KR102352250B1 - 세포 배양 배지에 사용하기 위한 폴록사머를 제조하는 방법 - Google Patents

세포 배양 배지에 사용하기 위한 폴록사머를 제조하는 방법 Download PDF

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KR102352250B1
KR102352250B1 KR1020167029244A KR20167029244A KR102352250B1 KR 102352250 B1 KR102352250 B1 KR 102352250B1 KR 1020167029244 A KR1020167029244 A KR 1020167029244A KR 20167029244 A KR20167029244 A KR 20167029244A KR 102352250 B1 KR102352250 B1 KR 102352250B1
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poloxamer
minutes
cell culture
cell
culture medium
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KR20160138161A (ko
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가네쉬 프라사드 비스베스바란
로버트 데이빗 키스
스티븐 제이. 마이어
인찬 권
카라 칼훈
케이트 윈체스터
아멜리아 아담스
마리온 글렌
스테판 쾨니크
앨런 디스
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제넨테크, 인크.
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/30—Post-polymerisation treatment, e.g. recovery, purification, drying
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/34—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/34—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
    • C08G65/48—Polymers modified by chemical after-treatment
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2650/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G2650/28—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type
    • C08G2650/50—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type containing nitrogen, e.g. polyetheramines or Jeffamines(r)
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2650/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G2650/28—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type
    • C08G2650/58—Ethylene oxide or propylene oxide copolymers, e.g. pluronics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/50—Soluble polymers, e.g. polyethyleneglycol [PEG]

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
KR1020167029244A 2014-03-25 2015-03-25 세포 배양 배지에 사용하기 위한 폴록사머를 제조하는 방법 Active KR102352250B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461970281P 2014-03-25 2014-03-25
US61/970,281 2014-03-25
PCT/US2015/022592 WO2015148736A1 (en) 2014-03-25 2015-03-25 Methods of preparing a poloxamer for use in cell culture medium

Publications (2)

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KR20160138161A KR20160138161A (ko) 2016-12-02
KR102352250B1 true KR102352250B1 (ko) 2022-01-17

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US (2) US11034793B2 (https=)
EP (2) EP3778702B1 (https=)
JP (3) JP6655548B2 (https=)
KR (1) KR102352250B1 (https=)
CN (2) CN106414552B (https=)
AU (1) AU2015236008B2 (https=)
BR (1) BR112016021739B1 (https=)
CA (1) CA2943357C (https=)
ES (1) ES2778680T3 (https=)
HR (1) HRP20200372T1 (https=)
IL (2) IL247902B (https=)
MX (2) MX2016012288A (https=)
MY (1) MY178060A (https=)
PL (1) PL3122799T3 (https=)
RU (1) RU2710551C2 (https=)
SG (1) SG11201607929PA (https=)
SI (1) SI3122799T1 (https=)
WO (1) WO2015148736A1 (https=)
ZA (1) ZA201606711B (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112016021739B1 (pt) 2014-03-25 2021-11-03 Genentech, Inc Método para preparar um poloxâmero para uso em um meio de cultura de célula
EP3430072B1 (en) * 2016-03-17 2020-07-01 Merck Patent GmbH Method for purifying poloxamers
JP7135096B2 (ja) * 2017-12-21 2022-09-12 シグマ－アルドリッチ・カンパニー・リミテッド・ライアビリティ・カンパニー ポロキサマー組成物ならびにその製造方法およびその使用
EP3790597A4 (en) * 2018-07-12 2022-03-09 Arshintseva, Elena Valentinovna THERMAL PROCESS FOR THE STERILIZATION OF POLOXAMER WITH LIQUID PHARMACEUTICALS
CN112469814A (zh) * 2018-07-27 2021-03-09 味之素株式会社 动物细胞的悬浮培养用添加物、悬浮培养用培养基和悬浮培养方法

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US20110151506A1 (en) * 2009-12-23 2011-06-23 Sanofi Pasteur Sa Process for Culturing Adherent Cells

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Publication number Publication date
RU2710551C2 (ru) 2019-12-27
JP2023011566A (ja) 2023-01-24
BR112016021739A2 (pt) 2017-08-15
RU2016141568A (ru) 2018-04-28
US11912823B2 (en) 2024-02-27
KR20160138161A (ko) 2016-12-02
US11034793B2 (en) 2021-06-15
MX2021001981A (es) 2021-04-28
EP3122799B1 (en) 2020-01-15
JP2017516459A (ja) 2017-06-22
AU2015236008A1 (en) 2016-10-27
SI3122799T1 (sl) 2020-06-30
JP7472222B2 (ja) 2024-04-22
WO2015148736A8 (en) 2016-08-18
EP3778702B1 (en) 2023-06-28
CN106414552B (zh) 2020-08-25
SG11201607929PA (en) 2016-10-28
EP3122799B8 (en) 2020-03-11
PL3122799T3 (pl) 2020-06-29
RU2016141568A3 (https=) 2018-09-26
WO2015148736A1 (en) 2015-10-01
BR112016021739B1 (pt) 2021-11-03
CA2943357C (en) 2023-06-27
IL279583B (en) 2022-03-01
IL247902A0 (en) 2016-11-30
JP6655548B2 (ja) 2020-02-26
MX2016012288A (es) 2017-01-23
CA2943357A1 (en) 2015-10-01
ZA201606711B (en) 2019-12-18
MY178060A (en) 2020-09-30
EP3122799A1 (en) 2017-02-01
IL279583A (en) 2021-03-01
EP3778702A1 (en) 2021-02-17
IL247902B (en) 2021-01-31
ES2778680T3 (es) 2020-08-11
CN111808276A (zh) 2020-10-23
NZ725151A (en) 2021-05-28
US20210371587A1 (en) 2021-12-02
AU2015236008B2 (en) 2018-12-20
US20170009015A1 (en) 2017-01-12
CN106414552A (zh) 2017-02-15
HRP20200372T1 (hr) 2020-06-12
JP2020103290A (ja) 2020-07-09

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