RU2350327C2 - Составы, вызывающие потерю веса - Google Patents

Составы, вызывающие потерю веса Download PDF

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RU2350327C2
RU2350327C2 RU2005132453/15A RU2005132453A RU2350327C2 RU 2350327 C2 RU2350327 C2 RU 2350327C2 RU 2005132453/15 A RU2005132453/15 A RU 2005132453/15A RU 2005132453 A RU2005132453 A RU 2005132453A RU 2350327 C2 RU2350327 C2 RU 2350327C2
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compound
bupropion
naltrexone
amount
weight loss
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RU2005132453/15A
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RU2005132453A (ru
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Экард ВЕБЕР (US)
Экард Вебер
Майкл Александр КОВЛИ (US)
Майкл Александр КОВЛИ
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Ориксиджен Серапьютикс, Инкорпорэйтд
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Magnetic Ceramics (AREA)
  • Compositions Of Oxide Ceramics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Dental Preparations (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Настоящее изобретение относится к области лекарственных средств, в частности к составу для снижения веса, содержащему в синергетически эффективных количествах опиоидный антагонист налтрексон и бупропион. Кроме того, описывается способ снижения веса при введении: налтрексона и бупропиона или флуоксетина; или налмефена и флувоксамина. Также изобретение относится к применению указанных сочетаний для приготовления лекарственного средства для снижения веса. Технический результат - синергетический эффект указанных сочетаний. 4 н. и 14 з.п. ф-лы, 3 табл.

Description

Текст описания приведен в факсимильном виде.
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Claims (18)

1. Состав для снижения веса, содержащий в синергетически эффективных количествах первое соединение и второе соединение, где первое соединение является опиоидным антагонистом, представляющим собой налтрексон, а второе соединение является бупропионом.
2. Состав по п.1, в котором указанный бупропион представляет собой Бупропион-SR.
3. Состав по п.1, в котором указанный состав представляет собой единичную стандартную пероральную лекарственную форму.
4. Состав по любому из пп.1-3, в котором количество указанного бупропиона составляет от 30 до 500 мг.
5. Состав по любому из п.1 или 3, в котором количество указанного налтрексона составляет от 5 до 50 мг.
6. Способ снижения веса, включающий введение человеку, нуждающемуся в таком введении, в синергетически эффективном количестве налтрексона и бупропиона или флуоксетина
или налмефена и флувоксамина.
7. Способ по п.6, в котором вышеуказанный человек имеет индекс массы тела выше, чем 25.
8. Способ по п.6, в котором указанные соединения вводятся одновременно.
9. Способ по п.6, в котором первое соединение применяется перед вторым или первое соединение применяется после второго соединения.
10. Способ по п.6, в котором упомянутый человек не страдает депрессией, синдромом Прадера-Вилли или перееданием.
11. Способ по любому из пп.6-10, в котором количество указанного бупропиона составляет от 30 до 500 мг.
12. Способ по любому из пп.6-10, в котором количество указанного налтрексона составляет от 5 до 50 мг.
13. Применение первого соединения и второго соединения в синергетически эффективных количествах для приготовления лекарства, вызывающего потерю веса, при этом первое соединение представляет собой налтрексон, а второе соединение представляет собой бупропион или флуоксентин, или первое соединение представляет собой налмефен, а второе соединение представляет собой флувоксамин.
14. Применение по п.13, в котором количество указанного бупропиона составляет от 30 до 500 мг.
15. Применение по п.13, в котором количество указанного налтрексона составляет от 5 до 50 мг.
16. Применение сочетания в синергетически эффективных количествах налтрексона и бупропиона для приготовления лекарства, вызывающего потерю веса.
17. Применение по п.16, в котором количество указанного налтрексона составляет от 5 до 50 мг.
18. Применение по п.16, в котором количество указанного бупропиона составляет от 30 до 500 мг.
RU2005132453/15A 2003-04-29 2004-04-21 Составы, вызывающие потерю веса RU2350327C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46683803P 2003-04-29 2003-04-29
US60/466,838 2003-04-29

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EP (3) EP2316456B1 (ru)
JP (1) JP4343948B2 (ru)
KR (1) KR101167579B1 (ru)
CN (1) CN1784221B (ru)
AT (1) ATE388698T1 (ru)
AU (2) AU2004233846B2 (ru)
CA (1) CA2522708C (ru)
DE (1) DE602004012403T2 (ru)
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HK (2) HK1088850A1 (ru)
HU (2) HUE034290T2 (ru)
IL (3) IL171519A (ru)
MX (1) MXPA05011557A (ru)
PL (2) PL1617832T3 (ru)
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Cited By (5)

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Publication number Priority date Publication date Assignee Title
RU2616496C2 (ru) * 2010-01-11 2017-04-17 Ориксиджен Терапьютикс, Инк. Способы проведения терапии потери веса у пациентов с доминирующей депрессией (варианты)
RU2640561C2 (ru) * 2010-12-03 2018-01-09 Орексиджен Терапьютикс, Инк. Повышение биодоступности лекарственных средств при терапии налтрексоном
RU2664442C2 (ru) * 2012-05-24 2018-08-17 Найя Метаболик, Инк. Способ снижения веса
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RU2781141C2 (ru) * 2010-12-03 2022-10-06 Орексиджен Терапьютикс, Инк. Повышение биодоступности лекарственных средств при терапии налтрексоном

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