KR101764991B1 - 특히 높은 her2 단백질 농도를 갖는 신생물성 질환의 치료를 위한 타목시펜 유도체 - Google Patents

특히 높은 her2 단백질 농도를 갖는 신생물성 질환의 치료를 위한 타목시펜 유도체 Download PDF

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KR101764991B1
KR101764991B1 KR1020157030376A KR20157030376A KR101764991B1 KR 101764991 B1 KR101764991 B1 KR 101764991B1 KR 1020157030376 A KR1020157030376 A KR 1020157030376A KR 20157030376 A KR20157030376 A KR 20157030376A KR 101764991 B1 KR101764991 B1 KR 101764991B1
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general formula
tamoxifen
tax
derivative
her2
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KR20150144756A (ko
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지리 네우질
잔 스투르사
루카스 워너
Original Assignee
스마트 브레인 에스.알.오.
바이오테크놀로지키 우스타브 에이브이 씨알, 브이.브이.아이.
지리 네우질
케이케이씨쥐 아게
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Priority claimed from CZ2013-308A external-priority patent/CZ304553B6/cs
Priority claimed from CZ2014-66A external-priority patent/CZ305571B6/cs
Application filed by 스마트 브레인 에스.알.오., 바이오테크놀로지키 우스타브 에이브이 씨알, 브이.브이.아이., 지리 네우질, 케이케이씨쥐 아게 filed Critical 스마트 브레인 에스.알.오.
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Assigned to 스프링타이드 벤처스 에스.알.오. reassignment 스프링타이드 벤처스 에스.알.오. 권리지분의 전부이전등록 Assignors: 케이케이씨쥐 아게
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KR1020157030376A 2013-04-24 2014-04-07 특히 높은 her2 단백질 농도를 갖는 신생물성 질환의 치료를 위한 타목시펜 유도체 Expired - Fee Related KR101764991B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CZ2013-308A CZ304553B6 (cs) 2013-04-24 2013-04-24 Deriváty tamoxifenu účinné proti nádorům, zejména s vyšší hladinou proteinu HER2
CZPV2013-308 2013-04-24
CZPV2014-66 2014-01-29
CZ2014-66A CZ305571B6 (cs) 2014-01-29 2014-01-29 Deriváty tamoxifenu k léčbě neoplastických chorob, zejména s vyšší hladinou proteinu HER2
PCT/CZ2014/000035 WO2014173374A1 (en) 2013-04-24 2014-04-07 Tamoxifen derivatives for treatment of neoplastic diseases, especially with high her2 protein level

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KR20150144756A KR20150144756A (ko) 2015-12-28
KR101764991B1 true KR101764991B1 (ko) 2017-08-10

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KR1020157030376A Expired - Fee Related KR101764991B1 (ko) 2013-04-24 2014-04-07 특히 높은 her2 단백질 농도를 갖는 신생물성 질환의 치료를 위한 타목시펜 유도체

