KR101984500B1 - 날트렉손 요법에서 약물 생체이용률의 증가 - Google Patents
날트렉손 요법에서 약물 생체이용률의 증가 Download PDFInfo
- Publication number
- KR101984500B1 KR101984500B1 KR1020187016354A KR20187016354A KR101984500B1 KR 101984500 B1 KR101984500 B1 KR 101984500B1 KR 1020187016354 A KR1020187016354 A KR 1020187016354A KR 20187016354 A KR20187016354 A KR 20187016354A KR 101984500 B1 KR101984500 B1 KR 101984500B1
- Authority
- KR
- South Korea
- Prior art keywords
- pharmaceutically acceptable
- naltrexone
- acceptable salt
- bupropion
- food
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- DQCKKXVULJGBQN-XFWGSAIBSA-N naltrexone Chemical compound N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=O)O)CC1)O)CC1CC1 DQCKKXVULJGBQN-XFWGSAIBSA-N 0.000 title claims abstract description 288
- 229960003086 naltrexone Drugs 0.000 title claims abstract description 282
- 239000003814 drug Substances 0.000 title claims abstract description 59
- 229940079593 drug Drugs 0.000 title claims abstract description 54
- 238000002560 therapeutic procedure Methods 0.000 title claims abstract description 39
- 230000001965 increasing effect Effects 0.000 title abstract description 38
- 239000000203 mixture Substances 0.000 claims abstract description 67
- 238000000034 method Methods 0.000 claims abstract description 52
- SNPPWIUOZRMYNY-UHFFFAOYSA-N bupropion Chemical compound CC(C)(C)NC(C)C(=O)C1=CC=CC(Cl)=C1 SNPPWIUOZRMYNY-UHFFFAOYSA-N 0.000 claims description 216
- 150000003839 salts Chemical class 0.000 claims description 214
- 229960001058 bupropion Drugs 0.000 claims description 209
- 235000013305 food Nutrition 0.000 claims description 96
- 238000011282 treatment Methods 0.000 claims description 71
- 208000016261 weight loss Diseases 0.000 claims description 49
- 230000004580 weight loss Effects 0.000 claims description 49
- 206010033307 Overweight Diseases 0.000 claims description 28
- 230000000694 effects Effects 0.000 claims description 24
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- 235000020824 obesity Nutrition 0.000 claims description 23
- 239000012730 sustained-release form Substances 0.000 claims description 21
- 238000009472 formulation Methods 0.000 claims description 20
- 239000008194 pharmaceutical composition Substances 0.000 claims description 19
- 238000013268 sustained release Methods 0.000 claims description 18
- 235000005911 diet Nutrition 0.000 claims description 10
- 230000037213 diet Effects 0.000 claims description 8
- 235000009200 high fat diet Nutrition 0.000 claims 2
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- 239000003826 tablet Substances 0.000 description 46
- 239000003925 fat Substances 0.000 description 43
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- 235000019786 weight gain Nutrition 0.000 description 17
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 16
- 235000021471 food effect Nutrition 0.000 description 15
- 230000004584 weight gain Effects 0.000 description 14
- 150000001875 compounds Chemical class 0.000 description 12
- 239000002207 metabolite Substances 0.000 description 12
- 230000003285 pharmacodynamic effect Effects 0.000 description 12
- 239000006186 oral dosage form Substances 0.000 description 11
- 238000002648 combination therapy Methods 0.000 description 8
- 238000010521 absorption reaction Methods 0.000 description 6
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- ZFSXKSSWYSZPGQ-UHFFFAOYSA-N (2-hydroxycyclopentyl)azanium;chloride Chemical compound Cl.NC1CCCC1O ZFSXKSSWYSZPGQ-UHFFFAOYSA-N 0.000 description 4
- 206010022489 Insulin Resistance Diseases 0.000 description 4
- 238000013270 controlled release Methods 0.000 description 4
- 235000020937 fasting conditions Nutrition 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- 229960000858 naltrexone hydrochloride Drugs 0.000 description 4
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 4
- 108010074051 C-Reactive Protein Proteins 0.000 description 3
- 206010056465 Food craving Diseases 0.000 description 3
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- 210000002966 serum Anatomy 0.000 description 3
