KR102089112B1 - 가열 용융 압출 담체용 히프로멜로오스 아세트산 에스테르 숙신산 에스테르, 가열 용융 압출용 조성물 및 가열 용융 압출 성형물의 제조 방법 - Google Patents

가열 용융 압출 담체용 히프로멜로오스 아세트산 에스테르 숙신산 에스테르, 가열 용융 압출용 조성물 및 가열 용융 압출 성형물의 제조 방법 Download PDF

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KR102089112B1
KR102089112B1 KR1020140101712A KR20140101712A KR102089112B1 KR 102089112 B1 KR102089112 B1 KR 102089112B1 KR 1020140101712 A KR1020140101712 A KR 1020140101712A KR 20140101712 A KR20140101712 A KR 20140101712A KR 102089112 B1 KR102089112 B1 KR 102089112B1
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hpmcas
melt extrusion
drug
hot melt
acid ester
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KR20150020073A (ko
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나오스케 마루야마
쇼고 와라시나
후미에 구사키
사카에 오바라
가즈키 기쿠치
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신에쓰 가가꾸 고교 가부시끼가이샤
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
KR1020140101712A 2013-08-12 2014-08-07 가열 용융 압출 담체용 히프로멜로오스 아세트산 에스테르 숙신산 에스테르, 가열 용융 압출용 조성물 및 가열 용융 압출 성형물의 제조 방법 Active KR102089112B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JPJP-P-2013-167572 2013-08-12
JP2013167572 2013-08-12

Publications (2)

Publication Number Publication Date
KR20150020073A KR20150020073A (ko) 2015-02-25
KR102089112B1 true KR102089112B1 (ko) 2020-03-13

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ID=51225402

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KR1020140101712A Active KR102089112B1 (ko) 2013-08-12 2014-08-07 가열 용융 압출 담체용 히프로멜로오스 아세트산 에스테르 숙신산 에스테르, 가열 용융 압출용 조성물 및 가열 용융 압출 성형물의 제조 방법

Country Status (6)

Country Link
US (1) US11090295B2 (https=)
EP (1) EP2837391B1 (https=)
JP (1) JP6162662B2 (https=)
KR (1) KR102089112B1 (https=)
CN (1) CN104371030B (https=)
IN (1) IN2014DE02197A (https=)

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US10604588B2 (en) 2016-04-05 2020-03-31 Shin-Etsu Chemical Co., Ltd. Hypromellose acetate succinate powder excellent in dissolved state and production method thereof, and production methods for composition for solid dispersion, coating composition, drug-containing particle, and solid preparation
WO2017032908A1 (en) * 2016-07-08 2017-03-02 Synthon B.V. Pharmaceutical composition comprising amorphous posaconazole
JP6683561B2 (ja) * 2016-07-12 2020-04-22 信越化学工業株式会社 腸溶性硬カプセル用組成物及び腸溶性硬カプセルの製造方法
JP6644656B2 (ja) 2016-08-29 2020-02-12 信越化学工業株式会社 ヒプロメロース酢酸エステルコハク酸エステルの製造方法
JP6742197B2 (ja) 2016-08-29 2020-08-19 信越化学工業株式会社 ヒプロメロースフタル酸エステルの製造方法
US20190038754A1 (en) * 2017-08-07 2019-02-07 SE Tylose, USA, Inc. Pharmaceutical composition in solid extruded form
TR201722852A2 (tr) * 2017-12-29 2019-07-22 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Mesalazi̇ni̇n oral farmasöti̇k kompozi̇syonlari
JP6905035B2 (ja) * 2019-11-29 2021-07-21 Ｎｉｓｓｈａ株式会社 可食性フィルムの製造方法、フィルム製剤及び可食性フィルム
JP7399061B2 (ja) * 2020-10-01 2023-12-15 信越化学工業株式会社 ヒドロキシプロピルメチルセルロースフタレートの製造方法
EP4497760A1 (en) * 2023-07-26 2025-01-29 Shin-Etsu Chemical Co., Ltd. Hydroxypropyl methylcellulose acetate succinate powder, and method of producing the same
CN120938940A (zh) * 2025-10-15 2025-11-14 成都药宜立康医药科技有限公司 一种苯磺酸美洛加巴林药物组合物及其制备方法

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WO2010114928A2 (en) * 2009-04-03 2010-10-07 F.Hoffmann-La Roche Ag Compositions and uses thereof

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IN2014DE02197A (https=) 2015-06-19
CN104371030A (zh) 2015-02-25
JP2015057380A (ja) 2015-03-26
CN104371030B (zh) 2017-08-08
US11090295B2 (en) 2021-08-17
EP2837391B1 (en) 2017-05-10
EP2837391A1 (en) 2015-02-18
KR20150020073A (ko) 2015-02-25
US20150044289A1 (en) 2015-02-12
JP6162662B2 (ja) 2017-07-12

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