KR102185762B1 - Ｃａｒ 효소들 및 지방족 알코올들의 개선된 생산 - Google Patents

Ｃａｒ 효소들 및 지방족 알코올들의 개선된 생산 Download PDF

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KR102185762B1
KR102185762B1 KR1020197017717A KR20197017717A KR102185762B1 KR 102185762 B1 KR102185762 B1 KR 102185762B1 KR 1020197017717 A KR1020197017717 A KR 1020197017717A KR 20197017717 A KR20197017717 A KR 20197017717A KR 102185762 B1 KR102185762 B1 KR 102185762B1
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KR20190076059A (ko
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데렉 엘. 그린필드
엘리자베스 제이. 클라크
엘리 에스. 그로반
비크란트 알라가다
성원 이
쉐지 리
지하오 흐
바오롱 주
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알이지 라이프 사이언시스, 엘엘씨
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
    • C12Y102/0105—Long-chain-fatty-acyl-CoA reductase (1.2.1.50)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/99—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with other acceptors (1.2.99)
    • C12Y102/99006—Carboxylate reductase (1.2.99.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01041—Beta-ketoacyl-acyl-carrier-protein synthase I (2.3.1.41)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/02—Thioester hydrolases (3.1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P2203/00—Fermentation products obtained from optionally pretreated or hydrolyzed cellulosic or lignocellulosic material as the carbon source
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

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  • Chemical & Material Sciences (AREA)
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  • General Engineering & Computer Science (AREA)
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  • Molecular Biology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
KR1020197017717A 2012-04-02 2013-04-02 Ｃａｒ 효소들 및 지방족 알코올들의 개선된 생산 Expired - Fee Related KR102185762B1 (ko)

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KR1020207009760A KR102282677B1 (ko) 2012-04-02 2013-04-02 Ｃａｒ 효소들 및 지방족 알코올들의 개선된 생산

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US201261619309P 2012-04-02 2012-04-02
US61/619,309 2012-04-02
PCT/US2013/035040 WO2013152052A2 (en) 2012-04-02 2013-04-02 Novel car enzymes and improved production of fatty alcohols

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KR1020177026945A Division KR20170113710A (ko) 2012-04-02 2013-04-02 Ｃａｒ 효소들 및 지방족 알코올들의 개선된 생산

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KR102185762B1 true KR102185762B1 (ko) 2020-12-02

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KR1020197017717A Expired - Fee Related KR102185762B1 (ko) 2012-04-02 2013-04-02 Ｃａｒ 효소들 및 지방족 알코올들의 개선된 생산
KR1020217023277A Ceased KR20210095226A (ko) 2012-04-02 2013-04-02 Ｃａｒ 효소들 및 지방족 알코올들의 개선된 생산
KR1020177026945A Ceased KR20170113710A (ko) 2012-04-02 2013-04-02 Ｃａｒ 효소들 및 지방족 알코올들의 개선된 생산
KR1020197005741A Expired - Fee Related KR102114841B1 (ko) 2012-04-02 2013-04-02 Ｃａｒ 효소들 및 지방족 알코올들의 개선된 생산
KR1020207009760A Expired - Fee Related KR102282677B1 (ko) 2012-04-02 2013-04-02 Ｃａｒ 효소들 및 지방족 알코올들의 개선된 생산
KR1020147030704A Active KR101831331B1 (ko) 2012-04-02 2013-04-02 Ｃａｒ 효소들 및 지방족 알코올들의 개선된 생산

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KR1020177026945A Ceased KR20170113710A (ko) 2012-04-02 2013-04-02 Ｃａｒ 효소들 및 지방족 알코올들의 개선된 생산
KR1020197005741A Expired - Fee Related KR102114841B1 (ko) 2012-04-02 2013-04-02 Ｃａｒ 효소들 및 지방족 알코올들의 개선된 생산
KR1020207009760A Expired - Fee Related KR102282677B1 (ko) 2012-04-02 2013-04-02 Ｃａｒ 효소들 및 지방족 알코올들의 개선된 생산
KR1020147030704A Active KR101831331B1 (ko) 2012-04-02 2013-04-02 Ｃａｒ 효소들 및 지방족 알코올들의 개선된 생산

