KR101945962B1 - 돌연변이 채널로돕신 2 - Google Patents

돌연변이 채널로돕신 2 Download PDF

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KR101945962B1
KR101945962B1 KR1020137008660A KR20137008660A KR101945962B1 KR 101945962 B1 KR101945962 B1 KR 101945962B1 KR 1020137008660 A KR1020137008660 A KR 1020137008660A KR 20137008660 A KR20137008660 A KR 20137008660A KR 101945962 B1 KR101945962 B1 KR 101945962B1
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retinal
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ion channel
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KR20130108335A (ko
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에른스트 밤베르크
크리스티안 바만
쏘냐 클라인로겔
필립 우드
로버트 이. 뎀프스키
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막스-플랑크-게젤샤프트 츄어 푀르더룽 데어 비쎈샤프텐 에.파우.
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/405Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from algae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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    • C12N5/10Cells modified by introduction of foreign genetic material
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872Intracellular protein regulatory factors and their receptors, e.g. including ion channels

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KR1020137008660A 2010-09-08 2011-09-08 돌연변이 채널로돕신 2 Active KR101945962B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US38079310P 2010-09-08 2010-09-08
US61/380,793 2010-09-08
EP10175832 2010-09-08
EP10175832.4 2010-09-08
PCT/EP2011/065510 WO2012032103A1 (en) 2010-09-08 2011-09-08 Mutant channelrhodopsin 2

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KR20130108335A KR20130108335A (ko) 2013-10-02
KR101945962B1 true KR101945962B1 (ko) 2019-02-08

