KR102177195B1 - 폴리펩티드 안정성 및 활성을 증가시키는 조성물 및 관련된 방법 - Google Patents

폴리펩티드 안정성 및 활성을 증가시키는 조성물 및 관련된 방법 Download PDF

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KR102177195B1
KR102177195B1 KR1020207004032A KR20207004032A KR102177195B1 KR 102177195 B1 KR102177195 B1 KR 102177195B1 KR 1020207004032 A KR1020207004032 A KR 1020207004032A KR 20207004032 A KR20207004032 A KR 20207004032A KR 102177195 B1 KR102177195 B1 KR 102177195B1
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polymerase
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올레브 카레
카드리 아트마
티이나 카레
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솔리스 바이오다인 오위
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/5759—Products of obesity genes, e.g. leptin, obese (OB), tub, fat
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C12N9/1252—DNA-directed DNA polymerase (2.7.7.7), i.e. DNA replicase
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    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C12N9/1276—RNA-directed DNA polymerase (2.7.7.49), i.e. reverse transcriptase or telomerase
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • C—CHEMISTRY; METALLURGY
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C—CHEMISTRY; METALLURGY
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
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    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/07—Nucleotidyltransferases (2.7.7)
    • C12Y207/07049—RNA-directed DNA polymerase (2.7.7.49), i.e. telomerase or reverse-transcriptase
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • C—CHEMISTRY; METALLURGY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin
    • C—CHEMISTRY; METALLURGY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site

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KR1020207004032A 2009-11-19 2010-11-19 폴리펩티드 안정성 및 활성을 증가시키는 조성물 및 관련된 방법 Active KR102177195B1 (ko)

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US26291909P 2009-11-19 2009-11-19
US61/262,919 2009-11-19
US35045710P 2010-06-01 2010-06-01
US61/350,457 2010-06-01
US35654110P 2010-06-18 2010-06-18
US61/356,541 2010-06-18
US39085710P 2010-10-07 2010-10-07
US61/390,857 2010-10-07
PCT/IB2010/003127 WO2011061625A2 (en) 2009-11-19 2010-11-19 Compositions for increasing polypeptide stability and activity, and related methods

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KR1020177023312A Ceased KR20170098985A (ko) 2009-11-19 2010-11-19 폴리펩티드 안정성 및 활성을 증가시키는 조성물 및 관련된 방법
KR1020127015034A Active KR101773636B1 (ko) 2009-11-19 2010-11-19 폴리펩티드 안정성 및 활성을 증가시키는 조성물 및 관련된 방법
KR1020187033851A Active KR102078756B1 (ko) 2009-11-19 2010-11-19 폴리펩티드 안정성 및 활성을 증가시키는 조성물 및 관련된 방법

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KR1020127015034A Active KR101773636B1 (ko) 2009-11-19 2010-11-19 폴리펩티드 안정성 및 활성을 증가시키는 조성물 및 관련된 방법
KR1020187033851A Active KR102078756B1 (ko) 2009-11-19 2010-11-19 폴리펩티드 안정성 및 활성을 증가시키는 조성물 및 관련된 방법

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US (6) US9321999B2 (cg-RX-API-DMAC7.html)
EP (3) EP2501716B1 (cg-RX-API-DMAC7.html)
KR (4) KR102177195B1 (cg-RX-API-DMAC7.html)
CN (1) CN102858962A (cg-RX-API-DMAC7.html)
CA (1) CA2780678A1 (cg-RX-API-DMAC7.html)
DK (1) DK2501716T3 (cg-RX-API-DMAC7.html)
ES (1) ES2533536T3 (cg-RX-API-DMAC7.html)
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KR101503726B1 (ko) * 2013-04-30 2015-03-19 (주)진매트릭스 Ｄｎａ 제한효소에 의해 활성 조절이 가능한 프라이머 및 이를 이용한 유전자 증폭방법 그리고 이러한 프라이머의 설계방법
CN104004857B (zh) * 2014-05-27 2015-10-28 广州博至生物科技有限公司 一种快速区分不同基因型犬细小病毒的pcr-hrm引物和方法
US11091745B2 (en) 2015-05-12 2021-08-17 Dna Polymerase Technology, Inc. Mutant polymerases and uses thereof
CN106319092B (zh) * 2016-09-27 2018-03-09 广州维佰生物科技有限公司 一种快速鉴别猪流行性腹泻病毒经典株与变异株的hrm检测引物、试剂盒及方法
CN106754816B (zh) * 2017-02-24 2020-10-27 依科赛生物科技（太仓）有限公司 一种高保真快速扩增融合酶及其制备方法
CN109628423A (zh) * 2018-12-06 2019-04-16 北京春雷杰创生物科技有限公司 一种热启动Taq DNA聚合酶组合优化分子试剂的方法
CN113391067B (zh) * 2021-06-16 2023-07-25 军事科学院军事医学研究院军事兽医研究所 抗尼帕病毒g蛋白抗体的间接elisa检测方法
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