AU2011336304B2 - Increasing drug bioavailability in naltrexone therapy - Google Patents

Increasing drug bioavailability in naltrexone therapy Download PDF

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Publication number
AU2011336304B2
AU2011336304B2 AU2011336304A AU2011336304A AU2011336304B2 AU 2011336304 B2 AU2011336304 B2 AU 2011336304B2 AU 2011336304 A AU2011336304 A AU 2011336304A AU 2011336304 A AU2011336304 A AU 2011336304A AU 2011336304 B2 AU2011336304 B2 AU 2011336304B2
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Australia
Prior art keywords
acceptable salt
pharmaceutically acceptable
naltrexone
bupropion
food
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AU2011336304A
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AU2011336304A1 (en
Inventor
Eduardo Dunayevich
Shawn Flanagan
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Nalpropion Pharmaceuticals LLC
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Nalpropion Pharmaceuticals LLC
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Application filed by Nalpropion Pharmaceuticals LLC filed Critical Nalpropion Pharmaceuticals LLC
Publication of AU2011336304A1 publication Critical patent/AU2011336304A1/en
Application granted granted Critical
Publication of AU2011336304B2 publication Critical patent/AU2011336304B2/en
Priority to AU2017204309A priority Critical patent/AU2017204309A1/en
Assigned to NALPROPION PHARMACEUTICALS, INC. reassignment NALPROPION PHARMACEUTICALS, INC. Request for Assignment Assignors: OREXIGEN THERAPEUTICS, INC.
Assigned to NALPROPION PHARMACEUTICALS LLC reassignment NALPROPION PHARMACEUTICALS LLC Request to Amend Deed and Register Assignors: NALPROPION PHARMACEUTICALS, INC.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Physics & Mathematics (AREA)
  • Acoustics & Sound (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
AU2011336304A 2010-12-03 2011-12-02 Increasing drug bioavailability in naltrexone therapy Active AU2011336304B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2017204309A AU2017204309A1 (en) 2010-12-03 2017-06-26 Increasing Drug Bioavailability in Naltrexone Therapy

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41939510P 2010-12-03 2010-12-03
US61/419,395 2010-12-03
PCT/US2011/063177 WO2012075459A1 (en) 2010-12-03 2011-12-02 Increasing drug bioavailability in naltrexone therapy

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2017204309A Division AU2017204309A1 (en) 2010-12-03 2017-06-26 Increasing Drug Bioavailability in Naltrexone Therapy

Publications (2)

Publication Number Publication Date
AU2011336304A1 AU2011336304A1 (en) 2013-07-11
AU2011336304B2 true AU2011336304B2 (en) 2017-03-30

Family

ID=46172304

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2011336304A Active AU2011336304B2 (en) 2010-12-03 2011-12-02 Increasing drug bioavailability in naltrexone therapy
AU2017204309A Abandoned AU2017204309A1 (en) 2010-12-03 2017-06-26 Increasing Drug Bioavailability in Naltrexone Therapy

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2017204309A Abandoned AU2017204309A1 (en) 2010-12-03 2017-06-26 Increasing Drug Bioavailability in Naltrexone Therapy

Country Status (27)

