KR101998000B1 - 신규한 화합물 - Google Patents

신규한 화합물 Download PDF

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Publication number
KR101998000B1
KR101998000B1 KR1020177007738A KR20177007738A KR101998000B1 KR 101998000 B1 KR101998000 B1 KR 101998000B1 KR 1020177007738 A KR1020177007738 A KR 1020177007738A KR 20177007738 A KR20177007738 A KR 20177007738A KR 101998000 B1 KR101998000 B1 KR 101998000B1
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South Korea
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compound
formula
fluoro
tetrahydro
ethyl
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Expired - Fee Related
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Korean (ko)
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KR20170055489A (ko
Inventor
니알 앤드류 앤더슨
매튜 하워드 제임스 캠벨-크라우포드
애슐리 폴 한코크
존 마틴 프리차드
조안나 메리 레드몬드
Original Assignee
글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드
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Publication of KR20170055489A publication Critical patent/KR20170055489A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020177007738A 2014-09-26 2015-09-22 신규한 화합물 Expired - Fee Related KR101998000B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1417002.1A GB201417002D0 (en) 2014-09-26 2014-09-26 Novel compound
GB1417002.1 2014-09-26
PCT/EP2015/071776 WO2016046225A1 (en) 2014-09-26 2015-09-22 Novel compounds

Publications (2)

Publication Number Publication Date
KR20170055489A KR20170055489A (ko) 2017-05-19
KR101998000B1 true KR101998000B1 (ko) 2019-07-08

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KR1020177007738A Expired - Fee Related KR101998000B1 (ko) 2014-09-26 2015-09-22 신규한 화합물

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US (3) US9956209B2 (enExample)
EP (2) EP3197892B1 (enExample)
JP (1) JP6611799B2 (enExample)
KR (1) KR101998000B1 (enExample)
CN (1) CN107074848B (enExample)
AR (1) AR101994A1 (enExample)
AU (1) AU2015320858B2 (enExample)
BR (1) BR112017006251A2 (enExample)
CA (1) CA2962315A1 (enExample)
CL (1) CL2017000705A1 (enExample)
CO (1) CO2017002714A2 (enExample)
CR (1) CR20170112A (enExample)
CY (1) CY1121071T1 (enExample)
DK (1) DK3197892T3 (enExample)
DO (1) DOP2017000081A (enExample)
EA (1) EA031481B1 (enExample)
ES (1) ES2690748T3 (enExample)
GB (1) GB201417002D0 (enExample)
HR (1) HRP20181796T1 (enExample)
HU (1) HUE041827T2 (enExample)
IL (1) IL250592A0 (enExample)
JO (1) JO3413B1 (enExample)
LT (1) LT3197892T (enExample)
MA (1) MA40580B1 (enExample)
MX (1) MX2017003948A (enExample)
PE (1) PE20170502A1 (enExample)
PH (1) PH12017500361B1 (enExample)
PL (1) PL3197892T3 (enExample)
PT (1) PT3197892T (enExample)
RS (1) RS58000B1 (enExample)
SG (1) SG11201701183YA (enExample)
SI (1) SI3197892T1 (enExample)
SM (1) SMT201800513T1 (enExample)
TW (1) TW201629056A (enExample)
UA (1) UA119181C2 (enExample)
UY (1) UY36314A (enExample)
WO (1) WO2016046225A1 (enExample)