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US (1) US9896466B2 (https=)
EP (1) EP2989110B1 (https=)
JP (1) JP6375091B2 (https=)
KR (1) KR101764991B1 (https=)
CN (1) CN105452265B (https=)
AU (1) AU2014256546B2 (https=)
CA (1) CA2909994C (https=)
CY (1) CY1120821T1 (https=)
DK (1) DK2989110T3 (https=)
EA (1) EA029881B1 (https=)
ES (1) ES2699099T3 (https=)
GE (2) GEAP201813996A (https=)
HR (1) HRP20181872T1 (https=)
HU (1) HUE042239T2 (https=)
MD (1) MD4626C1 (https=)
NZ (1) NZ713589A (https=)
PL (1) PL2989110T3 (https=)
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MX383279B (es) * 2015-07-03 2025-03-13 Bayer Cropscience Ag Derivados de n-(1,3,4-oxadiazol-2-il)aril carboxamida con accion herbicida.
EA033155B1 (ru) * 2015-07-03 2019-09-30 Байер Кропсайенс Акциенгезельшафт Гербицидно активные производные n-(тетразол-5-ил)арилкарбоксамида
CN108495618B (zh) * 2016-07-12 2019-08-16 冰洲石生物科技公司 新的化合物及其用途
AU2017312499B2 (en) 2016-08-19 2023-02-02 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Selective estrogen-receptor modulators (SERMs) confer protection against photoreceptor degeneration
EP3330274A1 (en) * 2016-12-01 2018-06-06 Springtide Ventures s.r.o. Compounds for treatment of senescence-related disorders
EP3612177A4 (en) 2017-04-21 2021-01-13 Lunella Biotech, Inc. TARGETING HYPOXIC CARCINOUS STEM CELLS (SCC) USING DOXYCYCLINE: IMPLICATIONS FOR IMPROVING ANTI-ANGIOGENIC THERAPY
US11197872B2 (en) 2017-04-21 2021-12-14 Lunella Biotech, Inc. Vitamin C and doxycycline: a synthetic lethal combination therapy for eradicating cancer stem cells (CSCs)
PH12019502594A1 (en) 2017-05-19 2020-10-26 Lunella Biotech Inc Antimitoscins: targeted inhibitors of mitochondrial biogenesis for eradicating cancer stem cells
JP2021500374A (ja) 2017-10-24 2021-01-07 ルネラ・バイオテック・インコーポレーテッド 標的フラビン含有酵素がミトコンドリア呼吸を阻害することにより癌幹細胞（ｃｓｃｓ）を排除するミトフラボスチン
WO2019104115A1 (en) 2017-11-24 2019-05-31 Lunella Biotech, Inc. Triphenylphosphonium-derivative compounds for eradicating cancer stem cells
WO2019108729A1 (en) 2017-12-01 2019-06-06 Lunella Biotech, Inc. Repurposcins: targeted inhibitors of mitochondrial biogenesis for eradicating cancer stem cells
WO2019113210A1 (en) 2017-12-05 2019-06-13 Anthos Partners, Lp Phosphonium-based ionic drug conjugates
US11559527B2 (en) 2017-12-20 2023-01-24 Lunella Biotech, Inc. Targeting mitochondrial fission through mDIVI-1 derivatives
WO2020214754A1 (en) * 2019-04-16 2020-10-22 Lunella Biotech, Inc. Alkyl-tpp compounds for mitochondria targeting and anti-cancer treatments
EP3753944A1 (en) 2019-06-17 2020-12-23 Institute Of Biotechnology Cas, V.V.I. 3,5-bis(phenyl)-1h-heteroaryl derivatives as medicaments

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EP0551434B1 (en) * 1990-10-01 1995-11-15 The Board Of Regents, The University Of Texas System High affinity tamoxifen derivatives and uses thereof
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CN1997403A (zh) * 2004-07-13 2007-07-11 奥里迪斯生物医学研究及开发有限责任公司 靶向线粒体的抗氧化剂在治疗肝病和上皮癌中的用途
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US9896466B2 (en) 2018-02-20
CA2909994C (en) 2018-06-26
PL2989110T3 (pl) 2019-03-29
MD4626B1 (ro) 2019-04-30
JP6375091B2 (ja) 2018-08-15
HUE042239T2 (hu) 2019-06-28
ES2699099T3 (es) 2019-02-07
GEP20186868B (en) 2018-06-25
AU2014256546A1 (en) 2015-11-12
HRP20181872T1 (hr) 2019-02-08
GEAP201813996A (en) 2018-03-12
JP2016522179A (ja) 2016-07-28
DK2989110T3 (en) 2018-12-03
CN105452265B (zh) 2017-05-10
PT2989110T (pt) 2018-11-15
WO2014173374A1 (en) 2014-10-30
EP2989110B1 (en) 2018-08-08
MD20150117A2 (ro) 2016-08-31
MD4626C1 (ro) 2019-11-30
EP2989110A1 (en) 2016-03-02
EA029881B1 (ru) 2018-05-31
CA2909994A1 (en) 2014-10-30
AU2014256546B2 (en) 2017-03-30
HK1216317A1 (zh) 2016-11-04
SI2989110T1 (sl) 2019-01-31
KR20150144756A (ko) 2015-12-28
US20160075726A1 (en) 2016-03-17
EA201591918A1 (ru) 2016-02-29
CN105452265A (zh) 2016-03-30
CY1120821T1 (el) 2019-12-11
NZ713589A (en) 2017-12-22
UA116469C2 (uk) 2018-03-26

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