KR102341193B1 - 구충 및 살충성의 이속사졸린 화합물 - Google Patents
구충 및 살충성의 이속사졸린 화합물 Download PDFInfo
- Publication number
- KR102341193B1 KR102341193B1 KR1020167014400A KR20167014400A KR102341193B1 KR 102341193 B1 KR102341193 B1 KR 102341193B1 KR 1020167014400 A KR1020167014400 A KR 1020167014400A KR 20167014400 A KR20167014400 A KR 20167014400A KR 102341193 B1 KR102341193 B1 KR 102341193B1
- Authority
- KR
- South Korea
- Prior art keywords
- alkyl
- haloalkyl
- hydrogen
- carbon atom
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- AOPBMHFGTICZCV-MGLVMYNNSA-N C/C=C\C(\Br)=C/COC(F)(F)F Chemical compound C/C=C\C(\Br)=C/COC(F)(F)F AOPBMHFGTICZCV-MGLVMYNNSA-N 0.000 description 1
- 0 CC1(C(IN(C2)C(*)(*)N(*)C2=O)=O)Br=*C(C(C2)=NOC2(C(F)(F)F)c2cc(*)cc(*)c2)=CC1* Chemical compound CC1(C(IN(C2)C(*)(*)N(*)C2=O)=O)Br=*C(C(C2)=NOC2(C(F)(F)F)c2cc(*)cc(*)c2)=CC1* 0.000 description 1
- RUUCMFKXWSHUDP-UHFFFAOYSA-N CCCN(C(CN(C1)C(c(cc2)c(C(F)(F)F)cc2C(C2)=NOC2(C(F)(F)F)c2cc(Cl)cc(C(F)(F)F)c2)=O)=O)C1=O Chemical compound CCCN(C(CN(C1)C(c(cc2)c(C(F)(F)F)cc2C(C2)=NOC2(C(F)(F)F)c2cc(Cl)cc(C(F)(F)F)c2)=O)=O)C1=O RUUCMFKXWSHUDP-UHFFFAOYSA-N 0.000 description 1
- PIEQAHCSAGDYDI-UHFFFAOYSA-N CCN(C)OC(C)(C(F)(F)F)c1cc(C(F)(F)F)cc(Cl)c1 Chemical compound CCN(C)OC(C)(C(F)(F)F)c1cc(C(F)(F)F)cc(Cl)c1 PIEQAHCSAGDYDI-UHFFFAOYSA-N 0.000 description 1
- LUDYWBKLSKRLDP-UHFFFAOYSA-N COC(c(c(C(F)(F)F)c1)ccc1C(C1)=NOC1(C(F)(F)F)c1cc(Cl)cc(C(F)(F)F)c1)=O Chemical compound COC(c(c(C(F)(F)F)c1)ccc1C(C1)=NOC1(C(F)(F)F)c1cc(Cl)cc(C(F)(F)F)c1)=O LUDYWBKLSKRLDP-UHFFFAOYSA-N 0.000 description 1
- ZJHPYBAFBBSOAC-UHFFFAOYSA-N Cc1cc(C(C2)=NOC2(C(F)(F)F)c(cc2Cl)cc(Cl)c2F)ccc1C(N(C1)CN(CCC(F)(F)F)C1=O)=O Chemical compound Cc1cc(C(C2)=NOC2(C(F)(F)F)c(cc2Cl)cc(Cl)c2F)ccc1C(N(C1)CN(CCC(F)(F)F)C1=O)=O ZJHPYBAFBBSOAC-UHFFFAOYSA-N 0.000 description 1
- QVYOKMZNIKOGQE-UHFFFAOYSA-N Cc1cc(C(C2)=NOC2(C(F)(F)F)c2cc(C(F)(F)F)cc(Cl)c2)ccc1C(N(C1)CNC1=O)=O Chemical compound Cc1cc(C(C2)=NOC2(C(F)(F)F)c2cc(C(F)(F)F)cc(Cl)c2)ccc1C(N(C1)CNC1=O)=O QVYOKMZNIKOGQE-UHFFFAOYSA-N 0.000 description 1
- NJOUSMMJZIOCAK-UHFFFAOYSA-N Cc1cc(C(C2)=NOC2(C(F)(F)F)c2cc(Cl)cc(C(F)(F)F)c2)ccc1C(N(C1)CN(CCC(F)(F)F)C1=O)=O Chemical compound Cc1cc(C(C2)=NOC2(C(F)(F)F)c2cc(Cl)cc(C(F)(F)F)c2)ccc1C(N(C1)CN(CCC(F)(F)F)C1=O)=O NJOUSMMJZIOCAK-UHFFFAOYSA-N 0.000 description 1
- YTCGOUNVIAWCMG-UHFFFAOYSA-N FC(c1cccc(Cl)c1)(F)F Chemical compound FC(c1cccc(Cl)c1)(F)F YTCGOUNVIAWCMG-UHFFFAOYSA-N 0.000 description 1
- CYJAWBVQRMVFEO-UHFFFAOYSA-N O=C(CNC1)NC1=O Chemical compound O=C(CNC1)NC1=O CYJAWBVQRMVFEO-UHFFFAOYSA-N 0.000 description 1