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GB201305668D0 (en) 2013-03-28 2013-05-15 Glaxosmithkline Ip Dev Ltd Avs6 Integrin Antagonists
GB201417011D0 (en) 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compounds
GB201417018D0 (en) 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compounds
GB201417002D0 (en) 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compound
GB201417094D0 (en) 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compounds
GB201604589D0 (en) * 2016-03-18 2016-05-04 Glaxosmithkline Ip Dev Ltd Chemical compound
GB201604681D0 (en) 2016-03-21 2016-05-04 Glaxosmithkline Ip Dev Ltd Chemical Compounds
GB201604680D0 (en) 2016-03-21 2016-05-04 Glaxosmithkline Ip Dev Ltd Chemical Compounds
EA201991123A1 (ru) 2016-11-08 2019-11-29 ИНДАЗОЛОВЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ АНТАГОНИСТОВ ИНТЕГРИНА αV
WO2018089353A1 (en) 2016-11-08 2018-05-17 Bristol-Myers Squibb Company 3-substituted propionic acids as alpha v integrin inhibitors
CA3042710A1 (en) 2016-11-08 2018-05-17 Bristol-Myers Squibb Company Cyclobutane- and azetidine-containing mono and spirocyclic compounds as .alpha.v integrin inhibitors
BR112019009245A2 (pt) 2016-11-08 2019-07-16 Bristol-Myers Squibb Company azol amidas e aminas como inibidores de alfav integrina
PL3538528T3 (pl) * 2016-11-08 2021-05-31 Bristol-Myers Squibb Company Amidy pirolu jako inhibitory integryny alfa v
EP3558303A4 (en) 2016-12-23 2020-07-29 Pliant Therapeutics, Inc. AMINO ACID COMPOUNDS AND PROCESSES FOR USE
EP3760202A1 (en) 2017-02-28 2021-01-06 Morphic Therapeutic, Inc. Inhibitors of (alpha-v)(beta-6) integrin
IL316954A (en) 2017-02-28 2025-01-01 Morphic Therapeutic Inc (Alpha-V)(beta-6)integrin inhibitors
WO2018167295A1 (en) * 2017-03-17 2018-09-20 Technische Universität München LIGANDS FOR INTEGRIN αvβ8, SYNTHESIS AND USES THEREOF
BR112020008893A2 (pt) 2017-11-07 2020-10-13 Bristol-Myers Squibb Company derivados de pirrolopirazina como inibidores de alfa v integrina
CN108208177A (zh) * 2017-11-28 2018-06-29 上海交通大学医学院附属新华医院 含丁酸类化合物的组合物及其应用
UY38353A (es) * 2018-08-29 2020-03-31 Morphic Therapeutic Inc Inhibición de integrina alfavbeta6
UY38352A (es) * 2018-08-29 2020-03-31 Morphic Therapeutic Inc Inhibidores de integrina alfavbeta6
WO2020047208A1 (en) 2018-08-29 2020-03-05 Morphic Therapeutic, Inc. Inhibitors of (alpha-v)(beta-6) integrin
EP3843728B1 (en) * 2018-08-29 2025-04-30 Morphic Therapeutic, Inc. Inhibitors of (alpha-v)(beta-6) integrin
JP2022512648A (ja) * 2018-10-09 2022-02-07 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 心筋線維化の処置のためのαＶ－インテグリン（ＣＤ５１）阻害剤の使用
MX2021006544A (es) * 2018-12-04 2021-07-07 Sumitomo Pharma Oncology Inc Inhibidores de cinasa dependiente de ciclina 9 (cdk9) y polimorfos de los mismos para uso como agentes para el tratamiento de cancer.
GB202010626D0 (en) 2020-07-10 2020-08-26 Univ Nottingham Compound

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WO2005082889A1 (en) 2004-02-18 2005-09-09 Janssen Pharmaceutica N.V. Piperidinyl targeting compounds that selectively bind integrins

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GB201417018D0 (en) 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compounds
GB201417002D0 (en) * 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compound
GB201417094D0 (en) 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compounds
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WO2001024797A1 (en) 1999-10-04 2001-04-12 Merck & Co., Inc. Integrin receptor antagonists
WO2005082889A1 (en) 2004-02-18 2005-09-09 Janssen Pharmaceutica N.V. Piperidinyl targeting compounds that selectively bind integrins

Also Published As

Publication number Publication date
SMT201800513T1 (it) 2018-11-09
US20180271845A1 (en) 2018-09-27
MX2017003948A (es) 2017-06-26
PH12017500361A1 (en) 2017-07-17
PT3197892T (pt) 2018-12-12
DK3197892T3 (en) 2018-11-26
EP3428167A1 (en) 2019-01-16
HRP20181796T1 (hr) 2018-12-28
EA201790715A1 (ru) 2017-07-31
AU2015320858A1 (en) 2017-03-09
MA40580B1 (fr) 2018-09-28
TW201629056A (zh) 2016-08-16
CL2017000705A1 (es) 2017-11-03
US10342783B2 (en) 2019-07-09
MA40580A (fr) 2017-08-02
SG11201701183YA (en) 2017-04-27
DOP2017000081A (es) 2017-04-30
CY1121071T1 (el) 2019-12-11
CN107074848A (zh) 2017-08-18
US20170290817A1 (en) 2017-10-12
ES2690748T3 (es) 2018-11-22
AU2015320858B2 (en) 2018-10-18
CA2962315A1 (en) 2016-03-31
AR101994A1 (es) 2017-01-25
CR20170112A (es) 2017-05-26
EP3197892B1 (en) 2018-09-05
CO2017002714A2 (es) 2017-06-30
US9956209B2 (en) 2018-05-01
US20190275016A1 (en) 2019-09-12
KR20170055489A (ko) 2017-05-19
JP6611799B2 (ja) 2019-11-27
BR112017006251A2 (pt) 2017-12-12
EA031481B1 (ru) 2019-01-31
PH12017500361B1 (en) 2017-07-17
EP3197892A1 (en) 2017-08-02
RS58000B1 (sr) 2019-01-31
PL3197892T3 (pl) 2019-05-31
WO2016046225A1 (en) 2016-03-31
GB201417002D0 (en) 2014-11-12
IL250592A0 (en) 2017-04-30
JO3413B1 (ar) 2019-10-20
HUE041827T2 (hu) 2019-05-28
LT3197892T (lt) 2018-12-10
SI3197892T1 (sl) 2018-12-31
PE20170502A1 (es) 2017-04-27
JP2017528507A (ja) 2017-09-28
UA119181C2 (uk) 2019-05-10
CN107074848B (zh) 2019-11-01
UY36314A (es) 2016-04-29

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