KR102008048B1 - 세포 배양 배지의 바이러스 여과 - Google Patents

세포 배양 배지의 바이러스 여과 Download PDF

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Publication number
KR102008048B1
KR102008048B1 KR1020157001269A KR20157001269A KR102008048B1 KR 102008048 B1 KR102008048 B1 KR 102008048B1 KR 1020157001269 A KR1020157001269 A KR 1020157001269A KR 20157001269 A KR20157001269 A KR 20157001269A KR 102008048 B1 KR102008048 B1 KR 102008048B1
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filtration
virus
cell culture
filter
viral
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KR20150032709A (ko
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볼프강 문트
아르투르 미테레르
만프레트 라이터
마인하르트 하슬라허
레오폴트 그릴베르거
토마스 크레일
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박스알타 인코퍼레이티드
박스앨타 게엠베하
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Publication of KR20150032709A publication Critical patent/KR20150032709A/ko
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Publication of KR102008048B1 publication Critical patent/KR102008048B1/ko
Assigned to 다케다 야쿠힌 고교 가부시키가이샤 reassignment 다케다 야쿠힌 고교 가부시키가이샤 권리의 전부이전등록 Assignors: 박스알타 인코퍼레이티드, 박스앨타 게엠베하
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    • A61L2/0017—
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/02—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using physical processes
    • A61L2/022—Filtration
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/26—Conditioning fluids entering or exiting the reaction vessel
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
    • C12M37/02—Filters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2103/00—Materials or objects being the target of disinfection or sterilisation
    • A61L2103/05—Living organisms or biological materials

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Sustainable Development (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Filtering Materials (AREA)
KR1020157001269A 2012-06-21 2013-06-13 세포 배양 배지의 바이러스 여과 Active KR102008048B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261662814P 2012-06-21 2012-06-21
US61/662,814 2012-06-21
PCT/US2013/045663 WO2013192009A1 (en) 2012-06-21 2013-06-13 Virus filtration of cell culture media

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020197022413A Division KR20190092618A (ko) 2012-06-21 2013-06-13 세포 배양 배지의 바이러스 여과

Publications (2)

Publication Number Publication Date
KR20150032709A KR20150032709A (ko) 2015-03-27
KR102008048B1 true KR102008048B1 (ko) 2019-08-06

Family

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Family Applications (2)

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KR1020157001269A Active KR102008048B1 (ko) 2012-06-21 2013-06-13 세포 배양 배지의 바이러스 여과
KR1020197022413A Ceased KR20190092618A (ko) 2012-06-21 2013-06-13 세포 배양 배지의 바이러스 여과

Family Applications After (1)

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KR1020197022413A Ceased KR20190092618A (ko) 2012-06-21 2013-06-13 세포 배양 배지의 바이러스 여과

Country Status (27)

Country Link
US (3) US9670456B2 (https=)
EP (2) EP3103861B1 (https=)
JP (3) JP6220392B2 (https=)
KR (2) KR102008048B1 (https=)
CN (2) CN108795724A (https=)
AR (1) AR092847A1 (https=)
AU (2) AU2013277532B2 (https=)
BR (1) BR112014031842B1 (https=)
CA (1) CA2876473C (https=)
CO (1) CO7151484A2 (https=)
DK (2) DK3103861T3 (https=)
EA (2) EA201990887A1 (https=)
ES (2) ES2829968T3 (https=)
HR (1) HRP20161435T1 (https=)
HU (1) HUE031601T2 (https=)
IL (2) IL236073B (https=)
IN (1) IN2014DN10441A (https=)
MX (2) MX347319B (https=)
MY (2) MY195362A (https=)
NZ (1) NZ629083A (https=)
PL (2) PL3103861T3 (https=)
PT (2) PT2732020T (https=)
SG (2) SG10201701721TA (https=)
SI (1) SI2732020T1 (https=)
TW (2) TWI609962B (https=)
WO (1) WO2013192009A1 (https=)
ZA (1) ZA201409253B (https=)

