JP2021519829A - 広カッ香顆粒剤の噴霧乾燥方法 - Google Patents
広カッ香顆粒剤の噴霧乾燥方法 Download PDFInfo
- Publication number
- JP2021519829A JP2021519829A JP2021510502A JP2021510502A JP2021519829A JP 2021519829 A JP2021519829 A JP 2021519829A JP 2021510502 A JP2021510502 A JP 2021510502A JP 2021510502 A JP2021510502 A JP 2021510502A JP 2021519829 A JP2021519829 A JP 2021519829A
- Authority
- JP
- Japan
- Prior art keywords
- spray drying
- broad
- extract
- spray
- scent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/532—Agastache, e.g. giant hyssop
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Otolaryngology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
Description
(訳注:広カッ香の「カッ」は草冠に霍)
相対密度が1.05(60℃)である濃縮後の広カッ香エキス剤を取り、入口温度175℃、出口温度95℃の条件下で噴霧乾燥を行い、乾燥エキス剤粉末を収集した。
相対密度が1.05(60℃)である濃縮後の広カッ香エキス剤を取り、次に、2%のβ−シクロデキストリンを加え、均一に混合し、ろ過し、入口温度175℃、出口温度95℃の条件下で噴霧乾燥を行い、乾燥エキス剤粉末を収集した。
相対密度が1.05(60℃)である濃縮後の広カッ香エキス剤を取り、次に、3%のβ−シクロデキストリンを加え、均一に混合し、ろ過し、入口温度175℃、出口温度95℃の条件下で噴霧乾燥を行い、乾燥エキス剤粉末を収集した。
相対密度が1.05(60℃)である濃縮後の広カッ香エキス剤を取り、次に、4%のβ−シクロデキストリンを加え、均一に混合し、ろ過し、入口温度175℃、出口温度95℃の条件下で噴霧乾燥を行い、乾燥エキス剤粉末を収集した。
相対密度が1.03(60℃)である濃縮後の広カッ香エキス剤を取り、次に、3%のβ−シクロデキストリンを加え、均一に混合し、ろ過し、入口温度175℃、出口温度95℃の条件下で噴霧乾燥を行い、乾燥エキス剤粉末を収集した。
相対密度が1.08(60℃)である濃縮後の広カッ香エキス剤を取り、次に、3%のβ−シクロデキストリンを加え、均一に混合し、ろ過し、入口温度175℃、出口温度95℃の条件下で噴霧乾燥を行い、乾燥エキス剤粉末を収集した。
相対密度が1.10(60℃)である濃縮後の広カッ香エキス剤を取り、次に、3%のβ−シクロデキストリンを加え、均一に混合し、ろ過し、入口温度175℃、出口温度95℃の条件下で噴霧乾燥を行い、乾燥エキス剤粉末を収集した。
相対密度が1.01(60℃)である濃縮後の広カッ香エキス剤を取り、次に、3%のβ−シクロデキストリンを加え、均一に混合し、ろ過し、入口温度175℃、出口温度95℃の条件下で噴霧乾燥を行い、乾燥エキス剤粉末を収集した。
相対密度が1.11(60℃)である濃縮後の広カッ香エキス剤を取り、次に、3%のβ−シクロデキストリンを加え、均一に混合し、ろ過し、入口温度175℃、出口温度95℃の条件下で噴霧乾燥を行い、乾燥エキス剤粉末を収集した。
相対密度が1.05(60℃)である濃縮後の広カッ香エキス剤を取り、次に、1.5%のβ−シクロデキストリンを加え、均一に混合し、ろ過し、入口温度175℃、出口温度95℃の条件下で噴霧乾燥を行い、乾燥エキス剤粉末を収集した。
相対密度が1.05(60℃)である濃縮後の広カッ香エキス剤を取り、次に、6%のβ−シクロデキストリンを加え、均一に混合し、ろ過し、入口温度175℃、出口温度95℃の条件下で噴霧乾燥させ、乾燥エキス剤粉末を収集した。
Claims (7)
- 濃縮後の広カッ香エキス剤を取り、次に、2%〜5%のβ−シクロデキストリンを加え、均一に混合し、ろ過し、入口温度175℃〜180℃、出口温度90℃〜95℃の条件下で噴霧乾燥を行い、乾燥エキス剤粉末を収集することを含む、ことを特徴とする広カッ香の漢方薬顆粒剤の噴霧乾燥方法。
- 前記濃縮後のエキス剤の60℃における相対密度が1.02〜1.10であり、好ましくは1.03〜1.10である、請求項1に記載の噴霧乾燥方法。
- 前記濃縮後のエキス剤の60℃における相対密度が1.05〜1.08である、請求項1又は2に記載の噴霧乾燥方法。
- 前記広カッ香エキス剤に3%〜4%のβ−シクロデキストリンを加える、請求項1〜3のいずれか1項に記載の噴霧乾燥方法。
- 前記広カッ香エキス剤に3%のβ−シクロデキストリンを加える、請求項4に記載の噴霧乾燥方法。
- 前記噴霧乾燥では、入口温度が175℃であり、出口温度が95℃である、請求項1〜5のいずれか1項に記載の噴霧乾燥方法。
- 乾燥エキス剤の収率が78.02%〜96.56%であり、好ましくは78.02%、81.09%、81.15%、84.57%、95.44%又は96.56%である、請求項1〜6のいずれか1項に記載の噴霧乾燥方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810425303.6 | 2018-05-07 | ||
