KR102373930B1 - 정제된 재조합 폴리펩티드를 포함하는 방법 및 조성물 - Google Patents

정제된 재조합 폴리펩티드를 포함하는 방법 및 조성물 Download PDF

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KR102373930B1
KR102373930B1 KR1020167009338A KR20167009338A KR102373930B1 KR 102373930 B1 KR102373930 B1 KR 102373930B1 KR 1020167009338 A KR1020167009338 A KR 1020167009338A KR 20167009338 A KR20167009338 A KR 20167009338A KR 102373930 B1 KR102373930 B1 KR 102373930B1
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amino acid
seq
acid sequence
antibody
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KR20160052724A (ko
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엑스. 크리스토퍼 유
살로메 카드호데이안 피셔
수잔 씨. 피셔
존 로우에
아티아 나임
애일런 엠. 산체스
크리스토퍼 에이. 테스케
마틴 반더란
안나마리 아무라오
제이미 프랭클린
코라존 빅타
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제넨테크, 인크.
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    • C07—ORGANIC CHEMISTRY
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    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39516—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum from serum, plasma
    • A61K39/39525—Purification
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    • B01D15/325—Reversed phase
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography
    • B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G or L chromatography
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    • C07K1/14—Extraction; Separation; Purification
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    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081—DNA viruses
    • C07K16/085—Orthoherpesviridae (F), e.g. pseudorabies virus or Epstein-Barr virus
    • C07K16/088—Varicella-zoster virus
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    • C07K16/081—DNA viruses
    • C07K16/085—Orthoherpesviridae (F), e.g. pseudorabies virus or Epstein-Barr virus
    • C07K16/089—Cytomegalovirus
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
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    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
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    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
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    • C07K2317/565—Complementarity determining region [CDR]

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KR1020167009338A 2013-09-13 2014-09-12 정제된 재조합 폴리펩티드를 포함하는 방법 및 조성물 Active KR102373930B1 (ko)

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KR1020227007621A KR102571391B1 (ko) 2013-09-13 2014-09-12 정제된 재조합 폴리펩티드를 포함하는 방법 및 조성물

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US201361877517P 2013-09-13 2013-09-13
US61/877,517 2013-09-13
PCT/US2014/055387 WO2015038888A1 (en) 2013-09-13 2014-09-12 Methods and compositions comprising purified recombinant polypeptides

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KR102373930B1 true KR102373930B1 (ko) 2022-03-11

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KR1020227007621A Active KR102571391B1 (ko) 2013-09-13 2014-09-12 정제된 재조합 폴리펩티드를 포함하는 방법 및 조성물

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US (8) US9920120B2 (enExample)
EP (3) EP3683232A1 (enExample)
JP (4) JP6751344B2 (enExample)
KR (2) KR102373930B1 (enExample)
CN (2) CN105722532A (enExample)
AR (3) AR097651A1 (enExample)
AU (2) AU2014318615B2 (enExample)
BR (1) BR112016004413A2 (enExample)
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