KR101870003B1 - Trpv4 길항제 - Google Patents
Trpv4 길항제 Download PDFInfo
- Publication number
- KR101870003B1 KR101870003B1 KR1020147000958A KR20147000958A KR101870003B1 KR 101870003 B1 KR101870003 B1 KR 101870003B1 KR 1020147000958 A KR1020147000958 A KR 1020147000958A KR 20147000958 A KR20147000958 A KR 20147000958A KR 101870003 B1 KR101870003 B1 KR 101870003B1
- Authority
- KR
- South Korea
- Prior art keywords
- methyl
- carbonitrile
- oxa
- oxo
- azaspiro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 0 **(CC1C[C@](C*2c3cc(C#*)ccc3*=C2)(CO*)CCC1)C(O)=O Chemical compound **(CC1C[C@](C*2c3cc(C#*)ccc3*=C2)(CO*)CCC1)C(O)=O 0.000 description 2
- SNTBXOPQEULPMX-KYJUHHDHSA-N CC(C)(C)OC(OCC(C)(C)c1n[o]c(N(C[C@]2(C[C@@](C)(C[n]3c(cc(cc4)C#N)c4nc3)CCC2)O2)C2=O)c1)=O Chemical compound CC(C)(C)OC(OCC(C)(C)c1n[o]c(N(C[C@]2(C[C@@](C)(C[n]3c(cc(cc4)C#N)c4nc3)CCC2)O2)C2=O)c1)=O SNTBXOPQEULPMX-KYJUHHDHSA-N 0.000 description 1
- SGVXTPXDNMWLBA-UHFFFAOYSA-N CC(C)(C)c1n[o]c(N(CC2CC(C)(C[n]3c4cc(C#N)ccc4nc3)CCC2)C(O)=O)c1Cl Chemical compound CC(C)(C)c1n[o]c(N(CC2CC(C)(C[n]3c4cc(C#N)ccc4nc3)CCC2)C(O)=O)c1Cl SGVXTPXDNMWLBA-UHFFFAOYSA-N 0.000 description 1
- VUKWWYZEELRGAO-UHFFFAOYSA-N CC(C)(c1ncc(N(CC2CC(C)(C[n]3c4cc(C#N)ccc4nc3)CCC2)C(O)=O)nc1)O Chemical compound CC(C)(c1ncc(N(CC2CC(C)(C[n]3c4cc(C#N)ccc4nc3)CCC2)C(O)=O)nc1)O VUKWWYZEELRGAO-UHFFFAOYSA-N 0.000 description 1
- YMCKUWNDXUEZAN-IRXDYDNUSA-N C[C@](C[n]1c2cc(C#N)ccc2nc1)(CCC1)C[C@@]11OC1 Chemical compound C[C@](C[n]1c2cc(C#N)ccc2nc1)(CCC1)C[C@@]11OC1 YMCKUWNDXUEZAN-IRXDYDNUSA-N 0.000 description 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N c1ccncc1 Chemical compound c1ccncc1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N c1cncnc1 Chemical compound c1cncnc1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 description 1
- PBMFSQRYOILNGV-UHFFFAOYSA-N c1cnncc1 Chemical compound c1cnncc1 PBMFSQRYOILNGV-UHFFFAOYSA-N 0.000 description 1
- KYQCOXFCLRTKLS-UHFFFAOYSA-N c1nccnc1 Chemical compound c1nccnc1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
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- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
- C07D419/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Vascular Medicine (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Otolaryngology (AREA)
- Hospice & Palliative Care (AREA)
- Communicable Diseases (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161498110P | 2011-06-17 | 2011-06-17 | |
| US61/498,110 | 2011-06-17 | ||
| PCT/US2012/042622 WO2013012500A1 (en) | 2011-06-17 | 2012-06-15 | Trpv4 antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20140041733A KR20140041733A (ko) | 2014-04-04 |
| KR101870003B1 true KR101870003B1 (ko) | 2018-06-22 |
Family
ID=47558389
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020147000958A Active KR101870003B1 (ko) | 2011-06-17 | 2012-06-15 | Trpv4 길항제 |
Country Status (38)
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2595606T3 (es) * | 2011-06-17 | 2017-01-02 | Glaxosmithkline Intellectual Property (No. 2) Limited | Antagonistas TRPV4 |
| ES2571409T3 (es) | 2011-06-17 | 2016-05-25 | Glaxosmithkline Intellectual Property (No 2) Ltd | Antagonistas espiro-cíclicos de TRPV4 |