CN201810425303.6A CN110448593A (zh) | 2018-05-07 | 2018-05-07 | 一种广藿香配方颗粒喷雾干燥方法 |
PCT/CN2018/114811 WO2019214196A1 (zh) | 2018-05-07 | 2018-11-09 | 一种广藿香配方颗粒喷雾干燥方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2021519829A true JP2021519829A (ja) | 2021-08-12 |
JP7150142B2 JP7150142B2 (ja) | 2022-10-07 |
Family
ID=68467509
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2021510502A Active JP7150142B2 (ja) | 2018-05-07 | 2018-11-09 | 広カッ香顆粒剤の噴霧乾燥方法 |
Country Status (4)
Country | Link |
---|---|
JP (1) | JP7150142B2 (ja) |
KR (1) | KR102466375B1 (ja) |
CN (1) | CN110448593A (ja) |
WO (1) | WO2019214196A1 (ja) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111494458B (zh) * | 2020-05-18 | 2022-02-15 | 广州市香雪制药股份有限公司 | 一种广藿香配方颗粒制备方法 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5724306A (en) * | 1980-07-16 | 1982-02-08 | Wakunaga Yakuhin Kk | Preparation of solid chinese herbal pharmaceutical |
JPS615024A (ja) * | 1984-06-18 | 1986-01-10 | Takeda Chem Ind Ltd | 生薬製剤の製造法 |
CN101862458A (zh) * | 2010-06-21 | 2010-10-20 | 谭登平 | 一种改善中药配方颗粒喷雾干燥工艺的辅料组合及其应用 |
WO2015115512A1 (ja) * | 2014-01-29 | 2015-08-06 | 独立行政法人産業技術総合研究所 | シクロデキストリンの利用による抗がん活性が増強されたアシュワガンダ葉の水抽出物の調製方法、及びアシュワガンダ葉を含む医薬組成物 |
CN107397787A (zh) * | 2017-08-25 | 2017-11-28 | 徐自升 | 一种广藿香鲜榨喷雾干燥颗粒饮片的制备工艺 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20090131256A (ko) * | 2008-06-17 | 2009-12-28 | 주식회사파마펙스 | 함습 억제 및 방출속도 조절을 위한 생약추출물 함유 서방성 제제 |
JP2011079800A (ja) * | 2009-10-09 | 2011-04-21 | Kitasato Institute | 抗インフルエンザウイルス剤 |
CN104523862A (zh) * | 2015-01-15 | 2015-04-22 | 广东一方制药有限公司 | 一种具有泻下作用的高浓缩大黄配方颗粒及其制备方法 |
CN107157937A (zh) * | 2017-06-18 | 2017-09-15 | 徐漫 | 一种藿香鲜榨喷雾干燥颗粒饮片及其制备工艺 |
-
2018
- 2018-05-07 CN CN201810425303.6A patent/CN110448593A/zh active Pending
- 2018-11-09 KR KR1020207034397A patent/KR102466375B1/ko active IP Right Grant
- 2018-11-09 WO PCT/CN2018/114811 patent/WO2019214196A1/zh active Application Filing
- 2018-11-09 JP JP2021510502A patent/JP7150142B2/ja active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5724306A (en) * | 1980-07-16 | 1982-02-08 | Wakunaga Yakuhin Kk | Preparation of solid chinese herbal pharmaceutical |
JPS615024A (ja) * | 1984-06-18 | 1986-01-10 | Takeda Chem Ind Ltd | 生薬製剤の製造法 |
CN101862458A (zh) * | 2010-06-21 | 2010-10-20 | 谭登平 | 一种改善中药配方颗粒喷雾干燥工艺的辅料组合及其应用 |
