KR101886945B1 - 감마-세크레타제 조절제로서의 크로멘 및 1,1a,2,7b-테트라히드로시클로프로파[c]크로멘 피리도피라진디온 - Google Patents

감마-세크레타제 조절제로서의 크로멘 및 1,1a,2,7b-테트라히드로시클로프로파[c]크로멘 피리도피라진디온 Download PDF

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KR101886945B1
KR101886945B1 KR1020167030135A KR20167030135A KR101886945B1 KR 101886945 B1 KR101886945 B1 KR 101886945B1 KR 1020167030135 A KR1020167030135 A KR 1020167030135A KR 20167030135 A KR20167030135 A KR 20167030135A KR 101886945 B1 KR101886945 B1 KR 101886945B1
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alkyl
alkoxy
hydroxy
halo
cycloalkyl
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KR20160137635A (ko
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크리스토퍼 윌리엄 암 엔데
존 마이클 험프리
더글라스 스캇 존슨
그레고리 웨인 카우프만
마틴 영진 페터슨
다니카 안토니아 란킥
안토니아 프레데리케 스테판
페트릭 로버트 베로이스트
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화이자 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020167030135A 2014-04-01 2015-03-18 감마-세크레타제 조절제로서의 크로멘 및 1,1a,2,7b-테트라히드로시클로프로파[c]크로멘 피리도피라진디온 Expired - Fee Related KR101886945B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461973436P 2014-04-01 2014-04-01
US61/973,436 2014-04-01
PCT/IB2015/051988 WO2015150957A1 (en) 2014-04-01 2015-03-18 Chromene and 1,1 a,2,7b-tetrahydrocyclopropa[c]chromene pyridopyrazinediones as gamma-secretase modulators

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KR20160137635A KR20160137635A (ko) 2016-11-30
KR101886945B1 true KR101886945B1 (ko) 2018-08-08

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KR1020167030135A Expired - Fee Related KR101886945B1 (ko) 2014-04-01 2015-03-18 감마-세크레타제 조절제로서의 크로멘 및 1,1a,2,7b-테트라히드로시클로프로파[c]크로멘 피리도피라진디온

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EP (1) EP3126361B1 (enExample)
JP (1) JP6643247B2 (enExample)
KR (1) KR101886945B1 (enExample)
CN (1) CN106211770B (enExample)
AP (1) AP2016009465A0 (enExample)
AR (1) AR099874A1 (enExample)
AU (1) AU2015242330B2 (enExample)
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CA (1) CA2944308A1 (enExample)
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DO (1) DOP2016000266A (enExample)
EA (1) EA031419B1 (enExample)
EC (1) ECSP16078289A (enExample)
ES (1) ES2759277T3 (enExample)
IL (1) IL248154B (enExample)
MD (1) MD20160102A2 (enExample)
MX (1) MX369074B (enExample)
NI (1) NI201600149A (enExample)
PE (1) PE20161364A1 (enExample)
PH (1) PH12016501864A1 (enExample)
SG (1) SG11201607465UA (enExample)
TW (1) TWI568733B (enExample)
UY (1) UY36054A (enExample)
WO (1) WO2015150957A1 (enExample)
ZA (1) ZA201606252B (enExample)

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CN106580997B (zh) * 2016-12-09 2018-01-19 张田 一种治疗先兆流产的药物组合物
EP3554502A4 (en) 2016-12-16 2021-01-06 Pipeline Therapeutics, Inc. METHOD FOR TREATMENT OF COCHLEA SYNAPTOPATHY
EP3849979A1 (en) 2018-09-12 2021-07-21 Novartis AG Antiviral pyridopyrazinedione compounds
CN110907542A (zh) * 2018-09-17 2020-03-24 复旦大学 一种液质联用检测唾液中司来吉兰及其代谢物的方法
EP3870292A4 (en) 2018-10-26 2022-11-09 The Research Foundation for The State University of New York COMBINATION OF SEROTONIN-SPECIFIC RESUPPUT INHIBITOR AND SEROTONIN 1A RECEPTOR PARTIAL AGONIST TO REDUCE L-DOPA-INDUCED DYSKINESIA
CN113543852A (zh) 2019-03-06 2021-10-22 第一三共株式会社 吡咯并吡唑衍生物
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EP4604955A1 (en) 2022-10-18 2025-08-27 Pfizer Inc. Use of patatin-like phospholipase domain-containing protein 3 compounds

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Also Published As

Publication number Publication date
AU2015242330B2 (en) 2017-08-17
EA201600619A1 (ru) 2017-03-31
IL248154B (en) 2020-09-30
MX369074B (es) 2019-10-28
DOP2016000266A (es) 2016-11-15
CR20160454A (es) 2016-12-06
HK1231481A1 (zh) 2017-12-22
SG11201607465UA (en) 2016-10-28
BR112016022519A8 (pt) 2018-03-06
JP6643247B2 (ja) 2020-02-12
EA031419B1 (ru) 2018-12-28
AP2016009465A0 (en) 2016-09-30
JP2017512803A (ja) 2017-05-25
UY36054A (es) 2015-10-30
AU2015242330A1 (en) 2016-09-22
PH12016501864A1 (en) 2016-12-19
WO2015150957A1 (en) 2015-10-08
US20150274721A1 (en) 2015-10-01
EP3126361B1 (en) 2019-11-06
PE20161364A1 (es) 2016-12-25
DK3126361T3 (da) 2020-01-02
ZA201606252B (en) 2018-05-30
TWI568733B (zh) 2017-02-01
CN106211770A (zh) 2016-12-07
AR099874A1 (es) 2016-08-24
ES2759277T3 (es) 2020-05-08
CL2016002422A1 (es) 2017-02-03
MX2016012904A (es) 2016-12-07
MD20160102A2 (ro) 2017-04-30
EP3126361A1 (en) 2017-02-08
TW201540716A (zh) 2015-11-01
CA2944308A1 (en) 2015-10-08
IL248154A0 (en) 2016-11-30
CN106211770B (zh) 2018-02-06
CU20160140A7 (es) 2017-02-02
NI201600149A (es) 2016-11-18
US20170166566A1 (en) 2017-06-15
KR20160137635A (ko) 2016-11-30
ECSP16078289A (es) 2017-02-24
BR112016022519A2 (pt) 2017-08-15

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