiviral agents

Publications (2)

Publication Number Publication Date
KR20180039666A KR20180039666A (ko) 2018-04-18
KR102630013B1 true KR102630013B1 (ko) 2024-01-25

Family

ID=57943734

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020187006431A KR102630013B1 (ko) 2015-08-06 2016-08-08 항바이러스제로서 유용한 피롤로피리미딘 뉴클레오시드 및 그의 유사체

Country Status (12)

Country Link
US (5) US9708359B2 (ja)
EP (1) EP3331895B1 (ja)
JP (1) JP2018523665A (ja)
KR (1) KR102630013B1 (ja)
CN (1) CN108026136A (ja)
AU (1) AU2016301188A1 (ja)
BR (1) BR112018002399A2 (ja)
CA (1) CA2992278A1 (ja)
EA (1) EA201890454A1 (ja)
MX (1) MX2018001073A (ja)
PH (1) PH12018500263A1 (ja)
WO (1) WO2017024310A1 (ja)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112017013858A2 (pt) 2014-12-26 2018-02-27 Univ Emory n4-hidroxicitidina e derivados e usos antivirais relacionados aos mesmos
MX2017010844A (es) * 2015-02-24 2017-12-07 Pfizer Derivados de nucleosidos sustituidos utiles como agentes anticancerosos.
CN110234656B (zh) 2016-09-09 2023-02-28 卡利泰拉生物科技公司 外核苷酸酶抑制剂及其使用方法
CA3047373A1 (en) * 2016-12-16 2018-06-21 Gifu University Nucleoside derivative and use thereof
US20200115404A1 (en) * 2017-03-31 2020-04-16 Peloton Therapeutics, Inc. Cd73 inhibitors and uses thereof
WO2019060692A1 (en) 2017-09-21 2019-03-28 Chimerix, Inc. MORPHIC FORMS OF 4-AMINO-7- (3,4-DIHYDROXY-5- (HYDROXYMETHYL) -ETRAHYDROFURAN-2-YL) -2-METHYL-7H-PYRROLO [2,3-D] PYRIMIDINE-5-CARBOXAMIDE AND THEIR USES
EP3712160A4 (en) 2017-10-31 2021-09-01 Yamasa Corporation NUCLEOSIDE DERIVATIVE AND ASSOCIATED USE
BR112020010581A2 (pt) 2017-12-07 2020-11-10 Emory University composição farmacêutica, recipiente pressurizado, e, métodos para tratar ou prevenir uma infecção viral e de tratamento ou prevenção de coronavírus humano, sars, coronavírus mers, vírus da encefalite equina oriental, vírus da encefalite equina ocidental, vírus da encefalite equina venezuelana, vírus chikungunya e infecção por infecção de ross river, vírus orthomyxoviridae ou vírus paramyxoviridae ou vírus rsv, ou infecção pelo vírus influenza a e vírus influenza b ou vírus filoviridae ou vírus ebola.
KR20200140274A (ko) * 2018-03-07 2020-12-15 에모리 유니버시티 4'-할로겐 함유 뉴클레오티드 및 뉴클레오시드 치료 조성물 및 이와 관련된 용도
TW202322824A (zh) 2020-02-18 2023-06-16 美商基利科學股份有限公司 抗病毒化合物
JP2023517579A (ja) * 2020-03-09 2023-04-26 オルガンズ ティシューズ リジェネレーション リパレーション レムプレースメント － オーティーアール３ 呼吸器系の病変の治療のための組成物
US20230233591A1 (en) * 2020-04-14 2023-07-27 Oyagen, Inc. Method for treating poxviridae infections
WO2022212365A1 (en) * 2021-03-29 2022-10-06 Chimerix, Inc. Pyrrolopyrimidine nucleosides for treating or preventing a sars-cov-2 infection
EP4323362A1 (en) 2021-04-16 2024-02-21 Gilead Sciences, Inc. Methods of preparing carbanucleosides using amides

