MA53352A - Dérivés de pyridin-2-(1h)-one-quinolinone en tant qu'inhibiteurs d'isocitrate déshydrogénase - Google Patents

Dérivés de pyridin-2-(1h)-one-quinolinone en tant qu'inhibiteurs d'isocitrate déshydrogénase

Info

Publication number
MA53352A
MA53352A MA053352A MA53352A MA53352A MA 53352 A MA53352 A MA 53352A MA 053352 A MA053352 A MA 053352A MA 53352 A MA53352 A MA 53352A MA 53352 A MA53352 A MA 53352A
Authority
MA
Morocco
Prior art keywords
pyridin
isocitrate dehydrogenase
dehydrogenase inhibitors
quinolinone derivatives
quinolinone
Prior art date
Application number
MA053352A
Other languages
English (en)
Inventor
Susan Ashwell
Ann-Marie Campbell
Justin Andrew Caravella
R Bruce Diebold
Anna Ericsson
Gary Gustafson
David R Lancia Jr
Jian Lin
Wei Lu
Zhongguo Wang
Original Assignee
Forma Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Forma Therapeutics Inc filed Critical Forma Therapeutics Inc
Publication of MA53352A publication Critical patent/MA53352A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
MA053352A 2014-09-19 2015-09-18 Dérivés de pyridin-2-(1h)-one-quinolinone en tant qu'inhibiteurs d'isocitrate déshydrogénase MA53352A (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462053006P 2014-09-19 2014-09-19
US201562128089P 2015-03-04 2015-03-04
US201562150812P 2015-04-21 2015-04-21

Publications (1)

Publication Number Publication Date
MA53352A true MA53352A (fr) 2021-09-15

Family

ID=54291606

Family Applications (2)

Application Number Title Priority Date Filing Date
MA040481A MA40481A (fr) 2014-09-19 2015-09-18 Dérivés de pyridin-2-(1h)-one-quinolinone à titre d'inhibiteurs d'isocitrate déshydrogénase mutante
MA053352A MA53352A (fr) 2014-09-19 2015-09-18 Dérivés de pyridin-2-(1h)-one-quinolinone en tant qu'inhibiteurs d'isocitrate déshydrogénase

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MA040481A MA40481A (fr) 2014-09-19 2015-09-18 Dérivés de pyridin-2-(1h)-one-quinolinone à titre d'inhibiteurs d'isocitrate déshydrogénase mutante

Country Status (36)

Country Link
US (8) US9834539B2 (fr)
EP (4) EP4257131A3 (fr)
JP (1) JP6648115B2 (fr)
KR (1) KR102209667B1 (fr)
CN (3) CN117695280A (fr)
AU (3) AU2015317329B2 (fr)
BR (1) BR112017005238B1 (fr)
CA (1) CA2961817C (fr)
CL (1) CL2017000658A1 (fr)
CO (1) CO2017003241A2 (fr)
CY (2) CY1121149T1 (fr)
DK (2) DK3447050T3 (fr)
EA (1) EA034336B1 (fr)
EC (1) ECSP17022933A (fr)
ES (3) ES2953347T3 (fr)
FI (1) FI3733662T3 (fr)
HR (1) HRP20200666T1 (fr)
HU (2) HUE062424T2 (fr)
IL (3) IL292608A (fr)
LT (2) LT3194376T (fr)
MA (2) MA40481A (fr)
ME (1) ME03776B (fr)
MX (2) MX2017003404A (fr)
MY (2) MY176250A (fr)
NZ (2) NZ730373A (fr)
PE (1) PE20171056A1 (fr)
PH (1) PH12017500517A1 (fr)
PL (3) PL3194376T3 (fr)
PT (3) PT3194376T (fr)
RS (2) RS60140B1 (fr)
SA (1) SA517381129B1 (fr)
SG (1) SG11201702194SA (fr)
SI (2) SI3194376T1 (fr)
TW (1) TWI686390B (fr)
WO (1) WO2016044789A1 (fr)
ZA (2) ZA201702127B (fr)

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US11311527B2 (en) 2018-05-16 2022-04-26 Forma Therapeutics, Inc. Inhibiting mutant isocitrate dehydrogenase 1 (mIDH-1)
WO2020232381A1 (fr) 2019-05-16 2020-11-19 Forma Therapeutics, Inc. Inhibition de l'isocitrate déshydrogénase 1 mutante (midh-1)
US11013733B2 (en) 2018-05-16 2021-05-25 Forma Therapeutics, Inc. Inhibiting mutant isocitrate dehydrogenase 1 (mlDH-1)
TW202104207A (zh) * 2019-04-17 2021-02-01 美商健生生物科技公司 二氫乳清酸脫氫酶抑制劑
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CN112321571B (zh) * 2020-10-27 2022-06-03 浙江工业大学 2-呋喃-喹啉-4-甲酰胺类化合物及其应用
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CN115850240B (zh) * 2022-12-28 2023-09-19 北京康立生医药技术开发有限公司 一种治疗急性髓系白血病药物奥卢他西尼的合成方法

