KR101874680B1 - 변형된 뉴클레오사이드 또는 뉴클레오타이드 - Google Patents
변형된 뉴클레오사이드 또는 뉴클레오타이드 Download PDFInfo
- Publication number
- KR101874680B1 KR101874680B1 KR1020157029560A KR20157029560A KR101874680B1 KR 101874680 B1 KR101874680 B1 KR 101874680B1 KR 1020157029560 A KR1020157029560 A KR 1020157029560A KR 20157029560 A KR20157029560 A KR 20157029560A KR 101874680 B1 KR101874680 B1 KR 101874680B1
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- South Korea
- Prior art keywords
- modified nucleotide
- nucleoside
- nucleotide
- hydrogen
- molecule
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/14—Pyrrolo-pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/173—Purine radicals with 2-deoxyribosyl as the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2013/055466 WO2014139596A1 (en) | 2013-03-15 | 2013-03-15 | Modified nucleosides or nucleotides |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020187018020A Division KR102230831B1 (ko) | 2013-03-15 | 2013-03-15 | 변형된 뉴클레오사이드 또는 뉴클레오타이드 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20150132474A KR20150132474A (ko) | 2015-11-25 |
| KR101874680B1 true KR101874680B1 (ko) | 2018-07-04 |
Family
ID=47915189
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020157029560A Expired - Fee Related KR101874680B1 (ko) | 2013-03-15 | 2013-03-15 | 변형된 뉴클레오사이드 또는 뉴클레오타이드 |
| KR1020187018020A Active KR102230831B1 (ko) | 2013-03-15 | 2013-03-15 | 변형된 뉴클레오사이드 또는 뉴클레오타이드 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020187018020A Active KR102230831B1 (ko) | 2013-03-15 | 2013-03-15 | 변형된 뉴클레오사이드 또는 뉴클레오타이드 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US9593373B2 (enExample) |
| EP (2) | EP3388442A1 (enExample) |
| JP (1) | JP6333297B2 (enExample) |
| KR (2) | KR101874680B1 (enExample) |
| CN (2) | CN105377869B (enExample) |
| AU (1) | AU2013382358B2 (enExample) |
| BR (1) | BR112015022448B1 (enExample) |
| CA (1) | CA2903095C (enExample) |
| DK (1) | DK2970356T3 (enExample) |
| ES (1) | ES2685549T3 (enExample) |
| WO (1) | WO2014139596A1 (enExample) |
Families Citing this family (78)
| Publication number | Priority date | Publication date | Assignee | Title |
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| GB0129012D0 (en) | 2001-12-04 | 2002-01-23 | Solexa Ltd | Labelled nucleotides |
| US11008359B2 (en) | 2002-08-23 | 2021-05-18 | Illumina Cambridge Limited | Labelled nucleotides |
| US7414116B2 (en) | 2002-08-23 | 2008-08-19 | Illumina Cambridge Limited | Labelled nucleotides |
| SI3363809T1 (sl) | 2002-08-23 | 2020-08-31 | Illumina Cambridge Limited | Modificirani nukleotidi za polinukleotidno sekvenciranje |
| WO2014139596A1 (en) | 2013-03-15 | 2014-09-18 | Illumina Cambridge Limited | Modified nucleosides or nucleotides |
| WO2016065248A1 (en) | 2014-10-23 | 2016-04-28 | Complete Genomics, Inc. | Signal confinement sequencing (scs) and nucleotide analogues for signal confinement sequencing |
| CN114805710B (zh) * | 2014-10-31 | 2023-11-17 | 伊鲁米纳剑桥有限公司 | 聚合物以及dna共聚物涂层 |
| CN108779138B (zh) | 2015-09-28 | 2022-06-17 | 哥伦比亚大学董事会 | 用作dna合成测序的可逆终止物的基于新的二硫键接头的核苷酸的设计与合成 |
| CN109661232B (zh) | 2016-05-23 | 2023-03-03 | 纽约哥伦比亚大学董事会 | 核苷酸衍生物及其使用方法 |