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Publication number Priority date Publication date Assignee Title
DK3103861T3 (da) * 2012-06-21 2020-11-16 Baxalta GmbH Virusfiltrering af cellekulturmedier
AR095196A1 (es) 2013-03-15 2015-09-30 Regeneron Pharma Medio de cultivo celular libre de suero
SG10201507931QA (en) * 2014-12-22 2016-07-28 Emd Millipore Corp Removal of microorganisms from cell culture media
US20180072769A1 (en) * 2015-03-23 2018-03-15 Alexion Pharmaceuticals, Inc. Virus filtration
EP3015542A1 (de) * 2015-05-07 2016-05-04 Bayer Technology Services GmbH Modulare anlage und verfahren zur kontinuierlichen, keimreduzierten produktion und/oder aufbereitung eines produktes
TW202440904A (zh) 2015-08-04 2024-10-16 美商再生元醫藥公司 補充牛磺酸之細胞培養基及用法（二）
WO2017180814A1 (en) * 2016-04-15 2017-10-19 Boehringer Ingelheim International Gmbh Cell retention device and method
WO2018107099A1 (en) * 2016-12-09 2018-06-14 Lonza Ltd Method for the reduction of viral titer in pharmaceuticals
KR102659791B1 (ko) * 2017-07-06 2024-04-23 리제너론 파마슈티칼스 인코포레이티드 당단백질을 만들기 위한 세포 배양 과정
TWI846694B (zh) * 2018-05-04 2024-07-01 美商健臻公司 具有過濾系統的灌注式生物反應器
SG11202109877RA (en) 2019-03-11 2021-10-28 Genzyme Corp Tangential viral filtration
KR20210149117A (ko) * 2019-04-03 2021-12-08 젠자임 코포레이션 재조합 단백질의 연속 생산
US12297451B1 (en) 2019-10-25 2025-05-13 Regeneron Pharmaceuticals, Inc. Cell culture medium
US20230181796A1 (en) * 2020-05-14 2023-06-15 North Carolina State University Fast automated approach for the derivation of acellular extracellular matrix scaffolds from tissues
CA3197305A1 (en) * 2020-10-02 2022-04-07 Regeneron Pharmaceuticals, Inc. Continuous virus retentive filtration
WO2025019797A2 (en) * 2023-07-19 2025-01-23 Hatchless Inc. System and method for low-cost sterilization of liquids

Citations (2)

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Publication number Priority date Publication date Assignee Title
JP2003506073A (ja) * 1999-08-06 2003-02-18 フルード テクノロジーズ パブリック リミテッド カンパニー 微生物の検出
JP2004269529A (ja) * 2003-03-06 2004-09-30 Probitas Pharma Sa フィブリノゲン溶液中のウイルスを除去する方法およびこの方法により得られるフィブリノゲン

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JPH0422874A (ja) * 1990-05-16 1992-01-27 Matsushita Electric Ind Co Ltd 波形表示装置
US6485686B1 (en) * 1999-09-17 2002-11-26 The United States Of America As Represented By The Secretary Of The Army Method and apparatus for counting submicron sized particles
US6861001B2 (en) 1999-12-02 2005-03-01 The General Hospital Corporation Methods for removal, purification, and concentration of viruses, and methods of therapy based thereupon
US6485688B1 (en) 2000-04-24 2002-11-26 General Electric Company On-line sparging sampling and monitoring systems and methods
US6835311B2 (en) * 2002-01-31 2004-12-28 Koslow Technologies Corporation Microporous filter media, filtration systems containing same, and methods of making and using
US6630016B2 (en) * 2002-01-31 2003-10-07 Koslow Technologies Corp. Microporous filter media, filtration systems containing same, and methods of making and using
EP1711513B1 (en) 2003-12-01 2014-07-02 Novo Nordisk Health Care AG Nanofiltration of factor vii solutions to remove virus
DE102005047301B4 (de) * 2005-09-30 2009-04-16 Sartorius Stedim Biotech Gmbh Verfahren zum Nachweis der Virenabreicherung für die Validierung von Filtern und Filtrationsprozessen
US20070084788A1 (en) 2005-10-14 2007-04-19 Millipore Corporation Ultrafiltration membranes and methods of making and use of ultrafiltration membranes
US8309029B1 (en) * 2009-03-26 2012-11-13 The United States Of America As Represented By The Secretary Of The Army Virus and particulate separation from solution
US8945895B2 (en) * 2009-07-31 2015-02-03 Baxter International Inc. Methods of purifying recombinant ADAMTS13 and other proteins and compositions thereof
AU2010284116B9 (en) * 2009-08-20 2015-03-26 Takeda Pharmaceutical Company Limited Purification of VWF for increased removal of non-lipid enveloped viruses
DK3103861T3 (da) * 2012-06-21 2020-11-16 Baxalta GmbH Virusfiltrering af cellekulturmedier