Country Link
US (1) US20130245056A1 (enExample)
EP (5) EP4349369B1 (enExample)
JP (4) JP6008866B2 (enExample)
KR (5) KR102391511B1 (enExample)
CN (1) CN103313711A (enExample)
AR (2) AR093182A1 (enExample)
AU (2) AU2011336304B2 (enExample)
BR (1) BR112013013390A2 (enExample)
CA (2) CA2819262C (enExample)
CL (1) CL2013001564A1 (enExample)
CY (2) CY1118968T1 (enExample)
DK (4) DK4349369T3 (enExample)
ES (3) ES2866879T3 (enExample)
FI (2) FI3884947T3 (enExample)
HR (4) HRP20251576T1 (enExample)
HU (3) HUE053831T2 (enExample)
IL (4) IL330443A (enExample)
LT (4) LT3222280T (enExample)
MX (2) MX384662B (enExample)
PL (4) PL3222280T3 (enExample)
PT (4) PT3222280T (enExample)
RS (4) RS67527B1 (enExample)
RU (1) RU2640561C2 (enExample)
SI (4) SI3222280T1 (enExample)
SM (4) SMT202100227T1 (enExample)
TW (1) TWI618536B (enExample)
WO (1) WO2012075459A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101167579B1 (ko) 2003-04-29 2012-07-27 오렉시젠 세러퓨틱스 인크. 체중감량용 조성물
PT2135603E (pt) 2005-11-22 2013-04-03 Orexigen Therapeutics Inc Composições e métodos para aumentar a sensibilidade à insulina
WO2007089318A2 (en) * 2005-11-23 2007-08-09 Orexigen Therapeutics, Inc. Compositions and methods for reducing food cravings
CA2725930A1 (en) 2008-05-30 2009-12-30 Orexigen Therapeutics, Inc. Methods for treating visceral fat conditions
ES2762113T3 (es) 2010-01-11 2020-05-22 Nalpropion Pharmaceuticals Inc Métodos de proporcionar terapia de pérdida de peso en pacientes con depresión mayor
PT3222280T (pt) * 2010-12-03 2021-04-22 Nalpropion Pharmaceuticals Llc Aumento da biodisponibilidade farmacológica numa terapêutica com naltrexona
PL4104824T3 (pl) 2012-06-06 2025-11-12 Nalpropion Pharmaceuticals Llc Kompozycja do zastosowania w sposobie leczenia nadwagi i otyłości u pacjentów z wysokim ryzykiem sercowo-naczyniowym
US20180015042A1 (en) * 2015-02-07 2018-01-18 Intas Pharmaceuticals Ltd. Pharmaceutical composition for the treatment of obesity
CA3083850A1 (en) * 2017-03-28 2019-10-04 LDN Pharma Limited An agent that increases the expression of the bcl2-associated agonist of cell death for the treatment of cancer
EP3482751A1 (en) 2017-11-14 2019-05-15 LDN Pharma Limited Cancer treatment
US12303604B1 (en) 2024-10-16 2025-05-20 Currax Pharmaceuticals Llc Pharmaceutical formulations comprising naltrexone and/or bupropion

Citations (5)

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US20080058407A1 (en) * 2006-07-20 2008-03-06 Cara Baron Methods of improving the pharmacokinetics of doxepin
US20080113026A1 (en) * 2006-11-09 2008-05-15 Orexigen Therapeutics, Inc Layered pharmaceutical formulations
US7375111B2 (en) * 2003-04-29 2008-05-20 Orexigen Therapeutics, Inc. Compositions for affecting weight loss
US7682633B2 (en) * 2006-06-19 2010-03-23 Alpharma Pharmaceuticals, Llc Pharmaceutical composition
US20100166889A1 (en) * 2007-09-13 2010-07-01 Lcs Group, Llc Method of treating depressive disorders