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- RTHCYVBBDHJXIQ-MRXNPFEDSA-N (R)-fluoxetine Chemical compound O([C@H](CCNC)C=1C=CC=CC=1)C1=CC=C(C(F)(F)F)C=C1 RTHCYVBBDHJXIQ-MRXNPFEDSA-N 0.000 description 2
- JLVNEHKORQFVQJ-PYIJOLGTSA-N 6alpha-Naltrexol Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]1(O)CC[C@H]3O)CN2CC1CC1 JLVNEHKORQFVQJ-PYIJOLGTSA-N 0.000 description 2
- 206010013710 Drug interaction Diseases 0.000 description 2
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- AKOAEVOSDHIVFX-UHFFFAOYSA-N Hydroxybupropion Chemical compound OCC(C)(C)NC(C)C(=O)C1=CC=CC(Cl)=C1 AKOAEVOSDHIVFX-UHFFFAOYSA-N 0.000 description 2
- 206010028813 Nausea Diseases 0.000 description 2
- 230000001133 acceleration Effects 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 2
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- -1 but not limited to Chemical compound 0.000 description 2
- 239000011111 cardboard Substances 0.000 description 2
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- 230000000378 dietary effect Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000002651 drug therapy Methods 0.000 description 2
- 230000008030 elimination Effects 0.000 description 2
- 238000003379 elimination reaction Methods 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 229960002464 fluoxetine Drugs 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 210000001596 intra-abdominal fat Anatomy 0.000 description 2
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- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 2
- NDPTTXIBLSWNSF-BXKDBHETSA-N (1s,2r)-2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-ol Chemical compound CC(C)(C)N[C@H](C)[C@@H](O)C1=CC=CC(Cl)=C1 NDPTTXIBLSWNSF-BXKDBHETSA-N 0.000 description 1
- NDPTTXIBLSWNSF-JOYOIKCWSA-N (1s,2s)-2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-ol Chemical compound CC(C)(C)N[C@@H](C)[C@@H](O)C1=CC=CC(Cl)=C1 NDPTTXIBLSWNSF-JOYOIKCWSA-N 0.000 description 1
- IKBZAUYPBWFMDI-UHFFFAOYSA-N 5-bromo-4-methoxy-7-methyl-2,3-dihydro-1h-indene Chemical compound C1=C(Br)C(OC)=C2CCCC2=C1C IKBZAUYPBWFMDI-UHFFFAOYSA-N 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 208000031226 Hyperlipidaemia Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 238000008214 LDL Cholesterol Methods 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 208000037063 Thinness Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000000556 agonist Substances 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 238000000540 analysis of variance Methods 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 235000021152 breakfast Nutrition 0.000 description 1
- 229960004367 bupropion hydrochloride Drugs 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 238000011260 co-administration Methods 0.000 description 1
- 238000011284 combination treatment Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
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- 235000007882 dietary composition Nutrition 0.000 description 1
- 235000008242 dietary patterns Nutrition 0.000 description 1
- 235000020805 dietary restrictions Nutrition 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 239000013583 drug formulation Substances 0.000 description 1
- 206010013781 dry mouth Diseases 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000008029 eradication Effects 0.000 description 1
- 229960003276 erythromycin Drugs 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 235000013410 fast food Nutrition 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 235000021059 hard food Nutrition 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
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- 238000001727 in vivo Methods 0.000 description 1
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- 206010022437 insomnia Diseases 0.000 description 1
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- 229940125396 insulin Drugs 0.000 description 1
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- 239000006194 liquid suspension Substances 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229960004715 morphine sulfate Drugs 0.000 description 1
