KR101882408B1 - 혈액응고시간 연장제 - Google Patents

혈액응고시간 연장제 Download PDF

Info

Publication number
KR101882408B1
KR101882408B1 KR1020187004669A KR20187004669A KR101882408B1 KR 101882408 B1 KR101882408 B1 KR 101882408B1 KR 1020187004669 A KR1020187004669 A KR 1020187004669A KR 20187004669 A KR20187004669 A KR 20187004669A KR 101882408 B1 KR101882408 B1 KR 101882408B1
Authority
KR
South Korea
Prior art keywords
blood coagulation
time
measurement
sample
reagent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
KR1020187004669A
Other languages
English (en)
Korean (ko)
Other versions
KR20180019781A (ko
Inventor
치츠루 모리카와
레미 나카무라
미츠아키 야마모토
Original Assignee
세키스이 메디칼 가부시키가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 세키스이 메디칼 가부시키가이샤 filed Critical 세키스이 메디칼 가부시키가이샤
Publication of KR20180019781A publication Critical patent/KR20180019781A/ko
Application granted granted Critical
Publication of KR101882408B1 publication Critical patent/KR101882408B1/ko
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/02—Guanidine; Salts, complexes or addition compounds thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/745—Assays involving non-enzymic blood coagulation factors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020187004669A 2009-05-20 2010-05-20 혈액응고시간 연장제 Active KR101882408B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2009121834 2009-05-20
JPJP-P-2009-121834 2009-05-20
PCT/JP2010/003401 WO2010134345A1 (ja) 2009-05-20 2010-05-20 血液凝固時間延長剤

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020117027191A Division KR20120024610A (ko) 2009-05-20 2010-05-20 혈액응고시간 연장제

Publications (2)

Publication Number Publication Date
KR20180019781A KR20180019781A (ko) 2018-02-26
KR101882408B1 true KR101882408B1 (ko) 2018-07-27

Family

ID=43126036

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020117027191A Ceased KR20120024610A (ko) 2009-05-20 2010-05-20 혈액응고시간 연장제
KR1020187004669A Active KR101882408B1 (ko) 2009-05-20 2010-05-20 혈액응고시간 연장제

Family Applications Before (1)

Application Number Title Priority Date Filing Date
KR1020117027191A Ceased KR20120024610A (ko) 2009-05-20 2010-05-20 혈액응고시간 연장제

Country Status (7)

Country Link
US (3) US20120064553A1 (enExample)
EP (2) EP3018481B1 (enExample)
JP (2) JPWO2010134345A1 (enExample)
KR (2) KR20120024610A (enExample)
CN (1) CN102428372A (enExample)
CA (1) CA2762611C (enExample)
WO (1) WO2010134345A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5903215B2 (ja) * 2011-02-28 2016-04-13 シスメックス株式会社 ループスアンチコアグラント検出用試薬キット及びループスアンチコアグラントの存否を判定する方法
IL312865B2 (en) 2013-09-11 2025-06-01 Eagle Biologics Inc Liquid protein formulations containing viscosity-lowering agents
CN107072955B (zh) 2014-05-15 2021-06-18 拉尼医疗有限公司 包含多肽和/或蛋白质的固体块的药物组合物和该固体块的制备方法
CA2962768C (en) 2014-10-01 2023-10-10 Alyssa M. Larson Polysaccharide and nucleic acid formulations containing viscosity-lowering agents
CN105372424A (zh) * 2015-11-12 2016-03-02 武汉景川诊断技术股份有限公司 肝促凝血活酶试验测定试剂盒及其制备方法
US20240218344A1 (en) * 2022-12-23 2024-07-04 Instrumentation Laboratory Company Liquid thrombin reagent

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040077092A1 (en) 2002-05-16 2004-04-22 Hans Wielinger Control and calibration material for blood coagulation tests
WO2006063789A1 (de) 2004-12-16 2006-06-22 Roche Diagnostics Gmbh System zur bestimmung von blutkoagulationsparametern

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3074611B2 (ja) 1991-08-30 2000-08-07 シスメックス株式会社 血液凝固測定方法
JP3180824B2 (ja) 1991-08-30 2001-06-25 シスメックス株式会社 血液凝固試薬
US5358853A (en) 1992-08-03 1994-10-25 Akzo Av Liquid thromboplastin reagent
JPH0815263A (ja) 1994-06-24 1996-01-19 Shimadzu Corp 血液凝固分析装置
JP2994557B2 (ja) * 1994-09-02 1999-12-27 株式会社アズウェル フィブリノゲン測定方法およびその測定試薬
DE19549118C2 (de) * 1995-12-29 2000-07-13 Thomas W Stief Hämostaseaktivierungs-Inhibitor und Verfahren zum Hemmen der Hämostaseaktivierung in Blut oder anderen biologischen Flüssigkeiten
TW499412B (en) * 1996-11-26 2002-08-21 Dimensional Pharm Inc Aminoguanidines and alkoxyguanidines as protease inhibitors
EA004180B1 (ru) * 1997-11-26 2004-02-26 3-Дименшенл Фамэсьютикэлс, Инк. Гетероарильные производные аминогуанидинов и алкоксигуанидинов (варианты), способ их получения и их применение в качестве ингибиторов протеаз
JP2004191367A (ja) * 2002-11-28 2004-07-08 Sysmex Corp トロンビン試薬及び検査試薬キット
CN1504580A (zh) * 2002-11-28 2004-06-16 希森美康株式会社 凝血酶试剂以及检查试剂套装
DE10325173B4 (de) * 2003-06-04 2007-11-08 Stief, Thomas, Dr.med. Nachweisverfahren für Fibrinogen und/oder Fibrinogen-Derivate

