KR102466375B1 - 광곽향 과립제의 분무 건조 방법 - Google Patents

광곽향 과립제의 분무 건조 방법 Download PDF

Info

Publication number
KR102466375B1
KR102466375B1 KR1020207034397A KR20207034397A KR102466375B1 KR 102466375 B1 KR102466375 B1 KR 102466375B1 KR 1020207034397 A KR1020207034397 A KR 1020207034397A KR 20207034397 A KR20207034397 A KR 20207034397A KR 102466375 B1 KR102466375 B1 KR 102466375B1
Authority
KR
South Korea
Prior art keywords
spray drying
extract
gwanggwakhyang
concentrated
cyclodextrin
Prior art date
Application number
KR1020207034397A
Other languages
English (en)
Korean (ko)
Other versions
KR20210005706A (ko
Inventor
바오시엔 장
옌잉 리
신신 리
Original Assignee
베이징 인크리즈팜 코퍼레이션 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 베이징 인크리즈팜 코퍼레이션 리미티드 filed Critical 베이징 인크리즈팜 코퍼레이션 리미티드
Publication of KR20210005706A publication Critical patent/KR20210005706A/ko
Application granted granted Critical
Publication of KR102466375B1 publication Critical patent/KR102466375B1/ko

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/532—Agastache, e.g. giant hyssop
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Otolaryngology (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
KR1020207034397A 2018-05-07 2018-11-09 광곽향 과립제의 분무 건조 방법 KR102466375B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201810425303.6 2018-05-07
CN201810425303.6A CN110448593A (zh) 2018-05-07 2018-05-07 一种广藿香配方颗粒喷雾干燥方法
PCT/CN2018/114811 WO2019214196A1 (fr) 2018-05-07 2018-11-09 Procédé de séchage par pulvérisation pour formulation granulaire de pogostemon cablin

Publications (2)

Publication Number Publication Date
KR20210005706A KR20210005706A (ko) 2021-01-14
KR102466375B1 true KR102466375B1 (ko) 2022-11-10

Family

ID=68467509

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020207034397A KR102466375B1 (ko) 2018-05-07 2018-11-09 광곽향 과립제의 분무 건조 방법

Country Status (4)

Country Link
JP (1) JP7150142B2 (fr)
KR (1) KR102466375B1 (fr)
CN (1) CN110448593A (fr)
WO (1) WO2019214196A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111494458B (zh) * 2020-05-18 2022-02-15 广州市香雪制药股份有限公司 一种广藿香配方颗粒制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107397787A (zh) * 2017-08-25 2017-11-28 徐自升 一种广藿香鲜榨喷雾干燥颗粒饮片的制备工艺

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5724306A (en) * 1980-07-16 1982-02-08 Wakunaga Yakuhin Kk Preparation of solid chinese herbal pharmaceutical
JPS615024A (ja) * 1984-06-18 1986-01-10 Takeda Chem Ind Ltd 生薬製剤の製造法
KR20090131256A (ko) * 2008-06-17 2009-12-28 주식회사파마펙스 함습 억제 및 방출속도 조절을 위한 생약추출물 함유 서방성 제제
JP2011079800A (ja) * 2009-10-09 2011-04-21 Kitasato Institute 抗インフルエンザウイルス剤
CN101862458B (zh) * 2010-06-21 2015-02-18 广东一方制药有限公司 一种改善中药配方颗粒喷雾干燥工艺的辅料组合及其应用
WO2015115512A1 (fr) * 2014-01-29 2015-08-06 独立行政法人産業技術総合研究所 Procédé de préparation d'un extrait aqueux de feuilles d'ashwagandha à activité anticancéreuse renforcée utilisant la cyclodextrine, et composition pharmaceutique contenant des feuilles d'ashwagandha
CN104523862A (zh) * 2015-01-15 2015-04-22 广东一方制药有限公司 一种具有泻下作用的高浓缩大黄配方颗粒及其制备方法
CN107157937A (zh) * 2017-06-18 2017-09-15 徐漫 一种藿香鲜榨喷雾干燥颗粒饮片及其制备工艺

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107397787A (zh) * 2017-08-25 2017-11-28 徐自升 一种广藿香鲜榨喷雾干燥颗粒饮片的制备工艺

Also Published As

Publication number Publication date
WO2019214196A1 (fr) 2019-11-14
KR20210005706A (ko) 2021-01-14
CN110448593A (zh) 2019-11-15
JP2021519829A (ja) 2021-08-12
JP7150142B2 (ja) 2022-10-07

Similar Documents

Publication Publication Date Title
CN109846940A (zh) 一种黄精多糖提取物及其提取方法和用途
CN107669780B (zh) 一种感冒灵颗粒及其制备方法
CN103933116A (zh) 一种益母草膏的制备工艺
KR20080074872A (ko) 허브 분말 추출물 및 그의 제조 방법 및 그의 사용 방법
CN106511484A (zh) 一种复方金银花颗粒的提取制备工艺
CN104856968A (zh) 一种具有消栓通络作用的中药片剂及其制备方法
CN102961414A (zh) 中草药原浆及其应用
CN105231450A (zh) 一种南瓜含片及其制备方法
KR102466375B1 (ko) 광곽향 과립제의 분무 건조 방법
CN105169094B (zh) 一种箬叶总黄酮的提取与纯化方法
CN109172637B (zh) 一种治疗风湿的胶囊的制备方法
CN104958328A (zh) 一种应用闪式提取技术制备茯苓配方颗粒的方法
CN109169726A (zh) 一种含有杀菌效果的复配剂
CN110551777A (zh) 一种芦荟多糖的制备方法
CN114159394A (zh) 栀子配方颗粒制备工艺
CN113995784A (zh) 白芍配方颗粒制备工艺
CN110448588A (zh) 一种中药配方颗粒喷雾干燥方法
CN112156141B (zh) 一种管花肉苁蓉枸杞片及其制备方法
CN103694301A (zh) 一种从斯亚旦中提取异株五加甲苷的方法
CN108815213A (zh) 一种穿心莲提取物的制备方法
CN102233126A (zh) 一种杏仁复方冲剂
CN109771491A (zh) 一种从山楂粉残渣生产山楂提取物的制备方法
CN101491650B (zh) 一种精制银翘解毒制剂及其制备方法
CN107050265B (zh) 一种兽用桑仁清肺口服液的制备方法
CN109846923B (zh) 一种滇鸡血藤的提取方法

Legal Events

Date Code Title Description
E902 Notification of reason for refusal
E701 Decision to grant or registration of patent right
GRNT Written decision to grant