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009067409A1 (en) 2007-11-20 2009-05-28 Pharmasset, Inc. 2',4'-substituted nucleosides as antiviral agents

Family Cites Families (124)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3037980A (en) * 1955-08-18 1962-06-05 Burroughs Wellcome Co Pyrrolopyrimidine vasodilators and method of making them
US3423398A (en) 1965-05-10 1969-01-21 Pfizer & Co C Sangivamycin and derivatives thereof
US4140851A (en) 1977-11-21 1979-02-20 The United States Of America As Represented By The Department Of Health, Education And Welfare Synthesis and antitumor activity of 2,4,5-trisubstituted-pyrrolo2,3-d]-pyrimidine nucleosides
JPS61189225A (ja) 1985-02-15 1986-08-22 Airin:Kk 抗アレルギ−剤
US4892865A (en) 1987-12-01 1990-01-09 The Regents Of The University Of Michigan Pyrrolo[2,3-d]pyrimidine nucleosides as antiviral agents
US5721356A (en) 1989-09-15 1998-02-24 Gensia, Inc. Orally active adenosine kinase inhibitors
US5674998A (en) 1989-09-15 1997-10-07 Gensia Inc. C-4' modified adenosine kinase inhibitors
US5726302A (en) 1989-09-15 1998-03-10 Gensia Inc. Water soluble adenosine kinase inhibitors
US5763596A (en) 1989-09-15 1998-06-09 Metabasis Therapeutics, Inc. C-4' modified adenosine kinase inhibitors
US5646128A (en) 1989-09-15 1997-07-08 Gensia, Inc. Methods for treating adenosine kinase related conditions
US5177064A (en) 1990-07-13 1993-01-05 University Of Florida Targeted drug delivery via phosphonate derivatives
WO1992005200A1 (en) 1990-09-18 1992-04-02 Chemex Pharmaceuticals, Inc. Xenobiotic-antibody conjugates
CA2108041A1 (en) 1991-03-29 1992-09-30 Nicholas S. Bodor Targeted drug delivery via mixed phosphate derivatives
DE69216509T2 (de) 1991-08-12 1997-05-28 Takeda Chemical Industries Ltd Kondensierte Pyrimidinderivate, ihre Herstellung und ihre Verwendung als Antitumormittel
DE69333073T2 (de) 1992-02-12 2004-04-15 Chromagen, Inc., San Diego Verwendungen von fluoreszierenden n-nukleosiden und dessen analogen
US5502187A (en) 1992-04-03 1996-03-26 The Upjohn Company Pharmaceutically active bicyclic-heterocyclic amines
GB9226879D0 (en) 1992-12-23 1993-02-17 Iaf Biochem Int Anti-viral compounds
JPH08506343A (ja) 1993-02-03 1996-07-09 ジェンシア・インコーポレイテッド リキソフラノシル誘導体を含むアデノシンキナーゼ阻害物質
US5656745A (en) 1993-09-17 1997-08-12 Gilead Sciences, Inc. Nucleotide analogs
US5798340A (en) 1993-09-17 1998-08-25 Gilead Sciences, Inc. Nucleotide analogs
JPH07124252A (ja) 1993-11-07 1995-05-16 Masashi Funayama 化学療法剤を固定化した不溶性担体を用いた、負に帯電した 生理活性物質の吸着、分離および定量方法。
WO1995033752A1 (en) 1994-06-09 1995-12-14 Smithkline Beecham Corporation Endothelin receptor antagonists
US5554608A (en) 1994-09-28 1996-09-10 Ahluwalia; Gurpreet S. Inhibition of hair growth
US6051578A (en) 1996-02-12 2000-04-18 Pfizer Inc. Pyrazolopyrimidines for treatment of CNS disorders
EP0906329B1 (en) 1996-06-06 2003-10-08 Novartis AG 2'-substituted nucleosides and oligonucleotide derivatives
US5955446A (en) 1997-01-16 1999-09-21 Pentose Pharmaceuticals, Inc. Method of treating herpes infections with 2',5'-oligoadenylate-2',3'-cyclophosphate compounds