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US (1) US8748578B2 (enExample)
EP (1) EP2614079B1 (enExample)
JP (1) JP5933556B2 (enExample)
KR (1) KR101945962B1 (enExample)
CN (1) CN103261219B (enExample)
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US10052497B2 (en) 2005-07-22 2018-08-21 The Board Of Trustees Of The Leland Stanford Junior University System for optical stimulation of target cells
US9238150B2 (en) 2005-07-22 2016-01-19 The Board Of Trustees Of The Leland Stanford Junior University Optical tissue interface method and apparatus for stimulating cells
EP2465925A1 (en) 2005-07-22 2012-06-20 The Board Of Trustees Of The Leland Light-activated cation channel and uses thereof
CA2685900A1 (en) 2006-05-04 2007-11-15 Wayne State University Restoration of visual responses by in vivo delivery of rhodopsin nucleic acids
WO2008086470A1 (en) 2007-01-10 2008-07-17 The Board Of Trustees Of The Leland Stanford Junior University System for optical stimulation of target cells
US8401609B2 (en) 2007-02-14 2013-03-19 The Board Of Trustees Of The Leland Stanford Junior University System, method and applications involving identification of biological circuits such as neurological characteristics
WO2008106694A2 (en) 2007-03-01 2008-09-04 The Board Of Trustees Of The Leland Stanford Junior University Systems, methods and compositions for optical stimulation of target cells
US10035027B2 (en) 2007-10-31 2018-07-31 The Board Of Trustees Of The Leland Stanford Junior University Device and method for ultrasonic neuromodulation via stereotactic frame based technique
US10434327B2 (en) 2007-10-31 2019-10-08 The Board Of Trustees Of The Leland Stanford Junior University Implantable optical stimulators
EP3165534B1 (en) 2008-04-23 2018-09-26 The Board of Trustees of The Leland Stanford Junior University Systems, methods and compositions for optical stimulation of target cells
EP2610350B1 (en) 2008-05-29 2014-12-17 The Board Of Trustees Of The Leland Stanford Junior University Cell line, system and method for optical control of secondary messengers
ES2612052T3 (es) 2008-06-17 2017-05-11 The Board Of Trustees Of The Leland Stanford Junior University Dispositivos para la estimulación óptica de células diana, utilizando un elemento de transmisión óptica
US10711242B2 (en) 2008-06-17 2020-07-14 The Board Of Trustees Of The Leland Stanford Junior University Apparatus and methods for controlling cellular development
US9101759B2 (en) 2008-07-08 2015-08-11 The Board Of Trustees Of The Leland Stanford Junior University Materials and approaches for optical stimulation of the peripheral nervous system
NZ602416A (en) 2008-11-14 2014-08-29 Univ Leland Stanford Junior Optically-based stimulation of target cells and modifications thereto
CN106011073A (zh) 2010-03-17 2016-10-12 小利兰·斯坦福大学托管委员会 光敏离子透过性分子
US9453241B2 (en) 2010-05-04 2016-09-27 Wayne State University AAV-mediated subcellular targeting of heterologous rhodopsins in retinal ganglion cells
US9992981B2 (en) 2010-11-05 2018-06-12 The Board Of Trustees Of The Leland Stanford Junior University Optogenetic control of reward-related behaviors
CN110215614A (zh) 2010-11-05 2019-09-10 斯坦福大学托管董事会 用于光遗传学方法的光的上转换
CN103384469B (zh) 2010-11-05 2016-06-15 斯坦福大学托管董事会 光控cns功能障碍
CA2816990A1 (en) * 2010-11-05 2012-05-10 The Board Of Trustees Of The Leland Stanford Junior University Stabilized step function opsin proteins and methods of using the same
EP3486253A1 (en) 2010-11-05 2019-05-22 The Board of Trustees of The Leland Stanford Junior University Light-activated chimeric opsins and methods of using the same
CA2816972C (en) 2010-11-05 2019-12-03 The Board Of Trustees Of The Leland Stanford Junior University Control and characterization of memory function
US8696722B2 (en) 2010-11-22 2014-04-15 The Board Of Trustees Of The Leland Stanford Junior University Optogenetic magnetic resonance imaging
CA3036859A1 (en) 2011-12-16 2013-06-20 The Board Of Trustees Of The Leland Stanford Junior University Opsin polypeptides and methods of use thereof
AU2013222443B2 (en) 2012-02-21 2017-12-14 Circuit Therapeutics, Inc. Compositions and methods for treating neurogenic disorders of the pelvic floor
DK2822964T3 (en) 2012-03-05 2018-12-10 Univ Wayne State IDENTIFICATION OF CHANNEL RHODOPSIN-2- (CHOP2) MUTATIONS AND METHODS OF USE
WO2014144409A1 (en) 2013-03-15 2014-09-18 The Board Of Trustees Of The Leland Stanford Junior University Optogenetic control of behavioral state
US9636380B2 (en) 2013-03-15 2017-05-02 The Board Of Trustees Of The Leland Stanford Junior University Optogenetic control of inputs to the ventral tegmental area
JP6549559B2 (ja) 2013-04-29 2019-07-24 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 標的細胞における活動電位の光遺伝学的調節のための装置、システム及び方法
EP3033427A4 (en) 2013-08-14 2017-05-31 The Board Of Trustees Of The University Of the Leland Stanford Junior University Compositions and methods for controlling pain
JP6118239B2 (ja) * 2013-11-29 2017-04-19 雅敏 堀 害虫の防除方法及び防除装置
WO2015167639A1 (en) * 2014-02-07 2015-11-05 Massachusetts Institute Of Technology Blue light-activated ion channel molecules and uses thereof
WO2015142984A1 (en) * 2014-03-18 2015-09-24 Washington University Methods and compositions for red-shifted chromophore substitution for optogenetic applications
WO2015161308A1 (en) * 2014-04-18 2015-10-22 Massachusetts Institute Of Technology Mutant channelrhodopsins with altered ion selectivity
US10568516B2 (en) 2015-06-22 2020-02-25 The Board Of Trustees Of The Leland Stanford Junior University Methods and devices for imaging and/or optogenetic control of light-responsive neurons
KR102471929B1 (ko) * 2016-06-03 2022-11-28 막스-플랑크-게젤샤프트 츄어 푀르더룽 데어 비쎈샤프텐 에.파우. 크림슨의 돌연변이 광-유도성 이온 채널
KR20190020702A (ko) 2016-06-03 2019-03-04 막스-플랑크-게젤샤프트 츄어 푀르더룽 데어 비쎈샤프텐 에.파우. 채널로돕신의 돌연변이 광-유도성 이온 채널
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US11180537B2 (en) 2016-11-06 2021-11-23 Nancoscope Technologies LLC Optogenetic modulation by Multi-Characteristic Opsins for vision restoration and other applications
US11294165B2 (en) 2017-03-30 2022-04-05 The Board Of Trustees Of The Leland Stanford Junior University Modular, electro-optical device for increasing the imaging field of view using time-sequential capture
WO2018189247A1 (en) * 2017-04-12 2018-10-18 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. New optogenetic tool
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WO2022176754A1 (ja) * 2021-02-18 2022-08-25 国立大学法人名古屋工業大学 青色光もしくは藍色光応答性タンパク質及びその利用
EP4223768A1 (en) 2022-02-04 2023-08-09 Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin Novel mutant bacteriorhodopsin-like-channelrhodopsin ion channel
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WO2012032103A1 (en) 2012-03-15
AU2011298745B2 (en) 2015-05-07
PL2614079T3 (pl) 2016-01-29
US20130281379A1 (en) 2013-10-24
SI2614079T1 (sl) 2015-10-30
MX347453B (es) 2017-04-27
JP5933556B2 (ja) 2016-06-15
ES2545992T3 (es) 2015-09-17
BR112013005634A2 (pt) 2017-06-27
JP2013544494A (ja) 2013-12-19
AU2011298745A1 (en) 2013-03-21
MX2013002591A (es) 2013-07-22
US8748578B2 (en) 2014-06-10
CA2810757C (en) 2020-06-09
DK2614079T3 (en) 2015-08-10
PT2614079E (pt) 2015-10-06
KR20130108335A (ko) 2013-10-02
SG188409A1 (en) 2013-04-30
CN103261219B (zh) 2017-05-17
CA2810757A1 (en) 2012-03-15
EP2614079A1 (en) 2013-07-17
RU2595384C2 (ru) 2016-08-27
EP2614079B1 (en) 2015-07-15
HUE025952T2 (en) 2016-04-28
CN103261219A (zh) 2013-08-21
HRP20150846T1 (hr) 2015-09-11
IL225060A (en) 2016-10-31
RU2013115454A (ru) 2014-10-20

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