CN107496618A - 一种治疗感冒、发热的中药组合物及其制备方法 - Google Patents

一种治疗感冒、发热的中药组合物及其制备方法 Download PDF

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CN107496618A
CN107496618A CN201710932202.3A CN201710932202A CN107496618A CN 107496618 A CN107496618 A CN 107496618A CN 201710932202 A CN201710932202 A CN 201710932202A CN 107496618 A CN107496618 A CN 107496618A
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赵宽
徐旭东
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HEFEI HAIDA BIOPHARMACEUTICAL TECHNOLOGY Co Ltd
Anhui Tiankang Group Co Ltd
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HEFEI HAIDA BIOPHARMACEUTICAL TECHNOLOGY Co Ltd
Anhui Tiankang Group Co Ltd
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Abstract

本发明公开了一种治疗感冒、发热的中药组合物及其制备方法。该中药组合物由山银花、板蓝根、墨旱莲、青蒿、荆芥、蒲公英、柴胡、党参、桔梗、紫苏、薄荷、野菊花、大青叶、连翘等中药为原料，按一定的重量份配比制备而成，它可以制备成任何一种常用口服制剂。本品具有疏风解表，清热解毒、提高免疫功能之功效。临床上用于治疗普通感冒、流行性感冒属风热证，证见：发热，微恶风，鼻塞流涕，咳嗽，咽痛，头痛，全身酸痛，苔薄白或微黄，脉浮数。本发明药材采用钠米粉碎、生产工艺采用不加热超声萃取、相对低温快速浓缩，大大地保留了中药的有效成分，是一个显著的创新，并对疗效而言，带来了显著的效果。经临床验证，有效率为100％，在治疗过程中，患者未见明显的不良反应。