US6468991B1 (en) 1997-01-16 2002-10-22 Cyclis Pharmaceuticals, Inc. Method of treating rhinoviral infections
US6419934B1 (en) * 1999-02-24 2002-07-16 Edward L. Tobinick TNF modulators for treating neurological disorders associated with viral infection
US6831069B2 (en) 1999-08-27 2004-12-14 Ribapharm Inc. Pyrrolo[2,3-d]pyrimidine nucleoside analogs
IL139197A0 (en) 1999-10-29 2001-11-25 Pfizer Prod Inc Use of corticotropin releasing factor antagonists and related compositions
BR0016415A (pt) 1999-12-16 2002-12-24 Alcon Inc Inibidores de adenosina cinase para o tratamento de dano retinal e de nervo ótico
KR100385281B1 (ko) 2000-02-15 2003-05-23 이승기 새로운 세포 주기 조절 인자 억제제
US6455508B1 (en) * 2000-02-15 2002-09-24 Kanda S. Ramasamy Methods for treating diseases with tirazole and pyrrolo-pyrimidine ribofuranosyl nucleosides
EP1149583A3 (en) 2000-04-13 2001-11-14 Pfizer Products Inc. Combinations of corticotropin releasing factor antagonists and growth hormone secretagogues
NZ526703A (en) 2001-01-22 2004-12-24 Merck & Co Inc Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase
WO2002069949A2 (en) 2001-03-06 2002-09-12 Prendergast Patrick T Combination therapy for reduction of toxycity of chemotherapeutic agents
US20020127593A1 (en) 2001-03-12 2002-09-12 Regents Of The University Of California Fluorescence assay for DNA modifying enzymes
AU2002329970A1 (en) 2001-09-04 2003-03-18 Isis Pharmaceuticals, Inc. Pyrrolo(2,3-d)pyrimidines for inhibiting rna-dependent rna viral polymerase
US7115741B2 (en) 2001-09-06 2006-10-03 Levy Daniel E 4-thieno[2,3-D]pyrimidin-4-YL piperazine compounds
WO2003026675A1 (en) 2001-09-28 2003-04-03 Idenix (Cayman) Limited Methods and compositions for treating flaviviruses and pestiviruses using 4'-modified nucleoside
US7361671B2 (en) 2001-11-15 2008-04-22 The Institute For Pharmaceutical Discovery, Inc. Substituted heteroarylalkanoic acids
AU2002353165A1 (en) * 2001-12-17 2003-06-30 Ribapharm Inc. Deazapurine nucleoside libraries and compounds
CA2470521A1 (en) * 2001-12-21 2003-07-10 Micrologix Biotech Inc. Anti-viral 7-deaza l-nucleosides
WO2003062256A1 (en) 2002-01-17 2003-07-31 Ribapharm Inc. 2'-beta-modified-6-substituted adenosine analogs and their use as antiviral agents
CA2474563C (en) 2002-02-13 2010-11-09 Merck & Co., Inc. Methods of inhibiting orthopoxvirus replication with nucleoside compounds
JP2003321472A (ja) 2002-02-26 2003-11-11 Takeda Chem Ind Ltd Ｇｒｋ阻害剤
FR2836995B1 (fr) 2002-03-05 2006-09-22 Centre Nat Rech Scient Utilisation de derives de nucleosides comportant un groupement citrate pour la production d'anticorps ayant une affinite pour des nucleosides triphosphorylees et leurs applications
FR2836996A1 (fr) 2002-03-05 2003-09-12 Centre Nat Rech Scient PRECURSEURS DE TRACEURS IMMUNOLOGIQUES NON-PEPTIDIQUES COMPRENANT UN MOTIF TYROSYL-(X)n-LYSINE-(X)n-TYROSINE, PROCEDE DE PREPARATION ET LEURS APPLICATIONS
US6664266B2 (en) 2002-03-14 2003-12-16 Children's Medical Center Corporation Axon regeneration with PKC inhibitiors
