KR102511807B1 - 인간 ｅｚｈ2의 억제제 및 이의 사용 방법 - Google Patents

인간 ｅｚｈ2의 억제제 및 이의 사용 방법 Download PDF

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KR102511807B1
KR102511807B1 KR1020227007164A KR20227007164A KR102511807B1 KR 102511807 B1 KR102511807 B1 KR 102511807B1 KR 1020227007164 A KR1020227007164 A KR 1020227007164A KR 20227007164 A KR20227007164 A KR 20227007164A KR 102511807 B1 KR102511807 B1 KR 102511807B1
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ezh2
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glu
asp
arg
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KR20220035268A (ko
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로버트 알렌 코프랜드
빅토리아 마리 리숑
마가렛 데이비스 스콧
크리스토퍼 존 스니어링거
케빈 웨인 쿤츠
사라 캐슬린 넛슨
로이 맥팔레인 폴록
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에피자임, 인코포레이티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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KR1020227007164A 2010-09-10 2011-09-12 인간 ｅｚｈ2의 억제제 및 이의 사용 방법 Active KR102511807B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US38168410P 2010-09-10 2010-09-10
US61/381,684 2010-09-10
PCT/US2011/051258 WO2012034132A2 (en) 2010-09-10 2011-09-12 Inhibitors of human ezh2, and methods of use thereof
KR1020197037651A KR102373074B1 (ko) 2010-09-10 2011-09-12 인간 ｅｚｈ2의 억제제 및 이의 사용 방법

Related Parent Applications (1)

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KR1020197037651A Division KR102373074B1 (ko) 2010-09-10 2011-09-12 인간 ｅｚｈ2의 억제제 및 이의 사용 방법

Publications (2)

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KR20220035268A KR20220035268A (ko) 2022-03-21
KR102511807B1 true KR102511807B1 (ko) 2023-03-20

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KR1020227007164A Active KR102511807B1 (ko) 2010-09-10 2011-09-12 인간 ｅｚｈ2의 억제제 및 이의 사용 방법
KR1020197037651A Expired - Fee Related KR102373074B1 (ko) 2010-09-10 2011-09-12 인간 ｅｚｈ2의 억제제 및 이의 사용 방법
KR1020137009166A Expired - Fee Related KR102061353B1 (ko) 2010-09-10 2011-09-12 인간 ｅｚｈ2의 억제제 및 이의 사용 방법

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KR1020197037651A Expired - Fee Related KR102373074B1 (ko) 2010-09-10 2011-09-12 인간 ｅｚｈ2의 억제제 및 이의 사용 방법
KR1020137009166A Expired - Fee Related KR102061353B1 (ko) 2010-09-10 2011-09-12 인간 ｅｚｈ2의 억제제 및 이의 사용 방법

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US (6) US8895245B2 (enExample)
EP (1) EP2614369B2 (enExample)
JP (5) JP6389036B2 (enExample)
KR (3) KR102511807B1 (enExample)
CN (2) CN105797158B (enExample)
AU (4) AU2011298987B2 (enExample)
BR (1) BR112013005806B1 (enExample)
CA (2) CA3176977A1 (enExample)
DK (1) DK2614369T3 (enExample)
ES (1) ES2570380T3 (enExample)
HU (1) HUE028977T2 (enExample)
PL (1) PL2614369T3 (enExample)
RU (2) RU2765155C2 (enExample)
WO (1) WO2012034132A2 (enExample)

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BR112013005806B1 (pt) * 2010-09-10 2022-05-10 Epizyme, Inc Métodos para detectar se um indivíduo é um candidato para o tratamento com ou responsivo a um inibidor de ezh2 e usos terapêuticos do dito inibidor de ezh2
WO2012118812A2 (en) 2011-02-28 2012-09-07 Epizyme, Inc. Substituted 6,5-fused bicyclic heteroaryl compounds
TW201733984A (zh) 2011-04-13 2017-10-01 雅酶股份有限公司 經取代之苯化合物
JO3363B1 (ar) 2011-04-13 2019-03-13 Epizyme Inc مركبات بنزين مستبدلة بأريل أو أريل غير متجانس
US9730925B2 (en) 2011-09-30 2017-08-15 Glaxomithkline Llc Methods of treating cancer
US9206128B2 (en) 2011-11-18 2015-12-08 Constellation Pharmaceuticals, Inc. Modulators of methyl modifying enzymes, compositions and uses thereof
WO2013075084A1 (en) 2011-11-18 2013-05-23 Constellation Pharmaceuticals Modulators of methyl modifying enzymes, compositions and uses thereof
US9085583B2 (en) 2012-02-10 2015-07-21 Constellation—Pharmaceuticals, Inc. Modulators of methyl modifying enzymes, compositions and uses thereof
KR102149860B1 (ko) 2012-02-27 2020-08-31 브리티쉬 콜롬비아 캔써 에이전시 브랜치 암의 후생적 결함을 교정하기 위한 작동자 단백질의 상호작용을 리프로그래밍하는 방법
CA3177515A1 (en) * 2012-03-12 2013-09-19 Epizyme, Inc. Inhibitors of human ezh2, and methods of use thereof
ES2617379T3 (es) 2012-04-13 2017-06-16 Epizyme, Inc. Forma de sal de un inhibidor de histona metiltransferasa EZH2 humana
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CN104540946A (zh) 2012-05-16 2015-04-22 Rana医疗有限公司 用于调节utrn表达的组合物和方法
CN104583402A (zh) 2012-05-16 2015-04-29 Rana医疗有限公司 用于调节mecp2表达的组合物和方法
JP2015523854A (ja) 2012-05-16 2015-08-20 ラナ セラピューティクス インコーポレイテッド Ｓｍｎ遺伝子ファミリー発現を調節するための組成物及び方法
US10174315B2 (en) 2012-05-16 2019-01-08 The General Hospital Corporation Compositions and methods for modulating hemoglobin gene family expression
EA201492120A1 (ru) 2012-05-16 2015-10-30 Рана Терапьютикс, Инк. Композиции и способы для модулирования экспрессии atp2a2
US10837014B2 (en) 2012-05-16 2020-11-17 Translate Bio Ma, Inc. Compositions and methods for modulating SMN gene family expression
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US20120071418A1 (en) 2012-03-22
AU2011298987B2 (en) 2017-09-28
JP2019070653A (ja) 2019-05-09
RU2765155C2 (ru) 2022-01-26
CN105797158B (zh) 2019-11-08
CN105797158A (zh) 2016-07-27
CA2810998A1 (en) 2012-03-15
JP2017096944A (ja) 2017-06-01
US20180271892A1 (en) 2018-09-27
JP2021169450A (ja) 2021-10-28
ES2570380T3 (es) 2016-05-18
AU2022242157A1 (en) 2022-10-27
JP6496296B2 (ja) 2019-04-03
US20170065628A1 (en) 2017-03-09
US8691507B2 (en) 2014-04-08
CN103261890A (zh) 2013-08-21
BR112013005806A2 (pt) 2018-01-30
DK2614369T3 (en) 2016-05-02
BR112013005806B1 (pt) 2022-05-10
EP2614369A2 (en) 2013-07-17
EP2614369B2 (en) 2025-05-28
RU2017113351A3 (enExample) 2020-08-26
KR20140019770A (ko) 2014-02-17
CN103261890B (zh) 2016-04-06
JP2013543114A (ja) 2013-11-28
WO2012034132A3 (en) 2012-06-07
AU2011298987A1 (en) 2013-03-28
KR20200003422A (ko) 2020-01-09
KR102373074B1 (ko) 2022-03-11
PL2614369T3 (pl) 2016-08-31

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