Description

一种治疗感冒、发热的中药组合物及其制备方法
技术领域
本发明是涉及一种中药组合物，具体的说，涉及一种感冒、发热的中药组合物及其制备方法。
背景技术
感冒是最常见的上呼吸道感染疾患，民间又俗称“伤风”，是由于受风受寒后，呼吸道局部抵抗力下降，而感染病毒或细菌所致。常见表现有头痛、鼻塞、流涕、喷嚏、流泪、恶寒、发热、周身不适或伴有轻微咳嗽等。症状严重，且在一个时期内广泛流行者，称为“流感”。本病四季皆可发病，但以冬春两季多见。
目前，西药治疗会产生药物依赖性与毒副作用，对患者的身体健康产生不利；中成药治疗如：感冒灵胶囊等，提取工艺采用水或乙醇长时间高温加热，浓缩也是长时间高温，致使中药部分有效成分失去相应的治疗作用，疗效受到一定的限制。本发明人在中医药理论的指导下，发明的经验方，并运用创新的生产工艺，临床应用安全性好，疗效高，很值得临床推广应用。
发明内容
本发明的目的是提供一种治疗感冒、发热的中药组合物。
本发明的目的还在于提供一种感冒、发热的中药组合物及其制备方法。
本发明解决的方案是发明人，在中医药理论的指导下，多年来结合自己的临床经验，运用创新的生产工艺，精心研制而成的，本品具有疏风解表，清热解毒、提高免疫功能之功效。临床上用于治疗普通感冒、流行性感冒属风热证，证见：发热，微恶风，鼻塞流涕，咳嗽，咽痛，头痛，全身酸痛，苔薄白或微黄，脉浮数。
本发明是通过下列方案实现的，本发明药物主要是由下述重量份配比的原料药制成的：
本发明药物主要各原料的优选重量份配比是：
本发明药物主要各原料的最佳重量份配比是：
山银花3份、板蓝根3份、墨旱莲2份、青蒿3.6份、荆芥2份、蒲公英3份、柴胡1.5份、党参2份、桔梗1.5份、紫苏1份、薄荷1份、野菊花3.6份、大青叶3份、连翘2份、鸭跖草4份、白芍2份、淡豆豉2份、前胡2份、黄芩2份、桂枝1.5份、甘草0.6份、茯苓1.5份、蛹虫草1份。
本发明药物的制备方法，其方法步骤如下：
(1)将配方中所述重量份配比的山银花、板蓝根、墨旱莲、青蒿、荆芥、蒲公英、柴胡、党参、桔梗、紫苏、薄荷、野菊花、大青叶、连翘、鸭跖草、白芍、淡豆豉、前胡、黄芩、桂枝、甘草、茯苓、蛹虫草纳米粉碎，加6-8倍量50-95％的乙醇浸泡12-24小时；
(2)采用不加热，超声循环萃取1-2次，每次15-30分钟，合并静置，取上清液用旋转蒸发设备，相对低温快速浓缩至相对密度为1.30～1.35(80℃)的浸膏，冷藏，用于制备各种制剂。
本发明提取的浓缩液中可以加入制备不同剂型时所需要的辅料，再以常规的中药制剂方法制备成常用口服剂型，如胶囊、颗粒剂、糖浆剂等。
具体实施方式
实施例1：本发明的治疗感冒、发热胶囊剂的制备方法，其步骤如下：
山银花3份、板蓝根3份、墨旱莲2份、青蒿3.6份、荆芥2份、蒲公英3份、柴胡1.5份、党参2份、桔梗1.5份、紫苏1份、薄荷1份、野菊花3.6份、大青叶3份、连翘2份、鸭跖草4份、白芍2份、淡豆豉2份、前胡2份、黄芩2份、桂枝1.5份、甘草0.6份、茯苓1.5份、蛹虫草1份。
(1)将配方中所述重量份配比的山银花、板蓝根、墨旱莲、青蒿、荆芥、蒲公英、柴胡、党参、桔梗、紫苏、薄荷、野菊花、大青叶、连翘、鸭跖草、白芍、淡豆豉、前胡、黄芩、桂枝、甘草、茯苓、蛹虫草纳米粉碎，加8倍量95％的乙醇浸泡12小时；
(2)采用不加热，超声循环萃取1次，每次30分钟，合并静置，取上清液用旋转蒸发设备，相对低温快速浓缩至相对密度为1.30～1.35(80℃)的浸膏，加微晶纤维素制粒，干燥，粉碎，过筛，装入胶囊，即制成胶囊剂。
实施例2：本发明的治疗感冒、发热颗粒剂的制备方法，其步骤如下：
山银花3份、板蓝根3份、墨旱莲2份、青蒿3.6份、荆芥2份、蒲公英3份、柴胡1.5份、党参2份、桔梗1.5份、紫苏1份、薄荷1份、野菊花3.6份、大青叶3份、连翘2份、鸭跖草4份、白芍2份、淡豆豉2份、前胡2份、黄芩2份、桂枝1.5份、甘草0.6份、茯苓1.5份、蛹虫草1份。
(1)将配方中所述重量份配比的山银花、板蓝根、墨旱莲、青蒿、荆芥、蒲公英、柴胡、党参、桔梗、紫苏、薄荷、野菊花、大青叶、连翘、鸭跖草、白芍、淡豆豉、前胡、黄芩、桂枝、甘草、茯苓、蛹虫草纳米粉碎，加6倍量50％的乙醇浸泡24小时；
(2)采用不加热，超声循环萃取2次，每次15分钟，合并静置，取上清液用旋转蒸发设备，相对低温快速浓缩至相对密度为1.30～1.35(80℃)的浸膏，加入糊精、甜菊素、混匀，制粒，干燥，包装，即制成颗粒剂。
实施例3：本发明的治疗感冒、发热糖浆剂的制备方法，其步骤如下：
山银花3份、板蓝根3份、墨旱莲2份、青蒿3.6份、荆芥2份、蒲公英3份、柴胡1.5份、党参2份、桔梗1.5份、紫苏1份、薄荷1份、野菊花3.6份、大青叶3份、连翘2份、鸭跖草4份、白芍2份、淡豆豉2份、前胡2份、黄芩2份、桂枝1.5份、甘草0.6份、茯苓1.5份、蛹虫草1份。
(1)将配方中所述重量份配比的山银花、板蓝根、墨旱莲、青蒿、荆芥、蒲公英、柴胡、党参、桔梗、紫苏、薄荷、野菊花、大青叶、连翘、鸭跖草、白芍、淡豆豉、前胡、黄芩、桂枝、甘草、茯苓、蛹虫草纳米粉碎，加7倍量70％的乙醇浸泡18小时；
(2)采用不加热，超声循环萃取2次，每次20分钟，合并静置，取上清液用旋转蒸发设备，相对低温快速浓缩至相对密度为1.30～1.35(80℃)的浸膏，蔗糖、山梨酸钾及适量蒸馏水，搅匀，滤过，包装，即制成糖浆剂。
实验例
以下均选用同一处方：
治疗组：采用本发明实施例1：制成的胶囊剂。
对照组1：采用水加热提取，每次加8倍量的水，煎煮2次，每次2小时，合并煎液，滤过，浓缩至相对密度为1.30～1.35(80℃)的浸膏，加微晶纤维素制粒，干燥，粉碎，过筛，装入胶囊，即制成胶囊剂。
对照组2：采用70％乙醇加热提取，每次加8倍量的醇，每次2小时，合并醇液，滤过，浓缩至相对密度为1.30～1.35(80℃)的浸膏，加微晶纤维素制粒，干燥，粉碎，过筛，装入胶囊，即制成胶囊剂。
选择31例感冒患者，年龄18-50岁，随机分为治疗组和对照组，每日3次，每次2粒，疗程均为3天。结果如下：
采用本发明实施例1：制成的胶囊剂，药材采用钠米粉碎、生产工艺采用不加热超声萃取、相对低温快速浓缩，大大地保留了中药的有效成分，是一个显著的创新，并对疗效而言，带来了显著的效果。经临床验证，有效率为100％，在治疗过程中，患者未见明显的不良反应。
虽然，上文中已经用一般性说明及具体实施方案对本发明做了详尽的描述，但在本发明基础上，可以对之作一些修改或改进，这对本领域技术人员而言是显而易见的。因此，在不偏离本发明精神的基础上所做的这些修改或改进，均属于本发明要求保护的范围。