- GRVOTVYEFDAHCL-RTSZDRIGSA-N morphine sulfate pentahydrate Chemical compound O.O.O.O.O.OS(O)(=O)=O.O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O.O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O GRVOTVYEFDAHCL-RTSZDRIGSA-N 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
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- 206010048828 underweight Diseases 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Acoustics & Sound (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Physics & Mathematics (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41939510P | 2010-12-03 | 2010-12-03 | |
| US61/419,395 | 2010-12-03 | ||
| PCT/US2011/063177 WO2012075459A1 (en) | 2010-12-03 | 2011-12-02 | Increasing drug bioavailability in naltrexone therapy |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020137017317A Division KR20140035320A (ko) | 2010-12-03 | 2011-12-02 | 날트렉손 요법에서 약물 생체이용률의 증가 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020197014576A Division KR102105857B1 (ko) | 2010-12-03 | 2011-12-02 | 날트렉손 요법에서 약물 생체이용률의 증가 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20180069089A KR20180069089A (ko) | 2018-06-22 |
| KR101984500B1 true KR101984500B1 (ko) | 2019-05-31 |
Family
ID=46172304
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020187016354A Active KR101984500B1 (ko) | 2010-12-03 | 2011-12-02 | 날트렉손 요법에서 약물 생체이용률의 증가 |
| KR1020137017317A Ceased KR20140035320A (ko) | 2010-12-03 | 2011-12-02 | 날트렉손 요법에서 약물 생체이용률의 증가 |
| KR1020207011510A Active KR102258043B1 (ko) | 2010-12-03 | 2011-12-02 | 날트렉손 요법에서 약물 생체이용률의 증가 |
| KR1020217015625A Active KR102391511B1 (ko) | 2010-12-03 | 2011-12-02 | 날트렉손 요법에서 약물 생체이용률의 증가 |
| KR1020197014576A Active KR102105857B1 (ko) | 2010-12-03 | 2011-12-02 | 날트렉손 요법에서 약물 생체이용률의 증가 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020137017317A Ceased KR20140035320A (ko) | 2010-12-03 | 2011-12-02 | 날트렉손 요법에서 약물 생체이용률의 증가 |
| KR1020207011510A Active KR102258043B1 (ko) | 2010-12-03 | 2011-12-02 | 날트렉손 요법에서 약물 생체이용률의 증가 |
| KR1020217015625A Active KR102391511B1 (ko) | 2010-12-03 | 2011-12-02 | 날트렉손 요법에서 약물 생체이용률의 증가 |
| KR1020197014576A Active KR102105857B1 (ko) | 2010-12-03 | 2011-12-02 | 날트렉손 요법에서 약물 생체이용률의 증가 |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US20130245056A1 (enExample) |
| EP (5) | EP3222280B1 (enExample) |
| JP (5) | JP6008866B2 (enExample) |
| KR (5) | KR101984500B1 (enExample) |
| CN (1) | CN103313711A (enExample) |
| AR (2) | AR093182A1 (enExample) |
| AU (2) | AU2011336304B2 (enExample) |
| BR (1) | BR112013013390A2 (enExample) |
| CA (2) | CA3239386A1 (enExample) |
| CL (1) | CL2013001564A1 (enExample) |
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| RU2350327C2 (ru) | 2003-04-29 | 2009-03-27 | Ориксиджен Серапьютикс, Инкорпорэйтд | Составы, вызывающие потерю веса |
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| WO2007089318A2 (en) * | 2005-11-23 | 2007-08-09 | Orexigen Therapeutics, Inc. | Compositions and methods for reducing food cravings |
| EP2303025A4 (en) | 2008-05-30 | 2012-07-04 | Orexigen Therapeutics Inc | METHOD FOR TREATING DIGITAL FAT SWITCHES |
| EP3659604A1 (en) | 2010-01-11 | 2020-06-03 | Nalpropion Pharmaceuticals, Inc. | Methods of providing weight loss therapy in patients with major depression |
| TWI618536B (zh) * | 2010-12-03 | 2018-03-21 | 歐瑞根治療有限公司 | 於納曲酮療法中增加藥物生物可利用性 |
| PT3730132T (pt) | 2012-06-06 | 2022-08-16 | Nalpropion Pharmaceuticals Llc | Composição para utilização num método de tratamento de excesso de peso e obesidade em doentes com alto risco cardiovascular |
| US20180015042A1 (en) * | 2015-02-07 | 2018-01-18 | Intas Pharmaceuticals Ltd. | Pharmaceutical composition for the treatment of obesity |
| KR20200072445A (ko) * | 2017-03-28 | 2020-06-22 | 엘디엔 파마 리미티드 | 암의 치료를 위한 세포 사멸의 bcl2-관련 효능제의 발현을 증가시키는 제제 |
| EP3482751A1 (en) | 2017-11-14 | 2019-05-15 | LDN Pharma Limited | Cancer treatment |
| US12303604B1 (en) | 2024-10-16 | 2025-05-20 | Currax Pharmaceuticals Llc | Pharmaceutical formulations comprising naltrexone and/or bupropion |
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