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US (4) US9340801B2 (enExample)
EP (6) EP4186974A1 (enExample)
JP (1) JP6230594B2 (enExample)
KR (6) KR102185762B1 (enExample)
CN (1) CN104704113B (enExample)
AU (2) AU2013243602B2 (enExample)
BR (2) BR112014024674B1 (enExample)
CA (1) CA2883064A1 (enExample)
CO (1) CO7170148A2 (enExample)
ES (3) ES2666157T3 (enExample)
MX (2) MX358177B (enExample)
MY (1) MY170889A (enExample)
SI (1) SI3385374T1 (enExample)
WO (1) WO2013152052A2 (enExample)

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CN109182238A (zh) 2012-08-10 2019-01-11 嘉吉有限公司 用于生产脂肪酸和脂肪酸衍生产物的微生物及方法
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JP6603658B2 (ja) 2013-07-19 2019-11-06 カーギル インコーポレイテッド 脂肪酸及び脂肪酸誘導体の製造のための微生物及び方法
BR112017001105A2 (pt) * 2014-07-18 2018-07-24 REG Life Sciences, LLC produção microbiana de dióis graxos
EP2993228B1 (en) 2014-09-02 2019-10-09 Cargill, Incorporated Production of fatty acid esters
CN105985987B (zh) * 2015-03-02 2020-01-31 苏州安捷生物科技有限公司 一种生物法制备脂肪醇的方法
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CN111094558A (zh) 2017-04-03 2020-05-01 基因组股份公司 对产生中链脂肪酸衍生物具有改善的活性的硫酯酶变体
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US12098168B2 (en) 2018-08-31 2024-09-24 Genomatica, Inc. XylR mutant for improved xylose utilization or improved co-utilization of glucose and xylose preliminary
WO2022209763A1 (ja) 2021-03-30 2022-10-06 旭化成株式会社 カルボン酸還元活性を有する組換えポリペプチド
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JP6230594B2 (ja) 2017-11-15
MX343296B (es) 2016-11-01
EP3674399B1 (en) 2021-09-22
KR20210095226A (ko) 2021-07-30
JP2015512645A (ja) 2015-04-30
US9758769B2 (en) 2017-09-12
WO2013152052A2 (en) 2013-10-10
US20150064757A1 (en) 2015-03-05
EP4186974A1 (en) 2023-05-31
CN104704113B (zh) 2018-01-23
US10301603B2 (en) 2019-05-28
KR20190076059A (ko) 2019-07-01
US20160326499A1 (en) 2016-11-10
EP3985108A1 (en) 2022-04-20
US20200109374A1 (en) 2020-04-09
ES2613553T3 (es) 2017-05-24
KR20170113710A (ko) 2017-10-12
SI3385374T1 (sl) 2020-09-30
EP3674399A1 (en) 2020-07-01
AU2016231497A1 (en) 2016-10-06
ES2786633T3 (es) 2020-10-13
KR20190022935A (ko) 2019-03-06
MX2014011903A (es) 2015-05-12
CO7170148A2 (es) 2015-01-28
BR112014024674A2 (pt) 2018-11-21
KR102282677B1 (ko) 2021-07-28
BR122019026987B1 (pt) 2022-01-18
WO2013152052A3 (en) 2014-03-13
KR20150032660A (ko) 2015-03-27
AU2013243602B2 (en) 2016-11-24
US20180135028A1 (en) 2018-05-17
BR112014024674B1 (pt) 2022-06-07
KR102114841B1 (ko) 2020-05-26
EP2834350A2 (en) 2015-02-11
CA2883064A1 (en) 2013-10-10
EP3385374B1 (en) 2020-01-08
EP3153579A1 (en) 2017-04-12
EP2834350B1 (en) 2016-11-16
EP3153579B1 (en) 2018-03-14
ES2666157T3 (es) 2018-05-03
KR20200038559A (ko) 2020-04-13
US11034937B2 (en) 2021-06-15
MX358177B (es) 2018-08-08
AU2016231497B2 (en) 2017-08-31
KR101831331B1 (ko) 2018-02-23
EP3385374A1 (en) 2018-10-10
US9340801B2 (en) 2016-05-17
MY170889A (en) 2019-09-12
CN104704113A (zh) 2015-06-10
AU2013243602A1 (en) 2014-11-13

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