WO2015115512A1 (ja) * | 2014-01-29 | 2015-08-06 | 独立行政法人産業技術総合研究所 | シクロデキストリンの利用による抗がん活性が増強されたアシュワガンダ葉の水抽出物の調製方法、及びアシュワガンダ葉を含む医薬組成物 |
CN107397787A (zh) * | 2017-08-25 | 2017-11-28 | 徐自升 | 一种广藿香鲜榨喷雾干燥颗粒饮片的制备工艺 |
Non-Patent Citations (2)
Title |
---|
INDUSTRIAL CROPS AND PRODUCTS, vol. 60, JPN6021041641, 2014, pages 39 - 44, ISSN: 0004625128 * |
徳島県立農業試験場試験研究報告, JPN6021041638, 1997, pages 18 - 24, ISSN: 0004625129 * |
Also Published As
Publication number | Publication date |
---|---|
KR102466375B1 (ko) | 2022-11-10 |
JP7150142B2 (ja) | 2022-10-07 |
CN110448593A (zh) | 2019-11-15 |
KR20210005706A (ko) | 2021-01-14 |
WO2019214196A1 (zh) | 2019-11-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP2023532621A (ja) | 抗菌抗ウイルス性医薬組成物およびその使用 | |
WO2018058261A1 (zh) | 一种治疗银屑病的中药组合物及其制备方法 | |
Zheng et al. | Ephedrae herba: A comprehensive review of its traditional uses, phytochemistry, pharmacology, and toxicology | |
JP2021519829A (ja) | 広カッ香顆粒剤の噴霧乾燥方法 | |
CN101690755B (zh) | 一种抗病毒提取物及其制备方法 | |
CN104001004A (zh) | 一种治疗骨折和骨质疏松的中药组合物及其制备方法和应用 | |
CN106580779A (zh) | 一种澳洲坚果提取物为主成分的中草药牙膏及其制备方法 | |
CN103271978A (zh) | 一种用于抗缺氧、缺糖及治疗高原病的银杏叶复方制剂 | |
CN105412415A (zh) | 祛痤疮的药物组合物 | |
CN101829291A (zh) | 一种治疗风湿病的中药制剂及其制备方法 | |
CN106539892B (zh) | 一种猫爪草中药组合物及其制备方法和应用 | |
CN107496618A (zh) | 一种治疗感冒、发热的中药组合物及其制备方法 | |
CN111358906B (zh) | 一种适用于外感症的中药组合物 | |
CN103690694B (zh) | 一种治疗过敏性鼻炎的中药组合物 | |
CN100522238C (zh) | 止痛化癥丸及制备方法 | |
CN106668117A (zh) | 一种提高滇橄榄多酚滋味能力的超临界萃取方法 | |
CN112656866A (zh) | 一种桃红四物颗粒及其制备方法 | |
CN100488543C (zh) | 大蒜局部外用止痒涂剂 | |
CN105687820A (zh) | 一种可降血脂的保健品 | |
RU2576238C1 (ru) | Сбор лекарственных растений для лечения функционального расстройства желчного пузыря при гипертонически-гиперкинетическом типе дискинезии | |
CN103446564A (zh) | 一种抗菌消炎的中药组合物及其制备方法 | |
CN103830371B (zh) | 一种促进脑部微循环的药物制剂 | |
CN1251705C (zh) | 香菊感冒软胶囊制剂的制备方法 | |
CN102406897A (zh) | 一种醒脑静固体药物组合物及其制备方法 | |
CN107998204B (zh) | 治疗脚癣、脚气、脚臭、瘙痒的中药足疗药方剂及其制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20201102 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20211026 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20220117 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20220531 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20220713 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20220906 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20220927 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 7150142 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |