KR102013512B1 - 신규 3-인돌 치환 유도체, 제약 조성물 및 사용 방법 - Google Patents
신규 3-인돌 치환 유도체, 제약 조성물 및 사용 방법 Download PDFInfo
- Publication number
- KR102013512B1 KR102013512B1 KR1020177029203A KR20177029203A KR102013512B1 KR 102013512 B1 KR102013512 B1 KR 102013512B1 KR 1020177029203 A KR1020177029203 A KR 1020177029203A KR 20177029203 A KR20177029203 A KR 20177029203A KR 102013512 B1 KR102013512 B1 KR 102013512B1
- Authority
- KR
- South Korea
- Prior art keywords
- fluoro
- indol
- methyl
- isothiazole
- dihydrobenzo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 CC=C=Cc(c(N=C=C)c(c(C(C)=C1CC1)c1N)-c2c(C)cc(C*)c3c2c(C)c(*)cc3C)c1I Chemical compound CC=C=Cc(c(N=C=C)c(c(C(C)=C1CC1)c1N)-c2c(C)cc(C*)c3c2c(C)c(*)cc3C)c1I 0.000 description 5
- BDGOEVVWLWASBG-UHFFFAOYSA-N CC(C(NC)=O)N(C(C)c1cc(-c2c[nH]c3cc(F)ccc23)ccc11)S1(=O)=O Chemical compound CC(C(NC)=O)N(C(C)c1cc(-c2c[nH]c3cc(F)ccc23)ccc11)S1(=O)=O BDGOEVVWLWASBG-UHFFFAOYSA-N 0.000 description 1
- RMVZJAAFRKPMCT-UHFFFAOYSA-N CC(C)C(c1cc(-c2c[nH]c3cc(F)ccc23)ccc11)NS1(=O)=O Chemical compound CC(C)C(c1cc(-c2c[nH]c3cc(F)ccc23)ccc11)NS1(=O)=O RMVZJAAFRKPMCT-UHFFFAOYSA-N 0.000 description 1
- YTBRDCJCTHUZLT-UHFFFAOYSA-N CC(c1c2ccc(-c3c[nH]c4c3ccc(F)c4)c1)N(CCS(C)=O)S2(=O)=O Chemical compound CC(c1c2ccc(-c3c[nH]c4c3ccc(F)c4)c1)N(CCS(C)=O)S2(=O)=O YTBRDCJCTHUZLT-UHFFFAOYSA-N 0.000 description 1
- IFHFGJOEEHLOLZ-UHFFFAOYSA-N CC(c1cc(-c2c[nH]c3c2ccc(F)c3)ccc11)N(CC(C(NC)=O)OC)S1(=O)=O Chemical compound CC(c1cc(-c2c[nH]c3c2ccc(F)c3)ccc11)N(CC(C(NC)=O)OC)S1(=O)=O IFHFGJOEEHLOLZ-UHFFFAOYSA-N 0.000 description 1
- XXTNKYNOLBHZFE-UHFFFAOYSA-N CC(c1cc(-c2c[nH]c3c2ccc(F)c3)ccc11)N(CCN(CCNC2)C2=O)S1(=O)=O Chemical compound CC(c1cc(-c2c[nH]c3c2ccc(F)c3)ccc11)N(CCN(CCNC2)C2=O)S1(=O)=O XXTNKYNOLBHZFE-UHFFFAOYSA-N 0.000 description 1
- AOZXHZJXUIVOLZ-UHFFFAOYSA-N CC(c1cc(-c2c[nH]c3cc(F)ccc23)ccc11)N(C(C2)CNC2=O)S1(=O)=O Chemical compound CC(c1cc(-c2c[nH]c3cc(F)ccc23)ccc11)N(C(C2)CNC2=O)S1(=O)=O AOZXHZJXUIVOLZ-UHFFFAOYSA-N 0.000 description 1
- LHISXZNJTXUYNI-UHFFFAOYSA-N CC(c1cc(-c2c[nH]c3cc(F)ccc23)ccc11)N(C(CC2)CN2C(C)=O)S1(=O)=O Chemical compound CC(c1cc(-c2c[nH]c3cc(F)ccc23)ccc11)N(C(CC2)CN2C(C)=O)S1(=O)=O LHISXZNJTXUYNI-UHFFFAOYSA-N 0.000 description 1
- OVOIQZIQNPJJQN-UHFFFAOYSA-N CC(c1cc(-c2c[nH]c3cc(F)ccc23)ccc11)N(C2CNC2)S1(=O)=O Chemical compound CC(c1cc(-c2c[nH]c3cc(F)ccc23)ccc11)N(C2CNC2)S1(=O)=O OVOIQZIQNPJJQN-UHFFFAOYSA-N 0.000 description 1
- ZFBAHGVOMVZGRE-UHFFFAOYSA-N CC(c1cc(-c2c[nH]c3cc(F)ccc23)ccc11)N(CCC(N2CCNCC2)=O)S1(=O)=O Chemical compound CC(c1cc(-c2c[nH]c3cc(F)ccc23)ccc11)N(CCC(N2CCNCC2)=O)S1(=O)=O ZFBAHGVOMVZGRE-UHFFFAOYSA-N 0.000 description 1
- VFYDGJNCGAVMBU-UHFFFAOYSA-N CN(C1)CC1N(Cc1cc(-c2c[nH]c3cc(F)ccc23)ccc11)S1(=O)=O Chemical compound CN(C1)CC1N(Cc1cc(-c2c[nH]c3cc(F)ccc23)ccc11)S1(=O)=O VFYDGJNCGAVMBU-UHFFFAOYSA-N 0.000 description 1
- SCRMJNXZQNDGNI-UHFFFAOYSA-N CNC(C(c1cc(-c2c[nH]c3c2ccc(F)c3)ccc11)NS1(=O)=O)=O Chemical compound CNC(C(c1cc(-c2c[nH]c3c2ccc(F)c3)ccc11)NS1(=O)=O)=O SCRMJNXZQNDGNI-UHFFFAOYSA-N 0.000 description 1
- NKWJEQRCSCFOHX-UHFFFAOYSA-N COC(NCC(c1cc(-c2c[nH]c3cc(F)ccc23)ccc11)NS1(=O)=O)=O Chemical compound COC(NCC(c1cc(-c2c[nH]c3cc(F)ccc23)ccc11)NS1(=O)=O)=O NKWJEQRCSCFOHX-UHFFFAOYSA-N 0.000 description 1
- KDNGDUUXYHSTBP-UHFFFAOYSA-N CS(NCC(c1cc(-c2c[nH]c3cc(F)ccc23)ccc11)NS1(=O)=O)(=O)=O Chemical compound CS(NCC(c1cc(-c2c[nH]c3cc(F)ccc23)ccc11)NS1(=O)=O)(=O)=O KDNGDUUXYHSTBP-UHFFFAOYSA-N 0.000 description 1
- AVRSXTDANSQCNG-UHFFFAOYSA-N O=S1(NC(C2CC2)c2c1ccc(-c1c[nH]c3cc(F)ccc13)c2)=O Chemical compound O=S1(NC(C2CC2)c2c1ccc(-c1c[nH]c3cc(F)ccc13)c2)=O AVRSXTDANSQCNG-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- AIDS & HIV (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Child & Adolescent Psychology (AREA)
- Gastroenterology & Hepatology (AREA)
- Obesity (AREA)
- Reproductive Health (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IB2015/051957 WO2015140717A1 (en) | 2014-03-18 | 2015-03-17 | Novel 3-indol substituted derivatives, pharmaceutical compositions and methods for use |
| IBPCT/IB2015/051957 | 2015-03-17 | ||
| US201562203032P | 2015-08-10 | 2015-08-10 | |
| US62/203,032 | 2015-08-10 | ||
| PCT/IB2016/051509 WO2016147144A1 (en) | 2015-03-17 | 2016-03-17 | Novel 3-indol substituted derivatives, pharmaceutical compositions and methods for use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20170132204A KR20170132204A (ko) | 2017-12-01 |
| KR102013512B1 true KR102013512B1 (ko) | 2019-08-22 |
Family
ID=56919874
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020177029203A Expired - Fee Related KR102013512B1 (ko) | 2015-03-17 | 2016-03-17 | 신규 3-인돌 치환 유도체, 제약 조성물 및 사용 방법 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US9873690B2 (https=) |
| EP (1) | EP3271354A1 (https=) |
| JP (1) | JP6775516B2 (https=) |
| KR (1) | KR102013512B1 (https=) |
| CN (1) | CN107635990A (https=) |
| AU (1) | AU2016231832B2 (https=) |
| BR (1) | BR112017019699A2 (https=) |
| CA (1) | CA2979616C (https=) |
| HK (1) | HK1243999A1 (https=) |
| IL (1) | IL254124A0 (https=) |
| MX (1) | MX2017011951A (https=) |
| RU (1) | RU2672252C1 (https=) |
| SG (1) | SG11201706992TA (https=) |
| WO (1) | WO2016147144A1 (https=) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20160336813A1 (en) | 2015-05-15 | 2016-11-17 | NeuSpera Medical Inc. | Midfield coupler |
| WO2015179225A1 (en) | 2014-05-18 | 2015-11-26 | Yeh Alexander Jueshyan | Midfield coupler |
| EA201792573A1 (ru) | 2015-05-21 | 2018-04-30 | Харпун Терапьютикс, Инк. | Триспецифические связанные белки и способы их применения |
| US11623958B2 (en) | 2016-05-20 | 2023-04-11 | Harpoon Therapeutics, Inc. | Single chain variable fragment CD3 binding proteins |
| EP3554494A4 (en) | 2016-12-19 | 2021-02-17 | Cellixbio Private Limited | INFLAMMATION TREATMENT COMPOSITIONS AND METHODS |
| AU2018265856B2 (en) | 2017-05-12 | 2023-04-27 | Harpoon Therapeutics, Inc. | Mesothelin binding proteins |
| US20210340250A1 (en) | 2017-05-30 | 2021-11-04 | Bristol-Myers Squibb Company | Compositions comprising a combination of an anti-lag-3 antibody, a pd-1 pathway inhibitor, and an immunotherapeutic agent |
| IL315737A (en) | 2017-10-13 | 2024-11-01 | Harpoon Therapeutics Inc | B-cell maturation antigen-binding proteins |
| HRP20241268T1 (hr) | 2017-10-13 | 2024-12-06 | Harpoon Therapeutics, Inc. | Trispecifični proteini i postupci primjene |
| WO2020061482A1 (en) | 2018-09-21 | 2020-03-26 | Harpoon Therapeutics, Inc. | Egfr binding proteins and methods of use |
| SG11202103022WA (en) | 2018-09-25 | 2021-04-29 | Harpoon Therapeutics Inc | Dll3 binding proteins and methods of use |
| WO2021024020A1 (en) | 2019-08-06 | 2021-02-11 | Astellas Pharma Inc. | Combination therapy involving antibodies against claudin 18.2 and immune checkpoint inhibitors for treatment of cancer |
| CN111166735B (zh) * | 2020-01-15 | 2023-08-18 | 延边大学 | 邻苯二甲酸-双-(2-乙基庚基)酯在抑制脂肪蓄积中的应用 |
| CN111499592B (zh) * | 2020-03-14 | 2023-06-23 | 江苏省农用激素工程技术研究中心有限公司 | 5-氨甲基糖精的合成方法 |
| WO2021218912A1 (zh) * | 2020-04-30 | 2021-11-04 | 南京明德新药研发有限公司 | 含苯基并内磺酰胺的化合物 |
| MX2023000197A (es) | 2020-07-07 | 2023-02-22 | BioNTech SE | Arn terapeutico para el cancer positivo para vph. |
| CN111777557B (zh) * | 2020-07-28 | 2022-11-22 | 中国科学院上海有机化学研究所 | 以芳香联苯烯为骨架的新型抗肿瘤先导化合物及其应用 |
| WO2022135667A1 (en) | 2020-12-21 | 2022-06-30 | BioNTech SE | Therapeutic rna for treating cancer |
| WO2022135666A1 (en) | 2020-12-21 | 2022-06-30 | BioNTech SE | Treatment schedule for cytokine proteins |
| TW202245808A (zh) | 2020-12-21 | 2022-12-01 | 德商拜恩迪克公司 | 用於治療癌症之治療性ｒｎａ |
| JP2024525758A (ja) | 2021-07-13 | 2024-07-12 | ビオンテック・ソシエタス・エウロパエア | がんのための併用療法におけるｃｄ４０およびｃｄ１３７に対する多重特異性結合剤 |
| TW202333802A (zh) | 2021-10-11 | 2023-09-01 | 德商拜恩迪克公司 | 用於肺癌之治療性rna(二) |
| CN119156403A (zh) | 2022-03-08 | 2024-12-17 | 阿伦蒂斯治疗股份公司 | 抗紧密连接蛋白-1抗体增加t细胞可用性的用途 |
| KR20250120305A (ko) | 2022-12-14 | 2025-08-08 | 아스텔라스 파마 유럽 비.브이. | Cldn18.2 및 cd3에 결합하는 2중 특이성 결합제와 면역 체크포인트 저해제를 수반한 조합 요법 |
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- 2016-03-17 SG SG11201706992TA patent/SG11201706992TA/en unknown
- 2016-03-17 BR BR112017019699-9A patent/BR112017019699A2/pt not_active Application Discontinuation
- 2016-03-17 HK HK18103418.8A patent/HK1243999A1/zh unknown
- 2016-03-17 MX MX2017011951A patent/MX2017011951A/es unknown
- 2016-03-17 CA CA2979616A patent/CA2979616C/en not_active Expired - Fee Related
- 2016-03-17 CN CN201680028408.7A patent/CN107635990A/zh active Pending
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| WO2008115804A1 (en) | 2007-03-16 | 2008-09-25 | Lankenau Institute For Medical Research | Novel ido inhibitors and methods of use thereof |
| WO2015140717A1 (en) | 2014-03-18 | 2015-09-24 | Iteos Therapeutics | Novel 3-indol substituted derivatives, pharmaceutical compositions and methods for use |
Also Published As
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| JP2018511587A (ja) | 2018-04-26 |
| JP6775516B2 (ja) | 2020-10-28 |
| CA2979616A1 (en) | 2016-09-22 |
| RU2672252C1 (ru) | 2018-11-13 |
| WO2016147144A1 (en) | 2016-09-22 |
| BR112017019699A2 (pt) | 2018-09-04 |
| KR20170132204A (ko) | 2017-12-01 |
| US9873690B2 (en) | 2018-01-23 |
| EP3271354A1 (en) | 2018-01-24 |
| US20160272628A1 (en) | 2016-09-22 |
| CN107635990A (zh) | 2018-01-26 |
| AU2016231832A1 (en) | 2017-09-14 |
| HK1243999A1 (zh) | 2018-07-27 |
| CA2979616C (en) | 2020-04-28 |
| IL254124A0 (en) | 2017-10-31 |
| AU2016231832B2 (en) | 2019-09-19 |
| SG11201706992TA (en) | 2017-09-28 |
| MX2017011951A (es) | 2018-06-15 |
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