JP6162662B2 - 加熱溶融押出担体用ヒプロメロース酢酸エステルコハク酸エステル、加熱溶融押出用組成物及び加熱溶融押出成型物の製造方法 - Google Patents

加熱溶融押出担体用ヒプロメロース酢酸エステルコハク酸エステル、加熱溶融押出用組成物及び加熱溶融押出成型物の製造方法 Download PDF

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Publication number
JP6162662B2
JP6162662B2 JP2014162437A JP2014162437A JP6162662B2 JP 6162662 B2 JP6162662 B2 JP 6162662B2 JP 2014162437 A JP2014162437 A JP 2014162437A JP 2014162437 A JP2014162437 A JP 2014162437A JP 6162662 B2 JP6162662 B2 JP 6162662B2
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hpmcas
heat
drug
melt extrusion
acetate succinate
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JP2014162437A
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Japanese (ja)
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JP2015057380A (ja
Inventor
直亮 丸山
直亮 丸山
彰吾 藁品
彰吾 藁品
史枝 草木
史枝 草木
栄 尾原
栄 尾原
一輝 菊池
一輝 菊池
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Shin Etsu Chemical Co Ltd
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Shin Etsu Chemical Co Ltd
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Application filed by Shin Etsu Chemical Co Ltd filed Critical Shin Etsu Chemical Co Ltd
Priority to JP2014162437A priority Critical patent/JP6162662B2/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
JP2014162437A 2013-08-12 2014-08-08 加熱溶融押出担体用ヒプロメロース酢酸エステルコハク酸エステル、加熱溶融押出用組成物及び加熱溶融押出成型物の製造方法 Active JP6162662B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2014162437A JP6162662B2 (ja) 2013-08-12 2014-08-08 加熱溶融押出担体用ヒプロメロース酢酸エステルコハク酸エステル、加熱溶融押出用組成物及び加熱溶融押出成型物の製造方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2013167572 2013-08-12
JP2013167572 2013-08-12
JP2014162437A JP6162662B2 (ja) 2013-08-12 2014-08-08 加熱溶融押出担体用ヒプロメロース酢酸エステルコハク酸エステル、加熱溶融押出用組成物及び加熱溶融押出成型物の製造方法

Publications (2)

Publication Number Publication Date
JP2015057380A JP2015057380A (ja) 2015-03-26
JP6162662B2 true JP6162662B2 (ja) 2017-07-12

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JP2014162437A Active JP6162662B2 (ja) 2013-08-12 2014-08-08 加熱溶融押出担体用ヒプロメロース酢酸エステルコハク酸エステル、加熱溶融押出用組成物及び加熱溶融押出成型物の製造方法

Country Status (6)

Country Link
US (1) US11090295B2 (https=)
EP (1) EP2837391B1 (https=)
JP (1) JP6162662B2 (https=)
KR (1) KR102089112B1 (https=)
CN (1) CN104371030B (https=)
IN (1) IN2014DE02197A (https=)

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US12285486B2 (en) 2017-08-07 2025-04-29 SE Tylose USA, Inc Pharmaceutical composition in solid extruded form

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US10604588B2 (en) 2016-04-05 2020-03-31 Shin-Etsu Chemical Co., Ltd. Hypromellose acetate succinate powder excellent in dissolved state and production method thereof, and production methods for composition for solid dispersion, coating composition, drug-containing particle, and solid preparation
WO2017032908A1 (en) * 2016-07-08 2017-03-02 Synthon B.V. Pharmaceutical composition comprising amorphous posaconazole
JP6683561B2 (ja) * 2016-07-12 2020-04-22 信越化学工業株式会社 腸溶性硬カプセル用組成物及び腸溶性硬カプセルの製造方法
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Publication number Priority date Publication date Assignee Title
US12285486B2 (en) 2017-08-07 2025-04-29 SE Tylose USA, Inc Pharmaceutical composition in solid extruded form

Also Published As

Publication number Publication date
IN2014DE02197A (https=) 2015-06-19
CN104371030A (zh) 2015-02-25
JP2015057380A (ja) 2015-03-26
CN104371030B (zh) 2017-08-08
US11090295B2 (en) 2021-08-17
EP2837391B1 (en) 2017-05-10
EP2837391A1 (en) 2015-02-18
KR102089112B1 (ko) 2020-03-13
KR20150020073A (ko) 2015-02-25
US20150044289A1 (en) 2015-02-12

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