Claims (4)

1.一种治疗感冒、发热的中药组合物，其特征在于它主要是由下列重量份配比的原料药制成：
。
2.根据权利要求1所述的治疗感冒、发热的中药组合物，其特征在于它主要是由下列优选的重量份配比的原料药制成：
。
3.根据权利要求1所述的治疗小感冒、发热的中药组合物，其特征在于它主要是由下列最佳重量份配比的原料药制成：
山银花3份、板蓝根3份、墨旱莲2份、青蒿3.6份、荆芥2份、蒲公英3份、柴胡1.5份、党参2份、桔梗1.5份、紫苏1份、薄荷1份、野菊花3.6份、大青叶3份、连翘2份、鸭跖草4份、白芍2份、淡豆豉2份、前胡2份、黄芩2份、桂枝1.5份、甘草0.6份、茯苓1.5份、蛹虫草1份。
4.一种制备权利要求1或2或3所述药物的方法，其特征在于它包括下列步骤：
(1)将配方中所述重量份配比的山银花、板蓝根、墨旱莲、青蒿、荆芥、蒲公英、柴胡、党参、桔梗、紫苏、薄荷、野菊花、大青叶、连翘、鸭跖草、白芍、淡豆豉、前胡、黄芩、桂枝、甘草、茯苓、蛹虫草纳米粉碎，加6-8倍量50-95％的乙醇浸泡12-24小时；
(2)采用不加热，超声循环萃取1-2次，每次15-30分钟，合并静置，取上清液用旋转蒸发设备，相对低温快速浓缩至相对密度为1.30～1.35(80℃)的浸膏，加入不同口服制剂的相关辅料，可制成胶囊剂、颗粒剂、糖浆剂等各种口服制剂。
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