| EP2832731A4 (en) | 2012-03-27 | 2015-08-19 | Shionogi & Co | AROMATIC HETEROCYCLIC CHAIN 5-CORE DERIVED DERIVATIVE HAVING TRPV4 INHIBITORY ACTIVITY |
| WO2015046193A1 (ja) | 2013-09-25 | 2015-04-02 | 塩野義製薬株式会社 | Ｔｒｐｖ４阻害活性を有する芳香族複素環式アミン誘導体 |
| WO2017199199A1 (en) | 2016-05-19 | 2017-11-23 | Glaxosmithkline Intellectual Property (No.2) Limited | Trpv4 antagonist |
| US10968209B2 (en) | 2016-05-19 | 2021-04-06 | Glaxosmithkline Intellectual Property (No.2) Limited | TRPV4 antagonist |
| CN115626935B (zh) | 2016-10-03 | 2025-07-15 | 詹森药业有限公司 | 用作prmt5抑制剂的单环和双环系统取代的卡巴核苷类似物 |
| WO2018185701A1 (en) | 2017-04-06 | 2018-10-11 | Glaxosmithkline Intellectual Property (No.2) Limited | Trpv4 antagonists as antitussive agents |
| KR102731924B1 (ko) * | 2017-11-01 | 2024-11-19 | 브리스톨-마이어스 스큅 컴퍼니 | 파르네소이드 x 수용체 조정제로서의 스피로시클릭 화합물 |
| WO2021170811A1 (en) | 2020-02-27 | 2021-09-02 | Glaxosmithkline Intellectual Property (No.2) Limited | Method of treating eye disease using trpv4 antagonists |
| WO2021221169A1 (en) | 2020-04-30 | 2021-11-04 | Raqualia Pharma Inc. | Pyrimidin-4(3h)-one derivatives as trpv4 antagonists |
| CN111704613B (zh) * | 2020-06-23 | 2021-07-06 | 中国人民解放军军事科学院军事医学研究院 | 咪唑类衍生物及其作为trpv4抑制剂的用途 |
| KR20230041680A (ko) * | 2020-07-16 | 2023-03-24 | 라퀄리아 파마 인코포레이티드 | 안구 질환 치료제로서의 trpv4 억제제 |
| CA3261160A1 (en) | 2022-07-08 | 2024-01-11 | Actio Biosciences, Inc. | COMPOUNDS AND THERAPEUTIC METHODS |
| WO2024217429A1 (zh) * | 2023-04-18 | 2024-10-24 | 河北乌图药业有限公司 | 化合物及其在慢性乙型肝炎、肝纤维化、肝癌的治疗中的应用 |
| CN120225516A (zh) * | 2023-04-18 | 2025-06-27 | 河北乌图药业有限公司 | 化合物及其在慢性乙型肝炎、肝纤维化、肝癌的治疗中的应用 |
| CN120641413A (zh) * | 2023-04-18 | 2025-09-12 | 河北乌图药业有限公司 | 化合物及其在慢性乙型肝炎、肝纤维化、肝癌的治疗中的应用 |
| WO2024217452A1 (zh) * | 2023-04-18 | 2024-10-24 | 河北乌图药业有限公司 | 化合物及其在慢性乙型肝炎、肝纤维化、肝癌的治疗中的应用 |
| CN121175303A (zh) * | 2023-04-18 | 2025-12-19 | 河北乌图药业有限公司 | 化合物及其在慢性乙型肝炎、肝纤维化、肝癌的治疗中的应用 |
| CN121511242A (zh) * | 2023-07-07 | 2026-02-10 | 爱克堤欧生物科学股份有限公司 | Trpv4拮抗剂的固体形式 |
| CN117945917A (zh) * | 2023-12-26 | 2024-04-30 | 衢州康鹏化学有限公司 | 一种3-氟-4-硝基苯甲酸的制备方法 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008129007A1 (en) * | 2007-04-24 | 2008-10-30 | Glaxo Group Limited | Benzimidazoles with a hetero spiro-decane residue as npy-y5 antagonists |
| WO2009095377A1 (en) * | 2008-01-29 | 2009-08-06 | Glaxo Group Limited | Spiro compounds as npy y5 receptor antagonists |
| WO2012024183A1 (en) | 2010-08-18 | 2012-02-23 | Merck Sharp & Dohme Corp. | Spiroxazolidinone compounds |
| WO2012174340A1 (en) | 2011-06-17 | 2012-12-20 | Glaxosmithkline Llc | Trpv4 antagonists |
| WO2012174342A1 (en) | 2011-06-17 | 2012-12-20 | Glaxosmithkline Llc | Trpv4 antagonists |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE482945T1 (de) * | 1998-05-26 | 2010-10-15 | Chugai Pharmaceutical Co Ltd | Heterozyklische indolderivate und mono- oder diazaindol-derivate |
| CA2531619A1 (en) * | 2003-07-16 | 2005-01-27 | Neurogen Corporation | Biaryl piperazinyl-pyridine analogues |
| WO2007059608A1 (en) * | 2005-11-23 | 2007-05-31 | Painceptor Pharma Corporation | Compositions and methods for modulating gated ion channels |
