LT3111938T - Fosfoinozitido 3-kinazės inhibitorius su cinko rišamąja dalimi - Google Patents

Fosfoinozitido 3-kinazės inhibitorius su cinko rišamąja dalimi

Info

Publication number
LT3111938T
LT3111938T LTEP16166266.3T LT16166266T LT3111938T LT 3111938 T LT3111938 T LT 3111938T LT 16166266 T LT16166266 T LT 16166266T LT 3111938 T LT3111938 T LT 3111938T
Authority
LT
Lithuania
Prior art keywords
phosphoinositide
kinase inhibitor
binding moiety
zinc binding
zinc
Prior art date
Application number
LTEP16166266.3T
Other languages
English (en)
Lithuanian (lt)
Inventor
Cai Xiong
Haixiao Zhai
Chengjung Lai
Changgeng Qian
Rudi Bao
Original Assignee
Curis, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Curis, Inc. filed Critical Curis, Inc.
Publication of LT3111938T publication Critical patent/LT3111938T/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
LTEP16166266.3T 2011-04-01 2012-03-30 Fosfoinozitido 3-kinazės inhibitorius su cinko rišamąja dalimi LT3111938T (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161470849P 2011-04-01 2011-04-01
US201161559489P 2011-11-14 2011-11-14

Publications (1)

Publication Number Publication Date
LT3111938T true LT3111938T (lt) 2019-06-25

Family

ID=46931927

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEP16166266.3T LT3111938T (lt) 2011-04-01 2012-03-30 Fosfoinozitido 3-kinazės inhibitorius su cinko rišamąja dalimi

Country Status (29)

Country Link
US (7) US8710219B2 (enExample)
EP (2) EP2694075B1 (enExample)
JP (3) JP6242331B2 (enExample)
KR (2) KR20180108848A (enExample)
CN (2) CN105461736B (enExample)
AU (1) AU2012236367B2 (enExample)
BR (1) BR112013025340B1 (enExample)
CA (1) CA2830822C (enExample)
CL (1) CL2013002823A1 (enExample)
CY (2) CY1117785T1 (enExample)
DK (2) DK3111938T3 (enExample)
EA (1) EA022434B9 (enExample)
ES (2) ES2577982T3 (enExample)
HR (2) HRP20160545T1 (enExample)
HU (2) HUE045041T2 (enExample)
IL (2) IL228588A (enExample)
LT (1) LT3111938T (enExample)
ME (2) ME03523B (enExample)
MX (1) MX340577B (enExample)
PE (1) PE20141382A1 (enExample)
PL (2) PL2694075T3 (enExample)
PT (2) PT3111938T (enExample)
RS (2) RS59219B1 (enExample)
SG (2) SG193563A1 (enExample)
SI (2) SI2694075T1 (enExample)
SM (2) SMT201900435T1 (enExample)
TW (1) TWI571469B (enExample)
WO (1) WO2012135571A1 (enExample)
ZA (2) ZA201307082B (enExample)

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CN104725301A (zh) * 2013-12-20 2015-06-24 北京蓝贝望生物医药科技股份有限公司 一种1,2-二氢吡啶-2-酮衍生物的制备方法
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WO2023212574A1 (en) * 2022-04-26 2023-11-02 Olivia Szu Hsieh Lee Nakaya Compositions and methods for modulating rhythmic activity of pacemaker cardiomyocytes

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Also Published As

Publication number Publication date
ME02451B (me) 2016-09-20
AU2012236367B2 (en) 2014-10-09
CY1117785T1 (el) 2017-05-17
PT3111938T (pt) 2019-07-10
US20130090335A1 (en) 2013-04-11
CA2830822C (en) 2018-10-02
RS54903B1 (sr) 2016-10-31
DK2694075T3 (en) 2016-08-01
HRP20191091T1 (hr) 2019-09-20
ME03523B (me) 2020-04-20
US9657032B2 (en) 2017-05-23
US20170304279A1 (en) 2017-10-26
JP2016188255A (ja) 2016-11-04
RS59219B1 (sr) 2019-10-31
JP6275784B2 (ja) 2018-02-07
SMT201600179B (it) 2016-08-31
US20140243330A1 (en) 2014-08-28
PT2694075T (pt) 2016-07-11
EA201301114A1 (ru) 2014-04-30
MX340577B (es) 2016-07-13
CL2013002823A1 (es) 2014-04-11
CN105461736B (zh) 2018-06-12
EA022434B1 (ru) 2015-12-30
SI2694075T1 (sl) 2016-07-29
ES2733128T3 (es) 2019-11-27
EP2694075A1 (en) 2014-02-12
US10543197B2 (en) 2020-01-28
CY1121825T1 (el) 2020-07-31
EP2694075A4 (en) 2014-10-01
BR112013025340B1 (pt) 2021-12-21
IL228588A0 (en) 2013-12-31
IL248597A0 (en) 2016-12-29
SG10201602569RA (en) 2016-05-30
MX2013011132A (es) 2014-03-12
SG193563A1 (en) 2013-11-29
EA022434B9 (ru) 2016-02-29
US11135205B2 (en) 2021-10-05
US8710219B2 (en) 2014-04-29
US10111864B2 (en) 2018-10-30
PL2694075T3 (pl) 2016-09-30
PL3111938T3 (pl) 2019-09-30
JP2018052987A (ja) 2018-04-05
JP2014509653A (ja) 2014-04-21
EP3111938A1 (en) 2017-01-04
KR101902325B1 (ko) 2018-09-28
NZ615586A (en) 2015-02-27
BR112013025340A2 (pt) 2016-12-13
ZA201406167B (en) 2015-03-25
US9249156B2 (en) 2016-02-02
DK3111938T3 (da) 2019-07-01
TWI571469B (zh) 2017-02-21
US20190091211A1 (en) 2019-03-28
WO2012135571A1 (en) 2012-10-04
CN103582483B (zh) 2016-02-17
EP2694075B1 (en) 2016-04-27
US20160185796A1 (en) 2016-06-30
AU2012236367A1 (en) 2013-04-18
JP6242331B2 (ja) 2017-12-06
TW201247678A (en) 2012-12-01
IL248597B (en) 2018-04-30
ZA201307082B (en) 2015-04-29
KR20180108848A (ko) 2018-10-04
CN103582483A (zh) 2014-02-12
NZ705039A (en) 2016-03-31
SI3111938T1 (sl) 2019-08-30
CN105461736A (zh) 2016-04-06
CA2830822A1 (en) 2012-10-04
EP3111938B1 (en) 2019-05-08
HK1194969A1 (zh) 2014-10-31
PE20141382A1 (es) 2014-11-04
ES2577982T3 (es) 2016-07-19
HUE028910T2 (en) 2017-01-30
HUE045041T2 (hu) 2019-12-30
US11654136B2 (en) 2023-05-23
KR20140023333A (ko) 2014-02-26
SMT201900435T1 (it) 2019-09-09
US20200215039A1 (en) 2020-07-09
IL228588A (en) 2016-11-30
HRP20160545T1 (hr) 2016-06-17
US20220168284A1 (en) 2022-06-02

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