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Also Published As

Publication number Publication date
HRP20200666T1 (hr) 2020-07-24
IL282363A (en) 2021-06-30
PL3447050T3 (pl) 2020-07-27
BR112017005238A2 (pt) 2017-12-19
US10550098B2 (en) 2020-02-04
PL3733662T3 (pl) 2024-01-22
EP3733662B1 (fr) 2023-06-07
PT3194376T (pt) 2019-02-04
RS60140B1 (sr) 2020-05-29
CN107001328A (zh) 2017-08-01
TWI686390B (zh) 2020-03-01
CA2961817A1 (fr) 2016-03-24
MA40481A (fr) 2017-07-26
AU2019283765A1 (en) 2020-01-16
KR102209667B1 (ko) 2021-01-29
MY197533A (en) 2023-06-21
ZA201702127B (en) 2019-06-26
US20210078973A1 (en) 2021-03-18
ES2953347T3 (es) 2023-11-10
ES2790640T3 (es) 2020-10-28
AU2019283765B2 (en) 2021-05-13
US20170174658A1 (en) 2017-06-22
CN117695280A (zh) 2024-03-15
LT3194376T (lt) 2019-02-25
US20180312487A1 (en) 2018-11-01
AU2015317329A1 (en) 2017-04-27
ES2704897T3 (es) 2019-03-20
PE20171056A1 (es) 2017-07-21
JP2017528487A (ja) 2017-09-28
PT3447050T (pt) 2020-09-17
AU2015317329B2 (en) 2019-10-31
CN111909130A (zh) 2020-11-10
EP4257131A2 (fr) 2023-10-11
HUE041460T2 (hu) 2019-05-28
CN107001328B (zh) 2020-06-05
AU2021215141B2 (en) 2023-10-19
WO2016044789A1 (fr) 2016-03-24
AU2021215141A1 (en) 2021-09-02
PT3733662T (pt) 2023-08-18
NZ730373A (en) 2019-11-29
BR112017005238B1 (pt) 2023-01-17
US20190263778A1 (en) 2019-08-29
MY176250A (en) 2020-07-24
IL251163A0 (en) 2017-04-30
MX2019013203A (es) 2020-01-20
SI3194376T1 (sl) 2019-03-29
US10889567B2 (en) 2021-01-12
ECSP17022933A (es) 2017-08-31
US10414752B2 (en) 2019-09-17
EA034336B1 (ru) 2020-01-29
EP3447050A1 (fr) 2019-02-27
CA2961817C (fr) 2024-03-12
EP4257131A3 (fr) 2024-01-10
CO2017003241A2 (es) 2017-09-20
DK3194376T3 (en) 2019-01-21
CN111909130B (zh) 2023-10-31
US9834539B2 (en) 2017-12-05
FI3733662T3 (fi) 2023-08-09
SA517381129B1 (ar) 2021-04-26
MX2017003404A (es) 2017-07-28
CL2017000658A1 (es) 2017-12-22
EP3447050B1 (fr) 2020-02-19
RS58184B1 (sr) 2019-03-29
HUE062424T2 (hu) 2023-11-28
US20230125739A1 (en) 2023-04-27
ZA201902446B (en) 2023-12-20
EP3194376B1 (fr) 2018-10-24
US11498913B2 (en) 2022-11-15
PL3194376T3 (pl) 2019-05-31
IL251163B (en) 2021-05-31
PH12017500517A1 (en) 2017-08-07
NZ758641A (en) 2023-12-22
CY1122865T1 (el) 2021-05-05
EP3733662A1 (fr) 2020-11-04
LT3447050T (lt) 2020-05-11
IL292608A (en) 2022-07-01
DK3447050T3 (da) 2020-03-09
EP3194376A1 (fr) 2017-07-26
KR20170063742A (ko) 2017-06-08
ME03776B (fr) 2021-04-20
US20160083366A1 (en) 2016-03-24
IL282363B (en) 2022-06-01
EA201790657A8 (ru) 2018-02-28
JP6648115B2 (ja) 2020-02-14
EA201790657A1 (ru) 2017-08-31
SI3447050T1 (sl) 2020-08-31
US20240150319A1 (en) 2024-05-09
SG11201702194SA (en) 2017-04-27
CY1121149T1 (el) 2020-05-29
US20200223822A1 (en) 2020-07-16
TW201617335A (zh) 2016-05-16

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