US20040014108A1 (en) 2002-05-24 2004-01-22 Eldrup Anne B. Oligonucleotides having modified nucleoside units
AU2003269892A1 (en) 2002-06-27 2004-01-19 Isis Pharmaceuticals, Inc. Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
US7608600B2 (en) 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
AU2003269902A1 (en) 2002-07-16 2004-02-02 Isis Pharmaceuticals, Inc. Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
PL376043A1 (en) 2002-09-30 2005-12-12 Genelabs Technologies, Inc. Nucleoside derivatives for treating hepatitis c virus infection
US7094768B2 (en) 2002-09-30 2006-08-22 Genelabs Technologies, Inc. Nucleoside derivatives for treating hepatitis C virus infection
AU2003286816B2 (en) 2002-10-31 2010-08-19 Metabasis Therapeutics, Inc. Novel cytarabine monophosphate prodrugs
CA2505330A1 (en) 2002-11-05 2004-05-27 Isis Pharmaceuticals, Inc. Sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation
DK1576138T3 (en) 2002-11-15 2017-05-01 Idenix Pharmaceuticals Llc 2'-METHYL NUCLEOSIDES IN COMBINATION WITH INTERFERON AND FLAVIVIRIDAE MUTATION
US20040175384A1 (en) 2003-12-12 2004-09-09 Mohapatra Shyam S. Protein kinase C as a target for the treatment of respiratory syncytial virus
US7358262B2 (en) 2003-01-29 2008-04-15 Whitehead Institute For Biomedical Research Identification of genotype-selective anti-tumor agents
WO2007038613A2 (en) 2005-09-26 2007-04-05 The Regents Of The University Of California Selective serine/threonine kinase inhibitors
US20040259934A1 (en) 2003-05-01 2004-12-23 Olsen David B. Inhibiting Coronaviridae viral replication and treating Coronaviridae viral infection with nucleoside compounds
WO2005020885A2 (en) 2003-05-21 2005-03-10 Isis Pharmaceuticals, Inc. Compositions and methods for the treatment of severe acute respiratory syndrome (sars)
US7230007B2 (en) 2003-06-12 2007-06-12 Sanofi-Aventis Deutschland Gmbh Derivatives of 3-(Guanidinocarbonyl) heterocycle, methods of preparation and intermediates thereof, their use as medicaments, and pharmaceutical compositions therefrom
AU2004291911A1 (en) 2003-11-14 2005-06-02 Children's Medical Center Corporation Self-cleaving ribozymes and uses thereof
AU2004293423A1 (en) 2003-11-21 2005-06-09 University Of Connecticut Heterocyclyl-substituted oxetanes for the treatment of proliferative or infectious diseases
US20050203151A1 (en) 2003-12-19 2005-09-15 Kalypsys, Inc. Novel compounds, compositions and uses thereof for treatment of metabolic disorders and related conditions
JP5080973B2 (ja) 2004-06-24 2012-11-21 メルク・シャープ・エンド・ドーム・コーポレイション Ｒｎａ依存性ｒｎａウイルスの感染を処置するためのヌクレオシドアリールホスホルアミダート
US20070015771A1 (en) 2004-07-29 2007-01-18 Threshold Pharmaceuticals, Inc. Lonidamine analogs
AP2446A (en) 2004-09-22 2012-08-31 Janssen Pharmaceutica Nv Inhibitors of the interaction between MDM2 and P53
DE102004054634A1 (de) 2004-11-12 2006-05-18 Schwarz Pharma Ag Azaindolcarboxamide
US20070161644A1 (en) 2005-01-25 2007-07-12 Stockwell Brent R Erastin analogs and uses thereof