- YYKPJCGAYXDHMB-UHFFFAOYSA-N O=C(c(c(C(F)(F)F)c1)ccc1C(C1)=NOC1(C(F)(F)F)c1cc(Cl)cc(C(F)(F)F)c1)N(CC(N1)=O)CC1=O Chemical compound O=C(c(c(C(F)(F)F)c1)ccc1C(C1)=NOC1(C(F)(F)F)c1cc(Cl)cc(C(F)(F)F)c1)N(CC(N1)=O)CC1=O YYKPJCGAYXDHMB-UHFFFAOYSA-N 0.000 description 1
- OQIVUGYRNNKIFT-UHFFFAOYSA-N O=C(c(c(CC(F)(F)F)c1)ccc1C(C1)=NOC1(C(F)(F)F)c1cc(Cl)cc(C(F)(F)F)c1)N(C1)CN(CCC(F)(F)F)C1=O Chemical compound O=C(c(c(CC(F)(F)F)c1)ccc1C(C1)=NOC1(C(F)(F)F)c1cc(Cl)cc(C(F)(F)F)c1)N(C1)CN(CCC(F)(F)F)C1=O OQIVUGYRNNKIFT-UHFFFAOYSA-N 0.000 description 1
- AXOYQAUGTHGMPR-UHFFFAOYSA-N OCc(cc1CC(F)(F)F)ccc1Br Chemical compound OCc(cc1CC(F)(F)F)ccc1Br AXOYQAUGTHGMPR-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
- A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Environmental Sciences (AREA)
- Dentistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Dispersion Chemistry (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361898578P | 2013-11-01 | 2013-11-01 | |
| US61/898,578 | 2013-11-01 | ||
| PCT/US2014/063074 WO2015066277A1 (en) | 2013-11-01 | 2014-10-30 | Antiparisitic and pesticidal isoxazoline compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20160079070A KR20160079070A (ko) | 2016-07-05 |
| KR102341193B1 true KR102341193B1 (ko) | 2021-12-17 |
Family
ID=51987452
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020167014400A Expired - Fee Related KR102341193B1 (ko) | 2013-11-01 | 2014-10-30 | 구충 및 살충성의 이속사졸린 화합물 |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US9447084B2 (https=) |
| EP (2) | EP3733664A1 (https=) |
| JP (2) | JP6484641B2 (https=) |
| KR (1) | KR102341193B1 (https=) |
| CN (1) | CN105873925B (https=) |
| AP (1) | AP2016009184A0 (https=) |
| AR (1) | AR098266A1 (https=) |
| AU (2) | AU2014342241B2 (https=) |
| CA (1) | CA2929234C (https=) |
| CL (1) | CL2016001043A1 (https=) |
| DK (1) | DK3063144T3 (https=) |
| EA (1) | EA030935B1 (https=) |
| ES (1) | ES2905848T3 (https=) |
| IL (1) | IL245384B (https=) |
| MX (1) | MX361516B (https=) |
| NZ (1) | NZ719916A (https=) |
| PL (1) | PL3063144T3 (https=) |
| PT (1) | PT3063144T (https=) |
| SG (1) | SG11201603430XA (https=) |
| TW (1) | TWI658040B (https=) |
| UY (1) | UY35810A (https=) |
| WO (1) | WO2015066277A1 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT3298027T (lt) | 2015-05-20 | 2021-08-10 | Boehringer Ingelheim Animal Health USA Inc. | Antihelmintiniai depsipeptido junginiai |
| BR112017027855B1 (pt) | 2015-06-23 | 2022-11-16 | Intervet International B.V. | Composição farmacêutica, seu uso, água potável medicamentosa e método para sua preparação |
| UY37137A (es) | 2016-02-24 | 2017-09-29 | Merial Inc | Compuestos antiparasitarios de isoxazolina, formulaciones inyectables de acción prolongada que los comprenden, métodos y usos de los mismos |
