AU2015242330B2 - Chromene and 1,1 a,2,7b-tetrahydrocyclopropa[c]chromene pyridopyrazinediones as gamma-secretase modulators - Google Patents

Chromene and 1,1 a,2,7b-tetrahydrocyclopropa[c]chromene pyridopyrazinediones as gamma-secretase modulators Download PDF

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Publication number
AU2015242330B2
AU2015242330B2 AU2015242330A AU2015242330A AU2015242330B2 AU 2015242330 B2 AU2015242330 B2 AU 2015242330B2 AU 2015242330 A AU2015242330 A AU 2015242330A AU 2015242330 A AU2015242330 A AU 2015242330A AU 2015242330 B2 AU2015242330 B2 AU 2015242330B2
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Australia
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crc6
alkyl
alkoxy
hydroxy
halo
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AU2015242330A
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AU2015242330A1 (en
Inventor
Christopher William Am Ende
John Michael Humphrey
Douglas Scott Johnson
Gregory Wayne KAUFFMAN
Martin Youngjin Pettersson
Danica Antonia RANKIC
Antonia Friederike STEPAN
Patrick Robert Verhoest
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Pfizer Inc
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Pfizer Inc
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Publication of AU2015242330A1 publication Critical patent/AU2015242330A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU2015242330A 2014-04-01 2015-03-18 Chromene and 1,1 a,2,7b-tetrahydrocyclopropa[c]chromene pyridopyrazinediones as gamma-secretase modulators Ceased AU2015242330B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461973436P 2014-04-01 2014-04-01
US61/973,436 2014-04-01
PCT/IB2015/051988 WO2015150957A1 (en) 2014-04-01 2015-03-18 Chromene and 1,1 a,2,7b-tetrahydrocyclopropa[c]chromene pyridopyrazinediones as gamma-secretase modulators

Publications (2)

Publication Number Publication Date
AU2015242330A1 AU2015242330A1 (en) 2016-09-22
AU2015242330B2 true AU2015242330B2 (en) 2017-08-17

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AU2015242330A Ceased AU2015242330B2 (en) 2014-04-01 2015-03-18 Chromene and 1,1 a,2,7b-tetrahydrocyclopropa[c]chromene pyridopyrazinediones as gamma-secretase modulators

Country Status (29)

Country Link
US (2) US20150274721A1 (enExample)
EP (1) EP3126361B1 (enExample)
JP (1) JP6643247B2 (enExample)
KR (1) KR101886945B1 (enExample)
CN (1) CN106211770B (enExample)
AP (1) AP2016009465A0 (enExample)
AR (1) AR099874A1 (enExample)
AU (1) AU2015242330B2 (enExample)
BR (1) BR112016022519A8 (enExample)
CA (1) CA2944308A1 (enExample)
CL (1) CL2016002422A1 (enExample)
CR (1) CR20160454A (enExample)
CU (1) CU20160140A7 (enExample)
DK (1) DK3126361T3 (enExample)
DO (1) DOP2016000266A (enExample)
EA (1) EA031419B1 (enExample)
EC (1) ECSP16078289A (enExample)
ES (1) ES2759277T3 (enExample)
IL (1) IL248154B (enExample)
MD (1) MD20160102A2 (enExample)
MX (1) MX369074B (enExample)
NI (1) NI201600149A (enExample)
PE (1) PE20161364A1 (enExample)
PH (1) PH12016501864A1 (enExample)
SG (1) SG11201607465UA (enExample)
TW (1) TWI568733B (enExample)
UY (1) UY36054A (enExample)
WO (1) WO2015150957A1 (enExample)
ZA (1) ZA201606252B (enExample)

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CN106580997B (zh) * 2016-12-09 2018-01-19 张田 一种治疗先兆流产的药物组合物
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CN110907542A (zh) * 2018-09-17 2020-03-24 复旦大学 一种液质联用检测唾液中司来吉兰及其代谢物的方法
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Also Published As

Publication number Publication date
ES2759277T3 (es) 2020-05-08
US20170166566A1 (en) 2017-06-15
US20150274721A1 (en) 2015-10-01
CN106211770B (zh) 2018-02-06
DK3126361T3 (da) 2020-01-02
EP3126361A1 (en) 2017-02-08
JP2017512803A (ja) 2017-05-25
AU2015242330A1 (en) 2016-09-22
CN106211770A (zh) 2016-12-07
IL248154A0 (en) 2016-11-30
PE20161364A1 (es) 2016-12-25
PH12016501864A1 (en) 2016-12-19
WO2015150957A1 (en) 2015-10-08
EA201600619A1 (ru) 2017-03-31
BR112016022519A8 (pt) 2018-03-06
MX2016012904A (es) 2016-12-07
HK1231481A1 (zh) 2017-12-22
CA2944308A1 (en) 2015-10-08
BR112016022519A2 (pt) 2017-08-15
EP3126361B1 (en) 2019-11-06
MX369074B (es) 2019-10-28
TW201540716A (zh) 2015-11-01
IL248154B (en) 2020-09-30
EA031419B1 (ru) 2018-12-28
CR20160454A (es) 2016-12-06
ZA201606252B (en) 2018-05-30
KR101886945B1 (ko) 2018-08-08
AP2016009465A0 (en) 2016-09-30
CL2016002422A1 (es) 2017-02-03
JP6643247B2 (ja) 2020-02-12
TWI568733B (zh) 2017-02-01
KR20160137635A (ko) 2016-11-30
AR099874A1 (es) 2016-08-24
DOP2016000266A (es) 2016-11-15
MD20160102A2 (ro) 2017-04-30
CU20160140A7 (es) 2017-02-02
NI201600149A (es) 2016-11-18
UY36054A (es) 2015-10-30
SG11201607465UA (en) 2016-10-28
ECSP16078289A (es) 2017-02-24

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