| US10385214B2 (en) | 2016-09-30 | 2019-08-20 | Illumina Cambridge Limited | Fluorescent dyes and their uses as biomarkers |
| WO2018107350A1 (zh) * | 2016-12-13 | 2018-06-21 | 深圳华大基因研究院 | 提纯可逆阻断脱氧核糖核苷三磷酸的方法和测序方法 |
| JP2020504074A (ja) | 2016-12-22 | 2020-02-06 | イルミナ ケンブリッジ リミテッド | クマリン化合物および蛍光標識としてのそれらの使用 |
| CN108239669B (zh) * | 2016-12-23 | 2021-03-16 | 深圳华大智造科技股份有限公司 | 检测可逆性阻断dNTP中非阻断杂质含量的方法和试剂盒 |
| US11591647B2 (en) | 2017-03-06 | 2023-02-28 | Singular Genomics Systems, Inc. | Nucleic acid sequencing-by-synthesis (SBS) methods that combine SBS cycle steps |
| EP3600339A4 (en) | 2017-03-28 | 2021-05-19 | The Trustees of Columbia University in the City of New York | 3'-O-MODIFIED NUCLEOTIDE ANALOGUE WITH DIFFERENT FITTING LINKS TO FIX FLUORESCENT MARKERS TO THE BASE FOR DNA SEQUENCING BY SYNTHESIS |
| WO2018197945A1 (en) | 2017-04-23 | 2018-11-01 | Illumina Cambridge Limited | Compositions and methods for improving sample identification in indexed nucleic acid libraries |
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| PT3663407T (pt) | 2017-08-01 | 2023-03-27 | Complete Genomics Inc | Método de sequenciamento de ácidos nucleicos |
| GB201716931D0 (en) | 2017-10-16 | 2017-11-29 | Illumina Cambridge Ltd | New fluorescent compounds and their use as biomarkers |
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| CN113039191B (zh) | 2018-10-25 | 2024-07-16 | 奇异基因组学系统公司 | 核苷酸类似物 |
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| JP7296409B2 (ja) * | 2018-12-17 | 2023-06-22 | イルミナ ケンブリッジ リミテッド | ポリヌクレオチドシーケンシングに使用するための組成物 |
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| KR102884006B1 (ko) | 2021-05-05 | 2025-11-10 | 일루미나 케임브리지 리미티드 | 비스-붕소 융합 헤테로사이클을 함유하는 형광 염료 및 서열분석에서의 용도 |
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Citations (3)
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| JP2006509040A (ja) * | 2002-08-23 | 2006-03-16 | ソレックサ リミテッド | 修飾されたヌクレオチド |
| WO2012083249A2 (en) | 2010-12-17 | 2012-06-21 | The Trustees Of Columbia University In The City Of New York | Dna sequencing by synthesis using modified nucleotides and nanopore detection |
| WO2012162429A2 (en) | 2011-05-23 | 2012-11-29 | The Trustees Of Columbia University In The City Of New York | Dna sequencing by synthesis using raman and infrared spectroscopy detection |
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| CN105377869B (zh) | 2018-07-10 |
| JP2016512206A (ja) | 2016-04-25 |
| JP6333297B2 (ja) | 2018-05-30 |
| EP2970356A1 (en) | 2016-01-20 |
| CA2903095C (en) | 2018-02-13 |
| US10407721B2 (en) | 2019-09-10 |
| DK2970356T3 (en) | 2018-08-27 |
| US20200087725A1 (en) | 2020-03-19 |
| US20160002721A1 (en) | 2016-01-07 |
| US10982277B2 (en) | 2021-04-20 |
| WO2014139596A1 (en) | 2014-09-18 |
| KR102230831B1 (ko) | 2021-03-22 |
| EP2970356B1 (en) | 2018-05-30 |
| KR20150132474A (ko) | 2015-11-25 |
| KR20180077296A (ko) | 2018-07-06 |
| AU2013382358B2 (en) | 2017-01-12 |
| BR112015022448A2 (pt) | 2017-07-18 |
| BR112015022448B1 (pt) | 2020-12-08 |
| CN108864232B (zh) | 2022-01-04 |
| US9593373B2 (en) | 2017-03-14 |
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