| CA3044038A1 (en) | 2016-11-16 | 2018-05-24 | Boehringer Ingelheim Animal Health USA Inc. | Anthelmintic depsipeptide compounds |
| WO2018192793A1 (en) * | 2017-04-20 | 2018-10-25 | Basf Se | Substituted rhodanine derivatives |
| AR113997A1 (es) | 2017-12-21 | 2020-07-08 | Intervet Int Bv | Composiciones antiparasitarias para unción dorsal continua |
| CN110305033B (zh) * | 2018-03-20 | 2020-08-28 | 鲁南制药集团股份有限公司 | 一种西司他汀钠中间体的纯化方法 |
| AU2019301510B2 (en) | 2018-07-09 | 2024-06-13 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Anthelminthic heterocyclic compounds |
| CA3133100A1 (en) | 2019-03-19 | 2020-09-24 | Boehringer Ingelheim Animal Health USA Inc. | Anthelmintic aza-benzothiophene and aza-benzofuran compounds |
| EP4077286A1 (en) | 2019-12-18 | 2022-10-26 | Elanco Tiergesundheit AG | Isoxazoline derivatives as pesticides |
| KR20230028268A (ko) | 2020-05-29 | 2023-02-28 | 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 | 구충성 헤테로시클릭 화합물 |
| JP7824305B2 (ja) | 2021-01-27 | 2026-03-04 | コルテバ アグリサイエンス エルエルシー | 魚における寄生生物に対するシクロプロピルアミド化合物 |
| US20240116854A1 (en) | 2021-01-27 | 2024-04-11 | Intervet Inc. | Cyclopropylamide compounds against parasites in fish |
| KR20230145066A (ko) * | 2021-02-11 | 2023-10-17 | 바스프 에스이 | 치환된 이속사졸린 유도체 |
| EP4043444A1 (en) * | 2021-02-11 | 2022-08-17 | Basf Se | Substituted isoxazoline derivatives |
| CN116888101A (zh) * | 2021-02-11 | 2023-10-13 | 巴斯夫欧洲公司 | 取代的异噁唑啉衍生物 |
| UY39995A (es) | 2021-11-01 | 2023-05-15 | Boehringer Ingelheim Vetmedica GmbH | Compuestos de pirrolopiridazina como antihelmínticos |
| CN116102511A (zh) * | 2023-02-10 | 2023-05-12 | 河北圣雪大成制药有限责任公司 | 一种高纯度氟雷拉纳中间体的制备方法 |
| NO20240925A1 (en) | 2023-09-15 | 2025-03-17 | Evah Atlantic Inc | Dihydroisoxazole compound for use in reducing ectoparasite infestations on fish |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070066617A1 (en) * | 2004-03-05 | 2007-03-22 | Nissan Chemical Industries, Ltd. | Isoxazoline-substituted benzamide compound and pesticide |
| US20100144808A1 (en) | 2007-06-29 | 2010-06-10 | Nissan Chemical Industries, Ltd. | Substituted isoxazoline or enone oxime compound, and pest control agent |
| US20130065846A1 (en) | 2011-09-12 | 2013-03-14 | Mark D. Soll | Parasiticidal compositions comprising an isoxazoline active agent, methods and uses thereof |
| US20130203692A1 (en) | 2012-02-06 | 2013-08-08 | Merial Limited | Parasiticidal oral veterinary compositions comprising systemically-acting active agents, methods and uses thereof |
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