IL225060A - Chanelrodopsin 2 mutant - Google Patents
Chanelrodopsin 2 mutantInfo
- Publication number
- IL225060A IL225060A IL225060A IL22506013A IL225060A IL 225060 A IL225060 A IL 225060A IL 225060 A IL225060 A IL 225060A IL 22506013 A IL22506013 A IL 22506013A IL 225060 A IL225060 A IL 225060A
- Authority
- IL
- Israel
- Prior art keywords
- cell
- light
- cys
- ion channel
- seq
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/405—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from algae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- General Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Plant Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Ophthalmology & Optometry (AREA)
- Public Health (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38079310P | 2010-09-08 | 2010-09-08 | |
| EP10175832 | 2010-09-08 | ||
| PCT/EP2011/065510 WO2012032103A1 (en) | 2010-09-08 | 2011-09-08 | Mutant channelrhodopsin 2 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL225060A true IL225060A (en) | 2016-10-31 |
Family
ID=42979822
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL225060A IL225060A (en) | 2010-09-08 | 2013-03-05 | Chanelrodopsin 2 mutant |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8748578B2 (enExample) |
| EP (1) | EP2614079B1 (enExample) |
| JP (1) | JP5933556B2 (enExample) |
| KR (1) | KR101945962B1 (enExample) |
| CN (1) | CN103261219B (enExample) |
| AU (1) | AU2011298745B2 (enExample) |
| BR (1) | BR112013005634A2 (enExample) |
| CA (1) | CA2810757C (enExample) |
| DK (1) | DK2614079T3 (enExample) |
| ES (1) | ES2545992T3 (enExample) |
| HR (1) | HRP20150846T1 (enExample) |
| HU (1) | HUE025952T2 (enExample) |
| IL (1) | IL225060A (enExample) |
| MX (1) | MX347453B (enExample) |
| PL (1) | PL2614079T3 (enExample) |
| PT (1) | PT2614079E (enExample) |
| RU (1) | RU2595384C2 (enExample) |
| SG (1) | SG188409A1 (enExample) |
| SI (1) | SI2614079T1 (enExample) |
| WO (1) | WO2012032103A1 (enExample) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10052497B2 (en) | 2005-07-22 | 2018-08-21 | The Board Of Trustees Of The Leland Stanford Junior University | System for optical stimulation of target cells |
| US20070053996A1 (en) | 2005-07-22 | 2007-03-08 | Boyden Edward S | Light-activated cation channel and uses thereof |
| US8926959B2 (en) | 2005-07-22 | 2015-01-06 | The Board Of Trustees Of The Leland Stanford Junior University | System for optical stimulation of target cells |
| US9274099B2 (en) | 2005-07-22 | 2016-03-01 | The Board Of Trustees Of The Leland Stanford Junior University | Screening test drugs to identify their effects on cell membrane voltage-gated ion channel |
| US9238150B2 (en) | 2005-07-22 | 2016-01-19 | The Board Of Trustees Of The Leland Stanford Junior University | Optical tissue interface method and apparatus for stimulating cells |
| US8470790B2 (en) | 2006-05-04 | 2013-06-25 | Wayne State University | Restoration of visual responses by in vivo delivery of rhodopsin nucleic acids |
| WO2008086470A1 (en) | 2007-01-10 | 2008-07-17 | The Board Of Trustees Of The Leland Stanford Junior University | System for optical stimulation of target cells |
