KR101902325B1 - 아연 결합 모이어티를 갖는 포스포이노시티드 ３-키나아제 억제제 - Google Patents

아연 결합 모이어티를 갖는 포스포이노시티드 ３-키나아제 억제제 Download PDF

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KR101902325B1
KR101902325B1 KR1020137028748A KR20137028748A KR101902325B1 KR 101902325 B1 KR101902325 B1 KR 101902325B1 KR 1020137028748 A KR1020137028748 A KR 1020137028748A KR 20137028748 A KR20137028748 A KR 20137028748A KR 101902325 B1 KR101902325 B1 KR 101902325B1
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compound
tumor
cancer
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KR20140023333A (ko
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슝 카이
하이시아오 자이
쳉정 라이
창겡 첸
루디 바오
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쿠리스 인코퍼레이션
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020137028748A 2011-04-01 2012-03-30 아연 결합 모이어티를 갖는 포스포이노시티드 ３-키나아제 억제제 Active KR101902325B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161470849P 2011-04-01 2011-04-01
US61/470,849 2011-04-01
US201161559489P 2011-11-14 2011-11-14
US61/559,489 2011-11-14
PCT/US2012/031361 WO2012135571A1 (en) 2011-04-01 2012-03-30 Phosphoinositide 3-kinase inhibitor with a zinc binding moiety

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KR1020187026847A Division KR20180108848A (ko) 2011-04-01 2012-03-30 아연 결합 모이어티를 갖는 포스포이노시티드 ３-키나아제 억제제

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KR20140023333A KR20140023333A (ko) 2014-02-26
KR101902325B1 true KR101902325B1 (ko) 2018-09-28

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KR1020187026847A Ceased KR20180108848A (ko) 2011-04-01 2012-03-30 아연 결합 모이어티를 갖는 포스포이노시티드 ３-키나아제 억제제

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EP (2) EP3111938B1 (enExample)
JP (3) JP6242331B2 (enExample)
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CN (2) CN103582483B (enExample)
AU (1) AU2012236367B2 (enExample)
BR (1) BR112013025340B1 (enExample)
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CY (2) CY1117785T1 (enExample)
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EA (1) EA022434B9 (enExample)
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RS (2) RS59219B1 (enExample)
SG (2) SG193563A1 (enExample)
SI (2) SI3111938T1 (enExample)
SM (2) SMT201900435T1 (enExample)
TW (1) TWI571469B (enExample)
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CN104725301A (zh) * 2013-12-20 2015-06-24 北京蓝贝望生物医药科技股份有限公司 一种1,2-二氢吡啶-2-酮衍生物的制备方法
CN107849045B (zh) * 2015-04-21 2019-12-24 贵州百灵企业集团制药股份有限公司 嘌呤基-n-羟基嘧啶甲酰胺衍生物及其制备方法和用途
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US11406647B2 (en) * 2017-11-06 2022-08-09 Cold Spring Harbor Laboratory Method and compositions for forming a copper-containing complex and uses thereof
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HRP20191091T1 (hr) 2019-09-20
EP2694075A1 (en) 2014-02-12
US20190091211A1 (en) 2019-03-28
US9249156B2 (en) 2016-02-02
CA2830822C (en) 2018-10-02
EP2694075A4 (en) 2014-10-01
CA2830822A1 (en) 2012-10-04
US20140243330A1 (en) 2014-08-28
PT2694075T (pt) 2016-07-11
AU2012236367B2 (en) 2014-10-09
EP2694075B1 (en) 2016-04-27
IL248597B (en) 2018-04-30
JP2016188255A (ja) 2016-11-04
JP2014509653A (ja) 2014-04-21
RS54903B1 (sr) 2016-10-31
CL2013002823A1 (es) 2014-04-11
US20130090335A1 (en) 2013-04-11
US11654136B2 (en) 2023-05-23
DK3111938T3 (da) 2019-07-01
RS59219B1 (sr) 2019-10-31
PE20141382A1 (es) 2014-11-04
PL2694075T3 (pl) 2016-09-30
ZA201307082B (en) 2015-04-29
US10111864B2 (en) 2018-10-30
HK1194969A1 (zh) 2014-10-31
US20200215039A1 (en) 2020-07-09
BR112013025340A2 (pt) 2016-12-13
CN105461736B (zh) 2018-06-12
ME03523B (me) 2020-04-20
SG10201602569RA (en) 2016-05-30
CN103582483A (zh) 2014-02-12
HUE028910T2 (en) 2017-01-30
HUE045041T2 (hu) 2019-12-30
BR112013025340B1 (pt) 2021-12-21
KR20140023333A (ko) 2014-02-26
EP3111938A1 (en) 2017-01-04
ZA201406167B (en) 2015-03-25
PT3111938T (pt) 2019-07-10
JP6242331B2 (ja) 2017-12-06
SMT201900435T1 (it) 2019-09-09
CY1117785T1 (el) 2017-05-17
KR20180108848A (ko) 2018-10-04
CN105461736A (zh) 2016-04-06
SI2694075T1 (sl) 2016-07-29
AU2012236367A1 (en) 2013-04-18
US9657032B2 (en) 2017-05-23
JP6275784B2 (ja) 2018-02-07
US20220168284A1 (en) 2022-06-02
IL228588A (en) 2016-11-30
ME02451B (me) 2016-09-20
TW201247678A (en) 2012-12-01
MX340577B (es) 2016-07-13
NZ705039A (en) 2016-03-31
CN103582483B (zh) 2016-02-17
IL248597A0 (en) 2016-12-29
US11135205B2 (en) 2021-10-05
DK2694075T3 (en) 2016-08-01
ES2577982T3 (es) 2016-07-19
SG193563A1 (en) 2013-11-29
EA022434B9 (ru) 2016-02-29
LT3111938T (lt) 2019-06-25
EA201301114A1 (ru) 2014-04-30
US10543197B2 (en) 2020-01-28
SMT201600179B (it) 2016-08-31
WO2012135571A1 (en) 2012-10-04
SI3111938T1 (sl) 2019-08-30
HRP20160545T1 (hr) 2016-06-17
CY1121825T1 (el) 2020-07-31
NZ615586A (en) 2015-02-27
EP3111938B1 (en) 2019-05-08
US20170304279A1 (en) 2017-10-26
ES2733128T3 (es) 2019-11-27
EA022434B1 (ru) 2015-12-30
MX2013011132A (es) 2014-03-12
US8710219B2 (en) 2014-04-29
PL3111938T3 (pl) 2019-09-30
US20160185796A1 (en) 2016-06-30
TWI571469B (zh) 2017-02-21
JP2018052987A (ja) 2018-04-05
IL228588A0 (en) 2013-12-31

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