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
JP2003506073A (ja) * 1999-08-06 2003-02-18 フルード テクノロジーズ パブリック リミテッド カンパニー 微生物の検出
JP2004269529A (ja) * 2003-03-06 2004-09-30 Probitas Pharma Sa フィブリノゲン溶液中のウイルスを除去する方法およびこの方法により得られるフィブリノゲン

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Publication number Publication date
EP2732020B1 (en) 2016-08-10
ZA201409253B (en) 2022-05-25
PT2732020T (pt) 2016-11-10
US20170260498A1 (en) 2017-09-14
AU2013277532B2 (en) 2017-06-15
KR20190092618A (ko) 2019-08-07
EP3103861A1 (en) 2016-12-14
HK1198335A1 (zh) 2015-04-02
HK1231502A1 (en) 2017-12-22
BR112014031842B1 (pt) 2020-09-15
ES2829968T3 (es) 2021-06-02
TW201816105A (zh) 2018-05-01
CA2876473C (en) 2021-05-11
DK2732020T3 (en) 2016-11-28
IL236073A0 (en) 2015-01-29
JP2019022526A (ja) 2019-02-14
EA201990887A1 (ru) 2019-08-30
EA201590059A1 (ru) 2015-04-30
MX386767B (es) 2025-03-19
SI2732020T1 (sl) 2017-03-31
AR092847A1 (es) 2015-05-06
WO2013192009A1 (en) 2013-12-27
JP6557706B2 (ja) 2019-08-07
CN104640969A (zh) 2015-05-20
EP3103861B1 (en) 2020-09-30
TW201412986A (zh) 2014-04-01
US20200277565A1 (en) 2020-09-03
HRP20161435T1 (hr) 2017-02-24
AU2013277532A1 (en) 2015-01-15
IL263479B (en) 2020-08-31
CO7151484A2 (es) 2014-12-29
SG10201701721TA (en) 2017-04-27
TWI698522B (zh) 2020-07-11
PL2732020T3 (pl) 2017-06-30
EA033006B1 (ru) 2019-08-30
MY195362A (en) 2023-01-16
HUE031601T2 (hu) 2017-07-28
JP2015529447A (ja) 2015-10-08
CN108795724A (zh) 2018-11-13
BR112014031842A2 (pt) 2017-08-22
IL236073B (en) 2019-01-31
TWI609962B (zh) 2018-01-01
US11421202B2 (en) 2022-08-23
DK3103861T3 (da) 2020-11-16
NZ629083A (en) 2016-11-25
MX347319B (es) 2017-04-21
JP6220392B2 (ja) 2017-10-25
JP2017184765A (ja) 2017-10-12
US20130344535A1 (en) 2013-12-26
EP2732020A1 (en) 2014-05-21
CA2876473A1 (en) 2013-12-27
KR20150032709A (ko) 2015-03-27
PT3103861T (pt) 2020-11-16
SG11201408490PA (en) 2015-01-29
MY173835A (en) 2020-02-24
PL3103861T3 (pl) 2021-03-22
AU2017228547B2 (en) 2019-02-21
MX2014015950A (es) 2015-07-17
AU2017228547A1 (en) 2017-10-05
US9670456B2 (en) 2017-06-06
IN2014DN10441A (https=) 2015-08-21
IL263479A (en) 2019-01-31
ES2601429T3 (es) 2017-02-15

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