| WO2008101128A1 (en) | 2007-02-14 | 2008-08-21 | The Board Of Trustees Of The Leland Stanford Junior University | System, method and applications involving identification of biological circuits such as neurological characteristics |
| WO2008106694A2 (en) | 2007-03-01 | 2008-09-04 | The Board Of Trustees Of The Leland Stanford Junior University | Systems, methods and compositions for optical stimulation of target cells |
| US10035027B2 (en) | 2007-10-31 | 2018-07-31 | The Board Of Trustees Of The Leland Stanford Junior University | Device and method for ultrasonic neuromodulation via stereotactic frame based technique |
| US10434327B2 (en) | 2007-10-31 | 2019-10-08 | The Board Of Trustees Of The Leland Stanford Junior University | Implantable optical stimulators |
| SG189813A1 (en) | 2008-04-23 | 2013-05-31 | Univ Leland Stanford Junior | Systems, methods and compositions for optical stimulation of target cells |
| JP5890176B2 (ja) | 2008-05-29 | 2016-03-22 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | セカンドメッセンジャーを光制御するためのセルライン、システム、および方法 |
| AU2009260029B2 (en) | 2008-06-17 | 2016-03-17 | The Board Of Trustees Of The Leland Stanford Junior University | Methods, systems and devices for optical stimulation of target cells using an optical transmission element |
| EP2303405A4 (en) | 2008-06-17 | 2017-12-27 | The Board of Trustees of the Leland Stanford Junior University | Apparatus and methods for controlling cellular development |
| US9101759B2 (en) | 2008-07-08 | 2015-08-11 | The Board Of Trustees Of The Leland Stanford Junior University | Materials and approaches for optical stimulation of the peripheral nervous system |
| NZ602416A (en) | 2008-11-14 | 2014-08-29 | Univ Leland Stanford Junior | Optically-based stimulation of target cells and modifications thereto |
| JP5866332B2 (ja) | 2010-03-17 | 2016-02-17 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 感光性イオンを通過させる分子 |
| US9453241B2 (en) | 2010-05-04 | 2016-09-27 | Wayne State University | AAV-mediated subcellular targeting of heterologous rhodopsins in retinal ganglion cells |
| WO2012061681A1 (en) | 2010-11-05 | 2012-05-10 | The Board Of Trustees Of The Leland Stanford Junior University. | Control and characterization of memory function |
| CN103491770B (zh) | 2010-11-05 | 2016-06-08 | 斯坦福大学托管董事会 | 稳定阶跃函数视蛋白及其使用方法 |
| US9992981B2 (en) | 2010-11-05 | 2018-06-12 | The Board Of Trustees Of The Leland Stanford Junior University | Optogenetic control of reward-related behaviors |
| CA2817175C (en) | 2010-11-05 | 2019-09-24 | The Board Of Trustees Of The Leland Stanford Junior University | Upconversion of light using lanthanide-doped nanoparticles for use in optogenetic methods |
| EP3486253A1 (en) | 2010-11-05 | 2019-05-22 | The Board of Trustees of The Leland Stanford Junior University | Light-activated chimeric opsins and methods of using the same |
| CN106106368A (zh) | 2010-11-05 | 2016-11-16 | 斯坦福大学托管董事会 | 光控cns功能障碍 |
| US8696722B2 (en) | 2010-11-22 | 2014-04-15 | The Board Of Trustees Of The Leland Stanford Junior University | Optogenetic magnetic resonance imaging |
| EP3524676A1 (en) | 2011-12-16 | 2019-08-14 | The Board of Trustees of The Leland Stanford Junior University | Opsin polypeptides and methods of use thereof |
| ES2628006T3 (es) | 2012-02-21 | 2017-08-01 | Circuit Therapeutics, Inc. | Composiciones para el tratamiento de trastornos neurogénicos del suelo pélvico |
