KR102156819B1 - 바이러스 폴리머라아제를 억제하기 위한 조성물 및 방법 - Google Patents

바이러스 폴리머라아제를 억제하기 위한 조성물 및 방법 Download PDF

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KR102156819B1
KR102156819B1 KR1020147032192A KR20147032192A KR102156819B1 KR 102156819 B1 KR102156819 B1 KR 102156819B1 KR 1020147032192 A KR1020147032192 A KR 1020147032192A KR 20147032192 A KR20147032192 A KR 20147032192A KR 102156819 B1 KR102156819 B1 KR 102156819B1
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KR20150002844A (ko
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프라빈 엘. 코티안
야라가다 에스. 바부
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바이오크리스트파마슈티컬즈,인코포레이티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
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    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
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    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/213—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020147032192A 2012-04-18 2013-04-17 바이러스 폴리머라아제를 억제하기 위한 조성물 및 방법 Active KR102156819B1 (ko)

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US201261625994P 2012-04-18 2012-04-18
US61/625,994 2012-04-18
PCT/US2013/036945 WO2013158746A1 (en) 2012-04-18 2013-04-17 Compositions and methods for inhibiting viral polymerase

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KR1020207016520A Division KR20200070428A (ko) 2012-04-18 2013-04-17 바이러스 폴리머라아제를 억제하기 위한 조성물 및 방법

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KR102156819B1 true KR102156819B1 (ko) 2020-09-16

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KR1020207016520A Ceased KR20200070428A (ko) 2012-04-18 2013-04-17 바이러스 폴리머라아제를 억제하기 위한 조성물 및 방법
KR1020217002466A Active KR102409853B1 (ko) 2012-04-18 2013-04-17 바이러스 폴리머라아제를 억제하기 위한 조성물 및 방법

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KR1020217002466A Active KR102409853B1 (ko) 2012-04-18 2013-04-17 바이러스 폴리머라아제를 억제하기 위한 조성물 및 방법

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US (2) US9580428B2 (cg-RX-API-DMAC10.html)
EP (1) EP2838535B1 (cg-RX-API-DMAC10.html)
JP (2) JP2015514772A (cg-RX-API-DMAC10.html)
KR (3) KR102156819B1 (cg-RX-API-DMAC10.html)
CN (1) CN104379146B (cg-RX-API-DMAC10.html)
AR (1) AR090699A1 (cg-RX-API-DMAC10.html)
AU (1) AU2013249344B2 (cg-RX-API-DMAC10.html)
BR (1) BR112014025909B1 (cg-RX-API-DMAC10.html)
CA (1) CA2870722C (cg-RX-API-DMAC10.html)
IL (1) IL235123A (cg-RX-API-DMAC10.html)
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CN104513249B (zh) * 2014-12-26 2016-08-31 苏州明锐医药科技有限公司 抗埃博拉病毒药物bcx4430的制备方法
JP2018502858A (ja) * 2015-01-07 2018-02-01 ユーロ−セルティック エス． ア． フォロデシンの製造方法
TWI775313B (zh) * 2020-02-18 2022-08-21 美商基利科學股份有限公司 抗病毒化合物
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CN113666941B (zh) * 2021-09-01 2023-03-10 浙江珲达生物科技有限公司 一种2,3-O-异亚丙基-D-核糖酸-γ-内酯的重结晶方法
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CN118359621B (zh) * 2024-04-16 2025-05-16 上海陶术生物科技股份有限公司 加利司伟及加利司伟中间体的制备方法和相应的加利司伟中间体
CN118359623B (zh) * 2024-04-16 2025-06-27 上海陶术生物科技股份有限公司 一种呋咯地辛的合成方法、中间体及应用
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JP2009513564A (ja) 2005-08-09 2009-04-02 メルク エンド カムパニー インコーポレーテッド Ｒｎａ依存性ｒｎａウイルス感染の治療用のリボヌクレオシド環状アセタール誘導体
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US9580428B2 (en) 2017-02-28
AR090699A1 (es) 2014-12-03
AU2013249344B2 (en) 2018-06-07
IL235123A (en) 2017-09-28
CN104379146B (zh) 2018-07-10
KR20200070428A (ko) 2020-06-17
MX2014012525A (es) 2015-01-15
JP2018111692A (ja) 2018-07-19
HK1206627A1 (en) 2016-01-15
JP6559266B2 (ja) 2019-08-14
TWI664180B (zh) 2019-07-01
TW201345912A (zh) 2013-11-16
US20150191472A1 (en) 2015-07-09
EP2838535A1 (en) 2015-02-25
AU2013249344A1 (en) 2014-11-27
KR102409853B1 (ko) 2022-06-15
RU2014145857A (ru) 2016-06-10
MX363270B (es) 2019-03-19
RU2654482C2 (ru) 2018-05-21
EP2838535A4 (en) 2015-09-09
WO2013158746A1 (en) 2013-10-24
US20170128454A1 (en) 2017-05-11
JP2015514772A (ja) 2015-05-21
EP2838535B1 (en) 2019-03-06
BR112014025909B1 (pt) 2021-09-14
KR20210011517A (ko) 2021-02-01
CA2870722A1 (en) 2013-10-24
BR112014025909A2 (cg-RX-API-DMAC10.html) 2017-06-20
KR20150002844A (ko) 2015-01-07
CN104379146A (zh) 2015-02-25

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