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DE10129265A1 (de) * 2001-06-18 2003-01-02 Hf Arzneimittelforsch Gmbh Wirkstoff-Kombination zur medikamentösen Sucht- oder Rauschmitteltherapie
US6972291B2 (en) * 2002-07-02 2005-12-06 Bernstein Richard K Method for reducing food intake
EP1772147A2 (en) * 2003-03-17 2007-04-11 Japan Tobacco, Inc. Method for increasing the oral bioavailability of S-[2-([[1-(2-ethylbutyl)cyclohexyl]carbonyl]amino)phenyl]-2-methylpropanethioate
JP2009502931A (ja) 2005-07-27 2009-01-29 オレキシジェン・セラピューティクス・インコーポレーテッド 体重減少を促すための組成物
US8921344B2 (en) * 2006-11-03 2014-12-30 Salix Pharmaceuticals, Inc. Formulations and uses of 2-hydroxy-5-phenylazobenzoic acid derivatives
PT2135603E (pt) 2005-11-22 2013-04-03 Orexigen Therapeutics Inc Composições e métodos para aumentar a sensibilidade à insulina
WO2007089318A2 (en) * 2005-11-23 2007-08-09 Orexigen Therapeutics, Inc. Compositions and methods for reducing food cravings
JP2009517393A (ja) 2005-11-28 2009-04-30 オレキシジェン・セラピューティクス・インコーポレーテッド 不安症の治療方法
US8916195B2 (en) 2006-06-05 2014-12-23 Orexigen Therapeutics, Inc. Sustained release formulation of naltrexone
KR101264789B1 (ko) 2006-06-30 2013-05-15 엘지디스플레이 주식회사 횡전계 방식 액정표시장치용 어레이 기판과 그 제조방법
WO2008060964A2 (en) * 2006-11-09 2008-05-22 Orexigen Therapeutics, Inc. Unit dosage package and methods for administering weight loss medications
KR20160065998A (ko) * 2007-04-11 2016-06-09 바이오마린 파머수티컬 인크. 테트라하이드로바이오프테린 투여 방법, 관련 조성물 및 측정 방법
DE102007036076A1 (de) 2007-08-01 2009-02-05 Bayer Healthcare Aktiengesellschaft Dipeptoid-Produgs und ihre Verwendung
CA2725930A1 (en) 2008-05-30 2009-12-30 Orexigen Therapeutics, Inc. Methods for treating visceral fat conditions
PT3222280T (pt) * 2010-12-03 2021-04-22 Nalpropion Pharmaceuticals Llc Aumento da biodisponibilidade farmacológica numa terapêutica com naltrexona

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US7375111B2 (en) * 2003-04-29 2008-05-20 Orexigen Therapeutics, Inc. Compositions for affecting weight loss
US7682633B2 (en) * 2006-06-19 2010-03-23 Alpharma Pharmaceuticals, Llc Pharmaceutical composition
US20080058407A1 (en) * 2006-07-20 2008-03-06 Cara Baron Methods of improving the pharmacokinetics of doxepin
US20080113026A1 (en) * 2006-11-09 2008-05-15 Orexigen Therapeutics, Inc Layered pharmaceutical formulations
US20100166889A1 (en) * 2007-09-13 2010-07-01 Lcs Group, Llc Method of treating depressive disorders

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GREENWAY FRANK L. ET AL, JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, (200912), vol. 94, no. 12, pages 4898 - 4906 *
HAUSENLOY D J, CLINICAL LIPIDOLOGY 2009 FUTURE MEDICINE LTD. GBR, (200906), vol. 4, no. 3, pages 279 - 285 *
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Also Published As