| CN111378020A (zh) * | 2012-03-05 | 2020-07-07 | 韦恩州立大学 | 通道视蛋白-2(Chop2)突变的鉴定及使用方法 |
| US9636380B2 (en) | 2013-03-15 | 2017-05-02 | The Board Of Trustees Of The Leland Stanford Junior University | Optogenetic control of inputs to the ventral tegmental area |
| US10974064B2 (en) | 2013-03-15 | 2021-04-13 | The Board Of Trustees Of The Leland Stanford Junior University | Optogenetic control of behavioral state |
| WO2014179331A2 (en) | 2013-04-29 | 2014-11-06 | The Board Of Trustees Of The Leland Stanford Junior University | Devices, systems and methods for optogenetic modulation of action potentials in target cells |
| CA2921221A1 (en) | 2013-08-14 | 2015-02-19 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for controlling pain |
| JP6118239B2 (ja) | 2013-11-29 | 2017-04-19 | 雅敏 堀 | 害虫の防除方法及び防除装置 |
| EP3102290A1 (en) | 2014-02-07 | 2016-12-14 | Massachusetts Institute Of Technology | Blue light-activated ion channel molecules and uses thereof |
| WO2015142984A1 (en) * | 2014-03-18 | 2015-09-24 | Washington University | Methods and compositions for red-shifted chromophore substitution for optogenetic applications |
| WO2015161308A1 (en) * | 2014-04-18 | 2015-10-22 | Massachusetts Institute Of Technology | Mutant channelrhodopsins with altered ion selectivity |
| WO2016209654A1 (en) | 2015-06-22 | 2016-12-29 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and devices for imaging and/or optogenetic control of light-responsive neurons |
| JP2019522469A (ja) * | 2016-06-03 | 2019-08-15 | マックス−プランク−ゲゼルシャフト ツア フェルデルンク デア ヴィッセンシャフテン エー．ファウ． | チャネルロドプシンの変異型光誘導性イオンチャネル |
| WO2017207761A1 (en) | 2016-06-03 | 2017-12-07 | Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V. | Mutant light-inducible ion channel of chrimson |
| RU2019109021A (ru) | 2016-08-29 | 2020-09-29 | Уэйн Стейт Юниверсити | Идентификация мутаций в вариантах каналопсина, имеющих улучшенную чувствительность к свету, и способы их применения |
| WO2018106369A2 (en) | 2016-11-06 | 2018-06-14 | Nanoscope Technologies Llc | Optogenetic modulation by multi-characteristic opsins for vision restoration and other applications thereof |
| US11294165B2 (en) | 2017-03-30 | 2022-04-05 | The Board Of Trustees Of The Leland Stanford Junior University | Modular, electro-optical device for increasing the imaging field of view using time-sequential capture |
| WO2018189247A1 (en) * | 2017-04-12 | 2018-10-18 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | New optogenetic tool |
| CN110483645B (zh) * | 2018-05-14 | 2023-05-12 | 郑州大学第一附属医院 | 线粒体定位质子泵型视紫红质、其突变蛋白及其应用 |
| GB2586751B (en) * | 2018-07-26 | 2022-12-07 | Council Scient Ind Res | Screening kit for detection of grades of cervical cancer and process for the preparation thereof |
| WO2020054868A1 (ja) * | 2018-09-14 | 2020-03-19 | 国立大学法人名古屋工業大学 | 光応答性タンパク質及びその利用 |
| JP7723983B2 (ja) * | 2020-03-13 | 2025-08-15 | 国立大学法人 名古屋工業大学 | 色認識のための光応答性タンパク質及びその利用 |
| WO2022176754A1 (ja) * | 2021-02-18 | 2022-08-25 | 国立大学法人名古屋工業大学 | 青色光もしくは藍色光応答性タンパク質及びその利用 |
| EP4223768A1 (en) | 2022-02-04 | 2023-08-09 | Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin | Novel mutant bacteriorhodopsin-like-channelrhodopsin ion channel |