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040077092A1 (en) 2002-05-16 2004-04-22 Hans Wielinger Control and calibration material for blood coagulation tests
WO2006063789A1 (de) 2004-12-16 2006-06-22 Roche Diagnostics Gmbh System zur bestimmung von blutkoagulationsparametern

Also Published As

Publication number Publication date
JP2015042652A (ja) 2015-03-05
WO2010134345A1 (ja) 2010-11-25
KR20180019781A (ko) 2018-02-26
EP2434290B1 (en) 2016-02-10
US9733262B2 (en) 2017-08-15
EP2434290A4 (en) 2013-01-30
EP3018481B1 (en) 2018-02-21
KR20120024610A (ko) 2012-03-14
CA2762611C (en) 2017-03-28
CN102428372A (zh) 2012-04-25
JP5840273B2 (ja) 2016-01-06
JPWO2010134345A1 (ja) 2012-11-08
EP2434290A1 (en) 2012-03-28
EP3018481A1 (en) 2016-05-11
US20150185236A1 (en) 2015-07-02
CA2762611A1 (en) 2010-11-25
US20140127727A1 (en) 2014-05-08
US20120064553A1 (en) 2012-03-15

Similar Documents

Publication Publication Date Title
KR101882408B1 (ko) 혈액응고시간 연장제
CN108226539B (zh) 一种活化部分凝血活酶时间检测试剂及检测方法
CN104076156A (zh) 活化部分凝血活酶时间测定法和活化部分凝血活酶时间测定用试剂盒
CN109884326B (zh) 血小板聚集功能检测试剂盒
WO1994007145A1 (en) Method of assaying activity of blood coagulation factor xiii and reagent kit therefor
JP2011133396A (ja) 活性化部分トロンボプラスチン時間測定試薬、活性化部分トロンボプラスチン時間測定方法、及び血液凝固抑制物質の有無の判定方法
US7422903B2 (en) Multi-analyte reference solutions
Chandler Initial evaluation of hemostasis: reagent and method selection
WO2001023536A1 (en) Means of stabilizing thrombin and compositions
CN101526538A (zh) 液体白陶土aptt试剂的制备方法
CN112162103A (zh) 一种全自动血栓弹力图活化凝血检测试剂及其制备方法和应用
JP6058726B2 (ja) 血液凝固反応における血液凝固時間延長剤
JP2013145238A (ja) 血液凝固反応における血液凝固時間延長剤
JP7473281B1 (ja) 凝固第ｖｉｉｉ、ｉｘ又はｘｉ因子欠乏血液検体の血液凝固時間調節剤、及び活性化部分トロンボプラスチン時間測定のための試薬
CN120019280A (zh) 缺乏凝血因子xii的血液检体的凝血时间缩短剂
CN115219486B (zh) 一种肝素和低分子肝素抗Xa活性的检测试剂盒及其非疾病诊断检测方法
JP2011069718A (ja) 血液凝固反応における血液凝固時間延長剤
CN108344875B (zh) 提高活化部分凝血活酶时间试剂对肝素敏感性的方法及用途
CN111638375B (zh) 一种用于测定活化部分凝血活酶时间的体外诊断试剂盒
JP6004744B2 (ja) 検体希釈浮遊液およびそれを含む容器
JP2014197019A (ja) 血液凝固反応における血液凝固時間延長剤
CN106596981A (zh) 一种用于测定凝血功能的试剂盒
Favaloro et al. Unfractionated heparin: optimizing laboratory monitoring and reducing unwanted interference in everyday hemostasis test practice
JPH05130899A (ja) 血液凝固測定方法
CN118731335A (zh) 一种抗干扰性强的达比加群含量检测试剂盒

Legal Events

Date Code Title Description
A107 Divisional application of patent
A201 Request for examination
PA0104 Divisional application for international application

Comment text: Divisional Application for International Patent

Patent event code: PA01041R01D

Patent event date: 20180214

Application number text: 1020117027191

Filing date: 20111115

PA0201 Request for examination
PG1501 Laying open of application
PE0701 Decision of registration

Patent event code: PE07011S01D

Comment text: Decision to Grant Registration

Patent event date: 20180511

PR0701 Registration of establishment

Comment text: Registration of Establishment

Patent event date: 20180720

Patent event code: PR07011E01D

PR1002 Payment of registration fee

Payment date: 20180720

End annual number: 3

Start annual number: 1

PG1601 Publication of registration
PR1001 Payment of annual fee

Payment date: 20210629

Start annual number: 4

End annual number: 4

PR1001 Payment of annual fee

Payment date: 20220620

Start annual number: 5

End annual number: 5

PR1001 Payment of annual fee

Payment date: 20230620

Start annual number: 6

End annual number: 6

PR1001 Payment of annual fee

Payment date: 20240620

Start annual number: 7

End annual number: 7

PR1001 Payment of annual fee

Payment date: 20250618

Start annual number: 8

End annual number: 8