DK2970378T3 - Hydrofob interaktionsproteinkromatografi under saltfrie betingelser - Google Patents

Hydrofob interaktionsproteinkromatografi under saltfrie betingelser Download PDF

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Publication number
DK2970378T3
DK2970378T3 DK14765488.3T DK14765488T DK2970378T3 DK 2970378 T3 DK2970378 T3 DK 2970378T3 DK 14765488 T DK14765488 T DK 14765488T DK 2970378 T3 DK2970378 T3 DK 2970378T3
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DK
Denmark
Prior art keywords
hydrophob
free conditions
chromatography under
under salt
interaction protein
Prior art date
Application number
DK14765488.3T
Other languages
English (en)
Inventor
Sanchayita Ghose
Yinying Tao
Original Assignee
Biogen Ma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Ma Inc filed Critical Biogen Ma Inc
Application granted granted Critical
Publication of DK2970378T3 publication Critical patent/DK2970378T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
DK14765488.3T 2013-03-15 2014-03-15 Hydrofob interaktionsproteinkromatografi under saltfrie betingelser DK2970378T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361791238P 2013-03-15 2013-03-15
PCT/US2014/029930 WO2014145208A1 (en) 2013-03-15 2014-03-15 Hydrophobic interaction protein chromatography under no-salt conditions

Publications (1)

Publication Number Publication Date
DK2970378T3 true DK2970378T3 (da) 2021-08-23

Family

ID=51537906

Family Applications (1)

Application Number Title Priority Date Filing Date
DK14765488.3T DK2970378T3 (da) 2013-03-15 2014-03-15 Hydrofob interaktionsproteinkromatografi under saltfrie betingelser

Country Status (6)

Country Link
US (3) US9994609B2 (da)
EP (2) EP2970378B1 (da)
JP (1) JP6592426B2 (da)
DK (1) DK2970378T3 (da)
PL (1) PL2970378T3 (da)
WO (1) WO2014145208A1 (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10023608B1 (en) 2013-03-13 2018-07-17 Amgen Inc. Protein purification methods to remove impurities
WO2014145208A1 (en) * 2013-03-15 2014-09-18 Biogen Idec Ma Inc. Hydrophobic interaction protein chromatography under no-salt conditions
CN106103477B (zh) * 2014-03-04 2021-08-17 默克专利股份公司 稳健的抗体纯化
AR102198A1 (es) 2014-10-09 2017-02-08 Regeneron Pharma Proceso para reducir partículas subvisibles en una formulación farmacéutica
JP2019529350A (ja) 2016-08-16 2019-10-17 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． 混合物から個々の抗体を定量する方法
AU2017350807B2 (en) 2016-10-25 2022-07-07 Regeneron Pharmaceuticals, Inc. Methods and systems for chromatography data analysis
TW202005694A (zh) 2018-07-02 2020-02-01 美商里珍納龍藥品有限公司 自混合物製備多肽之系統及方法

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US5641870A (en) * 1995-04-20 1997-06-24 Genentech, Inc. Low pH hydrophobic interaction chromatography for antibody purification
AU2004285928B2 (en) 2003-10-24 2012-02-02 Amgen, Inc. Process for purifying proteins in a hydrophobic interaction chromatography flow-through fraction
ES2377125T3 (es) * 2004-01-30 2012-03-22 Amgen Inc. Procedimiento de purificación de proteínas
EP1807205B1 (en) 2004-10-21 2012-09-26 GE Healthcare Bio-Sciences AB A method of antibody purification
US7408030B2 (en) * 2005-01-13 2008-08-05 North Carolina State University Purification of immunoglobulins using affinity chromatography and peptide ligands
CA2634495A1 (en) * 2005-12-22 2007-06-28 Conjuchem Biotechnologies Inc. Process for the production of preformed conjugates of albumin and a therapeutic agent
LT2436696T (lt) 2007-01-05 2017-08-25 University Of Zurich Anti-beta-amiloido antikūnas ir jo panaudojimas
EP2114984A2 (en) 2007-01-17 2009-11-11 Merck Serono S.A. Process for the purification of fc-containing proteins
US20110182809A1 (en) 2008-07-09 2011-07-28 University Of Zurich Method of Promoting Neurogenesis
EP2315779A2 (en) 2008-07-09 2011-05-04 Biogen Idec MA Inc. Compositions comprising antibodies to lingo or fragments thereof
US8497358B2 (en) 2008-12-19 2013-07-30 Takeda Pharmaceutical Company Limited Antibody purification method
JP5826180B2 (ja) * 2009-10-12 2015-12-02 ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ 分離マトリックス
MX341136B (es) * 2009-10-20 2016-08-09 Abbvie Inc Aislamiento y purificacion de los anticuerpos anti-il-13 al usar la cromatografia de afinidad con proteina a.
JP5699429B2 (ja) * 2009-12-18 2015-04-08 東ソー株式会社 Ｆｃレセプターの精製方法
US20120149878A1 (en) 2010-12-08 2012-06-14 Gillespie Ronald Protein purification
EA201400024A1 (ru) 2011-06-16 2014-04-30 ДСМ АйПи АССЕТС Б.В. Хроматографическая очистка антитела в одном устройстве
AU2012272790B2 (en) 2011-06-23 2016-10-06 Biogen International Neuroscience Gmbh Anti-alpha synuclein binding molecules
WO2013158279A1 (en) 2012-04-20 2013-10-24 Abbvie Inc. Protein purification methods to reduce acidic species
WO2013176754A1 (en) 2012-05-24 2013-11-28 Abbvie Inc. Novel purification of antibodies using hydrophobic interaction chromatography
US11718643B2 (en) 2012-11-13 2023-08-08 Cytiva Bioprocess R&D Ab Multimodal anion exchange matrices
WO2014145208A1 (en) 2013-03-15 2014-09-18 Biogen Idec Ma Inc. Hydrophobic interaction protein chromatography under no-salt conditions
US20160083453A1 (en) 2013-05-13 2016-03-24 Medlmmune, Llc Separation of recombinant polyclonal antibody multimers with minimal separation of monomers
EP3043820A4 (en) 2013-09-13 2017-07-12 F. Hoffmann-La Roche AG Methods and compositions comprising purified recombinant polypeptides
BR112016021717A2 (pt) * 2014-03-21 2018-07-10 Abbvie Inc anticorpos anti-egfr e conjugados anticorpo-fármaco

Also Published As

Publication number Publication date
PL2970378T3 (pl) 2021-12-06
EP2970378A1 (en) 2016-01-20
US11111269B2 (en) 2021-09-07
JP2016515529A (ja) 2016-05-30
US9994609B2 (en) 2018-06-12
US20230391820A1 (en) 2023-12-07
US20160024145A1 (en) 2016-01-28
EP2970378A4 (en) 2016-11-16
EP3936515A1 (en) 2022-01-12
WO2014145208A1 (en) 2014-09-18
US20190144495A1 (en) 2019-05-16
EP2970378B1 (en) 2021-05-26
JP6592426B2 (ja) 2019-10-16

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