| WO2007067756A2 (en) | 2005-12-08 | 2007-06-14 | Amphora Discovery Corporation | Certain chemical entities, compositions, and methods for modulating trpv1 |
| JP5858557B2 (ja) * | 2005-12-22 | 2016-02-10 | ハイドラ バイオサイエンシズ インコーポレイテッドＨｙｄｒａ Ｂｉｏｓｃｉｅｎｃｅｓ，Ｉｎｃ． | 疼痛を処置するためのｔｒｐａ１阻害剤 |
| TW200819457A (en) * | 2006-08-30 | 2008-05-01 | Actelion Pharmaceuticals Ltd | Spiro antibiotic derivatives |
| JP2010517967A (ja) * | 2007-02-01 | 2010-05-27 | グラクソ グループ リミテッド | 摂食障害の治療のための１−オキサ−３−アザスピロ［４，５］デカン−２−オン誘導体 |
| US7998982B2 (en) * | 2007-08-09 | 2011-08-16 | Abbott Laboratories | Amide derivatives as TRPV1 antagonists |
| JP5607046B2 (ja) * | 2008-07-25 | 2014-10-15 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | Ｔｒｐｖ４拮抗薬 |
| JP2012006837A (ja) * | 2008-09-30 | 2012-01-12 | Mochida Pharmaceut Co Ltd | ２−インドールアクリルアミド類縁体 |
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2012
- 2012-06-14 JO JOP/2012/0159A patent/JO3154B1/ar active
- 2012-06-15 AR ARP120102143A patent/AR086958A1/es active IP Right Grant
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- 2012-06-15 US US14/125,378 patent/US9187464B2/en active Active
- 2012-06-15 PE PE2013002807A patent/PE20141943A1/es active IP Right Grant
- 2012-06-15 JP JP2014516020A patent/JP5969017B2/ja active Active
- 2012-06-15 EA EA201490037A patent/EA023616B1/ru not_active IP Right Cessation
- 2012-06-15 EP EP12814591.9A patent/EP2721016B1/en active Active
- 2012-06-15 PH PH1/2013/502463A patent/PH12013502463A1/en unknown
- 2012-06-15 ME MEP-2016-120A patent/ME02416B/me unknown
- 2012-06-15 WO PCT/US2012/042622 patent/WO2013012500A1/en not_active Ceased
- 2012-06-15 EP EP16162808.6A patent/EP3121177B1/en active Active
- 2012-06-15 TW TW101121449A patent/TWI538912B/zh active
- 2012-06-15 BR BR112013032391-4A patent/BR112013032391B1/pt active IP Right Grant
- 2012-06-15 ES ES12814591T patent/ES2569193T3/es active Active
- 2012-06-15 UA UAA201400152A patent/UA113963C2/uk unknown
- 2012-06-15 DK DK12814591.9T patent/DK2721016T3/en active
- 2012-06-15 SG SG2013086483A patent/SG195106A1/en unknown
- 2012-06-15 PT PT128145919T patent/PT2721016E/pt unknown
- 2012-06-15 PL PL12814591T patent/PL2721016T3/pl unknown
- 2012-06-15 MX MX2013014898A patent/MX337440B/es active IP Right Grant
- 2012-06-15 KR KR1020147000958A patent/KR101870003B1/ko active Active
- 2012-06-15 AU AU2012284540A patent/AU2012284540B2/en active Active
- 2012-06-15 UY UY0001034138A patent/UY34138A/es not_active Application Discontinuation
- 2012-06-15 ES ES16162808T patent/ES2688733T3/es active Active
- 2012-06-15 CA CA2839743A patent/CA2839743C/en active Active
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| WO2009095377A1 (en) * | 2008-01-29 | 2009-08-06 | Glaxo Group Limited | Spiro compounds as npy y5 receptor antagonists |
| WO2012024183A1 (en) | 2010-08-18 | 2012-02-23 | Merck Sharp & Dohme Corp. | Spiroxazolidinone compounds |
| WO2012174340A1 (en) | 2011-06-17 | 2012-12-20 | Glaxosmithkline Llc | Trpv4 antagonists |
| WO2012174342A1 (en) | 2011-06-17 | 2012-12-20 | Glaxosmithkline Llc | Trpv4 antagonists |
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