| WO2024092248A1 (en) * | 2022-10-28 | 2024-05-02 | The Board Of Trustees Of The Leland Stanford Junior University | Enhanced light gated potassium selective channelrhodopsin |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2112501A1 (de) | 1998-02-05 | 2009-10-28 | Novartis Ag | Verfahren und Vorrichtung zur Lumineszenzmessung |
| DE10216005A1 (de) | 2002-04-11 | 2003-10-30 | Max Planck Gesellschaft | Verwendung von biologischen Photorezeptoren als direkt lichtgesteuerte Ionenkanäle |
| US8470790B2 (en) * | 2006-05-04 | 2013-06-25 | Wayne State University | Restoration of visual responses by in vivo delivery of rhodopsin nucleic acids |
| DE102008020152B4 (de) * | 2008-04-22 | 2012-04-05 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Verwendung von biologischen Photorezeptoren als direkt lichtgesteuerte Ionenkanäle |
| NZ602416A (en) * | 2008-11-14 | 2014-08-29 | Univ Leland Stanford Junior | Optically-based stimulation of target cells and modifications thereto |
-
2011
- 2011-09-08 SI SI201130552T patent/SI2614079T1/sl unknown
- 2011-09-08 WO PCT/EP2011/065510 patent/WO2012032103A1/en not_active Ceased
- 2011-09-08 EP EP11760432.2A patent/EP2614079B1/en active Active
- 2011-09-08 PT PT117604322T patent/PT2614079E/pt unknown
- 2011-09-08 AU AU2011298745A patent/AU2011298745B2/en active Active
- 2011-09-08 KR KR1020137008660A patent/KR101945962B1/ko active Active
- 2011-09-08 ES ES11760432.2T patent/ES2545992T3/es active Active
- 2011-09-08 CA CA2810757A patent/CA2810757C/en active Active
- 2011-09-08 HR HRP20150846TT patent/HRP20150846T1/hr unknown
- 2011-09-08 PL PL11760432T patent/PL2614079T3/pl unknown
- 2011-09-08 HU HUE11760432A patent/HUE025952T2/en unknown
- 2011-09-08 SG SG2013016332A patent/SG188409A1/en unknown
- 2011-09-08 US US13/821,353 patent/US8748578B2/en active Active
- 2011-09-08 MX MX2013002591A patent/MX347453B/es active IP Right Grant
- 2011-09-08 DK DK11760432.2T patent/DK2614079T3/en active
- 2011-09-08 RU RU2013115454/10A patent/RU2595384C2/ru active
- 2011-09-08 CN CN201180052156.9A patent/CN103261219B/zh active Active
- 2011-09-08 BR BR112013005634A patent/BR112013005634A2/pt not_active Application Discontinuation
- 2011-09-08 JP JP2013527595A patent/JP5933556B2/ja active Active
-
2013
- 2013-03-05 IL IL225060A patent/IL225060A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| JP2013544494A (ja) | 2013-12-19 |
| US20130281379A1 (en) | 2013-10-24 |
| AU2011298745A1 (en) | 2013-03-21 |
| PL2614079T3 (pl) | 2016-01-29 |
| HUE025952T2 (en) | 2016-04-28 |
| AU2011298745B2 (en) | 2015-05-07 |
| CA2810757A1 (en) | 2012-03-15 |
| EP2614079A1 (en) | 2013-07-17 |
| CA2810757C (en) | 2020-06-09 |
| PT2614079E (pt) | 2015-10-06 |
| MX2013002591A (es) | 2013-07-22 |
| US8748578B2 (en) | 2014-06-10 |
| CN103261219B (zh) | 2017-05-17 |
| SG188409A1 (en) | 2013-04-30 |
| RU2013115454A (ru) | 2014-10-20 |
| EP2614079B1 (en) | 2015-07-15 |
| HRP20150846T1 (hr) | 2015-09-11 |
| JP5933556B2 (ja) | 2016-06-15 |
| ES2545992T3 (es) | 2015-09-17 |
| DK2614079T3 (en) | 2015-08-10 |
| MX347453B (es) | 2017-04-27 |
| WO2012032103A1 (en) | 2012-03-15 |
| BR112013005634A2 (pt) | 2017-06-27 |
| CN103261219A (zh) | 2013-08-21 |
| KR20130108335A (ko) | 2013-10-02 |
| SI2614079T1 (sl) | 2015-10-30 |
| KR101945962B1 (ko) | 2019-02-08 |
| RU2595384C2 (ru) | 2016-08-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed |