KR102097343B1 - RAL GTPases를 타겟으로 하는 항암용 화합물 및 이의 사용방법 - Google Patents

RAL GTPases를 타겟으로 하는 항암용 화합물 및 이의 사용방법 Download PDF

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KR102097343B1
KR102097343B1 KR1020147020271A KR20147020271A KR102097343B1 KR 102097343 B1 KR102097343 B1 KR 102097343B1 KR 1020147020271 A KR1020147020271 A KR 1020147020271A KR 20147020271 A KR20147020271 A KR 20147020271A KR 102097343 B1 KR102097343 B1 KR 102097343B1
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pyrazole
mmol
amino
carbonitrile
dihydropyrano
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KR20150010696A (ko
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덴 테오도레스크
마이클 피츠패트릭 웸페
데이비드 로스
새미 머루에
마틴 에이 슈와르츠
필립 레이간
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더 리전츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코퍼레이트
유니버시티 오브 버지니아 페이턴트 파운데이션
인디아나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
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    • A61K31/47—Quinolines; Isoquinolines
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    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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KR1020147020271A 2011-12-21 2012-12-21 RAL GTPases를 타겟으로 하는 항암용 화합물 및 이의 사용방법 Expired - Fee Related KR102097343B1 (ko)

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US201161578869P 2011-12-21 2011-12-21
US61/578,869 2011-12-21
PCT/US2012/071341 WO2013096820A1 (en) 2011-12-21 2012-12-21 Anti-cancer compounds targeting ral gtpases and methods of using the same

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US (3) US9353121B2 (https=)
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CN (1) CN104271132B (https=)
AU (1) AU2012358317B2 (https=)
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US20160280715A1 (en) 2016-09-29
WO2013096820A1 (en) 2013-06-27
AU2012358317B2 (en) 2017-12-14
EP2793881B1 (en) 2018-10-31
EP2793881A4 (en) 2015-05-20
US20200270263A1 (en) 2020-08-27
JP2015503507A (ja) 2015-02-02
CN104271132B (zh) 2018-01-12
CA2859985C (en) 2020-11-03
AU2012358317A1 (en) 2014-07-17
CN104271132A (zh) 2015-01-07
US10689392B2 (en) 2020-06-23
CA2859985A1 (en) 2013-06-27
KR20150010696A (ko) 2015-01-28
US20140315894A1 (en) 2014-10-23
EP2793881A1 (en) 2014-10-29
US9353121B2 (en) 2016-05-31
JP6473330B2 (ja) 2019-02-20

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