BRPI0607306A2 (pt) 2005-01-25 2009-08-25 Prolexys Pharmaceuticals Inc derivados de quinoxalina como agentes anti-tumor
AU2006210787C1 (en) 2005-02-02 2013-01-17 Nexgenix Pharmaceuticals, L.L.C. Local treatment of neurofibromas
EP1876894A1 (en) 2005-04-26 2008-01-16 The Board of Trustees of the University of Illinois Nucleoside compounds and methods of use thereof
MY150958A (en) 2005-06-16 2014-03-31 Astrazeneca Ab Compounds for the treatment of multi-drug resistant bacterial infections
BRPI0615307A2 (pt) 2005-08-25 2009-08-04 Schering Corp agonistas de adrenorreceptor alfa2c
JP2007124252A (ja) 2005-10-27 2007-05-17 Sony Corp 放送受信装置と放送受信方法およびプログラム
AR057960A1 (es) 2005-12-02 2007-12-26 Osi Pharm Inc Inhibidores de proteina quinasa biciclicos
CN1923173B (zh) 2006-02-24 2010-05-19 济南康泉医药科技有限公司 一种同载抗癌抗生素及其增效剂的抗癌药物缓释剂
CN1923171B (zh) 2006-02-24 2010-05-19 济南康泉医药科技有限公司 同载抗癌抗生素及其增效剂的复方抗癌药物缓释剂
EP1889847A1 (en) 2006-07-10 2008-02-20 DeveloGen Aktiengesellschaft Pyrrolopyrimidines for pharmaceutical compositions
WO2008021981A2 (en) 2006-08-09 2008-02-21 Nexgenix Pharmaceuticals, Llc. Local treatment of epidermal and dermal hyperproliferative lesions
WO2008079980A1 (en) 2006-12-22 2008-07-03 Alcon Research, Ltd. Inhibitors of protein kinase c-delta for the treatment of glaucoma
TW200838550A (en) 2007-02-09 2008-10-01 Novartis Ag Organic compounds
US7964580B2 (en) 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
WO2008127613A1 (en) 2007-04-11 2008-10-23 Scynexis, Inc. New pharmaceutical compositions
US20100129933A1 (en) 2007-04-26 2010-05-27 Forschungszentrum Karlsruhe Gmbh Method for detecting the binding between mdm2 and the proteasome
FR2921342B1 (fr) 2007-09-20 2010-03-12 Airbus France Carenage aerodynamique arriere inferieur pour dispositif d'accrochage d'un moteur d'aeronef
EP2214670A2 (en) 2007-11-02 2010-08-11 Taiga Biotechnologies, Inc. Compounds for treating abnormal cellular proliferation
EP2219646A4 (en) 2007-12-21 2010-12-22 Univ Rochester METHOD FOR MODIFYING THE LIFETIME OF EUKARYOTIC ORGANISMS
WO2009105234A2 (en) 2008-02-19 2009-08-27 Combinatorx, Incorporated Methods and compositions for the treatment of disorders associated with defects of the cystic fibrosis transmembrane conductance regulator gene or protein
WO2009108551A2 (en) 2008-02-25 2009-09-03 H. Lundbeck A/S Heteroaryl amide analogues
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
WO2010015637A1 (en) * 2008-08-06 2010-02-11 Novartis Ag New antiviral modified nucleosides
WO2010015643A1 (en) 2008-08-06 2010-02-11 Novartis Ag New antiviral modified nucleosides
US20120014911A1 (en) 2009-01-09 2012-01-19 Serge Fuchs Regulators of the Interferon-Alpha Receptor 1 (IFNAR1) Chain of the Interferon Receptor
US8785446B2 (en) 2009-01-17 2014-07-22 Children's Medical Center Corporation Treating post-seizure patients
GB0900914D0 (en) 2009-01-20 2009-03-04 Angeletti P Ist Richerche Bio Antiviral agents
KR20120046099A (ko) 2009-02-04 2012-05-09 유니버시티 오브 조지아 리서치 파운데이션 인코퍼레이티드 섬유화를 억제하고 섬유화 질병을 치료하는 방법