Publication number Publication date
PT3884947T (pt) 2024-02-16
US20130245056A1 (en) 2013-09-19
KR20200044158A (ko) 2020-04-28
RS65198B1 (sr) 2024-03-29
HUE034393T2 (en) 2018-02-28
EP2646031A4 (en) 2014-04-23
TW201304780A (zh) 2013-02-01
KR20140035320A (ko) 2014-03-21
MX356801B (es) 2018-06-13
CN103313711A (zh) 2013-09-18
JP7025319B2 (ja) 2022-02-24
EP3884947A1 (en) 2021-09-29
MX2013006071A (es) 2013-10-01
AR093182A1 (es) 2015-05-27
PL3884947T3 (pl) 2024-05-06
KR101984500B1 (ko) 2019-05-31
IL270841A (en) 2020-01-30
KR20210063473A (ko) 2021-06-01
DK3884947T3 (da) 2024-01-22
EP2646031B1 (en) 2017-02-22
DK4349369T3 (da) 2025-12-22
DK2646031T3 (en) 2017-05-22
EP3222280A1 (en) 2017-09-27
CL2013001564A1 (es) 2014-05-02
KR102105857B1 (ko) 2020-05-04
HUE053831T2 (hu) 2021-07-28
BR112013013390A2 (pt) 2016-09-06
CA2819262A1 (en) 2012-06-07
RU2640561C2 (ru) 2018-01-09
JP2013544290A (ja) 2013-12-12
HRP20251576T1 (hr) 2026-01-30
LT3884947T (lt) 2024-03-12
JP2019056004A (ja) 2019-04-11
EP4696322A3 (en) 2026-04-15
IL330443A (en) 2026-08-01
AU2011336304A1 (en) 2013-07-11
ES3056642T3 (en) 2026-02-23
JP6008866B2 (ja) 2016-10-19
SMT201700232T1 (it) 2017-07-18
EP4349369A2 (en) 2024-04-10
LT4349369T (lt) 2026-01-12
KR102258043B1 (ko) 2021-05-28
KR102391511B1 (ko) 2022-04-26
SI2646031T1 (sl) 2017-07-31
WO2012075459A1 (en) 2012-06-07
HRP20240115T1 (hr) 2024-06-07
KR20180069089A (ko) 2018-06-22
FI4349369T3 (fi) 2025-12-17
RU2017144631A3 (enExample) 2021-04-13
KR20190058702A (ko) 2019-05-29
SI3222280T1 (sl) 2021-11-30
IL226504B (en) 2021-01-31
EP3884947B1 (en) 2023-11-15
ES2866879T3 (es) 2021-10-20
HRP20210618T1 (hr) 2021-09-17
JP2022060331A (ja) 2022-04-14
PL3222280T3 (pl) 2021-11-29
CA3239386A1 (en) 2012-06-07
LT2646031T (lt) 2017-06-26
JP2016210809A (ja) 2016-12-15
PT4349369T (pt) 2025-12-17
HUE065852T2 (hu) 2024-06-28
EP4696322A2 (en) 2026-02-18
ES2625527T9 (es) 2018-09-25
SMT202400038T1 (it) 2024-03-13
EP4349369B1 (en) 2025-09-17
CA2819262C (en) 2024-05-28
SI4349369T1 (sl) 2026-02-27
ES2625527T3 (es) 2017-07-19
CY1118968T1 (el) 2018-01-10
PL2646031T3 (pl) 2017-08-31
RS56014B1 (sr) 2017-09-29
FI3884947T3 (fi) 2024-01-30
EP2646031B9 (en) 2018-01-10
SMT202500474T1 (it) 2026-01-12
TWI618536B (zh) 2018-03-21
RU2013127423A (ru) 2015-01-10
PT2646031T (pt) 2017-05-25
JP2024071605A (ja) 2024-05-24
PT3222280T (pt) 2021-04-22
RS67527B1 (sr) 2026-01-30
AU2017204309A1 (en) 2017-07-13
EP2646031A1 (en) 2013-10-09
MX384662B (es) 2025-03-14
RU2017144631A (ru) 2019-02-18
SI3884947T1 (sl) 2024-06-28
EP3222280B1 (en) 2021-01-20
CY1124331T1 (el) 2022-07-22
EP4349369A3 (en) 2024-05-15
RS62149B1 (sr) 2021-08-31
AR124500A2 (es) 2023-04-05
JP6456890B2 (ja) 2019-01-23
LT3222280T (lt) 2021-05-10
DK3222280T3 (da) 2021-04-19
IL279626A (en) 2021-03-01
PL4349369T3 (pl) 2026-03-23
HRP20170734T1 (hr) 2017-08-11
SMT202100227T1 (it) 2021-07-12

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DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE NAME OF THE INVENTOR TO READ: FLANAGAN, SHAWN AND DUNAYEVICH, EDUARDO.

FGA Letters patent sealed or granted (standard patent)
PC Assignment registered

Owner name: NALPROPION PHARMACEUTICALS, INC.

Free format text: FORMER OWNER(S): OREXIGEN THERAPEUTICS, INC.

HB Alteration of name in register

Owner name: NALPROPION PHARMACEUTICALS LLC

Free format text: FORMER NAME(S): NALPROPION PHARMACEUTICALS, INC.