KR102500942B1 - Ac-225 용액의 제조 방법 및 Ac-225 용액을 사용한 의약의 제조 방법 - Google Patents
Ac-225 용액의 제조 방법 및 Ac-225 용액을 사용한 의약의 제조 방법 Download PDFInfo
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- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
- A61K51/121—Solutions, i.e. homogeneous liquid formulation
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
- A61K51/1096—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies radioimmunotoxins, i.e. conjugates being structurally as defined in A61K51/1093, and including a radioactive nucleus for use in radiotherapeutic applications
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- G—PHYSICS
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- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G4/00—Radioactive sources
- G21G4/04—Radioactive sources other than neutron sources
- G21G4/06—Radioactive sources other than neutron sources characterised by constructional features
- G21G4/08—Radioactive sources other than neutron sources characterised by constructional features specially adapted for medical application
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- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical & Material Sciences (AREA)
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- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- High Energy & Nuclear Physics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| JPJP-P-2021-002437 | 2021-01-08 | ||
| PCT/JP2022/000116 WO2022149578A1 (ja) | 2021-01-08 | 2022-01-05 | Ａｃ－２２５溶液の製造方法およびＡｃ－２２５溶液を用いた医薬の製造方法 |
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| KR1020237005090A Pending KR20230120627A (ko) | 2021-01-08 | 2022-01-05 | Ac-225 용액의 제조 방법 및 Ac-225 용액을 사용한 의약의 제조 방법 |
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| TW202233247A (zh) * | 2020-10-16 | 2022-09-01 | 日商日本醫事物理股份有限公司 | 抗ｈｅｒ２抗體之放射性複合體及放射性醫藥 |
| WO2026063503A1 (ja) * | 2024-09-20 | 2026-03-26 | 日本メジフィジックス株式会社 | Ａｃ－２２５溶液の製造方法および該溶液を用いたＡｃ－２２５標識錯体の製造方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002067999A2 (en) * | 2001-02-28 | 2002-09-06 | Dow Global Technologies Inc. | Actinium-225 complexes and conjugates for targeted radiotherapy |
| WO2021002275A1 (ja) * | 2019-07-02 | 2021-01-07 | 日本メジフィジックス株式会社 | ２２６Ｒａ含有溶液の精製方法、２２６Ｒａターゲットの製造方法および２２５Ａｃの製造方法 |
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| JPH07203974A (ja) | 1994-01-13 | 1995-08-08 | Tosoh Corp | 癌特異的ムチンを認識する抗体の遺伝子断片等 |
| JPH115749A (ja) | 1997-06-13 | 1999-01-12 | Tosoh Corp | 癌治療医薬品組成物 |
| US7282567B2 (en) * | 2002-06-14 | 2007-10-16 | Immunomedics, Inc. | Monoclonal antibody hPAM4 |
| US7087206B2 (en) * | 2002-04-12 | 2006-08-08 | Pg Research Foundation | Multicolumn selectivity inversion generator for production of high purity actinium for use in therapeutic nuclear medicine |
| DE10347459B3 (de) | 2003-10-13 | 2005-05-25 | Actinium Pharmaceuticals, Inc. | Radium-Target sowie Verfahren zu seiner Herstellung |
| WO2005084179A2 (en) * | 2003-12-01 | 2005-09-15 | Immunomedics, Inc. | Improved method for preparing conjugates of proteins and chelating agents |
| DE102006042191B4 (de) * | 2005-09-09 | 2010-08-05 | Actinium Pharmaceuticals, Inc. | Verfahren zur Reinigung von Radium aus verschiedenen Quellen |
| DE102006008023B4 (de) * | 2006-02-21 | 2008-05-29 | Actinium Pharmaceuticals, Inc. | Verfahren zum Reinigen von 225Ac aus bestrahlten 226Ra-Targets |
| CA2662932C (en) | 2006-09-08 | 2017-06-06 | Actinium Pharmaceuticals, Inc. | Method for the purification of radium from different sources |
| WO2013157105A1 (ja) | 2012-04-18 | 2013-10-24 | 公立大学法人大阪市立大学 | ムチンサブタイプ５ａｃ特異的ヒト化抗体およびその利用 |
| WO2013157102A1 (ja) | 2012-04-18 | 2013-10-24 | 公立大学法人大阪市立大学 | ムチンサブタイプ５ａｃ特異的ヒト化抗体およびその利用 |
| DE102014115154A1 (de) * | 2014-10-17 | 2016-04-21 | SCV-SpezialChemikalien-Vertrieb GmbH | Konjugierte Bisphosphonate für die Diagnostik und Therapie von Knochenerkrankungen |
| US10227383B2 (en) | 2015-05-20 | 2019-03-12 | Kagoshima University | Specific modification of antibody with IgG-binding peptide |
| SG10202012408UA (en) | 2016-06-13 | 2021-01-28 | Univ Kagoshima | SITE-SPECIFIC RADIOISOTOPE-LABELED ANTIBODY USING IgG-BINDING PEPTIDE |
| CN118430866A (zh) * | 2017-06-29 | 2024-08-02 | 南非核能Soc有限公司 | 放射性同位素的制备 |
| KR102533289B1 (ko) | 2019-06-19 | 2023-05-17 | 니혼 메디피직스 가부시키가이샤 | 226Ra 타깃의 제조 방법, 225Ac의 제조 방법 및 226Ra 타깃 제조용 전착액 |
| KR20220047974A (ko) | 2019-08-21 | 2022-04-19 | 니혼 메디피직스 가부시키가이샤 | 방사성 금속 착체의 제조 방법 |
| PH12022550919A1 (en) | 2019-10-18 | 2023-07-10 | Nihon Mediphysics Co Ltd | Method for producing radioactive metal-labeled antibody |
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2022
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002067999A2 (en) * | 2001-02-28 | 2002-09-06 | Dow Global Technologies Inc. | Actinium-225 complexes and conjugates for targeted radiotherapy |
| WO2021002275A1 (ja) * | 2019-07-02 | 2021-01-07 | 日本メジフィジックス株式会社 | ２２６Ｒａ含有溶液の精製方法、２２６Ｒａターゲットの製造方法および２２５Ａｃの製造方法 |
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| CN116711028A (zh) | 2023-09-05 |
| JP2022188190A (ja) | 2022-12-20 |
| KR20220101191A (ko) | 2022-07-19 |
| EP4276855A4 (en) | 2025-08-06 |
| US20230364275A1 (en) | 2023-11-16 |
| ZA202306906B (en) | 2024-10-30 |
| JPWO2022149578A1 (https=) | 2022-07-14 |
| TW202235093A (zh) | 2022-09-16 |
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| JP7846599B2 (ja) | 2026-04-15 |
| US11752223B2 (en) | 2023-09-12 |
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| KR20230120627A (ko) | 2023-08-17 |
| CA3207700A1 (en) | 2022-07-14 |
| US20220370651A1 (en) | 2022-11-24 |
| JP7154465B1 (ja) | 2022-10-17 |
| EP4276855A1 (en) | 2023-11-15 |
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