KR101774429B1 (ko) 2009-02-06 2017-09-04 코크리스탈 파마, 아이엔씨. 암 및 바이러스 감염 치료용 퓨린 뉴클레오시드 모노포스페이트 프로드럭
US8475804B2 (en) 2009-02-20 2013-07-02 U.S. Army Medical Research And Material Command Compositions and methods for treatment of filovirus-mediated diseases
US20100297079A1 (en) 2009-05-20 2010-11-25 Chimerix, Inc. Compounds, compositions and methods for treating viral infection
EP2482837A4 (en) 2009-09-29 2013-05-22 Joslin Diabetes Center Inc USE OF INHIBITORS OF PROTEIN KINASE C DELTA (PKCD) FOR THE TREATMENT OF DIABETES, OBESITY AND HEPATIC STEATOSIS
SI2490688T1 (sl) 2009-10-19 2015-01-30 Synta Pharmaceuticals Corp. Kombinirano zdravljenje raka s spojinami - zaviralci HSP90
WO2011057204A2 (en) 2009-11-06 2011-05-12 The Johns Hopkins University Lrrk2-mediated neuronal toxicity
EP2516428A1 (en) 2009-12-23 2012-10-31 Sanofi Tropinone benzylamines as beta-tryptase inhibitors
WO2011079103A1 (en) 2009-12-23 2011-06-30 Sanofi Spiropiperidine benzylamines as beta-tryptase inhibitors
US20130011393A1 (en) 2010-01-12 2013-01-10 Johnathan Mark Lancaster Bad pathway gene signature
CN102191233B (zh) 2010-03-04 2014-06-04 中国人民解放军军事医学科学院毒物药物研究所 新颖的10-23脱氧核酶类似物及其用途
US20130018010A1 (en) 2010-04-16 2013-01-17 Enzon Pharmaceuticals, Inc. Polymeric conjugates of adenine nucleoside analogs
WO2011153553A2 (en) 2010-06-04 2011-12-08 The Regents Of The University Of California Methods and compositions for kinase inhibition
EP2805960A1 (en) 2010-07-19 2014-11-26 Gilead Sciences, Inc. Methods for the preparation of diasteromerically pure phosphoramidate prodrugs
WO2012041965A1 (en) 2010-09-29 2012-04-05 Universidad Nacional De Quilmes Process for producing dialkylphosphotriesters of nucleosides by enzymatic transesterification and deprotection thereof for producing nucleoside monophosphates
RU2597609C2 (ru) 2010-11-18 2016-09-10 Касина Лайла Иннова Фармасьютикалз Прайвит Лимитед Замещенные 4-(селенофен-2(или 3)-иламино)пиримидиновые соединения и способы их применения
US9295673B2 (en) 2011-02-23 2016-03-29 Intellikine Llc Combination of mTOR inhibitors and P13-kinase inhibitors, and uses thereof
WO2012125900A1 (en) 2011-03-16 2012-09-20 Enanta Pharmaceuticals, Inc. 2'-allene-substituted nucleoside derivatives
GB201107768D0 (en) 2011-05-10 2011-06-22 Univ Manchester Riboswitches
CN102286048A (zh) 2011-06-24 2011-12-21 吉林大学 4-氨基-6-(3-(3-溴苯基)苯基)-5-氰基-7-(β-L-呋喃木糖)吡咯并[2, 3-d]嘧啶、同类衍生物及用于制备抗肿瘤药物
US8575119B2 (en) 2011-09-23 2013-11-05 Enanta Pharmaceuticals, Inc. 2′-chloroacetylenyl substituted nucleoside derivatives
WO2013071415A1 (en) 2011-11-15 2013-05-23 University Health Network Targeting the rb pathway for the prevention of cancer
US20150057243A1 (en) 2012-04-02 2015-02-26 Northern University Compositions and Methods for the Inhibition of Methyltransferases
WO2014060431A1 (en) 2012-10-16 2014-04-24 Almirall, S.A. Pyrrolotriazinone derivatives as pi3k inhibitors
CA2905306A1 (en) 2013-04-29 2014-11-06 Plasmia Biotech, S.L. Biocatalytic production of nucleoside analogues as active pharmaceutical ingredients

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009067409A1 (en) 2007-11-20 2009-05-28 Pharmasset, Inc. 2',4'-substituted nucleosides as antiviral agents

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
J. Med. Chem., 2014, 57, 1097-1110.

Also Published As

Publication number Publication date
US20200199167A1 (en) 2020-06-25
EP3331895A1 (en) 2018-06-13
US9708359B2 (en) 2017-07-18
US20170253628A1 (en) 2017-09-07
JP2018523665A (ja) 2018-08-23
US20170044202A1 (en) 2017-02-16
PH12018500263A1 (en) 2018-08-13
BR112018002399A2 (pt) 2018-09-25
MX2018001073A (es) 2018-06-12
US20220002335A1 (en) 2022-01-06
KR20180039666A (ko) 2018-04-18
US20170137454A1 (en) 2017-05-18
EA201890454A1 (ru) 2018-07-31
US9701706B2 (en) 2017-07-11
WO2017024310A1 (en) 2017-02-09
AU2016301188A1 (en) 2018-02-15
EP3331895B1 (en) 2020-07-29
CA2992278A1 (en) 2017-02-09
US11981700B2 (en) 2024-05-14
US10407457B2 (en) 2019-09-10
US10941175B2 (en) 2021-03-09
CN108026136A (zh) 2018-05-11

Similar Documents

Publication Publication Date Title
KR102630013B1 (ko) 항바이러스제로서 유용한 피롤로피리미딘 뉴클레오시드 및 그의 유사체
RU2599013C2 (ru) Способы и композиции для ингибирования полимеразы
CA2692460A1 (en) Hiv reverse transcriptase inhibitors
CN112062800B (zh) 核苷化合物的氨基磷酸酯衍生物及其用途
US6596771B2 (en) Drugs for treating viral infections
US20190201352A1 (en) Design, synthesis and methods of use of acyclic flexmier nucleoside analogues having anti-coronavirus activity
ES2829254T3 (es) Nucleósidos de pirrolopirimidina y análogos de los mismos útiles como agentes antivíricos
WO2021231784A1 (en) Perk inhibiting imidazolopyrazine compounds
EP4292658A2 (en) Alkynyl nucleoside analogs as inhibitors of human rhinovirus
WO2015085256A1 (en) Branched chain acyclic nucleoside phosphonate esters and methods of synthesis and uses thereof
WO2011071981A2 (en) Anti-cytomegalovirus activity of artemisinin-derived dimers
CN108201539B (zh) 联苯核苷氨基磷酸酯化合物的应用
CA3090294C (en) Methods of preparing tecovirimat
CN117362344A (zh) 一类磷酸酯类化合物、其制备方法及应用
WO2021231782A1 (en) Perk inhibitors for treating viral infections
WO2021231788A1 (en) Perk inhibiting pyrrolopyrimidine compounds to treat viral infections
EP3985010A1 (en) Spirocyclic inhibitors of hepatitis b virus
WO2022169882A1 (en) Methods and treatment of viral infection caused by sars-cov-2
WO2021151104A1 (en) Salicylamide derivatives and related methods of making
WO2020227180A1 (en) Sulfur and amide tropolone inhibitors of nucleotidyl transferases and uses therefor
JP2022538398A (ja) ウイルス感染症及び更なる疾患の処置用のキナゾリンプロドラッグ

Legal Events

Date Code Title Description
E902 Notification of reason for refusal
E701 Decision to grant or registration of patent right
GRNT Written decision to grant